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1. 发明授权

US5621519A Imaging system transfer function control method and apparatus 失效
标题翻译：成像系统传输功能控制方法和装置
公开(公告)号：US5621519A
公开(公告)日：1997-04-15
申请号：US509182
申请日：1995-07-31
申请人： Keith L. Frost , Seho Oh , Jon W. Hayenga , Kim J. Hansen
发明人： Keith L. Frost , Seho Oh , Jon W. Hayenga , Kim J. Hansen
IPC分类号： G01M11/02 , H04N17/00 , G01M11/00
CPC分类号： G01M11/0292 , H04N17/002
摘要： Accurately measuring and controlling the system transfer function of an imaging system, by eliminating interference from aliases. An image is captured of an image primitive with a uniaxial pattern, oriented at an angle to the primary axes of a sampling array. In order to accurately measure the system transfer function, a two-dimensional frequency representation is computed. The aliased components of the representation are separated from the unaliased components by translation in frequency along the axis perpendicular to the axis of the image primitive. Accurate measurement of the system transfer function makes it possible to accurately control the system transfer function.
摘要翻译：通过消除别名的干扰，准确测量和控制成像系统的系统传递功能。捕获具有与采样阵列的主轴成一角度定向的单轴图案的图像原语的图像。为了准确测量系统传递函数，计算二维频率表示。通过沿垂直于图像原语的轴的轴的频率平移将表示的混叠分量与未混合的分量分离。系统传输功能的精确测量可以准确控制系统传输功能。

2. 发明授权

US5933519A Cytological slide scoring apparatus 失效
标题翻译：细胞学评分仪
公开(公告)号：US5933519A
公开(公告)日：1999-08-03
申请号：US867017
申请日：1997-06-03
申请人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
发明人： Shih-Jong J. Lee , Paul S. Wilhelm , Michael G. Meyer , Wendy R. Bannister , Chih-Chau L. Kuan , William E. Ortyn , Larry A. Nelson , Keith L. Frost , Jon W. Hayenga
IPC分类号： G06K9/00 , G06K9/62 , G06K9/68 , G06K9/70
CPC分类号： G06K9/00127 , G06K9/6253 , G06K9/685
摘要： The invention detects areas of interest at low magnification, locating possible abnormal cells or other cells of interest using image processing and statistical pattern recognition techniques. Next, at high magnification, the areas identified at low magnification are re-examined. The information from the low magnification and high magnification scans is collated and a determination is made about the slide--whether it is normal, abnormal, contains endocervical component, and so forth. The invention also provides a method and apparatus to train object feature and slide feature classifiers. The invention provides an automated cytology system that can process training slides for use in a feed back classifier development environment. The invention also can classify endocervical groups of cells.
摘要翻译：本发明使用图像处理和统计模式识别技术来检测低放大倍数的感兴趣区域，定位可能的异常细胞或感兴趣的其它细胞。接下来，在高放大倍数下，重新检查在低倍率下识别的区域。对来自低放大倍数和高倍率扫描的信息进行整理，并确定载玻片是否正常，异常，包含宫颈内部成分等。本发明还提供了一种训练对象特征和幻灯片特征分类器的方法和装置。本发明提供了一种自动细胞学系统，其可以处理用于反馈分类器开发环境中的训练幻灯片。本发明还可以分类宫颈癌细胞群。

