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1. 发明授权

US5079232A Compound KS-505 useful for improving cerebral function 失效
标题翻译：化合物KS-505有助于改善小脑功能
公开(公告)号：US5079232A
公开(公告)日：1992-01-07
申请号：US447891
申请日：1989-12-08
申请人： Keiko Ohsawa , Satoshi Nakanishi , Hiroshi Kase , Isao Kawamoto , Tohru Yasuzawa , Yutaka Saito , Hiroshi Sano , Shizuo Shiozaki , Katsuichi Shutoh
发明人： Keiko Ohsawa , Satoshi Nakanishi , Hiroshi Kase , Isao Kawamoto , Tohru Yasuzawa , Yutaka Saito , Hiroshi Sano , Shizuo Shiozaki , Katsuichi Shutoh
IPC分类号： C07H15/26 , C12P19/62
CPC分类号： C07H15/26 , C12P19/62
摘要： A new compound designated KS-505 having amnesia-inhibiting activity may be prepared by fermentation of a suitable strain of Streptomyces, preferably Streptomyces argenteolus A-2 (FERM BP-2065). The compound is thought to have the structure: ##STR1##

2. 发明授权

US4692310A Substance K-259-2 and a process for producing the same 失效
标题翻译：物质K-259-2及其制备方法
公开(公告)号：US4692310A
公开(公告)日：1987-09-08
申请号：US852590
申请日：1986-04-16
申请人： Hiroshi Kase , Yuzuru Matsuda , Isao Kawamoto , Kozo Asano , Kunikatsu Shirahata , Tohru Yasuzawa , Koji Yamada
发明人： Hiroshi Kase , Yuzuru Matsuda , Isao Kawamoto , Kozo Asano , Kunikatsu Shirahata , Tohru Yasuzawa , Koji Yamada
IPC分类号： C07G11/00 , A61K35/74 , A61P9/08 , C07C66/02 , C12P1/06 , C12P15/00 , C12R1/29
CPC分类号： C12P1/06
摘要： A new substance K-259-2 having a molecular formula of C.sub.21 H.sub.18 O.sub.7, a molecular weight of 382 and an elemental analysis (%) of H: 4.50, C: 65.53 and N: 0. This substance is of interest in providing a new vasodilating agent in view of its ability to dilate the blood vessel, particularly the artery, of mammals. This substance may be obtained by fermentation of a microorganism Micromonospora sp. K-259 (FERM BP 569).
摘要翻译：分子式为C 21 H 18 O 7，分子量382，元素分析（％）H：4.50，C：65.53和N：0的新物质K-259-2。提供新的血管扩张剂鉴于其能够扩大哺乳动物的血管，特别是动脉的能力。该物质可以通过微生物微单孢菌发酵获得。 K-259（FERM BP 569）。

3. 发明授权

US5008271A DC-88A derivatives 失效
标题翻译： DC-88A衍生物
公开(公告)号：US5008271A
公开(公告)日：1991-04-16
申请号：US423788
申请日：1989-10-18
申请人： Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
发明人： Yutaka Kanda , Tohru Yasuzawa , Hiromitsu Saito , Hiroshi Sano , Eiji Kobayashi , Makoto Morimoto
IPC分类号： C07D471/04 , C07D487/04 , C07D487/10
CPC分类号： C07D471/04 , C07D487/04 , C07D487/10
摘要： A novel DC-88A derivative represented by general formula: ##STR1## wherein ##STR2## represents ##STR3## has an excellent antitumor activity and is useful as an antitumor agent.

