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1. 发明授权

US07553824B2 Kit for determining polysaccharide-binding activity of mononuclear cells present in peripheral blood 有权
标题翻译：用于测定外周血中存在的单核细胞的多糖结合活性的试剂盒
公开(公告)号：US07553824B2
公开(公告)日：2009-06-30
申请号：US12117999
申请日：2008-05-09
申请人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
发明人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
IPC分类号： A01N43/04
CPC分类号： G01N33/56972 , G01N2400/10 , Y10S435/975
摘要： A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide, and/or an immunostimulant polysaccharide which is not labeled with any fluorescent material and whose polysaccharide moiety is identical to that included in the fluorescence-labeled immunostimulant polysaccharide. The use of this kit would permit the estimation of the polysaccharide-binding ability of a peripheral blood mononuclear cell in a higher precision of estimation.
摘要翻译：用于测定外周血单核细胞与本文提供的多糖结合的能力的试剂盒包括含有荧光标记的免疫刺激多糖的检测试剂; 和包含不同于荧光标记的免疫刺激多糖中使用的多糖的荧光标记物质的参考试剂，和/或未用任何荧光材料标记的多糖部分与其中包含的多糖部分相同的免疫刺激多糖荧光标记免疫刺激多糖。该试剂盒的使用将允许以更高的估计精度估计外周血单核细胞的多糖结合能力。

2. 发明授权

US07449452B2 Method for estimating immunostimulant activity of a polysaccharide 有权
标题翻译：估计多糖免疫刺激活性的方法
公开(公告)号：US07449452B2
公开(公告)日：2008-11-11
申请号：US11580936
申请日：2006-10-16
申请人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
发明人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
IPC分类号： A61N31/715
CPC分类号： G01N33/56972 , G01N2400/10 , Y10S435/975
摘要： The ability of a polysaccharide to act as an immunostimulant may be assessed by comparing the degree of binding of a detection reagent, which contains a fluorescence-labeled version of the polysaccharide, with the binding of a reference reagent, which contains a fluorescence-labeled version of a different polysaccharide. The ability of a polysaccharide to act as an immunostimulant may also be assessed by comparing the degree of binding of a detection reagent, which contains a fluorescence-labeled version of the polysaccharide, with the binding of a different type of reference reagent, which contains both the same fluorescence-labeled version of the polysaccharide and an unlabelled version of the same polysaccharide.
摘要翻译：多糖用作免疫刺激剂的能力可以通过比较含有多糖的荧光标记形式的检测试剂与参考试剂的结合程度来评估，所述参考试剂含有荧光标记的版本的不同多糖。多糖用作免疫刺激剂的能力也可以通过比较含有多糖的荧光标记形式的检测试剂与不同类型参考试剂的结合的程度来评估，所述参考试剂含有两者多糖的相同的荧光标记版本和相同多糖的未标记的版本。

3. 发明授权

US5851983A Elastase inhibitory polypeptide and process for production thereof by recombinant gene technology 失效
标题翻译：弹性蛋白酶抑制多肽及其重组基因技术生产方法
公开(公告)号：US5851983A
公开(公告)日：1998-12-22
申请号：US963538
申请日：1992-10-20
申请人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
发明人： Takashi Sugiyama , Takashi Kamimura , Kenichi Masuda , Masahiro Okada , Eiko Ohtsuka , Atsushi Imaizumi , Kunihito Watanabe , Tetsuya Suga , Yohichi Matsumoto , Akiko Takeuchi
IPC分类号： A61K38/00 , C07K14/81 , A61K38/16 , C12N15/41
CPC分类号： C07K14/811 , A61K38/00 , C07K2319/50
摘要： The present invention provides an elastase inhibitory polypeptide comprising a C-terminal half of a human secretory leukocyte protease inhibitor (SLPI) and having an elastase inhibitory activity wherein inhibitory activity of a trypsin-like serine protease does not exceed 1/10 of elastase inhibitory activity, and polypeptides having the above-mentioned biological activity wherein one or more than one amino acid is added, one or more than one amino acid is deleted and/or one or more than one amino acid is replaced. The present invention also provides a process for the production of the above-mentioned protein or other protein via a corresponding fused protein.
摘要翻译：本发明提供了包含人分泌型白细胞蛋白酶抑制剂（SLPI）的C末端一半并且具有弹性蛋白酶抑制活性的弹性蛋白酶抑制性多肽，其中胰蛋白酶样丝氨酸蛋白酶的抑制活性不超过+ E， + EE的弹性蛋白酶抑制活性，以及具有上述生物活性的多肽，其中加入一个或多于一个氨基酸，一个或多于一个氨基酸被缺失和/或一个或多于一个氨基酸被替换。本发明还提供了通过相应的融合蛋白生产上述蛋白质或其它蛋白质的方法。

