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1. 发明授权

US6149818A Method for separating components in liquid specimen and apparatus used in said method 失效
标题翻译：用于分离液体试样中的组分的方法和用于所述方法的装置
公开(公告)号：US6149818A
公开(公告)日：2000-11-21
申请号：US386149
申请日：1999-08-31
申请人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
发明人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
IPC分类号： B01D15/08 , G01N30/16 , G01N30/24 , G01N30/40 , G01N30/88
CPC分类号： G01N30/40 , B01D15/1807 , B01D15/14 , G01N2030/402 , G01N2030/407 , G01N30/16 , G01N30/24 , G01N30/88
摘要： The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure. As a result, it is possible to avoid carryover, to prevent the increase of inner pressure in the column of the separation device and to prevent ineffective separating operation caused by clogging of the column.
摘要翻译：本发明的目的是提供一种用于分离液体试样中的组分和所述方法中使用的装置的方法，即使当使用洗涤溶液不洗涤试样注射器时也可以避免携带，并且避免即使使用相同的分离装置多次分离多个液体样品，分离装置的塔内部压力增加或分离操作无效。在本发明中，将液体试样从与保留吸附剂的分离装置的洗脱方向相反的方向引入分离装置，通过从洗脱液与洗脱液一起分离和洗脱试样，追踪微量的不溶物残留在样品导入通道上的样品可以通过洗脱程序除去。结果，可以避免残留，以防止分离装置的塔中的内压增加，并且防止由于柱的堵塞而导致的无效的分离操作。

2. 发明授权

US6156195A Method for separating components in liquid specimen and apparatus used in said method 失效
公开(公告)号：US6156195A
公开(公告)日：2000-12-05
申请号：US48327
申请日：1998-03-26
申请人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
发明人： Kenji Nakamura , Shinji Satomura , Masayoshi Hayashi , Hideyoshi Arashima , Tetsushi Okuyama , Nobuhiro Hanafusa , Koji Tanimizu
IPC分类号： B01D15/08 , G01N30/16 , G01N30/24 , G01N30/40 , G01N30/88
CPC分类号： G01N30/40 , B01D15/1807 , B01D15/14 , G01N2030/402 , G01N2030/407 , G01N30/16 , G01N30/24 , G01N30/88
摘要： The object of the present invention is to provide a method for separating components in a liquid specimen and an apparatus used in said method, by which it is possible to avoid carryover even when the specimen injector is not washed using washing solution and also to avoid the increase of inner pressure in column of the separation device or ineffective separating operation even when many liquid specimens are separated by many times using the same separation device. In the present invention, the liquid specimen is introduced into the separation device from a direction opposite to eluting direction of the separation device which retains an adsorbent, and by separating and eluting the specimen from eluting outlet together with the eluant, trace quantity of insoluble substances and the specimen remained on the specimen introducing passage can be removed by elution procedure. As a result, it is possible to avoid carryover, to prevent the increase of inner pressure in the column of the separation device and to prevent ineffective separating operation caused by clogging of the column.

3. 发明授权

US08187442B2 Microchip processing method and apparatus 有权
标题翻译： Microchip的加工方法和装置
公开(公告)号：US08187442B2
公开(公告)日：2012-05-29
申请号：US12347387
申请日：2008-12-31
申请人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
发明人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
IPC分类号： G01N27/453
CPC分类号： G01N27/44743 , G01N30/24 , G01N30/6095 , G01N30/88 , G01N2030/8827 , Y10T436/25 , Y10T436/25375
摘要： The processing apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part common to the multiple main flow paths for performing a pretreatment step prior to an analysis step in each of the multiple main flow paths; a processing part for performing analysis in each of the main flow paths independently of the others; and a control part controlling an operation in the pretreatment part so that when a pretreatment step for one main flow path ends, a pretreatment for a next main flow path starts and further controlling an operation in the processing part so that an analysis is subsequently performed for the main flow path where the pretreatment step has ended.
摘要翻译：用于微芯片的处理装置，每个至少具有在片状构件内执行用于分析的样品的迁移的主流路，包括保持微型芯片以使得设置多个主流路的保持部; 用于在多个主流路中的每一个中执行分析步骤之前的预处理步骤的多个主流路通用的预处理部分; 处理部，用于独立于其他主流路进行分析; 以及控制部，其控制所述预处理部的操作，使得当一个主流路的预处理步骤结束时，开始对下一主流路进行预处理，并且进一步控制所述处理部中的操作，以便随后进行分析预处理步骤结束的主流路。

