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1. 发明申请

US20050113738A1 Iontophoresis electrode device 审中-公开
标题翻译：离子电渗电极装置
公开(公告)号：US20050113738A1
公开(公告)日：2005-05-26
申请号：US10500537
申请日：2003-01-09
申请人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
发明人： Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi , Takuji Oikawa , Shuji Sato , Naruhito Higo , Hiroyuki Maeda , Kenji Mori
IPC分类号： A61N1/30
CPC分类号： A61N1/0436 , A61N1/044
摘要： There is provided an electrode device for iontophoresis capable of retaining a drug in a gel state with a force just enough so as not to disturb the treatment. In order to retain the gel (70), a sheet member (50) composed of a nonwoven fabric is laminated on a base film (20) including an electrode layer (30) so as to be integrated with the base film (20). The sheet member (50) has a property for allowing the gel (70) to permeate therein. Owing to this feature, the gel (70) loaded on the sheet member (50) is retained thereon with at least a part of the gel (70) permeated therein.
摘要翻译：提供了一种用于离子电渗疗法的电极装置，其能够以刚好足够的力将药物保持在凝胶状态，以免扰乱治疗。为了保持凝胶（70），将由非织造织物构成的片材（50）层叠在包含电极层（30）的基膜（20）上以与基膜（20）一体化。片材（50）具有使凝胶（70）渗透到其中的性质。由于这个特征，装载在片材（50）上的凝胶（70）保留在其上，凝胶（70）的至少一部分渗入其中。

2. 发明授权

US6141582A Iontophoresis system and its control process of current 失效
标题翻译：离子电渗系统及其电流控制过程
公开(公告)号：US6141582A
公开(公告)日：2000-10-31
申请号：US163
申请日：1998-05-05
申请人： Kenji Mori , Katsuhiro Nakamura , Naruhito Higo , Noriyuki Kuzumaki
发明人： Kenji Mori , Katsuhiro Nakamura , Naruhito Higo , Noriyuki Kuzumaki
IPC分类号： A61N1/32 , A61N1/30
CPC分类号： A61N1/044 , A61N1/0436 , A61N1/0448 , A61N1/325
摘要： An iontophoresis system and its control process for current are proposed, which system can decrease variation in drug delivery quantity due to the individual difference of impedance of skin or mucosal membrane, and avoid any decrease of the delivery quantity of drug in a donor device, thereby to obtain excellent medicinal effect, safety, reliability, and productivity, comprising said donor device, a reference device, a current detection unit for measuring as an effective current value the difference between the value of an applied current passing between the donor and reference devices during application of pulse voltage/current and the value of a discharged current whose electric charge which the living body has been equipped with is released by a short-circuit formed between said donor and reference devices when the application of pulse voltage/current is suspended, and a feedback control unit of making the amplitude of the pulse voltage/current variable to control the effective current value. The control process for current of the iontophoresis system of the present invention comprises an effective current measurement step of measuring said effective current value and a feedback control step of controlling said effective current value.
摘要翻译： PCT No.PCT / JP96 / 02286 Sec。 371日期：1998年5月5日 102（e）日期1998年5月5日PCT提交1996年8月12日PCT公布。公开号WO97 / 07853 日期1997年3月6日提出了离子电渗系统及其电流控制过程，由于皮肤或粘膜阻抗的个体差异，该系统可以减少药物输送量的变化，避免药物输送量的下降供体装置，从而获得优异的药物效果，安全性，可靠性和生产率，包括所述供体装置，参考装置，电流检测单元，用于将作为有效电流值的施加电流的值施加脉冲电压/电流时的供体和参考装置以及当所述供体和参考装置之间形成的短路而释放出具有活体的电荷的放电电流的值，当施加脉冲电压/ 电流被暂停，并且使得脉冲电压/电流的幅度可变的反馈控制单元控制t 他有效的当前价值。本发明的离子电渗系统的电流控制过程包括测量所述有效电流值的有效电流测量步骤和控制所述有效电流值的反馈控制步骤。

