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1. 发明授权

US5804410A Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme 失效
标题翻译：编码胰蛋白酶样酶的核酸序列及其制备方法
公开(公告)号：US5804410A
公开(公告)日：1998-09-08
申请号：US508448
申请日：1995-07-28
申请人： Kazuyoshi Yamaoka , Hiroko Ogawa , Yoshinori Sugimoto , Kenichi Masuda , Tetsuya Suga , Kenichiro Takagi , Susumu Yasuoka
发明人： Kazuyoshi Yamaoka , Hiroko Ogawa , Yoshinori Sugimoto , Kenichi Masuda , Tetsuya Suga , Kenichiro Takagi , Susumu Yasuoka
IPC分类号： C12N9/64 , C12N15/57 , C12P21/06 , C07H17/00 , C12N9/00
CPC分类号： C12N9/6424 , C12N2799/026
摘要： This invention provides a nucleic acid sequence encoding a trypsin-like enzyme which can be present at the trachea of human lungs, and can selectively digest a synthetic substrate for trypsin and a synthetic substrate for thrombin, and fibrinogen; and a process for producing the trypsin-like enzyme by genetic engineering utilizing the nucleic acid sequence.
摘要翻译：本发明提供编码胰蛋白酶样酶的核酸序列，其可以存在于人肺气管中，并且可以选择性地消化胰蛋白酶的合成底物和用于凝血酶和纤维蛋白原的合成底物; 以及利用核酸序列通过遗传工程生产胰蛋白酶样酶的方法。

2. 发明授权

US06346385B1 Analysis of predisposition based on human airway trypsin protease gene polymorphism 失效
标题翻译：基于人气道胰蛋白酶蛋白酶基因多态性的易感性分析
公开(公告)号：US06346385B1
公开(公告)日：2002-02-12
申请号：US09581617
申请日：2000-06-15
申请人： Hiroshi Eguchi , Kazuyoshi Yamaoka , Kenichi Masuda , Susumu Yasuoka
发明人： Hiroshi Eguchi , Kazuyoshi Yamaoka , Kenichi Masuda , Susumu Yasuoka
IPC分类号： C12Q168
CPC分类号： C12N9/6427 , C12Q1/6883 , C12Q2600/156 , C12Q2600/172
摘要： A method for predicting the constitution susceptible to the onset of specific diseases in individual humans, for example, respiratory diseases such as chronic obstructive pulmonary diseases, sinobronchial syndrome, pulmonary emphysema, diffuse panbronchiolitis or bronchiectasis, effects of treatment on patients or prognosis of the treatment by analyzing the genetic polymorphisms of a human trypsin-like enzyme of the respiratory tract.
摘要翻译：用于预测易患个体人群特定疾病发生的体质的方法，例如呼吸系统疾病如慢性阻塞性肺疾病，脊柱支气管综合征，肺气肿，弥漫性全细支气管炎或支气管扩张症，治疗效果或治疗预后通过分析呼吸道的人胰蛋白酶样酶的遗传多态性。

3. 发明授权

US07396642B2 Methods of screening for a compound that enhances thermogenesis 失效
标题翻译：筛选增强产热的化合物的方法
公开(公告)号：US07396642B2
公开(公告)日：2008-07-08
申请号：US10483627
申请日：2002-07-17
申请人： Kazuyoshi Yamaoka , Kenichiro Takagi , Kenichiro Kataoka , Masanori Yamamoto , Toshihiro Chikanishi
发明人： Kazuyoshi Yamaoka , Kenichiro Takagi , Kenichiro Kataoka , Masanori Yamamoto , Toshihiro Chikanishi
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/53
CPC分类号： G01N33/5079 , G01N33/6872
摘要： The present invention provides a method for screening a substance having a thermogenesis enhancing effect containing a compound having an effect activating PPAR δ, an agent containing the compound, and an agent having antidiabetic, antiobestic or visceral accumulated fat-lowering function.The present invention provides an agent containing a compound having an effect activating PPAR δ, which is a peroxisome proliferator activated receptor, and having effects which enhances nonshivering thermogenesis (nST), specifically enhances uncoupling respiration in mitochondria of cells in an adipose tissue or the like, or proton leak in inner membranes of mitochondria, and increases the amount of expression of UCP1, and provides an antidiabetic agent, an antiobestic gent and a visceral accumulated fat-lowering agent containing the compound. Further, the present invention provides a method for screening the compound by measuring a PPAR δ activating effect.
摘要翻译：本发明提供一种筛选具有生发增强效果的物质的方法，其含有具有活化PPARδ的作用的化合物，含有该化合物的药剂和具有抗糖尿病，抗胆固醇或内脏积累的降脂功能的药剂。本发明提供了含有具有活化PPARδ作用的化合物的化合物，其是过氧化物酶体增殖物激活受体，并且具有增强非发热生成（nST）的作用，特别地增强脂肪组织等中的细胞的线粒体中的解偶联呼吸或线粒体内膜中的质子泄漏，并增加UCP1的表达量，并提供含有该化合物的抗糖尿病药，抗胆碱剂和内脏累积降脂剂。此外，本发明提供了通过测量PPARδ激活效应来筛选化合物的方法。

4. 发明授权

US08030016B2 Method for screening for vitamin D receptor ligands 失效
标题翻译：维生素D受体配体筛选方法
公开(公告)号：US08030016B2
公开(公告)日：2011-10-04
申请号：US12375843
申请日：2007-07-30
申请人： Eiji Ochiai , Kazuyoshi Yamaoka , Ken-ichiro Takagi , Yu Tsushima , Shigeaki Kato , Hirochika Kitagawa , Ichiro Takada
发明人： Eiji Ochiai , Kazuyoshi Yamaoka , Ken-ichiro Takagi , Yu Tsushima , Shigeaki Kato , Hirochika Kitagawa , Ichiro Takada
IPC分类号： G01N33/53 , A01N1/02 , C12N15/00 , C07H21/04
CPC分类号： G01N33/566 , C12N15/1086 , C12Q1/025 , G01N33/5044 , G01N33/82 , G01N2500/00 , Y10S435/81
摘要： The present invention relates to a screening method for a compound and includes a step of detecting binding between a vitamin D receptor and CDP. A novel method enabling screening in vitro of a compound having strong bone forming action and low side effects, a compound participating in osteoblast differentiation and selected by the method of screening, a therapeutic agent containing the compound for diseases intervening in the increase in vitamin D-mediated transcriptional activity by a complex of a vitamin D receptor and CDP, and a kit for performing the screening method are provided.
摘要翻译：本发明涉及一种化合物的筛选方法，包括检测维生素D受体和CDP之间的结合的步骤。一种能够在体外筛选具有强的骨形成作用和低副作用的化合物的新方法，参与成骨细胞分化并通过筛选方法选择的化合物，含有该化合物的治疗剂，其涉及维生素D的增加，提供了维生素D受体和CDP复合物介导的转录活性，以及用于进行筛选方法的试剂盒。

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