4. 发明申请

US20100221816A1 REACTION KIT 失效
标题翻译：反应套
公开(公告)号：US20100221816A1
公开(公告)日：2010-09-02
申请号：US12279840
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
IPC分类号： C12M1/34 , G01N35/10 , B01L3/00 , G01N1/28 , G01N27/447
CPC分类号： B01L3/5085 , B01L3/0217 , B01L2200/04 , B01L2200/141 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/123
摘要： Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction of a sample and a reagent container (12) containing a reagent used for the reaction of a sample and sealed with a film (14); a dispensation tip (20) arranged on the top surface side of the reaction plate (2); a cover (24) covering a space above the top surface of the reaction plate (2) and movably supporting the dispensation tip (20) so that a distal end thereof is located inside the space covered with the cover (4) and a proximal end thereof is located outside the space; and a sample container (32) for introducing a sample into the space covered with the cover (24) from the outside through a sealable opening (31) provided in a part of the cover (24).
摘要翻译：公开了一种用于防止异物从外部进入反应板并引起周围环境污染的反应试剂盒。反应试剂盒包括：反应板（2），其顶表面上具有用于进行样品和含有用于反应的试剂的试剂容器（12）的反应的反应容器（4）用薄膜（14）取样并密封; 设置在所述反作用板（2）的上表面侧的分配头（20）; 覆盖反应板（2）的顶表面上方的空间并且可移动地支撑分配尖端（20）的盖（24），使得其远端位于用盖（4）覆盖的空间内部，并且近端位于空间外面; 以及用于通过设置在所述盖（24）的一部分中的可密封开口（31）将样品从外部引入到被所述盖（24）覆盖的空间中的样本容器（32）。

5. 发明申请

US20050161402A1 Microchip processing method and apparatus 有权
标题翻译： Microchip的加工方法和装置
公开(公告)号：US20050161402A1
公开(公告)日：2005-07-28
申请号：US11041425
申请日：2005-01-25
申请人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
发明人： Nobuhiro Hanafusa , Akihiro Arai , Koji Tanimizu
IPC分类号： G01N31/20 , G01N27/447 , G01N30/16 , G01N30/24 , G01N30/26 , G01N30/32 , G01N30/60 , G01N30/74 , G01N30/88 , G01N37/00 , B01D15/08
CPC分类号： G01N27/44743 , G01N30/24 , G01N30/6095 , G01N30/88 , G01N2030/8827 , Y10T436/25 , Y10T436/25375
摘要： The processing apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part common to the multiple main flow paths for performing a pretreatment step prior to an analysis step in each of the multiple main flow paths; a processing part for performing analysis in each of the main flow paths independently of the others; and a control part controlling an operation in the pretreatment part so that when a pretreatment step for one main flow path ends, a pretreatment for a next main flow path starts and further controlling an operation in the processing part so that an analysis is subsequently performed for the main flow path where the pretreatment step has ended.
摘要翻译：用于微芯片的处理装置，每个至少具有在片状构件内执行用于分析的样品的迁移的主流路，包括保持微型芯片以使得设置多个主流路的保持部; 用于在多个主流路中的每一个中执行分析步骤之前的预处理步骤的多个主流路通用的预处理部分; 处理部，用于独立于其他主流路进行分析; 以及控制部，其控制所述预处理部的操作，使得当一个主流路的预处理步骤结束时，开始对下一主流路进行预处理，并且进一步控制所述处理部中的操作，以便随后进行分析预处理步骤结束的主流路。