4. 发明授权

US5410626A Optical coupler having a tapered fused region 失效
标题翻译：具有锥形熔融区域的光耦合器
公开(公告)号：US5410626A
公开(公告)日：1995-04-25
申请号：US81479
申请日：1993-06-23
申请人： Michitaka Okuta , Tetsuya Suga , Akio Tsugawa , Kiyohiko Kuramoto
发明人： Michitaka Okuta , Tetsuya Suga , Akio Tsugawa , Kiyohiko Kuramoto
IPC分类号： G02B6/28 , G02B6/34 , G02B6/00 , G02B6/26
CPC分类号： G02B6/29332 , G02B6/2835 , G02B6/2856
摘要： An optical coupler having a tapered fused region produced by locally heating the periphery of a plurality of aligned optical fibers, each having a core and a cladding, so that the optical fibers fuse together at the heated part, and then drawing the resulting fused region by pulling. The length of the fused region is not longer than 10 mm. The tapered fused region may be provided in such a manner that a plurality of optical fibers are disposed to intersect each other at a predetermined angle, and the intersecting portions are locally heated so as to fuse together and then subjected to pulling. The tapered fused region may be provided at each of two or more positions. Also disclosed is an optical coupler wherein at least one of a plurality of optical fibers each having a core and a cladding is previously heat-treated at a high temperature to enlarge the core in a portion thereof, and the enlarged-core portion of this optical fiber is fused to the other optical fibers and then subjected to pulling, thereby forming a tapered fused region.
摘要翻译：一种具有锥形熔融区域的光耦合器，其通过局部加热多个对准的光纤的周边而产生，每个具有芯和包层，使得光纤在加热部分处熔合在一起，然后通过拉扯熔融区域的长度不大于10mm。锥形熔融区域可以以使得多个光纤以预定角度彼此相交的方式设置，并且交叉部分被局部加热以熔合在一起然后进行拉伸。可以在两个或更多个位置中的每一个处设置锥形熔合区域。还公开了一种光耦合器，其中每个具有芯和包层的多个光纤中的至少一个预先在高温下进行热处理以在其一部分中扩大芯部，并且该光学器件的放大芯部分纤维与其他光纤熔合，然后进行拉伸，从而形成锥形的熔融区域。

5. 发明授权

US4568683A Lipid metabolism with pantetheine-S-sulfonic acid 失效
标题翻译：泛油酸-S-磺酸的脂质代谢
公开(公告)号：US4568683A
公开(公告)日：1986-02-04
申请号：US598238
申请日：1984-04-09
申请人： Tetsuya Suga , Omanabu Katsumata , Tomoyasu Tashiro
发明人： Tetsuya Suga , Omanabu Katsumata , Tomoyasu Tashiro
IPC分类号： A61K31/255 , A61K31/205 , A61K31/185 , A61K31/44
CPC分类号： A61K31/255
摘要： A lipid metabolism improving drug or pharmaceutical composition contains pantetheine-S-sulfonic acid as an active ingredient. When an effective dose of pantetheine-S-sulfonic acid or a pharmaceutically active, non-toxic salt thereof is administered to an animal, such as a human, in pure form or composition form, the lipid concentration in the plasma is lowered, lipid peroxide concentration in the serum and liver is lowered, B-lipo protein-cholesterol concentration in serum is decreased and HDL-cholesterol concentration is increased.
摘要翻译：脂质代谢改善药物或药物组合物含有潘太奈辛-S-磺酸作为活性成分。当将有效剂量的泛ant碱-S-磺酸或其药学活性的无毒盐以纯形式或组合物形式施用于动物如人类时，血浆中的脂质浓度降低，脂质过氧化物血清和肝脏中的浓度降低，血清中的B脂蛋白 - 胆固醇浓度降低，HDL-胆固醇浓度升高。

