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1. 发明申请

US20100317126A1 AGGLUTINATION ASSAY METHOD IN POROUS MEDIUM LAYER 审中-公开
标题翻译：多孔介质层中的AGAGUTINATION测定方法
公开(公告)号：US20100317126A1
公开(公告)日：2010-12-16
申请号：US12835832
申请日：2010-07-14
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/53
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。可以方便地以高灵敏度获得分析物的快速定量分析。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

2. 发明申请

US20050106757A1 Agglutination assay method in porous medium layer 审中-公开
标题翻译：多孔介质层凝集测定法
公开(公告)号：US20050106757A1
公开(公告)日：2005-05-19
申请号：US11022510
申请日：2004-12-22
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/52 , G01N33/543 , G01N33/58 , G01N33/551
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element. A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。可以方便地以高灵敏度获得分析物的快速定量分析。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

3. 发明申请

US20050153460A1 Agglutination assay method in binder medium 审中-公开
标题翻译：粘合剂介质中的凝集测定法
公开(公告)号：US20050153460A1
公开(公告)日：2005-07-14
申请号：US10961242
申请日：2004-10-07
申请人： Kazuya Kawasaki , Kentaro Nakamura , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kazuya Kawasaki , Kentaro Nakamura , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/52 , G01N33/537 , G01N33/543 , G01N33/546 , G01N33/551
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/5375
摘要： An agglutination assay method for quantitatively determination of an analyte in a liquid sample using particles bearing an anti-analyte. The agglutination is conducted in a reagent layer composed of at least one binder selected from the group consisting of: a water-soluble polymer having a solution viscosity of 6 cP or less; a water-insoluble and water-swellable polymer; and gelatin having a molecular weight of 20,000 or less. A speedy quantitative determination of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the reagent layer medium, the anti-analyte can be stored with higher stability in the dry state. A dry analysis element for enabling such analysis method is also provided.
摘要翻译：用于使用带有抗分析物的颗粒定量测定液体样品中的分析物的凝集测定方法。凝集在由至少一种粘合剂组成的试剂层中进行，所述粘合剂选自：溶液粘度为6cP以下的水溶性聚合物; 水不溶性和水溶胀性聚合物; 和分子量为20,000以下的明胶。可以方便地以高灵敏度获得分析物的快速定量测定。当试剂层介质中含有颗粒标记的抗分析物时，可以在干燥状态下以更高的稳定性储存抗分析物。还提供了用于实现这种分析方法的干燥分析元件。

4. 发明申请

US20060205088A1 Agglutination Assay Method in Porous Medium Layer 审中-公开
标题翻译：多孔介质层中凝集测定法
公开(公告)号：US20060205088A1
公开(公告)日：2006-09-14
申请号：US11420147
申请日：2006-05-24
申请人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
发明人： Kentaro Nakamura , Kazuya Kawasaki , Osamu Seshimoto , Masahito Nagata , Toru Tanaka
IPC分类号： G01N33/558
CPC分类号： G01N33/54346 , G01N33/525 , G01N33/587
摘要： An agglutination assay method for quantitatively determination of an analyte in an aqueous liquid sample using particles bearing an anti-analyte. The agglutination is conducted in the porous medium layer of the analysis element A speedy quantitative analysis of the analyte can be conveniently attained with high sensitivity. When the particle-labeled anti-analyte is contained in the porous medium layer, the anti-analyte can be stored with higher stability in the dry state A dry analysis element for enabling such analysis method is also provided.
摘要翻译：一种用于使用带有抗分析物的颗粒定量测定含水液体样品中的分析物的凝集测定方法。凝集在分析元件的多孔介质层中进行。分析物的快速定量分析可以方便地以高灵敏度获得。当颗粒标记的抗分析物包含在多孔介质层中时，抗分析物可以在干燥状态下以更高的稳定性储存。还提供了用于实现这种分析方法的干燥分析元件。

