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1. 发明授权

US09023882B2 5-membered nitrogen containing heterocyclic derivatives and pharmaceutical compositions comprising the same 有权
标题翻译： 5元含氮杂环衍生物和包含它们的药物组合物
公开(公告)号：US09023882B2
公开(公告)日：2015-05-05
申请号：US13494380
申请日：2012-06-12
申请人： Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
发明人： Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
IPC分类号： A61K31/4025 , C07D231/10 , C07D207/30 , A61K31/4155 , C07D403/04 , A61K31/402 , A61K31/165 , A61K31/404 , A61K31/415 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D207/34 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/40 , C07D401/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/12 , C07D417/04
CPC分类号： A61K31/402 , A61K31/165 , A61K31/404 , A61K31/415 , A61K31/4155 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/5377 , A61K45/06 , C07D207/34 , C07D231/14 , C07D231/16 , C07D231/20 , C07D231/38 , C07D231/40 , C07D401/04 , C07D403/04 , C07D405/04 , C07D405/06 , C07D409/04 , C07D409/12 , C07D417/04 , A61K2300/00
摘要： 5-membered heterocyclic derivatives represented by general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro, cyano and the like; ring J represents aryl or heteroaryl; Q represents carboxy, 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, haloalkyl and the like; X1 and X2 independently represent CR2 or N; R2 represents H, alkyl and the like; R1 represents halogen, cyano, haloalkyl, A-D-E-G-L-M, —N(-D-L-M)2 and the like, A represents a single bond, O, S and the like; D, G and M independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E and L independently represent a single bond, O, S, COO, SO2 and the like.
摘要翻译：具有黄嘌呤氧化酶抑制活性的通式（I）表示的5元杂环衍生物，可用作预防或治疗与血清尿酸水平异常有关的疾病或其前药或其盐的药剂。在式（I）中，T表示硝基，氰基等; 环J表示芳基或杂芳基; Q表示羧基，5-四唑基等; Y表示H，OH，NH 2，卤素，卤代烷基等; X1和X2独立地表示CR2或N; R2代表H，烷基等; R 1表示卤素，氰基，卤代烷基，A-D-E-G-L-M，-N（-D-L-M）2等，A表示单键O，S等; D，G和M独立地表示任选取代的亚烷基，亚环烷基，亚杂环亚烷基，亚芳基，杂亚芳基等; E和L独立地表示单键O，S，COO，SO 2等。

2. 发明申请

US20130217878A1 (AZA)INDOLIZINE DERIVATIVE AND PHARMACEUTICAL USE THEREOF 有权
标题翻译：（AZA）吲哚衍生物及其药物用途
公开(公告)号：US20130217878A1
公开(公告)日：2013-08-22
申请号：US13824147
申请日：2011-09-28
申请人： Masato Iizuka , Kazuo Shimizu
发明人： Masato Iizuka , Kazuo Shimizu
IPC分类号： C07D487/04 , C07D471/04
CPC分类号： C07D487/04 , C07D471/04
摘要： (Aza)indolizine derivatives represented by Formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, salts thereof or the like. In Formula (I), 0 to 2 of X1, X2, X3 and X4 are a nitrogen atom and the others are CR1; one of T1 and T2 represents cyano and the other represents a group represented by Formula (A), with the proviso that when T1 is cyano, at least one of X1 to X4 is a nitrogen atom; R1 independently represents a hydrogen atom, a halogen atom, a hydroxy group, C1-6 alkyl, C1-6 alkoxy or the like; ring U represents a benzene ring or the like; m represents integral number from 0 to 2; R2 independently represents a fluorine atom, a hydroxy group or the like.
摘要翻译：具有黄嘌呤氧化酶抑制活性的式（I）表示的（Aza）中氮茚衍生物，可用作预防或治疗与血清尿酸水平异常相关的疾病，其前药，其盐等的药剂。在式（I）中，X 1，X 2，X 3和X 4的0〜2为氮原子，其余为CR 1; T1和T2之一表示氰基，另一个表示由式（A）表示的基团，条件是当T1为氰基时，X 1至X 4中的至少一个为氮原子; R1独立地表示氢原子，卤素原子，羟基，C1-6烷基，C1-6烷氧基等; 环U表示苯环等; m表示0〜2的整数; R2独立地表示氟原子，羟基等。