6. 发明申请

US20100213067A1 REACTION KIT TREATING EQUIPMENT 失效
标题翻译：反应套件处理设备
公开(公告)号：US20100213067A1
公开(公告)日：2010-08-26
申请号：US12279830
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
IPC分类号： G01N27/26 , G01N30/00 , G01N21/64 , G01N21/00 , G01N27/00
CPC分类号： G01N35/02 , G01N33/54366
摘要： Upper space on the front surface side of a reaction plate, provided with at least a reaction container causing reaction in a sample and a reagent container containing a reagent used for reaction with the sample, is covered with an airtight cover. A dispensation tip (20) for transporting liquid on the reaction plate is arranged in such a way that the distal end side is located on the inside of the covered space and the proximal portion is located on the outside. In order to handle a reaction kit (80) supported movably in the perpendicular direction and in the in-plane direction with respect to the front surface of the reaction plate, a table (82) for attaching the reaction kit (80), a drive unit (36) engaging with the proximal end of the dispensation tip (20) and driving the movement and the dispensation operation of the tip (20), a detection unit (38) for optically detecting a reaction product by receiving light generated through interaction with the reaction product on the reaction plate or the light generated from the reaction product, and a control section for controlling at least the dispensation operation by the drive unit (36) and the detection operation by the detection unit (38) are provided.
摘要翻译：反应板的前表面上的至少一个反应容器在样品中产生反应的反应容器和含有用于与样品反应的试剂的试剂容器被覆盖有气密盖。用于在反应板上输送液体的分注尖端（20）以使得远端侧位于被覆盖空间的内侧并且近端部位于外侧的方式布置。为了处理相对于反应板的前表面在垂直方向和面内方向上可移动地支撑的反应组件（80），用于安装反应组件（80）的工作台（82），驱动装置单元（36）与分注尖端（20）的近端接合并驱动尖端（20）的移动和分配操作;检测单元（38），用于通过接收通过与提供反应板上的反应产物或由反应产物产生的光，以及用于通过驱动单元（36）至少控制分配操作和由检测单元（38）进行的检测操作的控制部分。

7. 发明授权

US08333930B2 Reaction kit treating equipment 失效
标题翻译：反应试剂盒处理设备
公开(公告)号：US08333930B2
公开(公告)日：2012-12-18
申请号：US12279830
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi
IPC分类号： B01J8/00
CPC分类号： G01N35/02 , G01N33/54366
摘要： Upper space on the front surface side of a reaction plate, provided with at least a reaction container causing reaction in a sample and a reagent container containing a reagent used for reaction with the sample, is covered with an airtight cover. A dispensation tip (20) for transporting liquid on the reaction plate is arranged in such a way that the distal end side is located on the inside of the covered space and the proximal portion is located on the outside. In order to handle a reaction kit (80) supported movably in the perpendicular direction and in the in-plane direction with respect to the front surface of the reaction plate, a table (82) for attaching the reaction kit (80), a drive unit (36) engaging with the proximal end of the dispensation tip (20) and driving the movement and the dispensation operation of the tip (20), a detection unit (38) for optically detecting a reaction product by receiving light generated through interaction with the reaction product on the reaction plate or the light generated from the reaction product, and a control section for controlling at least the dispensation operation by the drive unit (36) and the detection operation by the detection unit (38) are provided.
摘要翻译：反应板的前表面上的至少一个反应容器在样品中产生反应的反应容器和含有用于与样品反应的试剂的试剂容器被覆盖有气密盖。用于在反应板上输送液体的分注尖端（20）以使得远端侧位于被覆盖空间的内侧并且近端部位于外侧的方式布置。为了处理相对于反应板的前表面在垂直方向和面内方向上可移动地支撑的反应组件（80），用于安装反应组件（80）的工作台（82），驱动装置单元（36）与分注尖端（20）的近端接合并驱动尖端（20）的移动和分配操作;检测单元（38），用于通过接收通过与提供反应板上的反应产物或由反应产物产生的光，以及用于通过驱动单元（36）至少控制分配操作和由检测单元（38）进行的检测操作的控制部分。

8. 发明授权

US08257966B2 Reaction kit 失效
标题翻译：反应试剂盒
公开(公告)号：US08257966B2
公开(公告)日：2012-09-04
申请号：US12279840
申请日：2007-02-14
申请人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
发明人： Nobuhiro Hanafusa , Koretsugu Ogata , Koji Tanimizu , Tomoichi Takahashi , Atsushi Inami , Ryuh Konoshita , Masami Maekawa , Takanori Mochizuki
IPC分类号： C12M1/34 , B01L3/00 , G01N35/10 , G01N1/28 , G01N27/447
CPC分类号： B01L3/5085 , B01L3/0217 , B01L2200/04 , B01L2200/141 , B01L2200/16 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/0681 , B01L2300/123
摘要： Disclosed is a reaction kit for preventing the entry of foreign matter into a reaction plate from the outside and the pollution of a surrounding environment. The reaction kit includes: a reaction plate (2) having, on the top surface side thereof, a reaction container (4) for carrying out the reaction of a sample and a reagent container (12) containing a reagent used for the reaction of a sample and sealed with a film (14); a dispensation tip (20) arranged on the top surface side of the reaction plate (2); a cover (24) covering a space above the top surface of the reaction plate (2) and movably supporting the dispensation tip (20) so that a distal end thereof is located inside the space covered with the cover (4) and a proximal end thereof is located outside the space; and a sample container (32) for introducing a sample into the space covered with the cover (24) from the outside through a sealable opening (31) provided in a part of the cover (24).
摘要翻译：公开了一种用于防止异物从外部进入反应板并引起周围环境污染的反应试剂盒。反应试剂盒包括：反应板（2），其顶表面上具有用于进行样品和含有用于反应的试剂的试剂容器（12）的反应的反应容器（4）用薄膜（14）取样并密封; 设置在所述反作用板（2）的上表面侧的分配头（20）; 覆盖反应板（2）的顶表面上方的空间并且可移动地支撑分配尖端（20）的盖（24），使得其远端位于用盖（4）覆盖的空间内部，并且近端位于空间外面; 以及用于通过设置在所述盖（24）的一部分中的可密封开口（31）将样品从外部引入到被所述盖（24）覆盖的空间中的样本容器（32）。

