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1. 发明授权

US07169812B2 Process for producing injectable gabapentin compositions 有权
标题翻译：生产可注射加巴喷丁组合物的方法
公开(公告)号：US07169812B2
公开(公告)日：2007-01-30
申请号：US10808113
申请日：2004-03-24
申请人： Keith R. Hildebrand , Linda M. Page , Deanna S. Lane , Dennis D. Elsberry , David A. Clarahan , Jayantha H. Ratnayake
发明人： Keith R. Hildebrand , Linda M. Page , Deanna S. Lane , Dennis D. Elsberry , David A. Clarahan , Jayantha H. Ratnayake
IPC分类号： A61K31/195
CPC分类号： A61K31/52 , A61K9/0019 , A61K9/0085 , A61K31/195 , A61L2/0017 , A61L2/0023 , A61M5/14276 , A61M2202/0464 , A61M2210/0693
摘要： Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
摘要翻译：讨论了含有加巴喷丁的可注射组合物和制备含有加巴喷丁的无菌可注射组合物的方法。该方法包括使组合物加热。加热导致加巴喷丁内酰胺的生产增加，其先前已被证明是有毒的。令人惊奇的是，发现含有加巴喷丁的加热可注射组合物在鞘内施用时是无毒的。因此，用于灭菌或确保无菌的加热为生产含有加巴喷丁的可注射组合物提供了可行的选择。

2. 发明授权

US5798114A Refillable body powered drug delivery techniques 失效
标题翻译：可补充身体动力的药物输送技术
公开(公告)号：US5798114A
公开(公告)日：1998-08-25
申请号：US640360
申请日：1996-04-30
申请人： Dennis D. Elsberry , Robert E. Kim
发明人： Dennis D. Elsberry , Robert E. Kim
IPC分类号： A61K9/00 , A61F2/02 , A61K9/22
CPC分类号： A61K9/0024
摘要： Techniques for implanting and refilling a device for delivering a treatment agent to a body. First and second chambers for holding treatment agent and delivery agent, respectively, are placed adjacent docking compartments adapted to receive a hypodermic needle through septums so that the expended delivery agent can be withdrawn and a new supply of treatment agent can be introduced without removing the device from its implanted position in a body.
摘要翻译：用于植入和再填充用于将治疗剂递送到身体的装置的技术。分别用于保持处理剂和递送剂的第一和第二室被放置在适于通过隔膜接纳皮下注射针的邻接对接室中，从而可以取出消耗的输送剂并且可以引入新的处理剂供应而不移除装置从其在体内的植入位置。

3. 发明授权

US06551290B1 Catheter for target specific drug delivery 有权
标题翻译：目标特异性药物输送导管
公开(公告)号：US06551290B1
公开(公告)日：2003-04-22
申请号：US09540444
申请日：2000-03-31
申请人： Dennis D. Elsberry , Chris Christiansen , Mary M. Morris , Douglas Owen Hankner , Robert Cushing Hamlen
发明人： Dennis D. Elsberry , Chris Christiansen , Mary M. Morris , Douglas Owen Hankner , Robert Cushing Hamlen
IPC分类号： A61M2500
CPC分类号： A61M25/0069 , A61M5/14276 , A61M27/006 , A61M2025/0057
摘要： A medical catheter comprising a proximal end having an opening for fluid containing a therapeutic drug, a distal end, the distal end defining at least one opening, and a porous portion covering the opening defined by the distal end. In one embodiment, the medical catheter comprises a proximal end having an opening for fluid containing a therapeutic drug, at least two distal ends. the proximal end connected to the two distal ends with a connector, the distal ends each defining at least, one opening, a diffuser covering the opening of each distal end, and a separate restrictor downstream of the connector and upstream of each distal end to provide substantially equal flow through each distal end. An additional restrictor can also be placed upstream of the connector. In another embodiment, a combination diffuser and restrictor covers the opening of each distal end.
摘要翻译：一种医疗导管，其包括具有用于含有治疗药物的流体的开口的近端，远端，限定至少一个开口的远端以及覆盖由远端限定的开口的多孔部分。在一个实施例中，医疗导管包括近端，其具有用于含有治疗药物的流体的开口，至少两个远端。所述近端与连接器连接到所述两个远端，所述远端各限定至少一个开口，覆盖每个远端的开口的扩散器，以及在所述连接器的下游和每个远端上游的单独限制器，以提供基本相等的流经每个远端。另外还可以在连接器的上游设置一个限流器。在另一个实施例中，组合扩散器和限流器覆盖每个远端的开口。

