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1. 发明授权

US08871180B2 Organic-inorganic hybrid particles containing contrast agent 有权
标题翻译：含有造影剂的有机 - 无机杂化颗粒
公开(公告)号：US08871180B2
公开(公告)日：2014-10-28
申请号：US12734808
申请日：2007-09-04
申请人： Kazunori Kataoka , Michiaki Kumagai , Keisuke Aikawa
发明人： Kazunori Kataoka , Michiaki Kumagai , Keisuke Aikawa
IPC分类号： A61K49/00 , B32B7/02 , B32B9/00 , C08L53/00 , A61K49/12 , A61K49/18 , A61K49/10 , C08K3/26 , C08K3/32
CPC分类号： A61K49/1824 , A61K49/105 , A61K49/126 , C08K3/26 , C08K3/32 , C08L53/00 , Y10T428/24975 , Y10T428/249921 , Y10T428/2998 , C08L2666/02
摘要： This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO43−) or carbonate ion (CO32−), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.
摘要翻译：本发明提供了含有不含电荷的亲水性聚合物链段和含有在其侧链具有羧酸根离子基团的重复结构单元的聚合物链段的嵌段共聚物作为必要成分的有机 - 无机杂化粒子，钙离子（Ca2 +），磷酸根离子（PO43-）或碳酸根离子（CO32-）或这些阴离子的混合物; 和造影剂。颗粒特别提供用于将MRI造影剂稳定递送至目标部位的载体。

2. 发明申请

US20100278737A1 ORGANIC-INORGANIC HYBRID PARTICLES CONTAINING CONTRAST AGENT 有权
标题翻译：含有对比剂的有机无机混合颗粒
公开(公告)号：US20100278737A1
公开(公告)日：2010-11-04
申请号：US12734808
申请日：2007-09-04
申请人： Kazunori Kataoka , Michiaki Kumagai , Keisuke Aikawa
发明人： Kazunori Kataoka , Michiaki Kumagai , Keisuke Aikawa
IPC分类号： A61K49/00 , A61P35/00
CPC分类号： A61K49/1824 , A61K49/105 , A61K49/126 , C08K3/26 , C08K3/32 , C08L53/00 , Y10T428/24975 , Y10T428/249921 , Y10T428/2998 , C08L2666/02
摘要： This invention provides organic-inorganic hybrid particles containing as the essential components a block copolymer comprising an uncharged hydrophilic polymer chain segment and a polymer chain segment containing a repeated structural unit having a carboxylate ion group at its side chain; calcium ion (Ca2+), phosphate ion (PO43−) or carbonate ion (CO32−), or a mixture of these anions; and a contrast agent. The particles provide, in particular, carriers for stably delivering an MRI contrast agent to a target site.
摘要翻译：本发明提供了含有不含电荷的亲水性聚合物链段和含有在其侧链具有羧酸根离子基团的重复结构单元的聚合物链段的嵌段共聚物作为必要成分的有机 - 无机杂化粒子，钙离子（Ca2 +），磷酸根离子（PO43-）或碳酸根离子（CO32-）或这些阴离子的混合物; 和造影剂。颗粒特别提供用于将MRI造影剂稳定递送至目标部位的载体。

3. 发明授权

US08961949B2 Polymer-metal complex composite having MRI contrast ability and MRI contrasting and/or antitumor composition using the same 有权
标题翻译：具有MRI对比能力和使用其的MRI对比和/或抗肿瘤成分的聚合物 - 金属络合物复合物
公开(公告)号：US08961949B2
公开(公告)日：2015-02-24
申请号：US13000836
申请日：2009-06-26
申请人： Kazunori Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
发明人： Kazunori Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
IPC分类号： A61K31/74 , C08G83/00 , A61K47/48 , A61K49/14 , A61K49/12
CPC分类号： A61K47/48315 , A61K47/60 , A61K47/645 , A61K49/128 , A61K49/146 , C08G83/001
摘要： The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
摘要翻译：本发明提供一种聚合物 - 金属络合物复合体，其包含能够作为聚合胶束的构成成分的嵌段共聚物和具有MRI对比能力的金属络合物，以肿瘤特异性的方式积聚，即使在少量，并且在血液中具有减少的副作用和长的保留时间。本发明的聚合物 - 金属配合物复合体包含具有通式（a）表示的嵌段共聚物（A）和具有MRI对比能力的金属络合物（B），其中复合物包含其中聚（A）中的碳）通过金属原子（M）与金属络合物（B）连接。

