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1. 发明申请

US20100324469A1 DRUG PRODUCT, A METHOD OF ADMINISTRATING A VACCINE USING THE DRUG PRODUCT, AND AN APPARATUS FOR IONTOPHORESIS 审中-公开
标题翻译：药物产品，使用药物产品的疫苗管理方法和用于静脉注射的装置
公开(公告)号：US20100324469A1
公开(公告)日：2010-12-23
申请号：US12681508
申请日：2008-10-03
申请人： Kenji Mori , Takamitsu Miyagi , Yayoi Shimada , Kuei-Chen Chiang , Naoya Ohmori , Takeshi Goto , Shuji Sato
发明人： Kenji Mori , Takamitsu Miyagi , Yayoi Shimada , Kuei-Chen Chiang , Naoya Ohmori , Takeshi Goto , Shuji Sato
IPC分类号： A61N1/30
CPC分类号： A61N1/0448 , A61K39/00 , A61K2039/53 , A61K2039/54 , A61N1/0436 , A61N1/0444 , A61N1/30 , A61N1/325
摘要： It is an object of the present invention to provide a method and an apparatus capable of noninvasively administrating vaccine through the skin, and thereby making the immune response activate. A drug product according to the present invention is characterized in that the drug product has a support medium, an electrode formed on the support medium and protected partly by an insulating material for avoiding a direct cutaneous contact, a vaccine containing layer for containing a vaccine, wherein the vaccine is an antigen for inducing an immune suppression protein. A method of administrating a vaccine according to the present invention is characterized in that the vaccine is administrated by the iontophoresis using the drug product according to the drug product of the present invention as an electrode. An apparatus for the iontophoresis according to the present invention is characterized in that the drug product according to the present invention is used as an electrode.
摘要翻译：本发明的目的是提供一种能够通过皮肤无刺激地施用疫苗，从而使免疫反应活化的方法和装置。根据本发明的药物产品的特征在于药物产品具有载体介质，形成在载体介质上的电极，部分地被绝缘材料保护以避免直接皮肤接触，含有疫苗的疫苗含有层，其中所述疫苗是用于诱导免疫抑制蛋白的抗原。本发明疫苗的施用方法的特征在于，使用本发明药物的药物作为电极，通过离子电渗法给予疫苗。本发明的离子电渗疗法的特征在于，将本发明的药物用作电极。

2. 发明授权

US09701739B2 Monoclonal antibody having immunosuppressive activity or antigen binding fragment thereof 有权
公开(公告)号：US09701739B2
公开(公告)日：2017-07-11
申请号：US13817714
申请日：2011-08-19
申请人： Shuji Sato , Takeshi Goto , Shigeru Goto , Toshiaki Nakano , Naoya Ohmori , Kueichen Chiang , Yayoi Shimada , Kenji Mori , Takamitsu Miyagi
发明人： Shuji Sato , Takeshi Goto , Shigeru Goto , Toshiaki Nakano , Naoya Ohmori , Kueichen Chiang , Yayoi Shimada , Kenji Mori , Takamitsu Miyagi
IPC分类号： A61K39/395 , C07K16/18 , C07K7/08
CPC分类号： C07K16/18 , A61K39/39541 , C07K7/08 , C07K2317/34
摘要： The present invention relates to a monoclonal antibody having excellent immunosuppressive activity or an antigen binding fragment thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide consisting an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1.

