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1. 发明授权

US5374418A Composition for use in oral cavity 失效
标题翻译：口腔用组合物
公开(公告)号：US5374418A
公开(公告)日：1994-12-20
申请号：US16234
申请日：1993-02-11
申请人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Kazushi Oshino , Atsushi Yamagishi , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/41 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/66 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61K8/43 , A61K8/416 , A61K8/44 , A61K8/4926 , A61K8/55 , A61K8/63 , A61K8/66 , A61Q11/00
摘要： A composition for use in the oral cavity is disclosed. The composition comprises (A) an antibacterial compound represented by the following general formula (1),A.sup.m+ .multidot.X.sub.m.sup.- (1)wherein A.sup.m+ is a nitrogen-containing antibacterial cation and the counter anion X.sup.- represents a monoalkyl phosphate ion, a monoalkenyl phosphate ion, a monoalkyl phosphonate ion, or a monoalkenyl phosphonate ion having a linear or branched alkyl or alkenyl group with 8 to 20 carbon atoms, and m is a valence of the cation A, and (B) a vehicle for use in the oral cavity. It exhibits a remarkablely rapid and continued disinfection effect action against oral cavity bacteria, while providing a good taste. Its disinfection effect is not reduced in the presence of surfactants. In addition, it does not color the tooth.
摘要翻译：公开了一种用于口腔中的组合物。该组合物包含（A）由以下通式（1）表示的抗菌化合物，Am + xXm-（1）其中Am +为含氮抗菌阳离子，抗衡阴离子X为磷酸单烷基酯离子，单链烯基磷酸酯离子，单烷基膦酸根离子或具有碳原子数为8〜20的直链或支链烷基或烯基的单烯基膦酸酯离子，m为阳离子A的化合价，（B）在口腔中使用的载体。它对口腔细菌表现出非常快速和持续的消毒效果，同时提供了良好的口味。在表面活性剂存在下，其消毒效果不会降低。此外，它不会使牙齿变色。

2. 发明授权

US5370865A Composition for use in oral cavity 失效
标题翻译：口腔用组合物
公开(公告)号：US5370865A
公开(公告)日：1994-12-06
申请号：US16233
申请日：1993-02-11
申请人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
发明人： Atsushi Yamagishi , Kazushi Oshino , Ryozo Nakai , Yasuteru Eguchi , Tetsuji Iwasaki , Yuichi Hioki
IPC分类号： A61K8/34 , A61K8/43 , A61K8/44 , A61K8/49 , A61K8/55 , A61K8/63 , A61K8/67 , A61Q11/00 , A61K7/16 , A61K7/22
CPC分类号： A61K8/43 , A61K8/347 , A61K8/44 , A61K8/4926 , A61K8/556 , A61K8/63 , A61K8/678 , A61Q11/00
摘要： A composition for use in the oral cavity comprising a monophosphate represented by the following general formula (1), ##STR1## wherein R.sup.1 is a linear or branched alkyl or alkenyl group with 6 to 20 carbon atoms, and may have a substituted fluorine atom; one of X.sup.1 or X.sup.2 is a basic amino acid residual group, while the other is a hydrogen atom, an alkali metal, an ammonium, an alkyl amine, an alkanol amine, or a basic amino acid residual group; and n is an integer from 0 to 4. The composition exhibits a superior action in protecting the tooth surface, is stable, and has a pleasant taste.
摘要翻译：一种用于口腔的组合物，其包含由以下通式（1）表示的单磷酸酯，其中R 1是具有6至20个碳原子的直链或支链烷基或烯基，并且可以具有取代基氟原子 X1或X2中的一个是碱性氨基酸残基，而另一个是氢原子，碱金属，铵，烷基胺，链烷醇胺或碱性氨基酸残基; n为0〜4的整数。该组合物在保护牙齿表面方面表现出优异的作用，稳定，味道好。

3. 发明授权

US08591867B2 Oral preparation system 有权
标题翻译：口服制剂系统
公开(公告)号：US08591867B2
公开(公告)日：2013-11-26
申请号：US10540266
申请日：2003-12-26
申请人： Kazushi Oshino , Atsushi Yamagishi , Tadayuki Tokunaga , Masanobu Wakasa
发明人： Kazushi Oshino , Atsushi Yamagishi , Tadayuki Tokunaga , Masanobu Wakasa
IPC分类号： A61Q11/00 , A61K8/00 , A61K8/18 , A61K8/19 , A61K8/21 , A61K8/24 , A61K8/30 , A61K8/55
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/55
摘要： An oral preparation of the present invention contains a multi-composition system including a calcium ion supplying compound; a fluoride ion supplying compound a polyolphosphate ion supplying compound; and, a monofluorophosphate ion supplying compound, wherein the calcium ion supplying compound and the fluoride ion supplying compound are separated within the oral preparation.
摘要翻译：本发明的口服制剂含有包含钙离子供给化合物的多组合体系; 氟化物离子供给化合物，多元醇磷酸盐离子供给化合物; 以及供给化合物的单氟磷酸盐离子，其中，所述钙离子供给化合物和所述氟化物离子供给化合物在所述口服制剂中分离。