3. 发明授权

US08262581B2 Solid tissue impedance estimating method, cardiac output calculating method, pulmonary artery wedge pressure calculating method, cardiac output monitoring device, cardiac output monitoring system, pulmonary artery wedge pressure monitoring device, and pulmonary artery wedge pressure monitoring system 有权
标题翻译：固体组织阻抗估计方法，心输出量计算方法，肺动脉楔压计算方法，心输出量监测装置，心输出量监测系统，肺动脉楔压监测装置和肺动脉楔压监测系统
公开(公告)号：US08262581B2
公开(公告)日：2012-09-11
申请号：US11950169
申请日：2007-12-04
申请人： Kazunori Uemura , Masashi Inagaki , Masaru Sugimachi , Kazuo Shimizu , Masatoshi Kobayashi
发明人： Kazunori Uemura , Masashi Inagaki , Masaru Sugimachi , Kazuo Shimizu , Masatoshi Kobayashi
IPC分类号： A61B5/02
CPC分类号： A61B5/029 , A61B5/0295 , A61B5/053
摘要： A practical method for estimating cardiac output and pulmonary artery wedge pressure with good accuracy is provided. A method is provided for estimating the impedance arising from solid tissue by determining the impedance at the intersection between the line of identity and the extrapolated regression line, where the regression line is obtained by linearly regressing the maximum value to the minimum value of the impedance signal of each of multiple data sets, where each data set contains the maximum value and the minimum value of the impedance signal during one cardiac cycle, where impedance signal is obtained between a can electrode implanted in the left thoracic wall and an electrode inserted into the coronary vein, over a specific period of time following the infusion of hypertonic saline into the pulmonary circulation.
摘要翻译：提供了一种准确估计心输出量和肺动脉楔形压力的实用方法。提供了一种用于通过确定身份线与外推回归线之间的交叉点处的阻抗来估计由固体组织产生的阻抗的方法，其中回归线通过将最大值线性回归到阻抗信号的最小值而获得其中每个数据集包含在一个心动周期期间的阻抗信号的最大值和最小值，其中在植入在左胸壁的罐电极和插入冠状动脉的电极之间获得阻抗信号在输注高渗盐水进入肺循环后的特定时间段内静脉。

4. 发明申请

US20110201815A1 FUSED HETEROCYCLIC DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 审中-公开
标题翻译：熔融杂环衍生物及其用于医疗用途的方法
公开(公告)号：US20110201815A1
公开(公告)日：2011-08-18
申请号：US13124336
申请日：2009-10-14
申请人： Kazuo Shimizu , Masato Iizuka , Hideki Fujikura , Yasushi Takigawa , Masahiro Hiratochi
发明人： Kazuo Shimizu , Masato Iizuka , Hideki Fujikura , Yasushi Takigawa , Masahiro Hiratochi
IPC分类号： C07D401/10 , C07D417/10
CPC分类号： C07D401/04 , A61K31/427 , A61K31/443 , A61K31/4439 , C07D405/04 , C07D417/04
摘要： The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal plasma uric acid level and the like. The present invention relates to fused heterocyclic derivatives represented by the following formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of plasma uric acid level, prodrugs thereof, salts thereof or the like. In the formula (I), T represents trifluoromethyl, nitro or cyano; ring Q represents heteroaryl; X1 and X2 independently represent CH or N; ring U represents aryl or heteroaryl; m represents integral number from 0 to 2; n represents integral number from 0 to 3; R1 represents a hydroxy group, amino or C1-6 alkyl; R2 represents C1-6 alkyl, C1-6 alkoxy C1-6 alkyl or the like.
摘要翻译：本发明提供了可用作预防或治疗与异常血浆尿酸水平等相关的疾病的药剂的化合物。本发明涉及具有黄嘌呤氧化酶抑制活性的由下式（I）表示的稠合杂环衍生物，可用作预防或治疗与血浆尿酸水平异常有关的疾病，其前体药物，其盐或类似物。在式（I）中，T代表三氟甲基，硝基或氰基; 环Q表示杂芳基; X1和X2独立地表示CH或N; 环U表示芳基或杂芳基; m表示0〜2的整数; n表示0〜3的整数; R1表示羟基，氨基或C1-6烷基; R 2表示C 1-6烷基，C 1-6烷氧基C 1-6烷基等。