4. 发明授权

US6107064A Process for producing xanthine derivatives with bacteria and fungi 失效
标题翻译：用细菌和真菌生产黄嘌呤衍生物的方法
公开(公告)号：US6107064A
公开(公告)日：2000-08-22
申请号：US581533
申请日：1996-01-17
申请人： Junichi Shimada , Tamotsu Eguchi , Kenichi Mochida , Akira Horiguchi , Tohru Yasuzawa , Hideaki Kusaka , Hiromi Nonaka , Fumio Suzuki
发明人： Junichi Shimada , Tamotsu Eguchi , Kenichi Mochida , Akira Horiguchi , Tohru Yasuzawa , Hideaki Kusaka , Hiromi Nonaka , Fumio Suzuki
IPC分类号： C07D473/04 , C07D473/06 , C12P17/18 , C12P17/16
CPC分类号： C07D473/04 , C07D473/06 , C12P17/18
摘要： The present invention relates to a process for producing a xanthine derivative represented by formula (II), comprising converting a xanthine derivative represented by formula (I) {hereinafter, referred to as Compound (I)}: ##STR1## (wherein R.sup.1 and R.sup.2 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl) into a xanthine derivative represented by formula (II) {hereinafter, referred to as Compound (II)}: ##STR2## (wherein R.sup.3 and R.sup.4 independently represent hydrogen, or hydroxy-substituted, oxo-substituted, or unsubstituted lower alkyl; R.sup.5 and R.sup.6 independently represent hydrogen, hydroxy, or oxo; with the proviso that R.sup.5 and R.sup.6 are both hydrogen, at least one of R.sup.3 and R.sup.4 is hydroxy-substituted or oxo-substituted lower alkyl; and X and Y both represent hydrogen or are combined with each other to form a single bond) in the presence of an enzyme source for catalyzing hydroxylation or carbonylation of Compound (I) into Compound (II), and collecting the produced Compound (II).
摘要翻译： PCT No.PCT / JP95 / 00929 Sec。 371日期1996年1月17日 102（e）日期1996年1月17日PCT提交1995年5月16日PCT公布。公开号WO95 / 31460 日本特开平9-1252号公报发明内容本发明涉及由式（II）表示的黄嘌呤衍生物的制造方法，其特征在于，将由式（I）表示的黄嘌呤衍生物{以下称为化合物（I）} 和R2独立地表示氢或羟基取代的，取代或未取代的低级烷基）转化为由式（II）表示的黄嘌呤衍生物（以下称为化合物（II）}：（其中R 3和R 4独立地表示氢或羟基取代的，取代或未取代的低级烷基; R 5和R 6独立地表示氢，羟基或氧代;条件是R 5和R 6都是氢，R 3和R 4中的至少一个是羟基取代的或氧代取代的低级烷基; X和Y均表示氢或彼此结合形成单键）在用于催化化合物（I）羟化或羰基化成化合物（II）的酶源的存在下，以及大学将所制备的化合物（II）。

5. 发明授权

US5395836A 8-tricycloalkyl xanthine derivatives 失效
标题翻译： 8-三环烷基黄嘌呤衍生物
公开(公告)号：US5395836A
公开(公告)日：1995-03-07
申请号：US222938
申请日：1994-04-05
申请人： Junichi Shimada , Takashi Kuwabara , Tohru Yasuzawa , Hiroshi Magara , Hiromi Nonaka , Hideaki Kusaka , Fumio Suzuki
发明人： Junichi Shimada , Takashi Kuwabara , Tohru Yasuzawa , Hiroshi Magara , Hiromi Nonaka , Hideaki Kusaka , Fumio Suzuki
IPC分类号： C07D473/04 , A61K31/52 , C07D473/06
CPC分类号： C07D473/04 , Y10S514/869
摘要： There is provided a novel xanthine Compound(I) ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each represent hydroxy-substituted, oxo-substituted or unsubstituted lower alkyl, Y is a single bond or alkylene, and Q is ##STR2## wherein R.sup.3 and R.sup.4 are the same or different and each represent hydrogen or hydroxy, n is 0 or 1; provided that when both of R.sup.3 and R.sup.4 are hydrogen, at least one of R.sup.1 and R.sup.2 is hydroxy-substituted or oxo-substituted lower alkyl; or a pharmaceutically acceptable salt thereof.The xanthine compound has adenosine A.sub.1 receptor antagonizing activity, and thus shows diuretic effect, renal-protecting effect, bronchodilatory effect, cerebral function improving effect and anti-dementia effect.
摘要翻译：提供了一种新颖的黄嘌呤化合物（I）其中R 1和R 2相同或不同，各自表示羟基取代的，取代或未取代的低级烷基，Y是单键或亚烷基，Q 其中R 3和R 4相同或不同，各自表示氢或羟基，n为0或1; 条件是当R 3和R 4都是氢时，R 1和R 2中的至少一个是羟基取代的或氧代取代的低级烷基; 或其药学上可接受的盐。黄嘌呤化合物具有腺苷A1受体拮抗活性，因此具有利尿作用，肾保护作用，支气管扩张作用，脑功能改善作用和抗痴呆作用。

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