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1. 发明申请

US20100030196A1 APHERESIS OF A TARGET MOLECULE FROM CEREBROSPINAL FLUID 审中-公开
标题翻译：从胚胎液中吸收目标分子
公开(公告)号：US20100030196A1
公开(公告)日：2010-02-04
申请号：US12511571
申请日：2009-07-29
申请人： Keith Hildebrand , Lisa Lynn Shafer , Deepak Ramesh Thakker
发明人： Keith Hildebrand , Lisa Lynn Shafer , Deepak Ramesh Thakker
IPC分类号： A61M1/16
CPC分类号： A61M27/006
摘要： A system includes (i) a medium having a solid support to which an antibody directed to target molecule is bound, (ii) a reservoir for containing the medium, (iii) a first catheter, and (iv) a second catheter. The first catheter has a proximal end portion, an opening for removal of cerebrospinal fluid from a subject, and a lumen extending from the proximal end portion to the opening. The first catheter is operably couplable to the reservoir such that fluid is capable of flowing from the lumen to the reservoir. The second catheter has a proximal end portion, a delivery region for returning cerebrospinal fluid to the subject, and a lumen extending from the proximal end portion to the delivery region. The second catheter is operably couplable to the reservoir such that fluid is capable of flowing from the reservoir to the lumen.
摘要翻译：系统包括（i）具有固定支持物的介质，针对靶分子的抗体被结合到其上，（ii）用于容纳培养基的储存器，（iii）第一导管和（iv）第二导管。第一导管具有近端部分，用于从对象除去脑脊液的开口以及从近端部分延伸到开口的内腔。第一导管可操作地联接到储存器，使得流体能够从内腔流动到储存器。第二导管具有近端部分，用于将脑脊液返回到受试者的输送区域以及从近端部分延伸到输送区域的内腔。第二导管可操作地连接到储存器，使得流体能够从储存器流到内腔。

2. 发明申请

US20060160899A1 Intrathecal Gabapentin for Treatment of Epilepsy 审中-公开
标题翻译：鞘内加巴喷丁治疗癫痫
公开(公告)号：US20060160899A1
公开(公告)日：2006-07-20
申请号：US11277786
申请日：2006-03-29
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/195 , A61K9/22
CPC分类号： A61K31/197 , A61K31/195
摘要： Methods for treating epilepsy by administering gabapentin to cerebrospinal fluid and brain tissue of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable device having a pump coupled to a reservoir for housing a composition, a catheter having a proximal end coupled to the pump and having a distal end adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, are also discussed.
摘要翻译：讨论了通过给予加巴喷丁至患者脑脊液和脑组织来治疗癫痫的方法。还讨论了含有加巴喷丁的组合物，特别是可注射组合物。另外，包括具有耦合到用于容纳组合物的储存器的泵的可植入装置的系统，具有联接到泵的近端并具有适于将组合物施用于患者的脑脊液的远端的导管，以及还讨论了包含加巴喷丁的组合物，其组合物容纳在泵的储存器中。

3. 发明申请

US20060111690A1 Method and system for treating depressive and anxiety disorders 审中-公开
标题翻译：治疗抑郁和焦虑症的方法和系统
公开(公告)号：US20060111690A1
公开(公告)日：2006-05-25
申请号：US11230808
申请日：2005-09-20
申请人： Keith Hildebrand
发明人： Keith Hildebrand
IPC分类号： A61M31/00
CPC分类号： A61M5/14276 , A61M5/1723
摘要： A method and system for treating depressive and anxiety disorders is disclosed. The method and system of the present invention comprises operating a programmable pump for the delivery of at least one therapeutic substance into the cerebrospinal fluid of a patient for the treatment of depressive or anxiety disorders. In an embodiment, a sensor implanted in a patient may be used in combination with the programmable pump and catheter.
摘要翻译：公开了一种治疗抑郁和焦虑症的方法和系统。本发明的方法和系统包括操作可编程泵，用于将至少一种治疗物质输送到患者的脑脊液中用于治疗抑郁症或焦虑症。在一个实施例中，植入患者体内的传感器可与可编程泵和导管组合使用。

4. 发明申请

US20050177135A1 Delivery of a sympatholytic cardiovascular agent to the central nervous system to counter heart failure and pathologies associated with heart failure 有权
标题翻译：向中枢神经系统递送交感神经心血管药物以对抗心力衰竭和与心力衰竭相关的病理
公开(公告)号：US20050177135A1
公开(公告)日：2005-08-11
申请号：US10773965
申请日：2004-02-06
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
IPC分类号： A61B5/02 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/39 , A61K9/22
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms and otherwise treat heart failure (HF) and pathologies associated with HF. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with HF (or pathologies associated with HF) and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist, e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine.
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解症状，另外治疗与HF有关的心力衰竭（HF）和病理学。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与HF相关的生理学参数（或与HF相关的病理学）和触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂组成的组之一，例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫西康定，甲基多巴，甲苯噻嗪，胍法辛，美托咪定，美托咪定和右美托咪定。