5. 发明申请

US20100224029A1 METHOD FOR SEPARATION AND RECOVERY OF NOBLE METALS 有权
标题翻译：用于分离和回收贵金属的方法
公开(公告)号：US20100224029A1
公开(公告)日：2010-09-09
申请号：US12160852
申请日：2007-01-12
申请人： Kazuhiro Niisawa , Kazuo Shimizu , Tadashi Nozaki
发明人： Kazuhiro Niisawa , Kazuo Shimizu , Tadashi Nozaki
IPC分类号： C22B11/00
CPC分类号： C22B11/04 , B01D15/1871 , B01D15/265 , B01D15/426 , B01J20/24 , B01J2220/4825 , C22B3/10 , C22B3/24 , C22B11/042 , C22B11/048 , C22B11/06 , Y02P10/214 , Y02P10/234
摘要： A method for separation and recovery of noble metals which makes it possible to isolate noble metal components efficiently by easy operation, that is, a method which comprises passing a solution of metals in hydrochloric acid prepared by treating a metal material with hydrochloric acid through the first cellulose column, eluting through development the noble metal component adsorbed on the cellulose with a hydrochloric acid/2-propanone mixture to obtain a fraction containing light platinum-group metals and a fraction containing heavy platinum-group metals and gold, separating the former fraction with the above mixture into fractions containing palladium, ruthenium and rhodium respectively, passing the fraction containing heavy platinum-group metals and gold through the second cellulose column to made them adsorbed on the cellulose, eluting them from the cellulose with a hydrochloric acid/1-butanol mixture to obtain fractions containing gold, osmium, iridium and platinum respectively, and recovering the noble metals from the fractions containing them respectively as simple substances.
摘要翻译：贵金属的分离回收方法，能够容易地使贵金属成分有效地分离，也就是将金属溶液中的金属在盐酸中的溶液通过第1次纤维素柱，通过用盐酸/ 2-丙酮混合物显影吸附在纤维素上的贵金属组分，得到含有轻铂族金属的部分和含有重铂族金属和金的部分，将前一部分与将上述混合物分别含有含有钯，钌和铑的级分，使含有重铂族金属和金的级分通过第二纤维素柱，使其吸附在纤维素上，用盐酸/ 1-丁醇从纤维素中洗脱出来混合物以分别得到含有金，锇，铱和铂的级分，a 并从分别含有它们的级分中回收贵金属作为简单物质。

6. 发明申请

US20100056521A1 (AZA)INDOLE DERIVATIVE AND USE THEREOF FOR MEDICAL PURPOSES 有权
标题翻译：（AZA）INDOLE DERIVATIVE及其用于医疗用途
公开(公告)号：US20100056521A1
公开(公告)日：2010-03-04
申请号：US12595476
申请日：2008-04-10
申请人： Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
发明人： Kazuo Shimizu , Yasushi Takigawa , Hideki Fujikura , Masato Iizuka , Masahiro Hiratochi , Norihiko Kikuchi
IPC分类号： A61K31/404 , C07D209/18 , C07D409/12 , C07D413/10 , C07D401/04 , C07D471/04 , A61K31/4439 , A61K31/5377 , A61P43/00
CPC分类号： C07D209/30 , A61K31/165 , A61K31/404 , A61K31/407 , A61K31/427 , A61K31/437 , A61K31/4439 , A61K31/5377 , A61K45/06 , C07D209/42 , C07D401/04 , C07D405/04 , C07D405/10 , C07D409/12 , C07D417/04 , C07D471/04 , C07D491/056 , A61K2300/00
摘要： The present invention provides compounds useful as agents for the prevention or treatment of a disease associated with abnormal serum uric acid level which has a uricosuric activity or the like. The present invention relates to (aza)indole derivatives represented by the following general formula (I) having xanthine oxidase inhibitory activities and useful as agents for the prevention or treatment of a disease associated with abnormality of serum uric acid level, prodrugs thereof, or salts thereof. In the formula (I), T represents nitro or cyano and the like; ring J represents aryl or heteroaryl and the like; Q represents carboxy or 5-tetazolyl and the like; Y represents H, OH, NH2, halogen, nitro, alkyl, alkoxy and the like; X1, X2 and X3 independently represent CR2 or N; R1 and R2 independently represent halogen, cyano, haloalkyl, A-D-E-G, —N(-D-E-G)2 and the like, in the formula, A represents a single bond, O, S and the like; D and G independently represent optionally substituted alkylene, cycloalkylene, heterocycloalkylene, arylene, heteroarylene and the like; E represents a single bond, O, S, COO, SO2 and the like.
摘要翻译：本发明提供可用作预防或治疗与具有尿酸活性等的异常血清尿酸水平相关的疾病的药剂的化合物。本发明涉及具有黄嘌呤氧化酶抑制活性的由以下通式（I）表示的（aza）吲哚衍生物，可用作预防或治疗与血清尿酸水平异常有关的疾病，其前药或盐其中。在式（I）中，T表示硝基或氰基等; 环J表示芳基或杂芳基等; Q表示羧基或5-四唑基等; Y表示H，OH，NH 2，卤素，硝基，烷基，烷氧基等; X1，X2和X3独立地表示CR2或N; R 1和R 2独立地表示卤素，氰基，卤代烷基，A-D-E-G，-N（-D-E-G）2等，式中，A表示单键O，S等; D和G独立地表示任选取代的亚烷基，亚环烷基，亚杂环亚烷基，亚芳基，杂亚芳基等; E表示单键O，S，COO，SO 2等。

