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1. 发明申请

US20100030196A1 APHERESIS OF A TARGET MOLECULE FROM CEREBROSPINAL FLUID 审中-公开
标题翻译：从胚胎液中吸收目标分子
公开(公告)号：US20100030196A1
公开(公告)日：2010-02-04
申请号：US12511571
申请日：2009-07-29
申请人： Keith Hildebrand , Lisa Lynn Shafer , Deepak Ramesh Thakker
发明人： Keith Hildebrand , Lisa Lynn Shafer , Deepak Ramesh Thakker
IPC分类号： A61M1/16
CPC分类号： A61M27/006
摘要： A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen.
摘要翻译：系统包括（i）具有固定支持物的介质，针对靶分子的抗体被结合到其上，（ii）用于容纳培养基的储存器，（iii）第一导管和（iv）第二导管。第一导管具有近端部分，用于从对象除去脑脊液的开口以及从近端部分延伸到开口的内腔。第一导管可操作地联接到储存器，使得流体能够从内腔流动到储存器。第二导管具有近端部分，用于将脑脊液返回到受试者的输送区域以及从近端部分延伸到输送区域的内腔。第二导管可操作地连接到储存器，使得流体能够从储存器流到内腔。

2. 发明申请

US20050004221A1 Intrathecal gabapentin compositions 审中-公开
标题翻译：鞘内加巴喷丁组合物
公开(公告)号：US20050004221A1
公开(公告)日：2005-01-06
申请号：US10808129
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/00 , A61K31/167 , A61K31/197 , A61K31/4045 , A61K31/42 , A61K31/445 , A61M5/142 , A61K31/195
CPC分类号： A61M5/14276 , A61K31/00 , A61K31/167 , A61K31/197 , A61K31/4045 , A61K31/42 , A61K31/445
摘要： Injectable compositions containing gabapentin and having reduced tonicity are discussed. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride. A process for preparing injectable gabapentin compositions are also discussed. The process includes determining and optionally adjusting tonicity of a gabapentin composition.
摘要翻译：讨论了含有加巴喷丁并具有降低的张力的可注射组合物。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml加巴喷丁，并且具有小于约900mOsm的张力。另一种不可接受的加巴喷丁组合物含有少于0.9％的氯化钠。还讨论了制备可注射加巴喷丁组合物的方法。该方法包括确定和任选地调节加巴喷丁组合物的张力。

3. 发明申请

US20050004219A1 Pump systems including injectable gabapentin compositions 审中-公开
标题翻译：泵系统包括可注射的加巴喷丁组合物
公开(公告)号：US20050004219A1
公开(公告)日：2005-01-06
申请号：US10808054
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Harris Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Harris Ratnayake
IPC分类号： A61B5/03 , A61K31/195 , A61K31/197 , A61M5/142
CPC分类号： A61M5/14276 , A61K31/197 , A61M2202/0464 , A61M2210/0693
摘要： A system including a reservoir, a pump coupled to the reservoir, a catheter coupled to the pump and adapted for delivering a therapeutic agent to a cerebrospinal fluid of a patient; and an injectable gabapentin composition housed in the reservoir and deliverable through the catheter, is discussed. The injectable gabapentin composition may have reduced tonicity. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride.
摘要翻译：一种包括储存器，耦合到储存器的泵，耦合到泵并适于将治疗剂递送到患者的脑脊液的导管的系统; 并且讨论了容纳在储存器中并可通过导管输送的可注射加巴喷丁组合物。可注射的加巴喷丁组合物可以具有降低的张力。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml加巴喷丁，并且具有小于约900mOsm的张力。另一种不可接受的加巴喷丁组合物含有少于0.9％的氯化钠。