3. 发明授权

US5647025A Automatic focusing of biomedical specimens apparatus 失效
标题翻译：生物医学标本设备自动对焦
公开(公告)号：US5647025A
公开(公告)日：1997-07-08
申请号：US309405
申请日：1994-09-20
申请人： Keith L. Frost , Jon W. Hayenga , James A. Stephanick , Robert C. Schmidt
发明人： Keith L. Frost , Jon W. Hayenga , James A. Stephanick , Robert C. Schmidt
IPC分类号： G02B7/28 , G02B21/00 , G06T5/20
CPC分类号： G02B7/28
摘要： A method for automatically focusing on a slide includes the steps of locating a coverslip, acquiring images from predetermined focal depths in the slide, and starting at an initial focal depth proximate the surface of the coverslip. A set of predetermined characteristics within each of the images are measured to generate at least one image measurement for each of the plurality of images. A focus measure is computed for each of the images, where each focus measure is a function of at least one image measurement. A best focus location is determined relative to a focal depth where an acquired image has a highest focus measure.
摘要翻译：用于自动聚焦在幻灯片上的方法包括以下步骤：定位盖玻片，从幻灯片中的预定焦点深度获取图像，并从靠近盖玻片表面的初始焦点深度开始。测量每个图像内的一组预定特征以对于多个图像中的每一个生成至少一个图像测量。为每个图像计算焦点测量，其中每个焦点测量是至少一个图像测量的函数。相对于获取的图像具有最高焦点测量的焦点深度来确定最佳聚焦位置。

4. 发明授权

US5581631A Cytological system image collection integrity checking apparatus 失效
标题翻译：细胞系统图像采集完整性检查装置
公开(公告)号：US5581631A
公开(公告)日：1996-12-03
申请号：US309078
申请日：1994-09-20
申请人： William E. Ortyn , Keith L. Frost , Jon W. Hayenga
发明人： William E. Ortyn , Keith L. Frost , Jon W. Hayenga
IPC分类号： G01N33/483 , G01N21/27 , G06K9/00 , G06T1/00
CPC分类号： G06K9/00127
摘要： An automated apparatus for checking cytological system image collection integrity in an automated cytological system including an imaging apparatus controlled by a digital processor. The automated apparatus includes linearity checking apparatus, coupled to the imaging apparatus and the digital processor. System frequency response is checked using a modulation transfer function, where the sampling frequency may be determined by pixel size so as to allow the MTF to be determined beyond the sampling frequency of a system detector. A system signal to noise ratio is also checked for specific regions of the frequency spectrum.
摘要翻译：一种用于在自动细胞学系统中检查细胞学系统图像收集完整性的自动化装置，包括由数字处理器控制的成像装置。该自动化装置包括耦合到成像装置和数字处理器的线性检查装置。使用调制传递函数检查系统频率响应，其中采样频率可以由像素尺寸确定，以便允许MTF被确定超过系统检测器的采样频率。还对频谱的特定区域检查系统信噪比。

5. 发明授权

US08254023B2 Optical tomography system with high-speed scanner 有权
标题翻译：光学断层扫描系统与高速扫描仪
公开(公告)号：US08254023B2
公开(公告)日：2012-08-28
申请号：US12391096
申请日：2009-02-23
申请人： Mathew D. Watson , Jon W. Hayenga
发明人： Mathew D. Watson , Jon W. Hayenga
IPC分类号： G02B23/14 , G02B21/00
CPC分类号： G02B21/025 , G01N21/4795 , G02B21/002
摘要： An object of interest is illuminated within the field of view of a microscope objective lens located to receive light passing through the object of interest. Light transmitted through the microscope objective lens impinges upon a variable power element. The variable power element is driven with respect to the microscope objective lens to scan through multiple focal planes in the object of interest. Light transmitted from the variable power element is sensed by a sensing element or array.
摘要翻译：感兴趣的物体在位于接收通过感兴趣物体的光的显微镜物镜的视场内被照亮。透过显微镜物镜的光照射在可变功率元件上。可变功率元件相对于显微镜物镜被驱动以扫描感兴趣对象中的多个焦平面。从可变功率元件发射的光由感测元件或阵列感测。