4. 发明授权

US06503242B1 Therapeutic method for treatment of Alzheimer's disease 有权
标题翻译：治疗阿尔茨海默病的治疗方法
公开(公告)号：US06503242B1
公开(公告)日：2003-01-07
申请号：US09539804
申请日：2000-03-30
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
IPC分类号： A61M3100
CPC分类号： A61M25/0068 , A61M25/0069 , A61M25/007 , A61M2025/0057
摘要： A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle through an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes. The catheter is part of a system for delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action to the hippocampus or lateral ventricle that includes a pump coupled to the catheter for delivering the indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action through the catheter to the hippocampus or lateral ventricle.
摘要翻译：公开了一种治疗阿尔茨海默病的方法和装置。该方法包括通过植入的导管将具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎剂直接递送至海马或侧脑室。作为优选实施例，导管具有直接植入在海马或侧脑室中的柔性远端。远端具有多孔尖端或封闭端。在远端封闭或多个洗脱孔存在的情况下，吲哚美辛通过多孔尖端或洗脱孔输送到海马或侧脑室。导管是用于将具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎药物输送到海马或侧脑室的系统的一部分，其包括耦合到导管的泵，用于递送具有环加氧酶抑制剂作用的吲哚美辛或非甾体抗炎药导管到海马或侧脑室。

5. 发明授权

US6093180A Intraparenchymal infusion catheter system 失效
公开(公告)号：US6093180A
公开(公告)日：2000-07-25
申请号：US912379
申请日：1997-08-18
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
IPC分类号： A61M25/00 , A61M31/00
CPC分类号： A61M25/001 , A61M25/0068 , A61M2025/0057 , A61M2025/0073 , A61M25/0009 , A61M25/0069 , Y10S128/12
摘要： An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.

6. 发明授权

US5711316A Method of treating movement disorders by brain infusion 失效
标题翻译：脑输液治疗运动障碍的方法
公开(公告)号：US5711316A
公开(公告)日：1998-01-27
申请号：US640359
申请日：1996-04-30
申请人： Dennis D. Elsberry , Mark T. Rise , Scott R. Ward
发明人： Dennis D. Elsberry , Mark T. Rise , Scott R. Ward
IPC分类号： A61M5/142 , A61M5/172 , A61B19/00
CPC分类号： A61M5/14276 , A61M5/1723 , A61M2202/0464 , A61M2210/0693
摘要： The present invention is directed to techniques and apparatus for infusing drugs into the brain to treat movement disorders resulting in abnormal motor behavior. The invention employs an implantable pump and a catheter, the catheter having a proximal end coupled to the pump and a discharge portion for placement adjacent a predetermined infusion site in the brain for infusing therapeutic dosages of the one or more drugs into the brain. The pump is operated to discharge a predetermined dosage of the one or more drugs through the discharge portion of the catheter into the infusion site. A sensor may be used in combination with the implantable pump and catheter, whereby the sensor generates a signal relating to the extent of the abnormal motor behavior. The therapeutic dosage may be regulated in response to the sensor signal so that the dosage is adjusted in response to an increase in the abnormal behavior to decrease the abnormal motor behavior.
摘要翻译：本发明涉及用于将药物输入脑中以治疗导致异常运动行为的运动障碍的技术和装置。本发明采用可植入泵和导管，所述导管具有联接到所述泵的近端和用于放置在脑中的预定输注部位附近的放电部分，用于将一种或多种药物的治疗剂量注入脑中。操作泵以将预定剂量的一种或多种药物通过导管的排出部分排出到输注部位中。传感器可以与可植入泵和导管组合使用，由此传感器产生与异常电动机行为的程度有关的信号。可以响应于传感器信号来调节治疗剂量，使得响应于异常行为的增加来调整剂量以减少异常运动行为。