4. 发明申请

US20060134019A1 Oral preparation system 有权
公开(公告)号：US20060134019A1
公开(公告)日：2006-06-22
申请号：US10540266
申请日：2003-12-26
申请人： Kazushi Oshino , Atsushi Yamagishi , Tadayuki Tokunaga , Masanobu Wakasa
发明人： Kazushi Oshino , Atsushi Yamagishi , Tadayuki Tokunaga , Masanobu Wakasa
IPC分类号： A61K8/21
CPC分类号： A61Q11/00 , A61K8/19 , A61K8/21 , A61K8/55
摘要： An oral preparation of the present invention contains a multi-composition system including a calcium ion supplying compound; a fluoride ion supplying compound a polyolphosphate ion supplying compound; and, a monofluorophosphate ion supplying compound, wherein the calcium ion supplying compound and the fluoride ion supplying compound are separated within the oral preparation.

5. 发明授权

US09301906B2 Dentrifice composition 有权
标题翻译：断瘘组成
公开(公告)号：US09301906B2
公开(公告)日：2016-04-05
申请号：US14008210
申请日：2011-04-06
申请人： Atsushi Yamagishi , Sei Tsutsui
发明人： Atsushi Yamagishi , Sei Tsutsui
IPC分类号： A61K8/21 , A61K8/34 , A61K8/60 , A61Q11/00 , A61K8/73 , A61K8/11
CPC分类号： A61K8/21 , A61K8/11 , A61K8/345 , A61K8/60 , A61K8/73 , A61K8/731 , A61K8/733 , A61K8/737 , A61Q11/00
摘要： Provided is a dentifrice composition which has excellent dental caries preventive effect by improving the uptake of fluoride ions into tooth enamel or dentin and improving acid resistance.A dentifrice composition comprising the following components (A), (B), (C) and (D): (A) from 0.002 to 5% by mass of a fluoride ion supplying compound in terms of fluorine, (B) from 25 to 65% by mass of a sugar alcohol, which is dissolved in an amount of 5 to 30 g in 100 g of an aqueous solution at 20° C., (C) from 10 to 25% by mass of water, and (D) from 0.1 to 1.2% by mass of a binder, wherein the mass ratio of the component (B) to the component (C), the mass ratio (B/C), is more than 1 and 6 or less.
摘要翻译：提供了通过改善氟化物离子进入牙釉质或牙本质并提高耐酸性而具有优异的龋齿预防效果的洁牙剂组合物。含有下列组分（A），（B），（C）和（D）的洁牙剂组合物：（A）以氟化合物计，氟化物离子供给化合物的含量为0.002至5质量％，（B）为25至 65质量％的在20℃下的100g水溶液中溶解5〜30g的糖醇，（C）为10〜25质量％的水，（D） 0.1〜1.2质量％的粘合剂，其中，成分（B）与成分（C）的质量比（质量比（B / C））为1以上6以下。

6. 发明授权

US6048913A Coating composition for teeth 失效
标题翻译：牙齿涂层组成
公开(公告)号：US6048913A
公开(公告)日：2000-04-11
申请号：US125420
申请日：1998-08-17
申请人： Atsushi Yamagishi , Akira Oshima , Shigeto Kayane , Yukihiro Nakano
发明人： Atsushi Yamagishi , Akira Oshima , Shigeto Kayane , Yukihiro Nakano
IPC分类号： A61K6/00 , A61K6/02 , A61K6/083 , A61K7/16
CPC分类号： A61K6/0017
摘要： The present invention relates to a dental coating composition comprising a polymer which has in its molecule one or more phosphorus series acid residues selected from the group consisting of phosphoric acid, phosphonic acid and phosphinic acid and halides and salts thereof and has a weight-average molecular weight of 10,000 to 5,000,000, and water or a lower alcohol. The composition is a dental coating agent which does not easily peel off when drinking or eating, can be removed easily if necessary and does not have a safety problem.
摘要翻译： PCT No.PCT / JP97 / 04533 Sec。 371日期1998年8月17日第 102（e）日期1998年8月17日PCT 1997年12月10日PCT公布。第WO98 / 26749号公报日期1998年6月25日本发明涉及一种牙科用涂料组合物，其包含在其分子中具有选自磷酸，膦酸和次膦酸及其卤化物及其盐中的一种或多种磷系酸残基的聚合物，并且具有重均分子量为10,000至5,000,000，以及水或低级醇。该组合物是在饮用或饮食时不容易剥离的牙科涂剂，如果需要，可以容易地除去并且没有安全问题。