3. 发明授权

US6006130A Iontophoresis electrode and iontophoresis device using the electrode 失效
标题翻译：离子电渗电极和离子电渗装置使用电极
公开(公告)号：US6006130A
公开(公告)日：1999-12-21
申请号：US750712
申请日：1997-02-24
申请人： Naruhito Higo , Kenji Mori , Kazuya Katagai , Katsuhiro Nakamura
发明人： Naruhito Higo , Kenji Mori , Kazuya Katagai , Katsuhiro Nakamura
IPC分类号： A61N1/04 , A61N1/05 , A61N1/30
CPC分类号： A61N1/0436 , A61N1/05 , A61N1/30
摘要： This invention relates to an iontophoresis electrode which is applicable to mucous membranes and oral mucous membranes, and especially capable of sticking directly on human oral mucous membranes and excellent in efficiently administering medicine and extremely easy to handle and lightweight.An iontophoresis electrode (Ka) of this invention comprises a backing layer (1) and, a conductive layer for current dispersion (2) made of silver or silver chloride that laminated on the backing layer (1) and, a spacer layer (3) of film, sheet, or cloth shape which is made of dried polymer layer with water soluble and swelling properties and laminated on the conductive layer for current dispersion, and can be sticked to the oral mucous membrane.
摘要翻译： PCT No.PCT / JP95 / 01193 Sec。 371日期1997年2月24日 102（e）日期1997年2月24日PCT提交1995年6月15日PCT公布。 WO95 / 35132 PCT出版物日期1995年12月28日本发明涉及一种适用于粘膜和口腔粘膜的离子电渗电极，特别是能够直接粘贴在人体口腔粘膜上，优异的高效投药，极易处理，重量轻。本发明的离子电渗电极（Ka）包括背衬层（1）和层压在背衬层（1）上的由银或氯化银制成的用于电流分散（2）的导电层，以及间隔层（3）由具有水溶性和溶胀性的干燥聚合物层制成的薄膜，片材或布料形状，层压在导电层上用于电流分散，并且可以粘贴到口腔粘膜上。

4. 发明申请

US20050085860A1 Transdermal/transmucosal preparations for electroporation 审中-公开
标题翻译：用于电穿孔的透皮/透粘膜制剂
公开(公告)号：US20050085860A1
公开(公告)日：2005-04-21
申请号：US10501946
申请日：2003-01-20
申请人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Seiji Tokumoto , Naruhito Higo , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/70 , A61K31/05 , A61K31/155 , A61K31/192 , A61K31/196 , A61K31/375 , A61K47/36 , A61N1/30 , A61P25/04 , A61P39/06 , A61P43/00
CPC分类号： A61N1/30
摘要： A preparation for transdermal or transmucosal administration for electroporation is provided that enables efficient administration of a compound to be administered such as a drug. The preparation for transdermal or transmucosal administration for electroporation includes a drug reservoir (11) having dispersed therein a compound to be administered (physiologically active substance), such as a drug, in a base of a solid or semisolid form, a backing (12) retaining the drug reservoir, and a pair of electrodes for electroporation (13) provided on the drug reservoir (11). An adhesive layer (14) is provided on a flange portion of the backing (12). An insulating layer (15) is provided on at least a section of the electrodes for electroporation (13) contacting an application site other than a section on the drug reservoir (11).
摘要翻译：提供了用于电穿孔的经皮或经粘膜给药的制剂，其能够有效施用待给药的化合物例如药物。透皮或经粘膜给药用于电穿孔的制剂包括其中分散有固体或半固体形式的基质中的待给药化合物（生理活性物质）如药物的药物储存器（11），背衬（12）保持药物储存器和设置在药物储存器（11）上的一对用于电穿孔的电极（13）。粘合剂层（14）设置在背衬（12）的凸缘部分上。绝缘层（15）设置在用于电穿孔（13）的电极的至少一部分上，接触除了药物储存器（11）上的部分之外的施用部位。

5. 发明授权

US06259946B1 Iontophoresis device structure 有权
标题翻译：离子电渗装置结构
公开(公告)号：US06259946B1
公开(公告)日：2001-07-10
申请号：US09331766
申请日：1999-09-27
申请人： Naruhito Higo , Kazutaka Inoue , Kenji Mori
发明人： Naruhito Higo , Kazutaka Inoue , Kenji Mori
IPC分类号： A61N130
CPC分类号： A61N1/044 , A61N1/0436
摘要： It is the object of the present invention to provide an iontophoresis device structure which has excellent contouring ability at its site of attachment, has very high safety, is of high quality with high product yields, and can be produced with fewer production steps to improve working efficiency and increase productivity to allow mass production at low cost. The iontophoresis device structure of the present invention has a construction provided with a cup-shaped support including a concave part, at least one electrification hole formed in the concave part, an electrode layer laid on the flat part of the rim of the concave part, and an electrolyte layer or drug-holding layer fitted into the concave part.
摘要翻译：本发明的目的是提供一种离子电渗装置结构，其在其附着部位具有优异的轮廓能力，具有非常高的安全性，具有高质量和高产率的离子电渗装置结构，并且可以用较少的生产步骤生产以改善工作提高效率并提高生产率，以便以低成本批量生产。本发明的离子电渗装置结构具有设置有杯状支撑体的结构，所述杯状支撑体包括凹部，在所述凹部中形成的至少一个带电孔，设置在所述凹部的边缘的平坦部分上的电极层，以及装配到凹部中的电解质层或药物保持层。

