专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US4643990A N-acyl peptide, processes for their preparation and pharmaceutical compositions thereof 失效
标题翻译： N-酰基肽，其制备方法及其药物组合物
公开(公告)号：US4643990A
公开(公告)日：1987-02-17
申请号：US452827
申请日：1982-12-23
申请人： Kazuyoshi Umehara , Keizo Yoshida , Hirokazu Tanaka , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka
发明人： Kazuyoshi Umehara , Keizo Yoshida , Hirokazu Tanaka , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka
IPC分类号： A61K38/00 , C07K5/06 , C07K5/065 , C07K5/068 , C07K5/072 , A61K37/43 , C07C67/02 , C07C69/52 , C07C101/26 , C07C101/30 , C07C143/12 , C07K5/08
CPC分类号： C07K5/06104 , C07K5/06052 , C07K5/06078 , C07K5/06086 , A61K38/00
摘要： N-acylpeptides are disclosed of the formula: ##STR1## wherein R.sup.1 is alkanoyloxy or alkenoyloxy; R.sup.2 is alkyl or alkenyl; R.sup.3 and R.sup.4 are each lower alkyl, hydroxy(lower)alkyl, ar(lower)alkyl, esterified carboxy(lower)alkyl, carboxy(lower)alkyl, protected amino(lower)alkyl or amino(lower)alkyl; R.sup.5 is hydrogen, hydroxy(lower)alkyl, protected amino(lower)alkyl, amino(lower)alkyl, carboxy(lower)alkyl or esterified carboxy(lower)alkyl; R.sup.6 is carboxy, esterified carboxy or sulfo(lower)alkyl; A.sup.1, A.sup.2 and A.sup.3 are each bond or lower alkylene; and m and n are each an integer of 0 or 1; or its pharmaceutically acceptable salt. These compounds have anti-complementary activity and fibrinolytic activity, and are useful as therapeutic agents for immune-complex diseases or autoimmune diseases such as nephritis, rheumatic diseases, systemic lupus erythematosus, etc. and thrombosis such as cerebral apoplexy, coronary insufficiency, pulmonary embolism, etc.
摘要翻译： N-酰基肽公开于下式：其中R 1是烷酰氧基或烯酰基氧基; R2是烷基或烯基; R 3和R 4各自为低级烷基，羟基（低级）烷基，芳（低级）烷基，酯化羧基（低级）烷基，羧基（低级）烷基，被保护的氨基（低级）烷基或氨基（低级） R5是氢，羟基（低级）烷基，被保护的氨基（低级）烷基，氨基（低级）烷基，羧基（低级）烷基或酯化羧基（低级）烷基; R6是羧基，酯化的羧基或磺基（低级）烷基; A1，A2和A3各自为键或低级亚烷基; m和n分别为0或1的整数; 或其药学上可接受的盐。这些化合物具有抗互补活性和纤维蛋白溶解活性，并且可用作免疫复合物疾病或自身免疫性疾病如肾炎，风湿性疾病，系统性红斑狼疮等的治疗剂，以及血栓形成如脑中风，冠状动脉功能不全，肺栓塞等等