5. 发明申请

US20050090548A1 Intrathecal gabapentin for treatment of epilepsy 审中-公开
标题翻译：鞘内加巴喷丁治疗癫痫
公开(公告)号：US20050090548A1
公开(公告)日：2005-04-28
申请号：US10807827
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61B5/03 , A61K31/195 , A61K31/197 , A61M31/00
CPC分类号： A61K31/197 , A61K31/195
摘要： Methods for treating epilepsy by administering gabapentin to cerebrospinal fluid and brain tissue of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable device having a pump coupled to a reservoir for housing a composition, a catheter having a proximal end coupled to the pump and having a distal end adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, are also discussed.
摘要翻译：讨论了通过给予加巴喷丁至患者脑脊液和脑组织来治疗癫痫的方法。还讨论了含有加巴喷丁的组合物，特别是可注射组合物。另外，包括具有耦合到用于容纳组合物的储存器的泵的可植入装置的系统，具有联接到泵的近端并具有适于将组合物施用于患者的脑脊液的远端的导管，以及还讨论了包含加巴喷丁的组合物，其组合物容纳在泵的储存器中。

6. 发明申请

US20050177097A1 Delivery of a sympatholytic cardiovascular agent to the central nervous system 有权
标题翻译：交配性心血管药物向中枢神经系统递送
公开(公告)号：US20050177097A1
公开(公告)日：2005-08-11
申请号：US10903599
申请日：2004-07-30
申请人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
发明人： Keith Hildebrand , Michael Ujhelyi , Xiaohong Zhou , Daniel Sigg , Linda Page
IPC分类号： A61B5/02 , A61M5/142 , A61M5/168 , A61M5/172 , A61N1/39 , A61K31/137 , A61K9/22 , A61K31/24
CPC分类号： A61M5/142 , A61M5/14276 , A61M5/1723 , A61M2005/14208 , A61M2205/3523 , A61M2230/00 , A61M2230/04 , A61M2230/63 , A61N1/3962
摘要： A sympatholytic cardiovascular agent delivered by a drug delivery pump to a central nervous system site to alleviate symptoms of acute or chronic cardiac insult or impaired cardiac performance. The drug delivery pump can be external or implantable infusion pump (IIP) coupled with a drug infusion catheter extending to the site. A patient activator can command delivery of a dosage and/or an implantable heart monitor (IHM) coupled with a sensor can detect physiologic parameters associated with cardiac insult or impaired cardiac performance and trigger dosage delivery. The IIP and IHM can be combined into a single implantable medical device (IMD) or can constitute separate IMDs that communicate by any of known communication mechanisms. The sympatholytic cardiovascular agent is one of the group consisting of an alpha-adrenergic agonist and an alpha2-adrenergic agonist (e.g., clonidine, p-aminoclonidine, guanabenz, lidamidine, tizanidine, moxonidine, methyldopa, xylazine, guanfacine, detomidine, medetomidine, and dexmedetomidine).
摘要翻译：由药物输送泵递送至中枢神经系统部位的交感神经心血管药物以缓解急性或慢性心脏损伤或心脏功能受损的症状。药物输送泵可以是外部或植入式输液泵（IIP），其与延伸到现场的药物输注导管结合。患者活化剂可以命令递送剂量和/或与传感器耦合的可植入心脏监测器（IHM）可以检测与心脏损伤相关的生理参数或心脏功能受损并触发剂量递送。 IIP和IHM可以组合成单个可植入医疗设备（IMD），或者可以构成通过任何已知的通信机制进行通信的单独IMD。交感神经心血管药剂是由α-肾上腺素能激动剂和α2-肾上腺素能激动剂（例如可乐定，对氨基可乐定，胍苯胺，利脒，替扎尼定，莫索尼定，甲基多巴，甲苯噻嗪，胍法西林，美托洛尼，美托咪定和右美托咪定）。

7. 发明申请

US20050090549A1 Intrathecal gabapentin for treatment of pain 审中-公开
标题翻译：鞘内加巴喷丁治疗疼痛
公开(公告)号：US20050090549A1
公开(公告)日：2005-04-28
申请号：US10807828
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/197 , A61K31/485 , A61M5/142 , A61K31/195 , A61M31/00
CPC分类号： A61M5/14276 , A61M2005/1405 , A61M2202/0464
摘要： Methods for treating pain by administering gabapentin to cerebrospinal fluid of a patient are discussed. Compositions, particularly injectable compositions, containing gabapentin are also discussed. In addition, systems including an implantable pump having a reservoir for housing a composition, a catheter having a proximal portion coupled to the pump and having a distal portion adapted for administrating a composition to a cerebrospinal fluid of a patient, and a composition containing gabapentin, which composition is housed in the reservoir of the pump, is also discussed.
摘要翻译：讨论了通过给予加巴喷丁至患者脑脊液治疗疼痛的方法。还讨论了含有加巴喷丁的组合物，特别是可注射组合物。另外，包括具有用于容纳组合物的储存器的可植入泵的系统，具有耦合到泵的近端部分并具有适于将组合物施用于患者的脑脊液的远端部分的导管和含有加巴喷丁的组合物，还讨论了哪种组合物容纳在泵的储存器中。