7. 发明授权

US08557224B2 Oral cavity composition 有权
标题翻译：口腔组成
公开(公告)号：US08557224B2
公开(公告)日：2013-10-15
申请号：US10564368
申请日：2004-07-14
申请人： Atsushi Yamagishi , Atsushi Takayanagi
发明人： Atsushi Yamagishi , Atsushi Takayanagi
IPC分类号： A61K8/21 , A61K8/00 , A61K8/46
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K8/55 , A61K31/19 , A61K33/16 , A61K33/42 , A61K2800/88 , A61K2300/00
摘要： The present invention provides an oral cavity composition with which brief treatment using the same yields a high effect for dental cavity prevention and an excellent dental hyperesthesia preventive and treatment effects, and a method of treatment using such a composition. The oral cavity composition according to the present invention contains a first composition (A) containing a fluoride ion-supplying compound, an inorganic phosphoric acid and a salt thereof, and a second composition (B) containing a calcium salt of organic acid, with an organic acid constituting said calcium salt of organic acid having a pKa value ranging from 3 to 11, or at least one pKa value ranging from 3 to 11 when said organic acid has plural pKa values, wherein said first composition (A) and said second composition (B) are discretely packed from each other so that said two compositions can be alternately used and then come to be mixed with each other at a tooth region when applied thereto.
摘要翻译：本发明提供了一种口腔组合物，其使用该口腔组合物的短期治疗对预防牙腔以及良好的牙齿感觉预防和治疗效果产生高效果，以及使用这种组合物的治疗方法。根据本发明的口腔组合物含有含有氟化物离子供给化合物，无机磷酸及其盐的第一组合物（A）和含有有机酸钙盐的第二组合物（B），其具有当所述有机酸具有多个pKa值时，构成所述有机酸钙盐的有机酸的pKa值为3至11，或至少1至3的pKa值，其中所述第一组合物（A）和所述第二组合物（B）彼此离散地填充，使得所述两种组合物可以交替使用，然后在施加到其上时在齿区域彼此混合。

8. 发明申请

US20060171903A1 Oral cavity composition 有权
公开(公告)号：US20060171903A1
公开(公告)日：2006-08-03
申请号：US10564368
申请日：2004-07-14
申请人： Atsushi Yamagishi , Atsushi Takayanagi
发明人： Atsushi Yamagishi , Atsushi Takayanagi
IPC分类号： A61K8/30 , A61K8/21
CPC分类号： A61Q11/00 , A61K8/21 , A61K8/24 , A61K8/55 , A61K31/19 , A61K33/16 , A61K33/42 , A61K2800/88 , A61K2300/00
摘要： The present invention provides an oral cavity composition with which brief treatment using the same yields a high effect for dental cavity prevention and an excellent dental hyperesthesia preventive and treatment effects, and a method of treatment using such a composition. The oral cavity composition according to the present invention contains a first composition (A) containing a fluoride ion-supplying compound, an inorganic phosphoric acid and a salt thereof, and a second composition (B) containing a calcium salt of organic acid, with an organic acid constituting said calcium salt of organic acid having a pKa value ranging from 3 to 11, or at least one pKa value ranging from 3 to 11 when said organic acid has plural pKa values, wherein said first composition (A) and said second composition (B) are discretely packed from each other so that said two compositions can be alternately used and then come to be mixed with each other at a tooth region when applied thereto.