2. 发明授权

US4436726A N-Acylpeptide compound, processes for the preparation thereof and the pharmaceutical compositions 失效
标题翻译： N-酰基肽化合物，其制备方法和药物组合物
公开(公告)号：US4436726A
公开(公告)日：1984-03-13
申请号：US329075
申请日：1981-12-09
申请人： Kazuyoshi Umehara , Hirokazu Tanaka , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Keizo Yoshida
发明人： Kazuyoshi Umehara , Hirokazu Tanaka , Itsuo Uchida , Masanobu Kohsaka , Hiroshi Imanaka , Keizo Yoshida
IPC分类号： C12P21/00 , A61K38/00 , A61P7/02 , A61P7/04 , A61P37/00 , C07C67/00 , C07C231/00 , C07C231/02 , C07C231/12 , C07C233/47 , C07C235/06 , C07C235/08 , C07C235/12 , C07C235/28 , C07C237/12 , C07C237/22 , C07K1/113 , C07K1/20 , C07K5/06 , C07K5/062 , C07K14/195 , C07K14/41 , C12R1/20 , C07C103/52 , A61K37/02 , C07C67/02
CPC分类号： C07K5/06026 , A61K38/00
摘要： This invention relates to new N-acylpeptide compounds of immunological activity, said compounds being of the formula: ##EQU1## wherein R.sup.1 and R.sup.2 are each alkyl or alkenyl;R.sup.3 is hydrogen, lower alkyl, hydroxy(lower)alkyl, heterocyclic(lower)alkyl or ar(lower)alkyl, wherein the aryl moiety may have hydroxy or protected hydroxy;R.sup.4 is carboxy, esterified carboxy, carboxy(lower)alkyl or esterified carboxy(lower)alkyl;X is bond or lower alkylene;Y is lower alkylene or lower alkylidene; andn is an integer of 0 to 1;or its pharmaceutically acceptable salt.
摘要翻译：本发明涉及免疫活性的新的N-酰基肽化合物，所述化合物具有下式：其中R 1和R 2各自为烷基或链烯基; R3是氢，低级烷基，羟基（低级）烷基，杂环（低级）烷基或芳（低级）烷基，其中芳基部分可以具有羟基或被保护的羟基; R4是羧基，酯化的羧基，羧基（低级）烷基或酯化的羧基（低级）烷基; X是键或低级亚烷基; Y为低级亚烷基或低级亚烷基; n为0〜1的整数。或其药学上可接受的盐。

3. 发明授权

US4297096A Alkyl, alkenyl, and aryl substituted triazene compounds, their salts and production thereof 失效
标题翻译：烷基，烯基和芳基取代的三氮烯化合物，其盐及其制备
公开(公告)号：US4297096A
公开(公告)日：1981-10-27
申请号：US143310
申请日：1980-04-24
申请人： Keizo Yoshida , Hirokazu Tanaka , Masanori Okamoto , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
发明人： Keizo Yoshida , Hirokazu Tanaka , Masanori Okamoto , Eiko Iguchi , Masanobu Kohsaka , Hatsuo Aoki , Hiroshi Imanaka
IPC分类号： C07C29/10 , C07C29/147 , C07C29/17 , C07C45/29 , C07D309/12 , C12P13/00 , C07C107/02
CPC分类号： C12R1/485 , C07C29/10 , C07C29/147 , C07C29/17 , C07C45/29 , C07D309/12 , C12P13/00 , C12P13/001 , C07B2200/09 , Y10S514/906
摘要： A new triazene compound of the formula:R--CH.dbd.N--N.dbd.N--OHwherein R is alkyl, alkenyl or aryl and its pharmaceutically acceptable salts thereof. The production and use of such compounds are also disclosed. The compounds are useful as smooth muscle relaxants and hypotensives.
摘要翻译：一种新的三氮烯化合物，其分子式为：R-CH = N-N = N-OH，其中R为烷基，烯基或芳基及其药学上可接受的盐。还公开了这些化合物的生产和使用。这些化合物可用作平滑肌松弛剂和低血压药。

4. 发明授权

US4661352A WS 7739 substances, their preparation and pharmaceutical composition containing the same 失效
标题翻译： WS 7739物质，其制剂和含有相同的药物组合物
公开(公告)号：US4661352A
公开(公告)日：1987-04-28
申请号：US662927
申请日：1984-10-19
申请人： Motoaki Nishikawa , Morita Iwami , Keizo Yoshida , Masanobu Kohsaka
发明人： Motoaki Nishikawa , Morita Iwami , Keizo Yoshida , Masanobu Kohsaka
IPC分类号： C07G11/00 , A61K35/74 , A61P7/02 , A61P9/02 , A61P11/14 , C12P1/06 , C12R1/465
CPC分类号： C12P1/06
摘要： This invention relates to a biologically active WS-7739-A substance and a biologically active WS-7739-B substance which have pharmacological activities and are useful for the treatment of asthma, thrombosis and the alike.
摘要翻译：本发明涉及具有药理活性并可用于治疗哮喘，血栓形成和类似物质的生物活性WS-7739-A物质和生物活性WS-7739-B物质。

