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1. 发明授权

US5439649A Automated staining apparatus 失效
标题翻译：自动染色装置
公开(公告)号：US5439649A
公开(公告)日：1995-08-08
申请号：US129243
申请日：1993-09-29
申请人： Ken Tseung , Wai Bun Wong , Glenn K. Takayama , Christopher M. Jones , Krishan L. Kalra
发明人： Ken Tseung , Wai Bun Wong , Glenn K. Takayama , Christopher M. Jones , Krishan L. Kalra
IPC分类号： G01N1/30 , B01L3/02 , G01N1/28 , G01N1/31 , G01N35/00 , G01N35/10 , G02B21/34 , B01L11/00
CPC分类号： B01L3/0275 , G01N1/312 , G02B21/34 , G01N2001/282 , G01N2001/317 , G01N2035/103 , G01N35/0099 , G01N35/109
摘要： An automated microscope-slide-staining apparatus, having a supporting framework; an arm moveable in three dimensions attached to the framework; apparatus for moving the arm; a hollow tip head located on the arm; apparatus for alternatively supplying positive or negative gas pressure to the hollow tip head; a removable wash/blow tip having an exit slit, the wash/blow tip being adapted to be removably attached to the hollow tip head by a preselected movement of the arm; a wash/blow tip holder at a first fixed location on the framework; a reagent application tip holder at a second fixed location on the framework for holding a reagent application tip, the reagent application tip being adapted to be removably attached to the hollow tip head by a preselected movement of the arm; a reagent container holder at a third fixed location on the framework; a microscope slide holder at a fourth fixed location on the framework, the microscope slide holder being adapted to removably contain the microscope slide; and control apparatus for controlling movement of the arm between the locations, whereby the tip head picks up the wash/blow tip or the reagent application tip in response to movement of the arm under control of the control apparatus and moves to one or more of the locations to pick up a reagent in the reagent container or dispense the reagent on the slide or to dispense a gas through the wash/blow tip over the slide. Components of the apparatus and methods of staining are also part of the invention.
摘要翻译：具有支撑框架的自动显微镜载玻片染色装置; 一个可移动的臂可以三维地连接到框架上; 用于移动臂的装置; 位于手臂上的中空尖头; 用于交替地向中空尖端头供应正或负气体压力的装置; 具有出口狭缝的可移除的洗涤/吹塑尖端，所述洗涤/吹塑尖端适于通过所述臂的预选运动可移除地附接到所述中空末端头部; 在框架上的第一固定位置处的洗涤/吹头保持器; 用于保持试剂应用尖端的框架上的第二固定位置处的试剂施用末端保持器，所述试剂施加末端适于通过所述臂的预选运动可移除地附接到所述中空末端头; 在框架上的第三固定位置的试剂容器支架; 在框架上的第四固定位置处的显微镜载玻片保持器，显微镜载玻片保持器适于可拆卸地容纳显微镜载玻片; 以及用于控制所述臂在所述位置之间的移动的控制装置，由此所述尖端头在所述控制装置的控制下响应于所述臂的移动而拾取所述洗涤/吹出尖端或所述试剂施加末端，并移动到所述控制装置中的一个或多个在试剂容器中取出试剂的位置或者将试剂分配在载玻片上，或者通过载玻片上的洗涤/吹塑尖端分配气体。设备的组分和染色方法也是本发明的一部分。

2. 发明授权

US07435383B2 Automated tissue staining system and reagent container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US07435383B2
公开(公告)日：2008-10-14
申请号：US11351159
申请日：2006-02-09
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： G01N1/31 , G01N1/30 , G01N35/10
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to the axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer for holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。基壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于保持试剂容器的一个可移除抽屉和用于保持滑块的另一个可移除抽屉。

3. 发明授权

US08142739B2 Automated tissue staining system and reagent container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US08142739B2
公开(公告)日：2012-03-27
申请号：US13041608
申请日：2011-03-07
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： B01L3/00 , G01N1/31
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to said axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。底壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于所述轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

4. 发明申请

US20100093079A1 Automated Tissue Staining System And Reagent Container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US20100093079A1
公开(公告)日：2010-04-15
申请号：US12644705
申请日：2009-12-22
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： C12N5/071
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to said axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。底壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于所述轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

5. 发明授权

US08236255B2 Slide treatment apparatus and methods for use 有权
标题翻译：滑动治疗仪和使用方法
公开(公告)号：US08236255B2
公开(公告)日：2012-08-07
申请号：US11002164
申请日：2004-12-02
申请人： Glenn K. Takayama , Ken K. Tseung , Norman K. Rhett , Wai Bun Wong , Samuel Burd , George A. Harter , Douglas C. Morrison
发明人： Glenn K. Takayama , Ken K. Tseung , Norman K. Rhett , Wai Bun Wong , Samuel Burd , George A. Harter , Douglas C. Morrison
IPC分类号： B01L3/00
CPC分类号： G01N1/312
摘要： An apparatus for treating slides has a base with a cavity, and a heater is located on a surface of the cavity. A tank, which supports a slide rack with the slides submerged in a slide treatment solution, is placed in the cavity with a tank surface immediately adjacent the heater. A temperature sensor is mounted in the base and is operable to provide a feedback signal representing a temperature of the liquid in the tank. A cover is removably hinged on the base to cover the tank. A control system is connected to the heater and the temperature sensor and has a user input/output that is operable to select a set temperature of the liquid and a cycle time.
摘要翻译：一种用于处理滑块的装置具有带空腔的基座，并且加热器位于空腔的表面上。支撑滑动架的油箱，其中滑块浸没在滑动处理溶液中，并且与紧邻加热器的罐表面放置在空腔中。温度传感器安装在基座中并且可操作以提供表示罐中的液体的温度的反馈信号。盖可拆卸地铰接在基座上以覆盖水箱。控制系统连接到加热器和温度传感器，并且具有可操作以选择液体的设定温度和循环时间的用户输入/输出。

