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1. 发明申请

US20110123458A1 POLYMER-METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME 有权
标题翻译：具有MRI对比度的聚合物复合复合材料和使用其的MRI对比和/或抗肿瘤剂组合物
公开(公告)号：US20110123458A1
公开(公告)日：2011-05-26
申请号：US13000836
申请日：2009-06-26
申请人： KazunoriI Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
发明人： KazunoriI Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
IPC分类号： A61K49/18 , A61K31/78 , A61K31/785 , A61K31/787 , A61K31/74 , A61P35/00
CPC分类号： A61K47/48315 , A61K47/60 , A61K47/645 , A61K49/128 , A61K49/146 , C08G83/001
摘要： The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
摘要翻译：本发明提供一种聚合物 - 金属络合物复合体，其包含能够作为聚合胶束的构成成分的嵌段共聚物和具有MRI对比能力的金属络合物，以肿瘤特异性的方式积聚，即使在少量，并且在血液中具有减少的副作用和长的保留时间。本发明的聚合物 - 金属配合物复合体包含具有通式（a）表示的嵌段共聚物（A）和具有MRI对比能力的金属络合物（B），其中复合物包含其中聚（A）中的碳）通过金属原子（M）与金属络合物（B）连接。

2. 发明授权

US08961949B2 Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same 有权
标题翻译：具有MRI对比能力和使用其的MRI对比和/或抗肿瘤成分的聚合物 - 金属络合物复合物
公开(公告)号：US08961949B2
公开(公告)日：2015-02-24
申请号：US13000836
申请日：2009-06-26
申请人： Kazunori Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
发明人： Kazunori Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
IPC分类号： A61K31/74 , C08G83/00 , A61K47/48 , A61K49/14 , A61K49/12
CPC分类号： A61K47/48315 , A61K47/60 , A61K47/645 , A61K49/128 , A61K49/146 , C08G83/001
摘要： The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
摘要翻译：本发明提供一种聚合物 - 金属络合物复合体，其包含能够作为聚合胶束的构成成分的嵌段共聚物和具有MRI对比能力的金属络合物，以肿瘤特异性的方式积聚，即使在少量，并且在血液中具有减少的副作用和长的保留时间。本发明的聚合物 - 金属配合物复合体包含具有通式（a）表示的嵌段共聚物（A）和具有MRI对比能力的金属络合物（B），其中复合物包含其中聚（A）中的碳）通过金属原子（M）与金属络合物（B）连接。

3. 发明授权

US06595982B2 Tubular medical device 有权
公开(公告)号：US06595982B2
公开(公告)日：2003-07-22
申请号：US10131071
申请日：2002-04-25
申请人： Masaki Sekino , Shin Maki
发明人： Masaki Sekino , Shin Maki
IPC分类号： A61M2500
CPC分类号： A61M25/0147 , A61B2018/00916 , A61M25/0144 , A61M2025/015
摘要： A tubular medical device comprises a tubular body, a lumen, a compression-resisting member inserted in the lumen so that it cannot move in the direction of the axis of the tubular body, with its distal end located at a predetermined distance from the distal end of the tubular body toward the proximal end, a pull wire whose distal end is secured near the distal end of the tubular body at a position deviated from the axis of the tubular body and which is led in the tubular body to the proximal end of the tubular body, and a pulling mechanism for pulling the pull wire toward the proximal end of the tubular body which is attached to the proximal end of the tubular body and has a manipulation dial. The compression-resisting member consists of a main body and a secured portion. The compression-resisting member main body, and has a property of resisting compression in the axial direction of the tubular body. The secured portion retains the main part in place in the lumen.

4. 发明授权

US06398776B1 Tubular medical device 失效
标题翻译：管状医疗器械
公开(公告)号：US06398776B1
公开(公告)日：2002-06-04
申请号：US08867508
申请日：1997-06-02
申请人： Masaki Sekino , Shin Maki
发明人： Masaki Sekino , Shin Maki
IPC分类号： A61M2500
CPC分类号： A61M25/0147 , A61B2018/00916 , A61M25/0144 , A61M2025/015
摘要： A tubular medical device comprises a tubular body, a lumen, a compression-resisting member inserted in the lumen so that it cannot move in the direction of the axis of the tubular body, with its distal end located at a predetermined distance from the distal end of the tubular body toward the proximal end, a pull wire whose distal end is secured near the distal end of the tubular body at a position deviated from the axis of the tubular body and which is led in the tubular body to the proximal end of the tubular body, and a pulling mechanism for pulling the pull wire toward the proximal end of the tubular body which is attached to the proximal end of the tubular body and has an manipulating dial. The compression-resisting member consists of a main body and a secured portion. The compression-resisting member main body, and has a property of resisting compression in the axial direction of he tubular body. The secured portion retains the rain part in place in the lumen.
摘要翻译：管状医疗装置包括管状体，内腔，插入内腔中的抗压构件，使得其不能在管状体的轴线方向上移动，其远端位于远离末端的预定距离所述管状体朝向所述近端，所述拉丝的远端在所述管状体的远端处固定在远离所述管状体的轴线的位置处并且被引导到所述管状体中的所述近端管状体和用于将拉线拉向管状体的近端的牵引机构，其连接到管状体的近端并具有操纵盘。抗压构件由主体和固定部分组成。耐压构件主体，具有抵抗筒状体的轴向压缩性。固定部分将雨水部分保持在内腔的适当位置。