4. 发明授权

US06386209B1 Cosmetic case 有权
标题翻译：化妆盒
公开(公告)号：US06386209B1
公开(公告)日：2002-05-14
申请号：US09688231
申请日：2000-10-16
申请人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
发明人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
IPC分类号： A45D3326
CPC分类号： A45D33/24 , A45C13/008 , A45C13/1084 , A45D33/006 , A45D40/22
摘要： A cosmetic case containing a replaceable inner case which can be easily removed or inserted, and which is specifically structure to maintain the cosmetic material contained therein in a fresh and useable condition. The invention is comprised of an outer case with a floor area and inner peripheral wall defining a space for an inner container, an outer cover attached by a hinge to the outer case, a main latch employed to hold the outer cover closed, a replaceable inner container providing a cosmetic holding space, an inner container cover capable of opening or closing over the cosmetic holding space, and a sub-latch employed to hold the inner cover closed against the inner container. The inner case is equipped with a hinge part to allow opening and closing of the inner cover, the hinge part fitting into a cutout section on the peripheral wall of the outer case so as to expose the hinge and thus allow wide angle opening of the inner case cover. Inner case installation is aided by small protruding ribs formed within the outer case with the purpose of indexing and securing the inner case. An orifice is provided in the floor of the main case to allow the inner case to be pushed up and removed by finger pressure applied from below. The cosmetic case is characterized by a push-type latch mechanism which opens the outer and inner case covers simultaneously in one movement, an effective sealing mechanism between the inner case and cover, and specific inner cover structures to inhibit the fall of condensation droplets onto the cosmetic surface.
摘要翻译：一种包含可以容易地移除或插入的可更换的内壳的化妆品盒，并且其具体结构用于将其中包含的化妆品材料保持在新鲜和可使用的状态。本发明包括具有底面积的外壳和限定用于内容器的空间的内周壁，由铰链连接到外壳的外盖，用于将外盖保持封闭的主闩锁，可更换的内部提供化妆品容纳空间的容器，能够打开或关闭化妆品容纳空间的内部容器盖以及用于将内盖保持抵靠内部容器的副闩锁。内壳配有铰链部分，以允许内盖的打开和关闭，铰链部分装配到外壳的周壁上的切口部分中，以便露出铰链，从而允许内侧的广角开度案例封面内壳安装由形成在外壳内的小突肋辅助，目的是分度和固定内壳。在主壳体的底板上设有孔口，以便通过从下方施加的手指压力将内壳推上和移开。该化妆箱的特征在于一种推式闩锁机构，其一次运动同时打开外壳和内壳盖，在内壳和盖之间有效的密封机构，以及特定的内盖结构，以防止冷凝液滴落到化妆品表面。