3. 发明申请

US20140010815A1 MONOCLONAL ANTIBODY HAVING IMMUNOSUPPRESSIVE ACTIVITY OR ANTIGEN BINDING FRAGMENT THEREOF 有权
标题翻译：具有免疫抑制活性的单克隆抗体或其抗体结合片段
公开(公告)号：US20140010815A1
公开(公告)日：2014-01-09
申请号：US13817714
申请日：2011-08-19
申请人： Shuji Sato , Takeshi Goto , Shigeru Goto , Toshiaki Nakano , Naoya Ohmori , Kueichen Chiang , Yayoi Shimada , Kenji Mori , Takamitsu Miyagi
发明人： Shuji Sato , Takeshi Goto , Shigeru Goto , Toshiaki Nakano , Naoya Ohmori , Kueichen Chiang , Yayoi Shimada , Kenji Mori , Takamitsu Miyagi
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K39/39541 , C07K7/08 , C07K2317/34
摘要： The present invention relates to a monoclonal antibody having excellent immunosuppressive activity or an antigen binding fragment thereof. More specifically, the present invention relates to a monoclonal antibody or an antigen binding fragment thereof, which binds to a peptide consisting an amino acid sequence represented by SSVLYGGPPSAA (SEQ ID NO: 1) or a conjugate of the peptide and a pharmaceutically acceptable carrier, the monoclonal antibody or an antigen binding fragment thereof having a higher binding affinity for core histone than for histone H1.
摘要翻译：本发明涉及具有优异免疫抑制活性的单克隆抗体或其抗原结合片段。更具体地，本发明涉及与由SSVLYGGPPSAA（SEQ ID NO：1）表示的氨基酸序列或肽与药学上可接受的载体的缀合物组成的肽结合的单克隆抗体或其抗原结合片段，对于核心组蛋白具有比组蛋白H1更高的结合亲和力的单克隆抗体或其抗原结合片段。

4. 发明申请

US20120165782A1 PHARMACEUTICAL COMPOSITION OF AN IONTOPHORESIS 有权
标题翻译：药物的药物组合物
公开(公告)号：US20120165782A1
公开(公告)日：2012-06-28
申请号：US13388295
申请日：2010-07-28
申请人： Akihiro Hasui , Takamitsu Miyagi
发明人： Akihiro Hasui , Takamitsu Miyagi
IPC分类号： A61K31/661 , A61P29/00 , A61N1/30 , A61P21/00 , A61P15/02 , A61K9/00 , A61P19/02
CPC分类号： A61K31/573 , A61K9/0009 , A61K47/18 , A61K47/32 , A61N1/0428 , A61N1/0432 , A61N1/0448 , A61N1/30
摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.
摘要翻译：本发明的目的是制备用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且在制造时容易混合和填充，并且可以以低成本制造。根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。此外，在本发明的离子电渗疗法用药物组合物的优选实施方式中，所述组合物的特征在于，所述非离子型合成聚合物为聚乙烯醇（PVA）。此外，在本发明的离子电渗用药物组合物的优选实施方式中，所述组合物的特征在于，所述聚乙烯醇（PVA）的混合量为0.5〜30.0重量％。

5. 发明授权

US08652522B2 Pharmaceutical composition of an iontophoresis 有权
标题翻译：离子电渗疗法的药物组成
公开(公告)号：US08652522B2
公开(公告)日：2014-02-18
申请号：US13388295
申请日：2010-07-28
申请人： Akihiro Hasui , Takamitsu Miyagi
发明人： Akihiro Hasui , Takamitsu Miyagi
IPC分类号： A61K9/14 , A61N1/30
CPC分类号： A61K31/573 , A61K9/0009 , A61K47/18 , A61K47/32 , A61N1/0428 , A61N1/0432 , A61N1/0448 , A61N1/30
摘要： It is an object of the present inventions to produce a pharmaceutical composition for the iontophoresis wherein a drug stability is excellent, and it is easy to blend and fill up when manufactured and it is possible to manufacture at low cost. A pharmaceutical composition for an iontophoresis according to the present invention, is characterized in that the composition contains a nonionic synthetic polymer, betamethasone sodium phosphate and solvent. Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the nonionic synthetic polymer is polyvinyl alcohol (PVA). Furthermore, in a preferred embodiment of a pharmaceutical composition for an iontophoresis according to the present invention, the composition is characterized in that the mixing amount of the polyvinyl alcohol (PVA) is 0.5 to 30.0 percent by weight.
摘要翻译：本发明的目的是制备用于离子电渗疗法的药物组合物，其中药物稳定性优异，并且在制造时容易混合和填充，并且可以以低成本制造。根据本发明的用于离子电渗疗法的药物组合物的特征在于，所述组合物含有非离子合成聚合物，倍他米松磷酸钠和溶剂。此外，在本发明的离子电渗疗法用药物组合物的优选实施方式中，所述组合物的特征在于，所述非离子型合成聚合物为聚乙烯醇（PVA）。此外，在本发明的离子电渗用药物组合物的优选实施方式中，所述组合物的特征在于，所述聚乙烯醇（PVA）的混合量为0.5〜30.0重量％。

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