6. 发明授权

US08090183B2 Pattern noise correction for pseudo projections 有权
标题翻译：伪投影的图案噪声校正
公开(公告)号：US08090183B2
公开(公告)日：2012-01-03
申请号：US12403231
申请日：2009-03-12
申请人： Michael G. Meyer , Jon W. Hayenga , Thomas M. Abbott , David E. Steinhauer
发明人： Michael G. Meyer , Jon W. Hayenga , Thomas M. Abbott , David E. Steinhauer
IPC分类号： G06K9/18
CPC分类号： G01N15/1475 , G01N15/147 , G06T5/002 , G06T7/136 , G06T11/005 , G06T2207/10072 , G06T2207/30024 , H04N5/365
摘要： Correcting pattern noise projection images includes acquiring a set of projection images with an optical tomography system including a processor, where each of the set of projection images is acquired at a different angle of view. A threshold is applied to each projection image produce a set of threshold images. Each threshold image may optionally be dilated to produce a set of dilated images that are summed to form an ensemble image. Each of the dilated images is processed to produce a set of binary images. The set of binary images are summed to form an ensemble mask. The ensemble image is divided by the ensemble mask to yield a background pattern noise image. Each projection image is multiplied by a scaling factor and divided by the background pattern noise to produce a quotient image that is filtered to produce a noise corrected projection image.
摘要翻译：校正图案噪声投影图像包括使用包括处理器的光学层析成像系统获取一组投影图像，其中以不同的视角获取投影图像集合中的每一个。对每个投影图像应用阈值产生一组阈值图像。每个阈值图像可以可选地被扩展以产生一组被累加以形成整体图像的扩张图像。每个扩张的图像被处理以产生一组二进制图像。将二进制图像的集合相加以形成集合掩码。整体图像由合成掩模划分以产生背景图案噪声图像。将每个投影图像乘以缩放因子并除以背景图案噪声，以产生被滤波以产生噪声校正投影图像的商图像。

7. 发明授权

US07787112B2 Depth of field extension for optical tomography 有权
标题翻译：光学层析成像的景深延伸
公开(公告)号：US07787112B2
公开(公告)日：2010-08-31
申请号：US11876658
申请日：2007-10-22
申请人： J. Richard Rahn , Jon W. Hayenga
发明人： J. Richard Rahn , Jon W. Hayenga
IPC分类号： G01J1/00
CPC分类号： G01N21/4795 , A61B5/0073 , G01N15/1468
摘要： An optical projection tomography system is illuminated with a light source. An object-containing tube, a portion of which is located within the region illuminated by the light source, contains an object of interest that has a feature of interest. A detector is located to receive emerging radiation from the object of interest. A lens, including optical field extension elements, is located in the optical path between the object region and the detector, such that light rays from multiple object planes in the object-containing tube simultaneously focus on the detector. The object-containing tube moves relatively to the detector and the lens operate to provide multiple views of the object region for producing an image of the feature of interest at each view.
摘要翻译：用光源照射光学投影断层摄影系统。其中一部分位于由光源照射的区域内的含有物体的管包含具有感兴趣特征的感兴趣对象。探测器被设置为接收来自感兴趣对象的新兴辐射。包括光场延伸元件的透镜位于物体区域和检测器之间的光路中，使得来自物体的管中的多个物平面的光线同时聚焦在检测器上。所述含物体的管相对于所述检测器移动并且所述透镜操作以提供所述物体区域的多个视图，以在每个视图处产生感兴趣特征的图像。