5. 发明申请

US20120305417A1 COMPACT CASE BUILT-IN WITH HINGE UNIT AND METHOD OF MANUFACTURING COMPACT CASE BUILT-IN WITH HINGE UNIT 有权
标题翻译：紧凑型箱体搭建铰链单元及制造紧凑型箱体的方法与铰链单元
公开(公告)号：US20120305417A1
公开(公告)日：2012-12-06
申请号：US13578762
申请日：2011-02-09
申请人： Yuzo Yoshida , Michiaki Kumagai , Yasuko Nakajima
发明人： Yuzo Yoshida , Michiaki Kumagai , Yasuko Nakajima
IPC分类号： B65D69/00
CPC分类号： A45D40/221 , A45D33/008
摘要： [Problem to be solved] To provide a compact case built-in with a hinge unit that can be easily assembled while reducing manufacturing costs of parts.[Solving Means] A compact case 1 with a lid body 20 connected, in an openable and closable manner, via a hinge using at least one or more hinge unit 30, to a back end of a flat box shaped container body 10, the compact case includes a frame body 41 of a plate-like member having a flat shape along a peripheral shape of an upper opening of the container body, the back end of the container body is formed with a hinge storing section 11 for storing a case section of the hinge unit so that a shaft section of the hinge unit is protruded, a back end of the lid body is formed with a receiving hole 21a in which the shaft section of the hinge unit is to be inserted, the frame body is attached to the container body so as to cover up the hinge storing section, the shaft section of the hinge unit is inserted in the receiving hole in a state the case section of the hinge unit is fixed to the container body, and the container body and the lid body are connected in an openable and closable manner.
摘要翻译： [待解决的问题]提供一种内置有铰链单元的小型外壳，可以轻松组装，同时降低零件的制造成本。 [解决方案]具有盖体20的紧凑型壳体1，其通过使用至少一个或多个铰链单元30的铰链以可开启和关闭的方式连接到扁平箱形容器主体10的后端，紧凑件壳体包括沿着容器主体的上开口的周边形状具有扁平形状的板状构件的框体41，容器主体的后端形成有铰链存储部11，用于存储所述铰链单元使得所述铰链单元的轴部突出，所述盖体的后端形成有容纳孔21a，所述铰链单元的轴部插入所述容纳孔21a中，所述框架主体附接到所述铰链单元容器主体，以覆盖铰链收容部，铰链单元的轴部在铰链单元的壳体部固定于容器主体的状态下插入容纳孔内，容器主体和盖体以可开闭的方式连接。

6. 发明授权

US06192895B1 Cosmetic case 失效
标题翻译：化妆盒
公开(公告)号：US06192895B1
公开(公告)日：2001-02-27
申请号：US09107178
申请日：1998-06-29
申请人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
发明人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
IPC分类号： A45D3326
CPC分类号： A45D33/24 , A45C13/008 , A45C13/1084 , A45D33/006 , A45D40/22
摘要： A cosmetic case containing a replaceable inner case which can be easily removed or inserted, and which is specifically structured to maintain the cosmetic material contained therein in a fresh and usable condition. The invention is comprised of an outer case with a floor area and inner peripheral wall defining a space for an inner container, an outer cover attached by a hinge to the outer case, a main latch employed to hold the outer cover closed, a replaceable inner container providing a cosmetic holding space, an inner container cover capable of opening or closing over the cosmetic holding space, and a sub-latch employed to hold the inner cover closed against the inner container. The inner case is equipped with a hinge part to allow opening and closing of the inner cover, said hinge part fitting into a cutout section on the peripheral wall of the outer case so as to expose the hinge and thus allow wide angle opening of the inner case cover. Inner case installation is aided by small protruding ribs formed within the outer case with the purpose of indexing and securing the inner case. An orifice is provided in the floor of the main case to allow the inner case to be pushed up and removed by finger pressure applied from below. The cosmetic case is characterized by a push-type latch mechanism which opens the outer and inner case covers simultaneously in one movement, an effective sealing mechanism between the inner case and cover, and specific inner cover structures to inhibit the fall of condensation droplets onto the cosmetic surface.
摘要翻译：一种包含可以容易地移除或插入的可更换的内壳的化妆品盒，其特征在于其中包含的化妆品材料保持在新鲜可用的状态下。本发明包括具有地板面积和内周的外壳一个用于内部容器的空间的壁，一个由铰链连接到外壳的外盖，一个用于将外盖保持封闭的主闩，一个提供化妆品容纳空间的可更换的内部容器，封闭在化妆品保持空间上，以及用于将内盖保持靠在内部容器上的副闩锁。内壳配备有铰链部分，以允许内盖的打开和关闭，所述铰链部分装配到切口在外壳的周壁上的部分，以便露出铰链，从而允许内壳盖的广角打开。内壳安装由形成在外壳内的小突肋辅助，目的是分度和固定内壳。在主壳体的底板上设有孔口，以便通过从下方施加的手指压力将内壳推上和移开。化妆箱的特征在于同时打开外壳盖和内壳盖的推式闩锁机构在一个运动中，内壳和盖之间的有效的密封机构以及特定的内盖结构，以防止冷凝液滴落到化妆品表面上。