7. 发明授权

US07547680B2 Benzimidazole derivatives and medical uses thereof 失效
标题翻译：苯并咪唑衍生物及其医疗用途
公开(公告)号：US07547680B2
公开(公告)日：2009-06-16
申请号：US11473957
申请日：2006-06-23
申请人： Norihiko Kikuchi , Yoshinori Nonaka , Kazuya Tatani , Masahiro Hiratochi , Yu Kuramochi , Masayuki Isaji , Kazuo Shimizu , Takashi Miyagi
发明人： Norihiko Kikuchi , Yoshinori Nonaka , Kazuya Tatani , Masahiro Hiratochi , Yu Kuramochi , Masayuki Isaji , Kazuo Shimizu , Takashi Miyagi
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07H19/052
摘要： The present invention provides benzimidazole derivatives represented by the following formula (I) or pharmaceutically acceptable salts thereof, or prodrugs thereof, which exert an inhibitory activity on sodium-dependent nucleoside transporter 2 and are useful for a disease associated with an abnormality of plasma uric acid level. The compounds of the present invention are useful for the prevention or treatment of gout, hyperuricemia, urinary lithiasis, hyperuricemic nephropathy or the like.In the formula, n is 1 or 2; R1 and R2 are H, a halogen atom, cyano group, optionally substituted alkyl group, optionally substituted aryl group or the like; R3 is H, a halogen atom, optionally substituted alkyl group or the like; R4 and R5 are H, a halogen atom, OH or the like; and R6 and RX are H or OH: RY is F or OH.
摘要翻译：本发明提供由下式（I）表示的苯并咪唑衍生物或其药学上可接受的盐或其前药，其对钠依赖性核苷转运蛋白2具有抑制活性，并且可用于与血浆尿酸异常有关的疾病水平。本发明的化合物可用于预防或治疗痛风，高尿酸血症，尿结石病，高尿酸性肾病等。在该式中，n为1或2; R 1和R 2是H，卤素原子，氰基，任选取代的烷基，任选取代的芳基等; R3是H，卤素原子，任选取代的烷基等; R 4和R 5是H，卤素原子，OH等; R6和RX是H或OH：RY是F或OH。