4. 发明申请

US20070253995A1 Drug Delivery Methods and Devices for Treating Stress Urinary Incontinence 审中-公开
标题翻译：用于治疗压力性尿失禁的药物递送方法和装置
公开(公告)号：US20070253995A1
公开(公告)日：2007-11-01
申请号：US11380919
申请日：2006-04-28
申请人： Keith Hildebrand
发明人： Keith Hildebrand
IPC分类号： A61K31/445 , A61K31/381 , A61K31/4184 , A61K31/4178 , A61K31/137 , A61K31/343
CPC分类号： A61K31/137 , A61K9/0019 , A61K31/343 , A61K31/381 , A61K31/4178 , A61K31/4184 , A61K31/445
摘要： The disclosure describes a method and system for delivering a drug to the Onuf's nucleus of a patient for the treatment or prevention of stress urinary incontinence. The system includes drug delivery devices that deliver one or more drugs to a site located adjacent to, around or within the Onuf's nucleus stress incontinence alleviation. A depot configured to release a therapeutically effective amount of a stress incontinence-reducing drug is one drug delivery device disclosed. Other drug delivery devices include implantable infusion pumps.
摘要翻译：本公开描述了用于将药物递送到患者的Onuf核的用于治疗或预防压力性尿失禁的方法和系统。该系统包括将一种或多种药物递送到位于Onuf的核应力失禁减轻附近，周围或内部的位置的药物递送装置。被配置为释放治疗有效量的应力失禁药物的贮存库是公开的一种药物递送装置。其他药物输送装置包括可植入输液泵。

5. 发明申请

US20070251530A1 SCREENING CANDIDATES FOR IMPLANTABLE INFUSION DEVICES 审中-公开
标题翻译：筛选用于可植入输注装置的候选药物
公开(公告)号：US20070251530A1
公开(公告)日：2007-11-01
申请号：US11380698
申请日：2006-04-28
申请人： Keith Hildebrand
发明人： Keith Hildebrand
IPC分类号： A61M5/14
CPC分类号： A61M5/14276 , A61K49/0004
摘要： Pharmaceutical depots and methods for screening patients to identify good candidates for implantable infusion device therapy are described. A pharmaceutical depot is placed in a target region of a patient of a pharmaceutical depot configured to release a therapeutic agent in a manner similar to what would be achieved by an implantable infusion system, e.g. small amounts over a period of time. Following depot placement, the patient can be evaluated to determine whether at least one symptom of a disease or general quality of life has improved. If an improvement results, the patient is identified as a good candidate for receiving an implantable infusion device to deliver the therapeutic agent to the target region to treat the disease.
摘要翻译：描述了用于筛选患者以鉴定可植入输注装置治疗的良好候选者的药物库和方法。将药物贮库放置在药物贮库的患者的目标区域中，其配置为以与通过植入式输注系统所实现的方式类似的方式释放治疗剂。一段时间内少量。在车间放置后，可以评估患者以确定疾病的至少一种症状或一般生活质量是否改善。如果改善结果，则将患者确定为用于接收可植入输注装置以将治疗剂递送至靶区域以治疗该疾病的良好候选者。

6. 发明申请

US20050177097A1 Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
标题翻译：交配性心血管药物向中枢神经系统递送
公开(公告)号：US20050177097A1
公开(公告)日：2005-08-11
申请号：US10903599
申请日：2004-07-30
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
IPC分类号： A61B5/02 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/39 , A61K31/137 , A61K9/22 , A61K31/24
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和右美托咪定）。

7. 发明申请

US20050090549A1 Intrathecal gabapentin for treatment of pain 审中-公开
标题翻译：鞘内加巴喷丁治疗疼痛
公开(公告)号：US20050090549A1
公开(公告)日：2005-04-28
申请号：US10807828
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/197 , A61K31/485 , A61M5/142 , A61K31/195 , A61M31/00
CPC分类号： A61M5/14276 , A61M2005/1405 , A61M2202/0464
摘要： Methods for treating pain by administering gabapentin to cerebrospinal fluid of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable pump having a reservoir for housing a composition, a catheter having a proximal portion coupled to the pump and having a distal portion adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, is also discussed.
摘要翻译：讨论了通过给予加巴喷丁至患者脑脊液治疗疼痛的方法。还讨论了含有加巴喷丁的组合物，特别是可注射组合物。另外，包括具有用于容纳组合物的储存器的可植入泵的系统，具有耦合到泵的近端部分并具有适于将组合物施用于患者的脑脊液的远端部分的导管和含有加巴喷丁的组合物，还讨论了哪种组合物容纳在泵的储存器中。