5. 发明申请

US20080019869A1 Multilayer Analysis Element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20080019869A1
公开(公告)日：2008-01-24
申请号：US10589556
申请日：2005-02-18
申请人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
发明人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
IPC分类号： B01L11/00
CPC分类号： G01N33/525
摘要： It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for liquid sample analysis wherein at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in this order on one side of a water-impermeable planar support, and the non-fibrous porous film has a bending rupture strength of 20 gram-weight or more and a tensile percentage of 2% or less when the film is stretched with a tensile force of 50 gram-weight.
摘要翻译：本发明的目的是提供一种具有很小的批量间和批间差异的多层分析元件，其具有高的测量精度并且尺寸小。本发明提供了一种用于液体样品分析的多层分析元件，其中至少一个功能层和非纤维多孔膜的至少一个多孔液体样品扩散层在不透水平面支撑体的一侧上依次一体地层叠，并且当以50克重的拉伸力拉伸膜时，非纤维状多孔膜的弯曲断裂强度为20克重以上，拉伸率为2％以下。

6. 发明申请

US20050186110A1 Multilayer analysis element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20050186110A1
公开(公告)日：2005-08-25
申请号：US11060777
申请日：2005-02-18
申请人： Kentaro Nakamura , Kazuya Kawasaki , Toshihisa Ito , Yoshiki Sakaino , Osamu Seshimoto
发明人： Kentaro Nakamura , Kazuya Kawasaki , Toshihisa Ito , Yoshiki Sakaino , Osamu Seshimoto
IPC分类号： G01N31/22
CPC分类号： G01N31/22
摘要： It is an object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein said spreading layer comprises a non-fibrous porous film such that, when a liquid sample containing a target substance to be measured is caused to become attached to the surface of said liquid sample spreading layer, where said liquid sample is spread and dispersed, 30% or more of said target substance to be measured can be transferred to the at least one functional layer below said liquid sample spreading layer.
摘要翻译：本发明的目的是提供一种具有很小的批量间和批间差异的多层分析元件，其具有高的测量精度并且尺寸小。本发明提供了一种用于分析液体样品的多层分析元件，其包括不透水平面支撑体，其一侧上至少一个功能层和至少一个非纤维多孔膜的多孔液体样品铺展层整体层压其中所述扩散层包括非纤维多孔膜，使得当将含有待测物体的液体样品附着在所述液体样品扩散层的表面上时，其中所述液体样品为扩散和分散，所述待测量的所述目标物质的30％以上可以转移到所述液体样品扩散层下方的至少一个功能层。

7. 发明申请

US20050186109A1 Multilayer analysis element 审中-公开
标题翻译：多层分析单元
公开(公告)号：US20050186109A1
公开(公告)日：2005-08-25
申请号：US11060775
申请日：2005-02-18
申请人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
发明人： Kentaro Nakamura , Kazuya Kawasaki , Yoshiki Sakaino , Toshihisa Ito , Osamu Seshimoto
IPC分类号： G01N31/22
CPC分类号： G01N31/22
摘要： An object of the invention to provide a multilayer analysis element with small intra-lot and lot-to-lot differences that has high measurement accuracy and which is small in size. The present invention provides a multilayer analysis element for the analysis of a liquid sample, comprising a water impermeable planar support on one side of which at least one functional layer and at least one porous liquid sample spreading layer of non-fibrous porous film are integrally laminated in the mentioned order, wherein the arithmetic mean deviation of the profile (Ra) of a contact surface of the at least one functional layer that is in contact with said porous liquid sample spreading layer of said non-fibrous porous film is 1 μm or less and/or the ten-point height of irregularities (Rz) of said contact surface is 8 μm or less.
摘要翻译：本发明的目的是提供一种具有很高的测量精度并且尺寸小的多批次间差异小的多层分析元件。本发明提供了一种用于分析液体样品的多层分析元件，其包括不透水平面支撑体，其一侧上至少一个功能层和至少一个非纤维多孔膜的多孔液体样品铺展层整体层压其中与所述非纤维多孔膜的所述多孔液体样品扩散层接触的所述至少一个功能层的接触表面的轮廓（Ra）的算术平均偏差为1μm以下和/或所述接触表面的十点高度的不规则（Rz）为8μm或更小。