6. 发明授权

US07018345B2 Iontophoresis system 有权
标题翻译：离子电渗系统
公开(公告)号：US07018345B2
公开(公告)日：2006-03-28
申请号：US10727582
申请日：2003-12-05
申请人： Kenji Mori , Naruhito Higo
发明人： Kenji Mori , Naruhito Higo
IPC分类号： A61B5/00
CPC分类号： A61N1/30
摘要： The present invention provides an iontophoresis system for non-invasively taking a physiological substance out of the living body, the system being suitably used for the mucous membrane. The present iontophoresis system non-invasively takes a physiological substance out of a living body. The system includes a plurality of electrode structures and a power supply device connected to the electrode structures. At least one of the electrode structures has a physiological substance extraction pad applied to the mucous membrane. In the present system, the time to apply electric energy to the living body by the power supply device is set between 30 seconds and 20 minutes. The physiological substance extraction pad which is provided in the electrode structure is applicable to the mucous membrane of the mouth and can be used, for example, to monitor glucose in the living body or an amount of drug administered.
摘要翻译：本发明提供了一种离子电渗系统，用于非生物地将生理物质从活体中取出，该系统适合用于粘膜。本离子电渗系统非侵入性地将生理物质从活体中取出。该系统包括多个电极结构和连接到电极结构的电源装置。电极结构中的至少一个具有应用于粘膜的生理物质提取垫。在本系统中，通过电源装置向生物体施加电能的时间设定为30秒〜20分钟。设置在电极结构体内的生理物质提取垫适用于口腔粘膜，例如可以用于监测生物体内的葡萄糖或给药量。

7. 发明申请

US20050271725A1 Adhesive gel composition for iontophoresis preparation and process for producing the same 审中-公开
标题翻译：用于离子电渗疗法制备的粘合剂凝胶组合物及其制备方法
公开(公告)号：US20050271725A1
公开(公告)日：2005-12-08
申请号：US10525531
申请日：2003-08-30
申请人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
发明人： Mitsuru Kuribayashi , Shuichi Ikeda , Seiji Tokumoto , Kenji Mori , Naruhito Higo
IPC分类号： A61K9/00 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/04 , A61N1/30 , A61P5/44 , A61K9/14
CPC分类号： A61N1/0428 , A61K9/0009 , A61K9/0014 , A61K31/573 , A61K47/02 , A61K47/10 , A61K47/16 , A61K47/26 , A61K47/32 , A61K47/34 , A61K47/36 , A61N1/0444 , A61N1/0496
摘要： The present invention provides an adhesive gel composition for iontophoretic formulations which is useful for the application through the skin or the mucosa, which excels in all of drug absorption, drug stability, gel shape retention and gel adhesion, which is easy to prepare and fill at the time of production, and which can be produced at low costs and a method for producing the same. The adhesive gel composition for iontophoretic formulations is produced by mixing an ionic synthetic polymer(s), a nonionic synthetic polymer(s), a naturally-occurring polymer(s), a polyhydric alcohol(s), a crosslinking agent(s) and a drug(s). In the production of the adhesive gel composition for iontophoretic formulations, oxygen dissolved in the gel is positively removed by carrying out replacement with nitrogen and/or vacuum kneading at the time of the ingredients are mixed and kneaded.
摘要翻译：本发明提供了一种用于离子电渗疗法制剂的粘合性凝胶组合物，其可用于通过皮肤或粘膜的应用，其在药物吸收，药物稳定性，凝胶形状保留和凝胶粘附方面均优异，易于制备和填充生产时间，可以以低成本制造的方法及其制造方法。用于离子电渗疗法制剂的粘合凝胶组合物通过将离子合成聚合物，非离子合成聚合物，天然存在的聚合物，多元醇，交联剂和一种药物。在用于离子电渗疗法制剂的粘合剂凝胶组合物的制备中，通过在混合和捏合成分时，用氮气和/或真空捏合进行置换，可以有效地去除溶解在凝胶中的氧气。