6. 发明授权

US07924493B2 Faraday rotator mirror and method for manufacturing the same 失效
标题翻译：法拉第旋转镜及其制造方法
公开(公告)号：US07924493B2
公开(公告)日：2011-04-12
申请号：US11816905
申请日：2006-02-24
申请人： Yusuke Takei , Tetsuya Suga , Satoru Tomie , Yasushi Sato , Michifumi Shoda
发明人： Yusuke Takei , Tetsuya Suga , Satoru Tomie , Yasushi Sato , Michifumi Shoda
IPC分类号： G02F1/09 , G01R33/02 , G02B6/00
CPC分类号： G02F1/09 , G01R15/246 , G01R15/247 , G01R33/032 , G02B6/0281 , G02B6/2746 , G02F2201/02 , G02F2201/34 , Y10T156/10
摘要： A Faraday rotator mirror which is compact, allows high workability of manufacturing and has high reliability and high coupling efficiency is provided. The Faraday rotator mirror comprises a graded-index fiber, a Faraday rotator and a reflector mirror, wherein light incident via the graded-index fiber passes through the Faraday rotator to be reflected on the reflector mirror, and the reflected light passes through the Faraday rotator and emerges through the graded-index fiber.
摘要翻译：一种紧凑的法拉第旋转镜，具有高的制造可加工性，并具有高可靠性和高耦合效率。法拉第旋转镜包括渐变折射率光纤，法拉第旋转器和反射镜，其中通过渐变折射率光纤入射的光通过法拉第旋转器以在反射镜上反射，并且反射光穿过法拉第旋转器并通过分级折射率纤维出现。

7. 发明申请

US20090231665A1 Faraday Rotator Mirror and Method for Manufacturing the Same 失效
标题翻译：法拉第旋转镜及其制造方法
公开(公告)号：US20090231665A1
公开(公告)日：2009-09-17
申请号：US11816905
申请日：2006-02-24
申请人： Yusuke Takei , Tetsuya Suga , Satoru Tomie , Yasushi Sato , Michifumi Shoda
发明人： Yusuke Takei , Tetsuya Suga , Satoru Tomie , Yasushi Sato , Michifumi Shoda
IPC分类号： G02F1/09 , B32B37/00
CPC分类号： G02F1/09 , G01R15/246 , G01R15/247 , G01R33/032 , G02B6/0281 , G02B6/2746 , G02F2201/02 , G02F2201/34 , Y10T156/10
摘要： A Faraday rotator mirror which is compact, allows high workability of manufacturing and has high reliability and high coupling efficiency is provided. The Faraday rotator mirror comprises a graded-index fiber, a Faraday rotator and a reflector mirror, wherein light incident via the graded-index fiber passes through the Faraday rotator to be reflected on the reflector mirror, and the reflected light passes through the Faraday rotator and emerges through the graded-index fiber.
摘要翻译：一种紧凑的法拉第旋转镜，具有高的制造可加工性，并具有高可靠性和高耦合效率。法拉第旋转镜包括渐变折射率光纤，法拉第旋转器和反射镜，其中通过渐变折射率光纤入射的光通过法拉第旋转器以在反射镜上反射，并且反射光穿过法拉第旋转器并通过分级折射率纤维出现。