7. 发明申请

US20110123458A1 POLYMER-METAL COMPLEX COMPOSITE HAVING MRI CONTRAST ABILITY AND MRI CONTRASTING AND/OR ANTITUMOR COMPOSITION USING THE SAME 有权
标题翻译：具有MRI对比度的聚合物复合复合材料和使用其的MRI对比和/或抗肿瘤剂组合物
公开(公告)号：US20110123458A1
公开(公告)日：2011-05-26
申请号：US13000836
申请日：2009-06-26
申请人： KazunoriI Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
发明人： KazunoriI Kataoka , Sachiko Kaida , Horacio Cabral , Michiaki Kumagai , Masaki Sekino
IPC分类号： A61K49/18 , A61K31/78 , A61K31/785 , A61K31/787 , A61K31/74 , A61P35/00
CPC分类号： A61K47/48315 , A61K47/60 , A61K47/645 , A61K49/128 , A61K49/146 , C08G83/001
摘要： The present invention provides a polymer-metal complex composite, which comprises a block copolymer capable of serving as a constituent member of a polymeric micelle and a metal complex having MRI contrast ability, accumulates in a tumor-specific manner, achieves high image contrast even in a small amount, and has reduced side effects and a long retention time in blood.The polymer-metal complex composite of the present invention comprises a block copolymer (A) represented by general formula (a) and a metal complex (B) having MRI contrast ability, wherein the composite comprises a structure in which a carboxyl anion of poly(carbo) in the copolymer (A) is attached to the metal complex (B) via a metal atom (M).
摘要翻译：本发明提供一种聚合物 - 金属络合物复合体，其包含能够作为聚合胶束的构成成分的嵌段共聚物和具有MRI对比能力的金属络合物，以肿瘤特异性的方式积聚，即使在少量，并且在血液中具有减少的副作用和长的保留时间。本发明的聚合物 - 金属配合物复合体包含具有通式（a）表示的嵌段共聚物（A）和具有MRI对比能力的金属络合物（B），其中复合物包含其中聚（A）中的碳）通过金属原子（M）与金属络合物（B）连接。

8. 发明授权

US08540077B2 Compact case built-in with hinge unit and method of manufacturing compact case built-in with hinge unit 有权
标题翻译：内置紧凑型外壳，铰链单元和内置铰链单元的小型外壳制造方法
公开(公告)号：US08540077B2
公开(公告)日：2013-09-24
申请号：US13578762
申请日：2011-02-09
申请人： Yuzo Yoshida , Michiaki Kumagai , Yasuko Nakajima
发明人： Yuzo Yoshida , Michiaki Kumagai , Yasuko Nakajima
IPC分类号： A45D33/24
CPC分类号： A45D40/221 , A45D33/008
摘要： [Problem to be solved] To provide a compact case built-in with a hinge unit that can be easily assembled while reducing manufacturing costs of parts.[Solving Means] A compact case 1 with a lid body 20 connected, in an openable and closable manner, via a hinge using at least one or more hinge unit 30, to a back end of a flat box shaped container body 10, the compact case includes a frame body 41 of a plate-like member having a flat shape along a peripheral shape of an upper opening of the container body, the back end of the container body is formed with a hinge storing section 11 for storing a case section of the hinge unit so that a shaft section of the hinge unit is protruded, a back end of the lid body is formed with a receiving hole 21a in which the shaft section of the hinge unit is to be inserted, the frame body is attached to the container body so as to cover up the hinge storing section, the shaft section of the hinge unit is inserted in the receiving hole in a state the case section of the hinge unit is fixed to the container body, and the container body and the lid body are connected in an openable and closable manner.
摘要翻译： [待解决的问题]提供一种内置有铰链单元的小型外壳，可以轻松组装，同时降低零件的制造成本。 [解决方案]具有盖体20的紧凑型壳体1，其通过使用至少一个或多个铰链单元30的铰链以可开启和关闭的方式连接到扁平箱形容器主体10的后端，紧凑件壳体包括沿着容器主体的上开口的周边形状具有扁平形状的板状构件的框体41，容器主体的后端形成有铰链存储部11，用于存储所述铰链单元使得所述铰链单元的轴部突出，所述盖体的后端形成有容纳孔21a，所述铰链单元的轴部插入所述容纳孔21a中，所述框架主体附接到所述铰链单元容器主体，以覆盖铰链收容部，铰链单元的轴部在铰链单元的壳体部固定于容器主体的状态下插入容纳孔内，容器主体和盖体以可开闭的方式连接。