8. 发明申请

US20050169976A1 Insulin administration apparatus 审中-公开
标题翻译：胰岛素给药装置
公开(公告)号：US20050169976A1
公开(公告)日：2005-08-04
申请号：US10510694
申请日：2003-03-28
申请人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
发明人： Kenji Mori , Naruhito Higo , Seiji Tokumoto , Shuji Sato , Kenji Sugibayashi
IPC分类号： A61K9/08 , A61K9/10 , A61K38/28 , A61K47/32 , A61K47/36 , A61M1/36 , A61N1/30 , A61N1/32 , A61P3/10
CPC分类号： A61N1/0416 , A61K38/28 , A61N1/0424 , A61N1/0432 , A61N1/044 , A61N1/30 , A61N1/327
摘要： The present invention provides an insulin-administering device enabling the effective administration of insulin via a percutaneous or submucous administration route. The present device is used to percutaneously or transmucosally administer an insulin lispro represented by the structural formula indicated below, or a pharmaceutically acceptable salt thereof, using iontophoresis and electroporation.
摘要翻译：本发明提供了能够通过经皮或粘膜下给药途径有效施用胰岛素的胰岛素给药装置。本发明的装置用于使用离子电渗疗法和电穿孔来经皮或经粘膜内施用由下述结构式表示的赖脯胰岛素或其药学上可接受的盐。

9. 发明申请

US20050131336A1 Electrode structure 审中-公开
标题翻译：电极结构
公开(公告)号：US20050131336A1
公开(公告)日：2005-06-16
申请号：US10501948
申请日：2003-01-23
申请人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
发明人： Kenji Mori , Hiroyuki Maeda , Yoshihiro Nishi , Tetsuya Arimoto , Naruhito Higo , Shuji Sato , Tatsuya Ogawa , Saori Takahashi , Yasushi Fuchita
IPC分类号： A61N1/04 , A61N1/30
CPC分类号： A61N1/0492 , A61N1/0412 , A61N1/0428 , A61N1/0496
摘要： An electrode structure is provided which is capable of efficiently using a material that can be a non-polarized electrode component, allowing the material to fully demonstrate the effect as the non-polarized electrode and maintaining the performance. This electrode structure comprises an insulating base (13), a polarized component layer (first layer) (12) laminated on the insulating base so as not to penetrate the insulating base, the polarized component layer comprising a conductive paste or metallic foil which is predominantly made of a component that can be a polarized electrode, and a non-polarized component layer (second layer) (11) provided on the polarized component layer, the non-polarized component layer comprising a conductive paste which is predominantly made of a component that can be a non-polarized electrode.
摘要翻译：提供一种电极结构，其能够有效地使用可以是非极化电极组分的材料，从而允许材料充分显示作为非极化电极的作用并保持性能。该电极结构包括绝缘基底（13），层叠在绝缘基底上的极化部件层（第一层）（12），以便不穿透绝缘基底，所述偏振构件层包括导电膏或金属箔，其主要是由可以是极化电极的部件和设置在偏振部件层上的非偏振部件层（第二层）（11）构成，非极化部件层包括主要由以下部件构成的导电膏可以是非极化电极。

10. 发明授权

US07502654B2 Electrode device having recessed part 失效
标题翻译：具有凹部的电极装置
公开(公告)号：US07502654B2
公开(公告)日：2009-03-10
申请号：US10517535
申请日：2003-06-11
申请人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
发明人： Kenji Mori , Hiroyuki Maeda , Naruhito Higo , Shuji Sato , Yasushi Fuchita , Tatsuya Ogawa , Saori Takahashi
IPC分类号： A61N1/00
CPC分类号： A61N1/0492 , A61B2562/187 , A61N1/0424 , A61N1/044 , A61N1/0448
摘要： The invention provides an electrode device that prevents disconnection of an electrode layer effectively by reducing stress at the time when a recess is formed.An electrode device (10) has a protrusion (70), which projects upward, in the part of an outward flange section (110f), other than a recess (60) formed by molding. The protrusion (70) is arranged so as to surround an outer periphery of the recess (60). When the recess (60) is cold-pressed, the protrusion (70) prevents warp (warp waving along a peripheral direction) in the outward flange section (110f) from occurring. Consequently, the protrusion (70) also eases warp of an electrode layer (30) extending on the outward flange section (110f) and prevents disconnection of the electrode layer (30).
摘要翻译：本发明提供一种电极装置，其通过在形成凹部时减少应力来有效地防止电极层的断开。电极装置（10）具有在外部凸缘部（110f）的不同于通过模制形成的凹部（60）的一部分中向上方突出的突起（70）。突出部70配置成包围凹部60的外周。当凹部（60）被冷压时，突起（70）防止在向外的凸缘部（110f）中发生翘曲（沿周向的翘曲）。因此，突起（70）也可以缓和在外侧凸缘部（110f）上延伸的电极层（30）的翘曲，防止电极层（30）断开。

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