6. 发明申请

US20110176977A1 Automated Tissue Staining System And Reagent Container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US20110176977A1
公开(公告)日：2011-07-21
申请号：US13041608
申请日：2011-03-07
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： B01L3/00
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to said axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。底壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于所述轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

7. 发明授权

US07642093B2 Automated tissue staining system and reagent container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US07642093B2
公开(公告)日：2010-01-05
申请号：US12250116
申请日：2008-10-13
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： G01N1/31 , G01N1/30 , B01L3/00
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to the axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。基壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

8. 发明申请

US20090042243A1 AUTOMATED TISSUE STAINING SYSTEM AND REAGENT CONTAINER 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US20090042243A1
公开(公告)日：2009-02-12
申请号：US12250116
申请日：2008-10-13
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： G01N1/30 , G01N1/31 , B67D5/54
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to said axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。底壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于所述轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

9. 发明授权

US06735531B2 Method and apparatus for automatic tissue staining 有权
标题翻译：自动组织染色的方法和装置
公开(公告)号：US06735531B2
公开(公告)日：2004-05-11
申请号：US10010830
申请日：2001-11-13
申请人： Norman K. Rhett , Ken K. Tseung , Mark V. Corl , Wai Bun Wong , Ngoc Van Le , Glenn K. Takayama
发明人： Norman K. Rhett , Ken K. Tseung , Mark V. Corl , Wai Bun Wong , Ngoc Van Le , Glenn K. Takayama
IPC分类号： G01N3353
CPC分类号： G01N35/00584 , G01N1/312 , G01N35/00663 , G01N2001/317 , G01N2035/0091
摘要： To simplify the process of preparing microscope slides, an automatic staining apparatus is disclosed. The disclosed automatic staining apparatus comprises an electromechanical automatic staining device that is coupled to a personal computer system using an interface card. An autostainer control program runs on the personal computer system. The autostainer control program allows a user to simply program the automatic staining apparatus using simple commands entered in the graphical user interface. The autostainer control program includes several features that simplify the programming such as safeguards that ensure compatible reagents are being used; automatic buffer solution requirement calculator; and the ability to determine optimal staining procedure. The electromechanical automatic staining device includes features such as dual waste bins for hazardous and nonhazardous waste storage, an automatic dispenser cleansing system; and a slide clip that minimizes capillary effect.
摘要翻译：为了简化制备显微镜载片的过程，公开了一种自动染色装置。所公开的自动染色装置包括使用接口卡耦合到个人计算机系统的机电自动染色装置。一个自动调色器控制程序在个人计算机系统上运行。自动涂布器控制程序允许用户使用在图形用户界面中输入的简单命令简单地编程自动染色装置。自动清洗器控制程序包括几个简化编程的功能，例如确保使用兼容试剂的保护措施; 自动缓冲溶液需求计算器; 以及确定最佳染色程序的能力。机电自动染色装置包括用于危险和非危险废物储存的双垃圾箱，自动分配器清洁系统等功能; 以及使毛细管效应最小化的滑动夹。

10. 发明授权

US08585987B2 Automated tissue staining system and reagent container 有权
标题翻译：自动组织染色系统和试剂容器
公开(公告)号：US08585987B2
公开(公告)日：2013-11-19
申请号：US13429518
申请日：2012-03-26
申请人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
发明人： Ken K. Tseung , Norman K. Rhett , Glenn K. Takayama , Wai Bun Wong , Delia P. Yuen
IPC分类号： B01L3/00 , G01N1/31
CPC分类号： G01N1/312 , B65D1/0223 , B65D47/06 , B65D51/18 , B65D2203/04 , B65D2251/0015 , B65D2251/0087 , B65D2501/0081 , G01N35/0099 , G01N35/1002 , G01N2035/00752 , G01N2035/0498 , G06Q50/22 , Y10T436/11 , Y10T436/112499 , Y10T436/25
摘要： An automated staining system and a reagent container designed for use with the automated staining apparatus. The reagent container includes a reagent containment section capable of containing a volume of a reagent. The reagent containment section includes an upper wall and a base wall that are spaced apart along an axis. The base wall includes a well having a nadir that is aligned axially with an access opening in the upper wall so that a reagent probe entering the opening parallel to the axis will travel toward the nadir. In another aspect of the invention, the reagent container may include a two-dimensional data element containing reagent information. The staining apparatus may include one removable drawer for holding reagent containers and another removable drawer holding slides.
摘要翻译：自动染色系统和设计用于自动染色装置的试剂容器。试剂容器包括能够容纳一定体积的试剂的试剂容纳部。试剂容纳部分包括沿轴线间隔开的上壁和底壁。基壁包括具有与上壁中的进入开口轴向对准的最低点的井，使得进入平行于轴线的开口的试剂探针将朝向最低点行进。在本发明的另一方面，试剂容器可以包括含有试剂信息的二维数据元素。染色装置可以包括用于容纳试剂容器的一个可移除抽屉和保持滑块的另一个可移除抽屉。

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