9. 发明授权

US06311701B1 Cosmetic case 有权
标题翻译：化妆盒
公开(公告)号：US06311701B1
公开(公告)日：2001-11-06
申请号：US09688099
申请日：2000-10-16
申请人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
发明人： Yukitomo Yuhara , Kiyokazu Miyokawa , Michiaki Kumagai , Takashi Sugiyama
IPC分类号： A45D3326
CPC分类号： A45D33/24 , A45C13/008 , A45C13/1084 , A45D33/006 , A45D40/22
摘要： A cosmetic case containing a replaceable inner case which can be easily removed or inserted, and which is specifically structured to maintain the cosmetic material contained therein in a fresh and useable condition. The invention is comprised of an outer case with a floor area and inner peripheral wall defining a space for an inner container, an outer cover attached by a hinge to the outer case, a main latch employed to hold the outer cover closed, a replaceable inner container providing a cosmetic holding space, an inner container cover capable of opening or closing over the cosmetic holding space, and a sub-latch employed to hold the inner cover closed against the inner container. The inner case is equipped with a hinge part to allow opening and closing of the inner cover, the hinge part fitting into a cutout section on the peripheral wall of the outer case so as to expose the hinge and thus allow wide angle opening of the inner case cover. Inner case installation is aided by small protruding ribs formed within the outer case with the purpose of indexing and securing the inner case. An orifice is provided in the floor of the main case to allow the inner case to be pushed up and removed by finger pressure applied from below. The cosmetic case is characterized by a push-type latch mechanism which opens the outer and inner case covers simultaneously in one movement, an effective sealing mechanism between the inner case and cover, and specific inner cover structures to inhibit the fall of condensation droplets onto the cosmetic surface.
摘要翻译：一种包含可以容易地移除或插入的可更换内壳的化妆盒，其特别构造为将其中所含的化妆品材料保持在新鲜和可使用的状态。本发明包括具有底面积的外壳和限定用于内容器的空间的内周壁，由铰链连接到外壳的外盖，用于将外盖保持封闭的主闩锁，可更换的内部提供化妆品容纳空间的容器，能够打开或关闭化妆品容纳空间的内部容器盖以及用于将内盖保持抵靠内部容器的副闩锁。内壳配有铰链部分，以允许内盖的打开和关闭，铰链部分装配到外壳的周壁上的切口部分中，以便露出铰链，从而允许内侧的广角开度案例封面内壳安装由形成在外壳内的小突肋辅助，目的是分度和固定内壳。在主壳体的底板上设有孔口，以便通过从下方施加的手指压力将内壳推上和移开。该化妆箱的特征在于一种推式闩锁机构，其一次运动同时打开外壳和内壳盖，在内壳和盖之间有效的密封机构，以及特定的内盖结构，以防止冷凝液滴落到化妆品表面。

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