8. 发明授权

US07569789B2 Cantilevered coaxial flow injector apparatus and method for sorting particles 有权
标题翻译：悬臂同轴流动注射器装置及粒子分选方法
公开(公告)号：US07569789B2
公开(公告)日：2009-08-04
申请号：US11377032
申请日：2006-03-16
申请人： Jon W. Hayenga , Alan C. Nelson
发明人： Jon W. Hayenga , Alan C. Nelson
IPC分类号： B07C5/00
CPC分类号： B01L3/502761 , B01L3/0293 , B01L3/502776 , B01L3/502784 , B01L2200/027 , B01L2200/0636 , B01L2300/0864 , B01L2400/0487 , G01N15/1459 , G01N15/1463 , G01N2015/149
摘要： An apparatus and method for sorting particles in a laminar flow microfluidic channel includes a cantilevered coaxial flow injector in a microfluidic device, the cantilevered coaxial flow injector including an elongated cantilever element integrated into the microfluidic device. A coaxial channel runs through the elongated cantilever element, where coaxial channel is sized to pass particles of a predetermined size. An actuator is coupled to the elongated cantilever element, for actuating said elongated cantilever element.
摘要翻译：用于在层流微流体通道中分选颗粒的装置和方法包括微流体装置中的悬臂同轴流注射器，所述悬臂同轴流动注射器包括集成到微流体装置中的细长悬臂元件。同轴通道穿过细长的悬臂元件，其中同轴通道的尺寸适于通过预定尺寸的颗粒。致动器联接到细长悬臂元件，用于致动所述细长悬臂元件。

9. 发明申请

US20090017423A1 DROPLET JET SYSTEM FOR CLEANSING 有权
标题翻译： DROPLET喷射清洗系统
公开(公告)号：US20090017423A1
公开(公告)日：2009-01-15
申请号：US11814060
申请日：2005-01-20
申请人： Bart Gottenbos , Jozef Johannes Maria Janssen , Marinus Karel Johannes De Jager , Adriaan Willem Cense , Paulus Cornelis Duineveld , Jon W. Hayenga , William E. Bryant , Martijn Jeroen Dekker
发明人： Bart Gottenbos , Jozef Johannes Maria Janssen , Marinus Karel Johannes De Jager , Adriaan Willem Cense , Paulus Cornelis Duineveld , Jon W. Hayenga , William E. Bryant , Martijn Jeroen Dekker
IPC分类号： A61C17/16
CPC分类号： A61C17/0202 , A61C17/028
摘要： The system includes a reservoir for fluid; a droplet generator for creating a stream of fluid droplets from the fluid wherein the velocity of the stream of droplets is within a range of 20 meters per second to 200 meters per second and the size of the droplets is within a range of 5 microns to 200 microns. A nozzle or nozzles direct the stream of droplets to safely clean a selected tooth or teeth surface area. The specific momentum of effective fluid droplets within the stream of fluid droplets is important in safe and effective cleaning.
摘要翻译：该系统包括用于流体的储存器; 用于从流体产生流体液滴的液滴发生器，其中液滴流的速度在20米/秒至200米/秒的范围内，并且液滴的尺寸在5微米至200埃的范围内微米。喷嘴或喷嘴引导液滴流以安全地清洁选定的牙齿或牙齿表面区域。流体液滴内有效流体液滴的特定动量在安全有效的清洗中是重要的。

10. 发明授权

US10028811B2 Droplet jet system for cleansing 有权
公开(公告)号：US10028811B2
公开(公告)日：2018-07-24
申请号：US11814060
申请日：2005-01-20
申请人： Bart Gottenbos , Jozef Johannes Maria Janssen , Marinus Karel Johannes Jager , Adriaan Willem Cense , Paulus Corenlis Duineveld , Jon W. Hayenga , William E. Bryant , Martijn Jeroen Dekker
发明人： Bart Gottenbos , Jozef Johannes Maria Janssen , Marinus Karel Johannes Jager , Adriaan Willem Cense , Paulus Corenlis Duineveld , Jon W. Hayenga , William E. Bryant , Martijn Jeroen Dekker
IPC分类号： A61C17/00 , A61C17/02 , A61C17/028
摘要： The system includes a reservoir for fluid; a droplet generator for creating a stream of fluid droplets from the fluid wherein the velocity of the stream of droplets is within a range of 20 meters per second to 200 meters per second and the size of the droplets is within a range of 5 microns to 200 microns. A nozzle or nozzles direct the stream of droplets to safely clean a selected tooth or teeth surface area. The specific momentum of effective fluid droplets within the stream of fluid droplets is important in safe and effective cleaning.

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