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1. 发明授权

US09938332B2 Modified ghrelin peptides 有权
公开(公告)号：US09938332B2
公开(公告)日：2018-04-10
申请号：US13494673
申请日：2012-06-12
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K14/47 , A61K38/00 , A61K48/00 , C07K14/575 , A61K9/00 , C07K14/46 , C07K14/465 , A61K47/42
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.

2. 发明授权

US08227570B2 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US08227570B2
公开(公告)日：2012-07-24
申请号：US12010838
申请日：2008-01-30
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

3. 发明授权

US07385026B1 Modified ghrelin polypeptides 有权
标题翻译：改良的生长素释放肽多肽
公开(公告)号：US07385026B1
公开(公告)日：2008-06-10
申请号：US09959577
申请日：2000-07-24
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/00 , C07K1/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

4. 发明申请

US20130172251A1 MODIFIED GHRELIN PEPTIDES 审中-公开
标题翻译：改性GHRELIN肽
公开(公告)号：US20130172251A1
公开(公告)日：2013-07-04
申请号：US13494673
申请日：2012-06-12
申请人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji KANGAWA , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K14/575
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

5. 发明授权

US09573986B2 Modified ghrelin peptides 有权
标题翻译：改良的生长素释放肽
公开(公告)号：US09573986B2
公开(公告)日：2017-02-21
申请号：US12728495
申请日：2010-03-22
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K9/00 , C07K14/47 , C07K14/575 , C07K14/46 , C07K14/465 , A61K38/00 , A61K47/42 , A61K48/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

6. 发明申请

US20110184153A1 MODIFIED GHERLIN PEPTIDES 有权
标题翻译：改良的GHERLIN PEPTIDES
公开(公告)号：US20110184153A1
公开(公告)日：2011-07-28
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/18
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

7. 发明授权

US08524871B2 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US08524871B2
公开(公告)日：2013-09-03
申请号：US13076844
申请日：2011-03-31
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： C07K16/00 , C07K1/00 , C07K14/00 , C07K17/00
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供诱导生长激素分泌的肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸化合物代替，或其药学上可接受的盐。

8. 发明申请

US20090170763A1 Modified gherlin peptides 有权
标题翻译：修饰的更小的蛋白肽
公开(公告)号：US20090170763A1
公开(公告)日：2009-07-02
申请号：US12010838
申请日：2008-01-30
申请人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
发明人： Kenji Kangawa , Masayasu Kojima , Hiroshi Hosoda , Hisayuki Matsuo , Yoshiharu Minamitake
IPC分类号： A61K38/16 , C12P21/02 , C12N1/21 , C12N15/00 , G01N33/566 , A61K38/08 , A61K38/07 , A61K31/711 , C07K14/00 , C07K7/00 , C07K16/18 , C12N15/11
CPC分类号： C07K14/575 , A01K2217/05 , A61K9/0019 , A61K38/00 , A61K47/42 , A61K48/00 , C07K14/461 , C07K14/463 , C07K14/465 , C07K14/47 , C07K14/4702
摘要： The present invention provides a novel peptide-type compound which induces secretion of growth hormone and which has the activity of increasing the intracellular calcium ion concentration, wherein at least one amino acid is replaced by a modified amino acid and/or a non-amino acid compound, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了诱导生长激素分泌的新型肽型化合物，其具有增加细胞内钙离子浓度的活性，其中至少一个氨基酸被修饰的氨基酸和/或非氨基酸替代化合物或其药学上可接受的盐。

9. 发明授权

US5973134A Rat CNP complementary DNA and precursor protein 失效
标题翻译：大鼠CNP互补DNA和前体蛋白
公开(公告)号：US5973134A
公开(公告)日：1999-10-26
申请号：US757606
申请日：1991-09-11
申请人： Hisayuki Matsuo , Masayasu Kojima , Kenji Kangawa , Naoto Minamito
发明人： Hisayuki Matsuo , Masayasu Kojima , Kenji Kangawa , Naoto Minamito
IPC分类号： C12N15/09 , A61K38/00 , A61K38/22 , A61P7/10 , A61P9/12 , C07H21/04 , C07K14/00 , C07K14/575 , C07K14/58 , C12N15/12 , C12P21/02 , C07H17/00
CPC分类号： C07K14/58 , A61K38/00
摘要： A cDNA coding for a rat derived CNP (rCNP: C-type natriuretic pepteide), and a rat derived CNP precursor protein and derivatives thereof are disclosed.The rat derived CNP precursor is represented by the following amino acid sequence.Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly CysThe rCNP precursor and its derivatives are novel and have natriuretic and hypotensive activities.
摘要翻译：公开了编码大鼠衍生的CNP（rCNP：C型利尿钠蛋白酶）的cDNA和大鼠衍生的CNP前体蛋白及其衍生物。大鼠衍生的CNP前体由以下氨基酸序列表示。 Met His Leu Ser Gln Leu Ile Ala Cys Ala Leu Leu Leu Ala Leu Leu Ser Leu Arg Pro Ser Glu Ala Lys Pro Gly Thr Pro Pro Lys Val Pro Arg Thr Pro Pro Gly Glu Glu Leu Ala Glu Pro Gln Ala Ala Gly Gly Asn Gln Lys Lys Gly Asp Lys Thr Pro Gly Gly Gly Gly Ala Asn Leu Lys Gly Asp Arg Ser Arg Leu Leu Arg Asp Leu Arg Val Asp Thr Lys Ser Arg Ala Ala Trp Ala Arg Leu Leu His Glu His Pro Asn Ala Arg Lys Tyr Lys Gly Gly Asn Lys Lys Gly Leu Ser Lys Gly Cys Phe Gly Leu Lys Leu Asp Arg Ile Gly Ser Met Ser Gly Leu Gly Cys rCNP前体及其衍生物是新颖的，具有钠尿和降血压活性。