5. 发明申请

US20070275831A1 Exercise Therapy Device 有权
标题翻译：运动疗法装置
公开(公告)号：US20070275831A1
公开(公告)日：2007-11-29
申请号：US10599782
申请日：2004-04-27
申请人： Keizo Yoshida , Takuya Hayashi , Mitsunobu Yoshida
发明人： Keizo Yoshida , Takuya Hayashi , Mitsunobu Yoshida
IPC分类号： A63B22/06
CPC分类号： A63B22/0605 , A61H1/0214 , A63B21/00181 , A63B21/0058 , A63B2220/833
摘要： An exercise therapy device includes pedals, a pedal rotation shaft connected to the pedals, a load motor for driving the pedal rotation shaft, and a load control device for controlling the load motor to cause rotating motion of the pedal rotation shaft to be started by the load motor.
摘要翻译：运动治疗装置包括踏板，连接到踏板的踏板旋转轴，用于驱动踏板旋转轴的负载马达，以及负载控制装置，用于控制负载马达，以使踏板旋转轴的旋转运动由负载电机

6. 发明授权

US4258134A Novel hyaluronidase BMP-8231 and production thereof 失效
标题翻译：新型透明质酸酶BMP-8231及其制备方法
公开(公告)号：US4258134A
公开(公告)日：1981-03-24
申请号：US35719
申请日：1979-05-03
申请人： Keizo Yoshida , Takashi Fujii , Hiroyuki Kikuchi
发明人： Keizo Yoshida , Takashi Fujii , Hiroyuki Kikuchi
IPC分类号： C12N9/26 , C12R1/465
CPC分类号： C12N9/2408 , Y10S435/886
摘要： Hyaluronidase obtained from Streptomyces koganeiensis has the following characteristics:(a) Acts as an endo B-hexosaminidase(b) Degrades hyaluronic acid but not chondroitin sulfate A, C, or chondroitin(c) Optimum pH around 4.0(d) Stable pH range 4.0-11.3(e) Optimum temperature around 60.degree. C.(f) Stable a temperature below 60.degree. C.(g) Stable against proteolytic enzymes
摘要翻译：从链霉菌（Streptomyces koganeiensis）获得的透明质酸酶具有以下特征：（a）作为内在的β-氨基己糖苷酶（b）降解透明质酸而不是硫酸软骨素A，C或软骨素（c）最佳pH约4.0（d）稳定的pH

7. 发明申请

US20080171635A1 Exercise Therapy Device 审中-公开
标题翻译：运动疗法装置
公开(公告)号：US20080171635A1
公开(公告)日：2008-07-17
申请号：US11962481
申请日：2007-12-21
申请人： Keizo Yoshida , Makoto Sakaue
发明人： Keizo Yoshida , Makoto Sakaue
IPC分类号： A63B24/00
CPC分类号： A63B24/0059 , A63B22/0235 , A63B22/0605 , A63B71/0622 , A63B71/0686 , A63B2024/0078 , A63B2220/30 , A63B2220/34 , A63B2225/20
摘要： To provide an exercise therapy device capable of highly motivating an exerciser to continue exercise therapy, the exercise therapy device equipped with AV equipment and a rotation shaft includes: a rotation speed detection unit; a display unit for displaying menu items of contents and the content reproduced by the AV equipment; a menu selection unit for sequentially displaying the menu items of contents when the rotation shaft is rotating and, when one of the menu items has been externally selected, confirming the one of the menu items as a menu to be displayed by the AV equipment; and a reproduction speed setting unit for setting a constant or a variable speed. The AV equipment reproduces the content at one of the predetermined constant speed or the variable speed which is set when the rotation shaft is rotating, and stops reproducing the content when the rotation shaft is stopped.
摘要翻译：为了提供能够高度激励锻炼者继续运动治疗的运动疗法装置，具备AV装置和旋转轴的运动疗法装置具备：旋转速度检测部; 用于显示内容的菜单项和由AV设备再现的内容的显示单元; 菜单选择单元，用于当旋转轴旋转时顺序地显示内容的菜单项，并且当已经从外部选择了其中一个菜单项时，将菜单项中的一个确认为由AV设备显示的菜单; 以及用于设定常数或可变速度的再现速度设定单元。 AV设备以预定的恒定速度或当旋转轴旋转时设定的可变速度中的一个再现内容，并且当旋转轴停止时停止再现内容。