7. 发明授权

US06594880B2 Intraparenchymal infusion catheter system 失效
标题翻译：实质内输液导管系统
公开(公告)号：US06594880B2
公开(公告)日：2003-07-22
申请号：US09864646
申请日：2001-05-23
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
IPC分类号： B23P1102
CPC分类号： A61M25/0068 , A61M25/001 , A61M25/0069 , A61M2025/0057 , A61M2025/0073 , Y10S128/12 , Y10T29/49865
摘要： An intraparenchymal infusion catheter system for delivering drugs or other agents to selected sites in an organism, such as a human, includes a pump that may be implanted or disposed outside the organism. A catheter is coupled to the pump. The catheter comprises a flexible biocompatible tubular portion terminating in a free distal end. The distal end of the catheter bears a rounded tip, a portion of which is slidably disposed within the lumen of the tubular portion. The tip is porous for discharging an agent or drug to a selected site. The tip has a microporosity of less than or equal to 0.22 microns. The tubular portion is composed from a material that will expand from its nominal size when exposed to a stimulus such as heat or a solvent and return to its nominal size when the stimulus is withdrawn. By expanding the tubular portion, a physician can select the amount of the tip that is exposed to the organism, thereby customizing the catheter to the structural size of the selected site within the body.
摘要翻译：用于将药物或其它试剂输送到诸如人的生物体中的选定部位的实质内输注导管系统包括可植入或设置在生物体外部的泵。导管联接到泵。导管包括终止于自由远端的柔性生物相容性管状部分。导管的远端具有圆形尖端，其一部分可滑动地设置在管状部分的内腔内。尖端是多孔的，用于将药剂或药物排出到选定的部位。尖端具有小于或等于0.22微米的微孔。管状部分由当暴露于诸如热或溶剂的刺激物时从其标称尺寸膨胀的材料组成，并且当刺激被撤回时返回其标称尺寸。通过扩大管状部分，医师可以选择暴露于生物体的尖端的量，从而将导管定制成体内所选部位的结构尺寸。

8. 发明授权

US06423029B1 System and method for detecting abnormal medicament pump fluid pressure 有权
标题翻译：用于检测异常药泵流体压力的系统和方法
公开(公告)号：US06423029B1
公开(公告)日：2002-07-23
申请号：US09301935
申请日：1999-04-29
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
IPC分类号： A61M3100
CPC分类号： A61M5/14276 , A61M5/16854 , A61M2005/16868 , Y10T428/31681 , Y10T428/31786 , Y10T428/31794
摘要： A system is disclosed for providing an indication of abnormal upstream fluid pressure, abnormal downstream fluid pressure, and/or abnormal differential upstream versus downstream fluid pressures for a medicament pump that is implantable within a person's body and has a pressurized source of fluid. The system includes upstream and downstream fluid pressure sensors, which could be commercially available strain gauges attached to, or incorporated into, the wall of the inlet tubing and the wall of the outlet tubing, respectively, for sensing the amount of deformation of the tubing walls as a result of fluid pressure changes. Fluid source overpressurization could be indicated, via activation of an alarm, based upon detection of either: abnormally high upstream fluid pressure; or the difference between the upstream fluid pressure and the downstream fluid pressure exceeding a predetermined range of acceptable values. Pump outlet tube occlusion could be indicated, via activation of an alarm, based upon detection of either: abnormally high downstream fluid pressure; or the difference between the upstream fluid pressure and the downstream fluid pressure being less than a predetermined range of acceptable values. Even when the differential pressure is within an acceptable range of values, the inlet and outlet pressure values can be used to distinguish between (1) normal conditions at both the inlet and outlet; and (2) abnormal conditions at both the inlet and outlet that can not be detected differentially, such as simultaneous overpressurization at both the inlet and outlet.
摘要翻译：公开了一种用于提供可植入人体内并且具有加压流体源的药物泵的异常上游流体压力，异常下游流体压力和/或异常上游与下游流体压力的指示的系统。该系统包括上游流体压力传感器和下游流体压力传感器，其可以分别连接到入口管壁和出口管壁上的市售应变计，用于感测管壁的变形量作为流体压力变化的结果。流体源超压可以通过激活报警来指示，基于以下两种情况之一：检测到异常高的上游流体压力; 或上游流体压力和下游流体压力之间的差超过可接受值的预定范围。泵出口管闭塞可以通过激活报警来指示，基于以下两种情况之一：下游流体压力异常高; 或者上游流体压力和下游流体压力之间的差小于可接受值的预定范围。即使当压差在可接受的值范围内时，入口和出口压力值也可用于区分（1）入口和出口两者的正常状态; 和（2）入口和出口两端的异常情况不能被差异地检测，例如在入口和出口处同时进行过压。