8. 发明授权

US5496708A Reagent composition for quantitative analysis of inorganic phosphorous and dry analysis element utilizing the same 失效
标题翻译：用于定量分析无机磷和干分析元素的试剂组合物
公开(公告)号：US5496708A
公开(公告)日：1996-03-05
申请号：US259616
申请日：1994-06-14
申请人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
发明人： Kazuya Kawasaki , Yoshikazu Amano , Osamu Seshimoto , Kiyoshi Yamada
IPC分类号： C12Q1/26 , C12Q1/28 , C12Q1/48 , G01N31/22
CPC分类号： C12Q1/48 , Y10S435/805 , Y10S435/97
摘要： A reagent composition for the quantitative analysis of inorganic phosphorus, composted of xanthosine, purine nucleoside phosphorylase, xanthine oxidase and a color-former. The color-former is a precursor for forming a dye in the presence of hydrogen peroxide and peroxidase. The reagent composition of the invention is improved in storage stability and has a wider determination range. Also provided is a dry analysis element composed of reagent layer containing the inventive reagent composition.
摘要翻译：用于定量分析无机磷的试剂组合物，堆肥的黄嘌呤，嘌呤核苷磷酸化酶，黄嘌呤氧化酶和成色剂。成色剂是在过氧化氢和过氧化物酶存在下形成染料的前体。本发明的试剂组合物的贮存稳定性提高，判定范围更广。还提供了由包含本发明试剂组合物的试剂层组成的干分析元件。

9. 发明授权

US06287785B1 Homogenous enzyme immunoassay process 失效
标题翻译：均质酶免疫测定法
公开(公告)号：US06287785B1
公开(公告)日：2001-09-11
申请号：US09488371
申请日：2000-01-20
申请人： Hiroshi Shinoki , Osamu Seshimoto
发明人： Hiroshi Shinoki , Osamu Seshimoto
IPC分类号： G01N33533
CPC分类号： G01N33/535 , G01N33/542 , G01N33/54306 , Y10S435/963 , Y10S435/964 , Y10S435/969 , Y10S435/972 , Y10S436/823 , Y10S530/866
摘要： An improved homogeneous enzyme immunoassay process for quantitatively analyzing an antigen by determining the change in the enzymatic activity caused by a reaction between the antigen and an enzyme-labeled antibody. The antigen is reacted with an enzyme-labeled antibody, followed by the reaction with a second antibody capable of recognizing and binding to a different epitope and then with a third antibody capable of recognizing and binding to the second antibody. The enzymatic activity of the labeling enzyme is determined by a water-insoluble substrate. Using the water-insoluble substrate, steric hindrance is enhanced. A highly-sensitive analysis can be carried out by a simple operation even when the antigen has a molecular weight falling within an intermediate range, for example, a range of M.W. 10,000 to 70,000.
摘要翻译：一种改进的均匀酶免疫测定方法，用于通过测定由抗原和酶标记的抗体之间的反应引起的酶活性的变化来定量分析抗原。使抗原与酶标记的抗体反应，然后与能够识别和结合不同表位的第二抗体反应，然后与能够识别和结合第二抗体的第三抗体反应。标记酶的酶活性由水不溶性底物决定。使用水不溶性底物，空间位阻增强。即使当抗原具有分子量落在中间范围内时，也可以通过简单的操作进行高灵敏度分析，例如，10,000至70000MW的范围。

10. 发明授权

US06280621B1 Blood filter cartridge with overflow receiver 失效
标题翻译：带有溢流接收器的滤芯
公开(公告)号：US06280621B1
公开(公告)日：2001-08-28
申请号：US09487679
申请日：2000-01-19
申请人： Kenichiro Yazawa , Takaki Arai , Osamu Seshimoto
发明人： Kenichiro Yazawa , Takaki Arai , Osamu Seshimoto
IPC分类号： B01D2905
CPC分类号： B01L3/502 , B01D61/18 , B01D61/20 , B01L3/0275 , B01L2300/0681 , G01N33/491
摘要： The blood filter cartridge of the invention can be used as a sample cup of an analyzer without sucking bubbles, which comprises a blood filtering material, a holder containing the blood filtering material and having a blood inlet and a filtrate outlet, and a filtrate receiver for receiving filtrate discharged from the filtrate outlet, the filtrate receiver has an upper end having a difference in height or structure for returning the filtrate from the upper end of the filtrate receiver to the filtrate outlet.
摘要翻译：本发明的血液过滤器滤芯可用作分析器的样品杯而不吸入气泡，其包括血液过滤材料，含有血液过滤材料并具有血液入口和滤液出口的保持器，以及用于接收从滤液出口排出的滤液，滤液接收器具有高度或结构差的上端，用于将滤液从滤液接收器的上端返回到滤液出口。

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