8. 发明授权

US07641599B2 Exercise therapy device 有权
标题翻译：运动疗法装置
公开(公告)号：US07641599B2
公开(公告)日：2010-01-05
申请号：US10599782
申请日：2004-04-27
申请人： Keizo Yoshida , Takuya Hayashi , Mitsunobu Yoshida
发明人： Keizo Yoshida , Takuya Hayashi , Mitsunobu Yoshida
IPC分类号： A63B22/06
CPC分类号： A63B22/0605 , A61H1/0214 , A63B21/00181 , A63B21/0058 , A63B2220/833
摘要： An exercise therapy device includes pedals, a pedal rotation shaft connected to the pedals, a load motor for driving the pedal rotation shaft, and a load control device for controlling the load motor to cause rotating motion of the pedal rotation shaft to be started by the load motor.
摘要翻译：运动治疗装置包括踏板，连接到踏板的踏板旋转轴，用于驱动踏板旋转轴的负载马达，以及负载控制装置，用于控制负载马达，以使踏板旋转轴的旋转运动由负载电机

9. 发明授权

US5866598A Medicament for treating or preventing cerebrovascular dementia 失效
标题翻译：用于治疗或预防脑血管性痴呆的药物
公开(公告)号：US5866598A
公开(公告)日：1999-02-02
申请号：US958317
申请日：1997-10-27
申请人： Kiyotaka Katsuta , Hiroyuki Takamatsu , Yoshiko Ueda , Hajime Nakanishi , Keizo Yoshida
发明人： Kiyotaka Katsuta , Hiroyuki Takamatsu , Yoshiko Ueda , Hajime Nakanishi , Keizo Yoshida
IPC分类号： C07D487/04 , A61K31/40 , A61K31/415 , A61K31/435 , A61K31/437 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/505 , A61P9/00 , C07D401/06 , C07D403/06 , C07D471/04
CPC分类号： A61K31/437 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505
摘要： Compounds for treating or preventing cerebrovascular diseases are disclosed. These compounds are 5-HT antagonists. More specifically, these compounds, when combined with pharmaceutically acceptable carriers or excipients and administered to animals including humans, are useful in treating or preventing cerebrovascular dementia.
摘要翻译：公开了治疗或预防脑血管疾病的化合物。这些化合物是5-HT拮抗剂。更具体地说，这些化合物当与药学上可接受的载体或赋形剂组合并施用于包括人在内的动物时可用于治疗或预防脑血管性痴呆。

10. 发明授权

US5698561A Medicament for treating or preventing cerebrovascular dementia 失效
标题翻译：用于治疗或预防脑血管性痴呆的药物
公开(公告)号：US5698561A
公开(公告)日：1997-12-16
申请号：US736248
申请日：1996-10-24
申请人： Kiyotaka Katsuta , Hiroyuki Takamatsu , Yoshiko Ueda , Hajime Nakanishi , Keizo Yoshida
发明人： Kiyotaka Katsuta , Hiroyuki Takamatsu , Yoshiko Ueda , Hajime Nakanishi , Keizo Yoshida
IPC分类号： C07D487/04 , A61K31/40 , A61K31/415 , A61K31/435 , A61K31/437 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/505 , A61P9/00 , C07D401/06 , C07D403/06 , C07D471/04
CPC分类号： A61K31/437 , A61K31/415 , A61K31/44 , A61K31/445 , A61K31/505
摘要： Compounds for treating or preventing cerebrovascular diseases are disclosed. These compounds are 5-HT antagonists. More specifically, these compounds, when combined with pharmaceutically acceptable carriers or excipients and administered to animals including humans, are useful in treating or preventing cerebrovascular dementia.
摘要翻译：公开了治疗或预防脑血管疾病的化合物。这些化合物是5-HT拮抗剂。更具体地说，这些化合物当与药学上可接受的载体或赋形剂组合并施用于包括人在内的动物时可用于治疗或预防脑血管性痴呆。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式