8. 发明授权

US07021991B2 Polishing apparatus 失效
标题翻译：抛光设备
公开(公告)号：US07021991B2
公开(公告)日：2006-04-04
申请号：US10670499
申请日：2003-09-26
申请人： Kazuo Shimizu , Shinro Ohta , Akihiro Tsukada
发明人： Kazuo Shimizu , Shinro Ohta , Akihiro Tsukada
IPC分类号： B24B49/00
CPC分类号： B24B37/013 , B23H5/08 , B24B37/046 , B24B49/12 , G01B11/0625
摘要： A polishing apparatus has a polishing table having a polishing surface, a top ring for holding a workpiece to be polished and pressing the workpiece against the polishing surface on the polishing table, and a film thickness measuring device embedded in the polishing table. The film thickness measuring device includes a light source for applying light having a predetermined wavelength to a surface of the workpiece, a spectroscope for separating light reflected from the surface of the workpiece, and a charge coupled device array for capturing light separated by the spectroscope. The polishing apparatus also has a controller operable to analyze information captured by the charge coupled device array over the entire surface of the workpiece to obtain a film thickness at a desired point on the surface of the workpiece.
摘要翻译：抛光装置具有：具有研磨面的研磨台，用于保持待研磨的工件的顶环，并将工件压靠在研磨台上的研磨面上，以及嵌入在研磨台中的膜厚测量装置。膜厚测量装置包括：用于将一个具有预定波长的光施加到工件的表面的光源，用于分离从工件表面反射的光的分光器和用于捕获由分光镜分离的光的电荷耦合器件阵列。抛光装置还具有控制器，其可操作以分析由电荷耦合器件阵列在工件的整个表面上捕获的信息，以在工件表面上的期望点处获得膜厚度。

9. 发明授权

US06984164B2 Polishing apparatus 有权
公开(公告)号：US06984164B2
公开(公告)日：2006-01-10
申请号：US10864322
申请日：2004-06-10
申请人： Norio Kimura , Hideji Isobe , Kazuo Shimizu , Hiroyuki Osawa
发明人： Norio Kimura , Hideji Isobe , Kazuo Shimizu , Hiroyuki Osawa
IPC分类号： B24B49/10
CPC分类号： B24B37/013 , B24B49/04 , B24B49/10 , H01L21/30625
摘要： A polishing apparatus is used for polishing a substrate such as a semiconductor wafer, and has a sensor capable of continuously detecting the thickness of an electrically conductive layer. The polishing apparatus includes a polishing table having a polishing surface, and a top ring for holding and pressing the substrate against the polishing surface to polish the surface of the substrate. A sensor such as an eddy-current sensor is disposed below the polishing surface of the polishing table for measuring the thickness of a conductive layer formed on the surface of the substrate.

10. 发明授权

US06837574B2 Line scan type ink jet recording device 有权
标题翻译：线扫描型喷墨记录装置
公开(公告)号：US06837574B2
公开(公告)日：2005-01-04
申请号：US10169162
申请日：2000-12-28
申请人： Takahiro Yamada , Shinya Kobayashi , Hitoshi Kida , Kunio Satou , Toshitaka Ogawa , Yoshikane Matsumoto , Katsunori Kawasumi , Kazuo Shimizu
发明人： Takahiro Yamada , Shinya Kobayashi , Hitoshi Kida , Kunio Satou , Toshitaka Ogawa , Yoshikane Matsumoto , Katsunori Kawasumi , Kazuo Shimizu
IPC分类号： B41J2/06 , B41J2/155
CPC分类号： B41J2/06 , B41J2002/061
摘要： A recording head 200 has a plurality of nozzle orifices aligned in a row extending in a first direction. The recording head 200 is arranged with the nozzle orifices in confrontation with a recording medium P. The recording medium P is moved in a second direction B with respect to the recording head 200. Also, ink droplets ejected from the nozzle orifices are charged to a charged amount that corresponds to deflection amount of the ink droplets. The charged ink droplets are deflected in a direction perpendicular to a main scanning line. The plurality of ink droplets ejected from the plurality of nozzle orifices impinge on the same pixel position or at a nearby position so that it is possible to impinge multiple droplets at the same pixel position or a nearby position. As a result, it is possible to back up broken nozzles and to reduce recording distortion.
摘要翻译：记录头200具有沿第一方向延伸的一排排列的多个喷嘴孔。记录头200配置有与记录介质P相对的喷嘴孔。记录介质P相对于记录头200沿第二方向B移动。此外，从喷嘴孔喷出的墨滴被装入对应于墨滴的挠曲量的充电量。带电的墨滴在垂直于主扫描线的方向上偏转。从多个喷嘴孔喷射的多个墨滴撞击在相同的像素位置或附近的位置，使得可以在相同的像素位置或附近的位置处撞击多个液滴。结果，可以备份破碎的喷嘴并减少记录失真。

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