10. 发明授权

US5434133A CNP analog peptides and their use 失效
标题翻译： CNP类似物及其用途
公开(公告)号：US5434133A
公开(公告)日：1995-07-18
申请号：US828450
申请日：1992-01-31
申请人： Shoji Tanaka , Yoshiharu Minamitake , Yasuo Kitajima , Mayumi Furuya , Hisayuki Matsuo
发明人： Shoji Tanaka , Yoshiharu Minamitake , Yasuo Kitajima , Mayumi Furuya , Hisayuki Matsuo
IPC分类号： A61K38/22 , A61K38/00 , A61P43/00 , C07K7/08 , C07K14/575 , C07K14/58 , C12N15/16 , C07K14/00 , A61K38/16 , A61K38/17 , C07K14/435
CPC分类号： C07K14/58 , A61K38/00 , Y02P20/55
摘要： Novel peptides represented by the general formula: ##STR1## and physiologically acceptable acid addition salts thereof; where (A) represents H-, H-Gly, H-Lys-Gly, H-Ser-Lys-Gly, H-Leu-Ser-Lys-Gly, H-Gly-Leu-Ser-Lys-Gly, H-ser, H-Ser-Ser, H-Arg-Ser-Ser, H-Arg-Arg-Ser-Ser, H-Leu-Arg-Arg-Ser-Ser, H-Ser-Leu-Arg-Arg-Ser-Ser;(B) represents H-Cys or Pmp;(C) represents Phe-, pCl-Phe, pF-Phe, pNO.sub.2 -Phe or Cha;(D) represents Ile, Val, Aib, tLeu, Gly or Leu;(E) represents Lys or Arg;(F) represents Ile, Leu or Met;(G) represents Ser or Ala;(H) represents Met or Gln;(I) represents --OH, -Asn-OH, -Asn-Ser-OH, -Asn-Ser-Phe-OH, -Asn-Ser-Phe-Arg-OH or -Asn-Ser-Phe-Arg-Tyr-OH; and the symbol " . . . " represents a disulfide bond;provided that 1) .alpha.-hANP, 2) .alpha.-hANP (7-28) and 3) CNP-22 are excluded from the scope of that general formula.Also disclosed are agents for suppressing the growth of vascular smooth muscle cells that contains those peptides as effective ingredients.
摘要翻译：由通式表示的新肽：其加成盐; 其中（A）表示H，H-Gly，H-Lys-Gly，H-Ser-Lys-Gly，H-Leu-Ser-Lys-Gly，H-Gly-Leu-Ser-Lys-Gly， Ser，H-Ser-Ser，H-Arg-Ser-Ser，H-Arg-Arg-Ser-Ser，H-Leu-Arg-Arg-Ser-Ser，H-Ser-Leu-Arg-Arg- 塞尔（B）代表H-Cys或Pmp; （C）表示Phe-，pCl-Phe，pF-Phe，pNO2-Phe或Cha; （D）代表Ile，Val，Aib，tLeu，Gly或Leu; （E）表示Lys或Arg; （F）表示Ile，Leu或Met; （G）表示Ser或Ala; （H）表示Met或Gln; （I）表示-OH，-Asn-OH，-Asn-Ser-OH，-Asn-Ser-Phe-OH，-Asn-Ser-Phe-Arg-OH或-Asn-Ser-Phe-Arg-Tyr- 哦; 符号“......”代表二硫键; 条件是1）α-hANP，2）α-hANP（7-28）和3）CNP-22被排除在该通式的范围之外。还公开了抑制含有那些肽作为有效成分的血管平滑肌细胞生长的药剂。

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