8. 发明申请

US20050048641A1 System and method for delivering polynucleotides to the central nervous system 审中-公开
标题翻译：将多核苷酸递送至中枢神经系统的系统和方法
公开(公告)号：US20050048641A1
公开(公告)日：2005-03-03
申请号：US10962732
申请日：2004-10-12
申请人： Keith Hildebrand , William Kaemmerer
发明人： Keith Hildebrand , William Kaemmerer
IPC分类号： A61K31/713 , A61M37/00 , C12N15/11 , C12M1/00
CPC分类号： A61M37/00 , A61K31/713
摘要： Methods and apparatuses for delivering RNA polynucleotides to a patient in need thereof are described. Programmable infusion pump systems that include a reservoir housing the RNA polynucleotide are implanted in the patient. The RNA polynucleotide is delivered to a target location in the patient via a catheter in communication with the reservoir. The pump system may include one or more sensors that may control rate or timing of delivery of the RNA polynucloetide based on a detected event. The pump system allows for controlled delivery of RNA polynucleotides for the treatment of diseases, disorders, or conditions.
摘要翻译：描述了将RNA多核苷酸递送给有需要的患者的方法和装置。包括容纳RNA多核苷酸的储存器的可编程输液泵系统植入患者体内。通过与储存器连通的导管将RNA多核苷酸递送至患者的目标位置。泵系统可以包括可以基于检测到的事件来控制RNA多核苷酸的递送速率或定时的一个或多个传感器。泵系统允许用于治疗疾病，病症或病症的RNA多核苷酸的受控递送。

9. 发明申请

US20070253994A1 Intraspinal Drug Delivery Methods and Devices To Alleviate Chronic Pelvic Pain 审中-公开
标题翻译：脊柱内给药方法和装置缓解慢性盆腔疼痛
公开(公告)号：US20070253994A1
公开(公告)日：2007-11-01
申请号：US11380814
申请日：2006-04-28
申请人： Keith Hildebrand
发明人： Keith Hildebrand
IPC分类号： A61K38/08 , A61K31/407 , A61K31/192 , A61K31/195
CPC分类号： A61K38/31 , A61K31/192 , A61K31/195 , A61K31/407
摘要： The disclosure describes methods and systems for alleviating chronic pelvic pain in a subject by intraspinally a therapeutically effective amount of a chronic pelvic pain-alleviating drug. The system includes drug delivery devices and systems for the controlled administration of drugs for alleviation of pelvic pain. The system may deliver drug therapy for pelvic pain in men or women.
摘要翻译：本公开内容描述了缓解慢性盆腔疼痛缓解药物的治疗有效量的受试者慢性骨盆疼痛的方法和系统。该系统包括药物输送装置和用于受控制的用于缓解盆腔疼痛的药物的系统。该系统可以为男性或女性的骨盆疼痛提供药物治疗。

10. 发明申请

US20060293389A1 PROCESS FOR PRODUCING INJECTABLE GABAPENTIN COMPOSITIONS 审中-公开
标题翻译：生产注射用加巴酚丁酯组合物的方法
公开(公告)号：US20060293389A1
公开(公告)日：2006-12-28
申请号：US11459200
申请日：2006-07-21
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/195
CPC分类号： A61K31/52 , A61K9/0019 , A61K9/0085 , A61K31/195 , A61L2/0017 , A61L2/0023 , A61M5/14276 , A61M2202/0464 , A61M2210/0693
摘要： Injectable compositions containing gabapentin and processes for preparing sterile injectable compositions containing gabapentin are discussed. The process includes subjecting the compositions to heat. Heating results in increased production of gabapentin lactam, which has previously been shown to be toxic. Surprisingly, heated injectable compositions containing gabapentin are found to be non-toxic when administered intrathecally. Thus, heating for the purposes of sterilization or to assure sterility provides a viable option in the production of injectable compositions containing gabapentin.
摘要翻译：讨论了含有加巴喷丁的可注射组合物和制备含有加巴喷丁的无菌可注射组合物的方法。该方法包括使组合物加热。加热导致加巴喷丁内酰胺的生产增加，其先前已被证明是有毒的。令人惊奇的是，发现含有加巴喷丁的加热可注射组合物在鞘内施用时是无毒的。因此，用于灭菌或确保无菌的加热为生产含有加巴喷丁的可注射组合物提供了可行的选择。

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