5. 发明申请

US20180160987A1 DEVICE FOR DETECTING BLOOD FLOW DISTURBANCE 审中-公开
公开(公告)号：US20180160987A1
公开(公告)日：2018-06-14
申请号：US15889457
申请日：2018-02-06
申请人： Masaki Sekino , Yoko Tomioka , Yusuke Inoue , Takao Someya , Shinri Sakai , Shintaro Enomoto
发明人： Masaki Sekino , Yoko Tomioka , Yusuke Inoue , Takao Someya , Shinri Sakai , Shintaro Enomoto
IPC分类号： A61B5/00 , A61B5/026 , A61B5/01 , A61B5/0205 , A61B5/103 , G01F9/00 , G01J3/50
CPC分类号： A61B5/7278 , A61B5/01 , A61B5/02055 , A61B5/02416 , A61B5/02438 , A61B5/0261 , A61B5/1032 , A61B5/413 , A61B5/6832 , A61B5/7282 , A61B2505/05 , A61B2562/063 , A61B2562/066 , A61B2562/164 , G01F9/001 , G01J3/50
摘要： A blood flow disorder detection device includes: a sensor sheet including a flexible substrate and a plurality of sensors provided on the flexible substrate; and an analyzer that analyzes outputs of the plurality of sensors. The plurality of sensors measure different types of blood flow information of a living tissue, the blood flow information being obtained by attaching the sensor sheet to the living tissue. The analyzer detects a blood flow disorder in the living tissue by analyzing the different types of blood flow information from the plurality of sensors.

6. 发明申请

US20080068581A1 POSITIONING STAGE, BUMP FORMING APPARATUS EQUIPPED WITH THE POSITIONING STAGE, AND BUMP FORMING METHOD PERFORMED USING THE POSITIONING STAGE 有权
标题翻译：定位阶段，配备定位阶段的成型装置，以及使用定位阶段执行的成型方法
公开(公告)号：US20080068581A1
公开(公告)日：2008-03-20
申请号：US11942320
申请日：2007-11-19
申请人： Naoya Adachi , Masayuki Sumita , Masaki Sekino
发明人： Naoya Adachi , Masayuki Sumita , Masaki Sekino
IPC分类号： G03B27/58
CPC分类号： H01L21/68728 , B23K3/0623 , B23K2101/40 , H01L21/68707 , H01L24/11 , H01L24/742 , H01L2224/1134 , H01L2224/13144 , H01L2924/00013 , H01L2924/01004 , H01L2924/01005 , H01L2924/01006 , H01L2924/01013 , H01L2924/01033 , H01L2924/01078 , H01L2924/01079 , H01L2924/01082 , H01L2924/014 , H01L2924/00014 , H01L2224/13099
摘要： A positioning stage that can prevent an excessive force from being imparted to a positioned wafer, a bump forming apparatus equipped with such a positioning stage, and a bump forming method performed using such a positioning stage are provided. A biasing member that biases a wafer towards a positioning member has a contact surface that substantially faces a wafer-holding surface at an angle. The contact surface is in contact with an outer peripheral area of the wafer so as to bias the wafer slantwise towards the wafer-holding surface. With a resiliently deformable member, the positioning member is brought into contact with the wafer and is held at a predetermined position. When a bias force exceeding a predetermined magnitude is imparted to the positioning member, the resiliently deformable member becomes resiliently deformed so as to allow the positioning member to recede from the predetermined position.
摘要翻译：提供了能够防止向定位晶片施加过大力的定位台，配备有这种定位台的凸块形成装置以及使用这种定位台进行的凸块形成方法。朝向定位构件偏置晶片的偏置构件具有基本上以一定角度面对晶片保持表面的接触表面。接触表面与晶片的外围区域接触，以使晶片朝向晶片保持表面倾斜。利用可弹性变形的构件，定位构件与晶片接触并保持在预定位置。当向定位构件施加超过预定幅度的偏压力时，弹性变形构件变得弹性变形，从而允许定位构件从预定位置退回。