9. 发明申请

US20140127142A1 TOOTHPASTE COMPOSITION FOR DENTIN HYPERSENSITIVITY 审中-公开
标题翻译：用于丹宁超敏性的牙膏组合物
公开(公告)号：US20140127142A1
公开(公告)日：2014-05-08
申请号：US14126303
申请日：2012-06-12
申请人： Noritaka Takahashi , Atsushi Yamagishi
发明人： Noritaka Takahashi , Atsushi Yamagishi
IPC分类号： A61K8/58 , A61Q11/00
CPC分类号： A61K8/58 , A61K6/0017 , A61K8/19 , A61K8/20 , A61K8/361 , A61K8/365 , A61K8/44 , A61K8/731 , A61Q11/00
摘要： Provided is a toothpaste composition for dentin hypersensitivity that effectively prevents pain attributed to dentin hypersensitivity, instantaneously and sufficiently seals the openings of dentinal tubules in an exposed dentinal surface, and has excellent sustainability of the effect of suppressing the pain attributed to dentin hypersensitivity. The toothpaste composition for dentin hypersensitivity comprises the following components (A), (B), and (C): (A) a powder having a sparingly water-soluble property selected from a fatty acid divalent metal salt (A-1) derived from a saturated fatty acid having from 12 to 18 carbon atoms, a fatty acid acyllysine (A-2) having an acyl group derived from a saturated fatty acid having from 12 to 18 carbon atoms, and a fatty acid acyltaurine divalent metal salt (A-3) having an acyl group derived from a saturated fatty acid having from 12 to 18 carbon atoms; (B) a desensitizing agent selected from potassium nitrate, potassium citrate, strontium chloride, and strontium acetate; and (C) water; in which a mass ratio ((A)/(B)) of the component (A) to the component (B) is from 0.02 to 0.5.
摘要翻译：提供一种用于牙质过敏的牙膏组合物，其有效地防止牙本质过敏引起的疼痛，瞬时和充分地密封暴露的牙质表面中的牙质小管的开口，并且具有抑制由牙本质过敏引起的疼痛的效果的优异的持续性。用于牙本质过敏的牙膏组合物包括以下组分（A），（B）和（C）：（A）具有少量水溶性的粉末，其选自脂肪酸二价金属盐（A-1）衍生自具有12至18个碳原子的饱和脂肪酸，具有衍生自具有12至18个碳原子的饱和脂肪酸的酰基的脂肪酸酰基赖氨酸（A-2）和脂肪酸酰基牛磺酸二价金属盐（A- 3）具有衍生自具有12至18个碳原子的饱和脂肪酸的酰基; （B）选自硝酸钾，柠檬酸钾，氯化锶和乙酸锶的脱敏剂; 和（C）水; 其中组分（A）与组分（B）的质量比（（A）/（B））为0.02至0.5。

10. 发明授权

US07640014B2 Mobile station and method for controlling mobile station side communication, base station and method for controlling base station side communication, and communication system 有权
标题翻译：用于控制移动台侧通信的移动站和方法，用于控制基站侧通信的基站和方法以及通信系统
公开(公告)号：US07640014B2
公开(公告)日：2009-12-29
申请号：US10557111
申请日：2004-06-01
申请人： Naoki Kanada , Kakuichi Shiomi , Atsushi Yamagishi , Naritomo Meguro
发明人： Naoki Kanada , Kakuichi Shiomi , Atsushi Yamagishi , Naritomo Meguro
IPC分类号： H04W4/00
CPC分类号： H04W52/281 , H04W4/90 , H04W76/50
摘要： When emergency communication etc. is sent, it aims at preferentially dealing with the emergency communication etc. by a simple and effective method. It is a communication system in which a base station 100 and a mobile station 200a establish communication for emergency situation, in time of emergency, wherein the mobile station 200a switches an output adjustment from the normal mode to the emergency mode and sends the communication for emergency situation at the largest output possible. The base station 100 receives a strong radio wave from the mobile station 200a which sent the communication for emergency situation. The base station 100 continues to output suppression signals for suppressing signal intensity to the other mobile stations. The other mobile stations are suppressed by the near-far effect, and it becomes impossible for the base station 100 to receive communication except for the communication for emergency situation. Only the mobile station 200a which sent the communication for emergency situation establishes a channel to the base station 100. After the establishment, the mobile station 200a which sent the communication for emergency situation performs communication according to the normal communication procedure.
摘要翻译：发送应急通信等时，通过简单有效的方式，优先处理应急通信等。基站100和移动台200a在紧急情况下建立紧急情况通信的通信系统，其中移动站200a将输出调整从正常模式切换到紧急模式，并发送紧急通信情况可能最大。基站100从发送紧急情况通信的移动台200a接收强大的无线电波。基站100继续输出用于抑制对其他移动台的信号强度的抑制信号。其他的移动台受到近距离的影响的抑制，基站100除了紧急情况的通信以外，不可能接收通信。发送用于紧急情况的通信的移动台200a仅向基站100建立信道。建立后，发送紧急情况通信的移动台200a根据通常的通信过程进行通信。

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