8. 发明申请

US20050048641A1 System and method for delivering polynucleotides to the central nervous system 审中-公开
标题翻译：将多核苷酸递送至中枢神经系统的系统和方法
公开(公告)号：US20050048641A1
公开(公告)日：2005-03-03
申请号：US10962732
申请日：2004-10-12
申请人： Keith Hildebrand , William Kaemmerer
发明人： Keith Hildebrand , William Kaemmerer
IPC分类号： A61K31/713 , A61M37/00 , C12N15/11 , C12M1/00
CPC分类号： A61M37/00 , A61K31/713
摘要： Methods and apparatuses for delivering RNA polynucleotides to a patient in need thereof are described. Programmable infusion pump systems that include a reservoir housing the RNA polynucleotide are implanted in the patient. The RNA polynucleotide is delivered to a target location in the patient via a catheter in communication with the reservoir. The pump system may include one or more sensors that may control rate or timing of delivery of the RNA polynucloetide based on a detected event. The pump system allows for controlled delivery of RNA polynucleotides for the treatment of diseases, disorders, or conditions.
摘要翻译：描述了将RNA多核苷酸递送给有需要的患者的方法和装置。包括容纳RNA多核苷酸的储存器的可编程输液泵系统植入患者体内。通过与储存器连通的导管将RNA多核苷酸递送至患者的目标位置。泵系统可以包括可以基于检测到的事件来控制RNA多核苷酸的递送速率或定时的一个或多个传感器。泵系统允许用于治疗疾病，病症或病症的RNA多核苷酸的受控递送。

9. 发明申请

US20050004221A1 Intrathecal gabapentin compositions 审中-公开
标题翻译：鞘内加巴喷丁组合物
公开(公告)号：US20050004221A1
公开(公告)日：2005-01-06
申请号：US10808129
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Jayantha Ratnayake
IPC分类号： A61K31/00 , A61K31/167 , A61K31/197 , A61K31/4045 , A61K31/42 , A61K31/445 , A61M5/142 , A61K31/195
CPC分类号： A61M5/14276 , A61K31/00 , A61K31/167 , A61K31/197 , A61K31/4045 , A61K31/42 , A61K31/445
摘要： Injectable compositions containing gabapentin and having reduced tonicity are discussed. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride. A process for preparing injectable gabapentin compositions are also discussed. The process includes determining and optionally adjusting tonicity of a gabapentin composition.
摘要翻译：讨论了含有加巴喷丁并具有降低的张力的可注射组合物。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml加巴喷丁，并且具有小于约900mOsm的张力。另一种不可接受的加巴喷丁组合物含有少于0.9％的氯化钠。还讨论了制备可注射加巴喷丁组合物的方法。该方法包括确定和任选地调节加巴喷丁组合物的张力。

10. 发明申请

US20050004219A1 Pump systems including injectable gabapentin compositions 审中-公开
标题翻译：泵系统包括可注射的加巴喷丁组合物
公开(公告)号：US20050004219A1
公开(公告)日：2005-01-06
申请号：US10808054
申请日：2004-03-24
申请人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Harris Ratnayake
发明人： Keith Hildebrand , Linda Page , Deanna Lane , Dennis Elsberry , David Clarahan , Harris Ratnayake
IPC分类号： A61B5/03 , A61K31/195 , A61K31/197 , A61M5/142
CPC分类号： A61M5/14276 , A61K31/197 , A61M2202/0464 , A61M2210/0693
摘要： A system including a reservoir, a pump coupled to the reservoir, a catheter coupled to the pump and adapted for delivering a therapeutic agent to a cerebrospinal fluid of a patient; and an injectable gabapentin composition housed in the reservoir and deliverable through the catheter, is discussed. The injectable gabapentin composition may have reduced tonicity. One such injectable gabapentin composition contains greater than about 30 mg/ml gabapentin and has a tonicity of less than about 900 mOsm. Another such injecable gabapentin composition contains less that 0.9% sodium chloride.
摘要翻译：一种包括储存器，耦合到储存器的泵，耦合到泵并适于将治疗剂递送到患者的脑脊液的导管的系统; 并且讨论了容纳在储存器中并可通过导管输送的可注射加巴喷丁组合物。可注射的加巴喷丁组合物可以具有降低的张力。一种这样的可注射加巴喷丁组合物含有大于约30mg / ml加巴喷丁，并且具有小于约900mOsm的张力。另一种不可接受的加巴喷丁组合物含有少于0.9％的氯化钠。

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