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1. 发明授权

US09938332B2 Modified ghrelin peptides 有权
公开(公告)号：US09938332B2
公开(公告)日：2018-04-10
申请号：US13494673
申请日：2012-06-12
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/575 , A61K9/00 , C07K14/46 , C07K14/465 , A61K47/42
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

2. 发明授权

US08227570B2 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US08227570B2
公开(公告)日：2012-07-24
申请号：US12010838
申请日：2008-01-30
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

3. 发明授权

US07385026B1 Modified ghrelin polypeptides 有权
标题翻译：改良的生长素释放肽多肽
公开(公告)号：US07385026B1
公开(公告)日：2008-06-10
申请号：US09959577
申请日：2000-07-24
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

4. 发明申请

US20130172251A1 MODIFIED GHRELIN PEPTIDES 审中-公开
标题翻译：改性GHRELIN肽
公开(公告)号：US20130172251A1
公开(公告)日：2013-07-04
申请号：US13494673
申请日：2012-06-12
申请人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

5. 发明授权

US08524871B2 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US08524871B2
公开(公告)日：2013-09-03
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/00 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

6. 发明申请

US20090170763A1 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US20090170763A1
公开(公告)日：2009-07-02
申请号：US12010838
申请日：2008-01-30
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/16 , C12P21/02 , C12N1/21 , C12N15/00 , G01N33/566 , A61K38/08 , A61K38/07 , A61K31/711 , C07K14/00 , C07K7/00 , C07K16/18 , C12N15/11
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

7. 发明授权

US09573986B2 Modified ghrelin peptides 有权
标题翻译：改良的生长素释放肽
公开(公告)号：US09573986B2
公开(公告)日：2017-02-21
申请号：US12728495
申请日：2010-03-22
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K9/00 , C07K14/47 , C07K14/575 , C07K14/46 , C07K14/465 , A61K38/00 , A61K47/42 , A61K48/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

8. 发明申请

US20110184153A1 MODIFIED GHERLIN PEPTIDES 有权
标题翻译：改良的GHERLIN PEPTIDES
公开(公告)号：US20110184153A1
公开(公告)日：2011-07-28
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/18
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

9. 发明申请

US20070219114A1 Preventives or Remedies for Hepatopathy 审中-公开
标题翻译：预防或治疗肝病
公开(公告)号：US20070219114A1
公开(公告)日：2007-09-20
申请号：US10554875
申请日：2004-04-30
申请人： Kenji Kangawa , Hiroshi Hosoda
发明人： Kenji Kangawa , Hiroshi Hosoda
IPC分类号： A61K38/02
CPC分类号： A61K31/00 , A61K38/25
摘要： The present invention relates to a preventive or a therapeutic agent for hepatopathy, comprising, as an effective ingredient, a polypeptide derivative having an activity of binding to growth hormone secretagogue receptor and thus elevating intracellular calcium ion concentration, and having one amino acid sequence selected from the group consisting of amino acid sequences represented by SEQ ID NOS: 1 to 22, or an amino acid sequence in which one to several amino acids are deleted, substituted or added at the amino acid residues other that the first to forth amino acid residues from the amino-terminus in the said amino acid sequence, or a pharmacologically acceptable salt thereof. The preventive or the therapeutic agent for hepatopathy in accordance with the present invention is useful as a drug suitable for treating or preventing hepatic diseases such as hepatitis, liver cirrhosis and hepatic insufficiency. Further, the preventive or the therapeutic agent for hepatopathy in accordance with the present invention is also useful as an agent of promoting hepatic regeneration and hepatic function recovery after hepatectomy.
摘要翻译：本发明涉及用于肝病的预防或治疗剂，其包含作为有效成分的具有与生长激素促分泌素受体结合的活性的多肽衍生物，从而提高细胞内钙离子浓度，并且具有一个选自以下的氨基酸序列由SEQ ID NO：1至22表示的氨基酸序列组成的组，或其中一至几个氨基酸缺失，氨基酸残基取代或加入的氨基酸序列，其中第一至第四氨基酸残基来自所述氨基酸序列中的氨基末端或其药理学上可接受的盐。根据本发明的肝病预防或治疗剂可用作适合于治疗或预防肝病，肝硬化和肝功能不全等肝病的药物。此外，根据本发明的肝病的预防或治疗剂也可用作肝切除术后促进肝再生和肝功能恢复的药剂。

10. 发明授权

US09233143B2 Medicinal agent for preventing exacerbation of malignant tumor, comprising combination of natriuretic peptide receptor GC-A and GC-B agonists 有权
标题翻译：用于预防恶性肿瘤恶化的药物，包括利钠肽受体GC-A和GC-B激动剂的组合
公开(公告)号：US09233143B2
公开(公告)日：2016-01-12
申请号：US14239301
申请日：2012-08-17
申请人： Kenji Kangawa , Hiroshi Hosoda , Takashi Nojiri , Meinoshin Okumura , Mayumi Furuya
发明人： Kenji Kangawa , Hiroshi Hosoda , Takashi Nojiri , Meinoshin Okumura , Mayumi Furuya
IPC分类号： A61K38/22 , A61K45/06
CPC分类号： A61K38/22 , A61K38/2242 , A61K45/06 , A61K2300/00
摘要： Provided are a medicinal agent which is highly safe for use as the treatment of a malignant tumor and is capable of efficiently treating a malignant tumor, that is, a medicinal agent for treating a malignant tumor or for suppressing or preventing the exacerbation thereof, comprising at least one kind of natriuretic peptide receptor GC-A agonist and at least one kind of natriuretic peptide receptor GC-B agonist to be administered in combination; a therapeutic method comprising administering the agent; etc.
摘要翻译：本发明提供作为恶性肿瘤的治疗高度安全的药剂，能够有效治疗恶性肿瘤，即用于治疗恶性肿瘤的药剂或抑制或预防恶化肿瘤的药物，其包含：至少一种利尿钠肽受体GC-A激动剂和至少一种利钠肽受体GC-B激动剂组合施用; 一种治疗方法，包括施用所述药剂; 等等

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