7. 发明授权

US08043279B2 Catheter and medical tube 有权
标题翻译：导管和医用管
公开(公告)号：US08043279B2
公开(公告)日：2011-10-25
申请号：US10603664
申请日：2003-06-26
申请人： Takatomo Hisamatsu , Katsuaki Soma , Masaki Sekino , Junichi Kobayashi
发明人： Takatomo Hisamatsu , Katsuaki Soma , Masaki Sekino , Junichi Kobayashi
IPC分类号： A61M25/00 , A61M29/00
CPC分类号： A61M25/104 , A61M25/0054 , A61M2025/0183 , A61M2025/1061
摘要： A catheter includes a proximal shaft having a relatively high rigidity, a distal shaft provided on a front portion of the proximal shaft so as to be in fluid communication with proximal shaft and having a rigidity lower than that of the proximal shaft, a hub mounted to the vicinity of a rear end of the proximal shaft and configured to allow a pressure applying apparatus to be mounted to the hub, and a balloon provided on a front portion of the distal shaft so as to be in fluid communication with the distal shaft and configured to receive pressure applied from the hub. The catheter also includes a guide wire lumen. In this catheter, at least a front portion of the distal shaft is configured as a grooved portion having a groove or grooves.
摘要翻译：导管包括具有相对较高刚性的近端轴，远端轴设置在近侧轴的前部，以便与近侧轴线流体连通并具有比近侧轴刚性更低的刚度;轮毂安装到近端轴的后端附近，并且构造成允许将压力施加装置安装到轮毂上，以及设置在远侧轴的前部以与远端轴流体连通的球囊，以接收从轮毂施加的压力。导管还包括导丝管腔。在该导管中，远侧轴的至少前部部分被构造为具有凹槽或沟槽的带槽部分。

8. 发明授权

US06624632B2 Method and apparatus for shortening T1 or T2, or lengthening the ADC of a substance by the use of electric current 失效
公开(公告)号：US06624632B2
公开(公告)日：2003-09-23
申请号：US10044524
申请日：2002-01-10
申请人： Norio Iriguchi , Masaki Sekino , Shoogo Ueno , Kikuo Yamaguchi
发明人： Norio Iriguchi , Masaki Sekino , Shoogo Ueno , Kikuo Yamaguchi
IPC分类号： G01V300
CPC分类号： G01R33/56341
摘要： In a method and apparatus for obtaining magnetic resonance data from water-containing substance, nuclear spins are excited in the substance in the presence of a homogenous static magnetic field, while an electrical current is flowing in the subject. The electrical current flowing in the subject shortens the spin-spin relaxation time and the spin-lattice relaxation time, and lengthens the apparent diffusion coefficient of the substance.

9. 发明授权

US11051764B2 Device for detecting blood flow disturbance 有权
公开(公告)号：US11051764B2
公开(公告)日：2021-07-06
申请号：US15889457
申请日：2018-02-06
申请人： Masaki Sekino , Yoko Tomioka , Takao Someya , PARAMOUNT BED CO., LTD. , KANEKA CORPORATION
发明人： Masaki Sekino , Yoko Tomioka , Yusuke Inoue , Takao Someya , Shinri Sakai , Shintaro Enomoto
IPC分类号： A61B5/00 , A61B5/026 , A61B5/01 , A61B5/0205 , A61B5/024 , G01J3/50 , A61B5/103 , G01F9/00
摘要： A blood flow disorder detection device includes: a sensor sheet including a flexible substrate and a plurality of sensors provided on the flexible substrate; and an analyzer that analyzes outputs of the plurality of sensors. The plurality of sensors measure different types of blood flow information of a living tissue, the blood flow information being obtained by attaching the sensor sheet to the living tissue. The analyzer detects a blood flow disorder in the living tissue by analyzing the different types of blood flow information from the plurality of sensors.

10. 发明授权

US10286222B2 Magnetic stimulator 有权
公开(公告)号：US10286222B2
公开(公告)日：2019-05-14
申请号：US13378333
申请日：2010-06-11
申请人： Atsushi Nishikawa , Youichi Saitoh , Taishi Fukushima , Masaki Sekino , Kuniyoshi Uchida
发明人： Atsushi Nishikawa , Youichi Saitoh , Taishi Fukushima , Masaki Sekino , Kuniyoshi Uchida
IPC分类号： A61N2/00 , A61N2/02 , A61B5/05 , A61B5/00 , A61B90/14
摘要： Provided is a magnetic stimulator for applying magnetic stimulation to a particular portion of a subject. This magnetic stimulator includes: a magnetic field generating means including at least a stimulation coil configured to generate a dynamic magnetic field so as to apply the magnetic stimulation; a coil holder operated to displace a relative position of the magnetic field generating means with respect to the particular portion of the subject; a plurality of magnetic field sensors each configured to detect the magnetic field generated by the magnetic field generating means; and a user interface section configured to provide instruction information based on a result of the detection of the magnetic field generated by the magnetic field generating means, the instruction information indicating an operation of displacement to be performed using the coil holder, the detection being made by the magnetic field sensors either before or during the magnetic stimulation.

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