9. 发明授权

US6056725A Therapeutic method for treatment of alzheimer's disease 有权
标题翻译：治疗阿尔茨海默病的治疗方法
公开(公告)号：US6056725A
公开(公告)日：2000-05-02
申请号：US127833
申请日：1998-08-03
申请人： Dennis D. Elsberry
发明人： Dennis D. Elsberry
IPC分类号： A61M25/00 , A61M1/00
CPC分类号： A61M25/0068 , A61M2025/0057 , A61M25/0069 , A61M25/007
摘要： A method and apparatus for treating Alzheimer's disease is disclosed. The method comprises delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action directly to the hippocampus or the lateral ventricle through an implanted catheter. The catheter has a flexible distal end that is implanted directly in the hippocampus or lateral ventricle as the preferred embodiment. The distal end has either a porous tip or a closed end. Where the distal end is closed, or a plurality of elution holes are present indomethacin is delivered to the hippocampus or lateral ventricle through either the porous tip or the elution holes. The catheter is part of a system for delivering indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action to the hippocampus or lateral ventricle that includes a pump coupled to the catheter for delivering the indomethacin or nonsteroidal anti-inflammatory agents having cyclooxygenase inhibitor action through the catheter to the hippocampus or lateral ventricle.
摘要翻译：公开了一种治疗阿尔茨海默病的方法和装置。该方法包括通过植入的导管将具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎剂直接递送至海马或侧脑室。作为优选实施例，导管具有直接植入在海马或侧脑室中的柔性远端。远端具有多孔尖端或封闭端。在远端封闭或多个洗脱孔存在的情况下，吲哚美辛通过多孔尖端或洗脱孔输送到海马或侧脑室。导管是用于将具有环氧合酶抑制剂作用的吲哚美辛或非甾体抗炎药物输送到海马或侧脑室的系统的一部分，其包括耦合到导管的泵，用于递送具有环加氧酶抑制剂作用的吲哚美辛或非甾体抗炎药导管到海马或侧脑室。

10. 发明授权

US6042579A Techniques for treating neurodegenerative disorders by infusion of nerve growth factors into the brain 失效
标题翻译：通过将神经生长因子输注入脑来治疗神经变性疾病的技术
公开(公告)号：US6042579A
公开(公告)日：2000-03-28
申请号：US846810
申请日：1997-04-30
申请人： Dennis D. Elsberry , Mark T. Rise
发明人： Dennis D. Elsberry , Mark T. Rise
IPC分类号： A61K9/22 , A61M5/142 , A61M5/172 , A61M11/00 , A61M9/22
CPC分类号： A61M5/14276 , A61M2210/0693 , A61M5/1723
摘要： Techniques for infusing nerve growth factors into the brain to treat neurodegenerative disorders by means of an implantable pump and catheter. A sensor is used to detect an attribute of the nervous system which reflects the degeneration of the nerve cells. A microprocessor algorithm analyzes the output from the sensor in order to regulate the amount of growth factor delivered to the brain.
摘要翻译：将神经生长因子注入脑中以通过可植入泵和导管治疗神经变性疾病的技术。传感器用于检测反映神经细胞退化的神经系统的属性。微处理器算法分析传感器的输出，以调节传递给大脑的生长因子的量。

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