8. 发明申请

US20070031898A1 Kit for determining polysaccharide-binding ability of mononuclear cells present in peripheral blood 有权
标题翻译：用于测定外周血中存在的单核细胞的多糖结合能力的试剂盒
公开(公告)号：US20070031898A1
公开(公告)日：2007-02-08
申请号：US11580936
申请日：2006-10-16
申请人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
发明人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
IPC分类号： G01N33/567 , A61K31/716
CPC分类号： G01N33/56972 , G01N2400/10 , Y10S435/975
摘要： A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide, and/or an immunostimulant polysaccharide which is not labeled with any fluorescent material and whose polysaccharide moiety is identical to that included in the fluorescence-labeled immunostimulant polysaccharide. The use of this kit would permit the estimation of the polysaccharide-binding ability of a peripheral blood mononuclear cell in a higher precision of estimation.
摘要翻译：用于测定外周血单核细胞与本文提供的多糖结合的能力的试剂盒包括含有荧光标记的免疫刺激多糖的检测试剂; 和包含不同于荧光标记的免疫刺激多糖中使用的多糖的荧光标记物质的参考试剂，和/或未用任何荧光材料标记的多糖部分与其中包含的多糖部分相同的免疫刺激多糖荧光标记免疫刺激多糖。该试剂盒的使用将允许以更高的估计精度估计外周血单核细胞的多糖结合能力。

9. 发明授权

US5804410A Nucleic acid sequence encoding trypsin-like enzyme and process for producing the enzyme 失效
标题翻译：编码胰蛋白酶样酶的核酸序列及其制备方法
公开(公告)号：US5804410A
公开(公告)日：1998-09-08
申请号：US508448
申请日：1995-07-28
申请人： Kazuyoshi Yamaoka , Hiroko Ogawa , Yoshinori Sugimoto , Kenichi Masuda , Tetsuya Suga , Kenichiro Takagi , Susumu Yasuoka
发明人： Kazuyoshi Yamaoka , Hiroko Ogawa , Yoshinori Sugimoto , Kenichi Masuda , Tetsuya Suga , Kenichiro Takagi , Susumu Yasuoka
IPC分类号： C12N9/64 , C12N15/57 , C12P21/06 , C07H17/00 , C12N9/00
CPC分类号： C12N9/6424 , C12N2799/026
摘要： This invention provides a nucleic acid sequence encoding a trypsin-like enzyme which can be present at the trachea of human lungs, and can selectively digest a synthetic substrate for trypsin and a synthetic substrate for thrombin, and fibrinogen; and a process for producing the trypsin-like enzyme by genetic engineering utilizing the nucleic acid sequence.
摘要翻译：本发明提供编码胰蛋白酶样酶的核酸序列，其可以存在于人肺气管中，并且可以选择性地消化胰蛋白酶的合成底物和用于凝血酶和纤维蛋白原的合成底物; 以及利用核酸序列通过遗传工程生产胰蛋白酶样酶的方法。

10. 发明申请

US20080220452A1 KIT FOR DETERMINING POLYSACCHARIDE-BINDING ABILITY OF MONONUCLEAR CELLS PRESENT IN PERIPHERAL BLOOD 有权
标题翻译：用于测定外周血中单核细胞多糖结合能力的试剂盒
公开(公告)号：US20080220452A1
公开(公告)日：2008-09-11
申请号：US12117999
申请日：2008-05-09
申请人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
发明人： Tetsuya Suga , Yasuyo Suga , Masahiro Murata
IPC分类号： G01N33/53
CPC分类号： G01N33/56972 , G01N2400/10 , Y10S435/975
摘要： A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide, and/or an immunostimulant polysaccharide which is not labeled with any fluorescent material and whose polysaccharide moiety is identical to that included in the fluorescence-labeled immunostimulant polysaccharide. The use of this kit would permit the estimation of the polysaccharide-binding ability of a peripheral blood mononuclear cell in a higher precision of estimation.
摘要翻译：用于测定外周血单核细胞与本文提供的多糖结合的能力的试剂盒包括含有荧光标记的免疫刺激多糖的检测试剂; 和包含不同于荧光标记的免疫刺激多糖中使用的多糖的荧光标记物质的参考试剂，和/或未用任何荧光材料标记的多糖部分与其中包含的多糖部分相同的免疫刺激多糖荧光标记免疫刺激多糖。该试剂盒的使用将允许以更高的估计精度估计外周血单核细胞的多糖结合能力。

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