9. 发明授权

US07678254B2 Microchip processing method and apparatus 有权
标题翻译： Microchip的加工方法和装置
公开(公告)号：US07678254B2
公开(公告)日：2010-03-16
申请号：US11041425
申请日：2005-01-25
申请人： Nobuhiro Hanafusa , Akihir{dot over (o)} Arai , Koji Tanimizu
发明人： Nobuhiro Hanafusa , Akihir{dot over (o)} Arai , Koji Tanimizu
IPC分类号： G01N27/447 , G01N27/453
CPC分类号： G01N27/44743 , G01N30/24 , G01N30/6095 , G01N30/88 , G01N2030/8827 , Y10T436/25 , Y10T436/25375
摘要： The processing apparatus for microchips, each at least having a main flow path performing migration of a sample for analysis inside a sheet-like member, comprises a holding part holding microchips so that the multiple main flow paths are provided; a pretreatment part common to the multiple main flow paths for performing a pretreatment step prior to an analysis step in each of the multiple main flow paths; a processing part for performing analysis in each of the main flow paths independently of the others; and a control part controlling an operation in the pretreatment part so that when a pretreatment step for one main flow path ends, a pretreatment for a next main flow path starts and further controlling an operation in the processing part so that an analysis is subsequently performed for the main flow path where the pretreatment step has ended.
摘要翻译：用于微芯片的处理装置，每个至少具有在片状构件内执行用于分析的样品的迁移的主流路，包括保持微型芯片以使得设置多个主流路的保持部; 用于在多个主流路中的每一个中执行分析步骤之前的预处理步骤的多个主流路通用的预处理部分; 处理部，用于独立于其他主流路进行分析; 以及控制部，其控制所述预处理部的操作，使得当一个主流路的预处理步骤结束时，开始对下一主流路进行预处理，并且进一步控制所述处理部中的操作，以便随后进行分析预处理步骤结束的主流路。

10. 发明授权

US5439646A Blood coagulation analyzer 失效
标题翻译：凝血分析仪
公开(公告)号：US5439646A
公开(公告)日：1995-08-08
申请号：US121375
申请日：1993-09-15
申请人： Koji Tanimizu , Toshimi Kadota
发明人： Koji Tanimizu , Toshimi Kadota
IPC分类号： B65G47/90 , G01N33/49 , G01N33/53 , G01N33/86 , G01N35/00 , G01N35/02 , G01N35/04 , G01N35/10
CPC分类号： G01N33/5302 , G01N33/4905 , G01N33/86 , G01N35/026 , G01N2035/0097 , G01N2035/0415 , G01N2035/1076 , G01N2035/1086 , G01N35/025 , Y10T436/11 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/2575
摘要： A plurality of measuring modules are arranged on a table of a reaction part. The measuring module has one removable cell, and is provided with light sources and photodetectors. In proximity to the reaction part is a cell transfer part for mounting and dismounting the cell on and from the measuring module, a sampling probe for dispensing a sample into the cell, and a reagent probe for dispensing a prescribed reagent into the cell in response to a measurement item. A time from supply of each cell or dispensing of each sample to or in the reaction part to dispensing of a first reagent is controlled to be constant with no regard to the measurement items.
摘要翻译：多个测量模块布置在反应部件的工作台上。测量模块有一个可拆卸的单元，并配有光源和光电探测器。在反应部分附近是用于在测量模块上安装和拆卸电池的电池转移部件，用于将样品分配到电池中的采样探针和用于响应于一个测量项目。将每个电池供应的时间或每个样品分配到反应部分中或在反应部分中分配第一试剂的时间被控制为恒定，而不考虑测量项目。

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