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1. 发明授权

US5151360A Effect of N,N,N-trimethylsphingosine on protein kinase-C activity, melanoma cell growth in vitro, metastatic potential in vivo and human platelet aggregation 失效
标题翻译： N，N，N-三甲基蝶呤对蛋白激酶C活性，血管内皮细胞生长，体细胞分化潜能和人血小板聚集的影响
公开(公告)号：US5151360A
公开(公告)日：1992-09-29
申请号：US724625
申请日：1991-07-02
申请人： Kazuko Handa , Yasuyuki Igarashi , Mahammad N. Ahmad , Sen-Itiroh Hakomori
发明人： Kazuko Handa , Yasuyuki Igarashi , Mahammad N. Ahmad , Sen-Itiroh Hakomori
IPC分类号： A61K31/13 , A61K31/133 , A61P7/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C215/40
CPC分类号： C07C215/40
摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory an anti-metastatic activity over related compounds.
摘要翻译：本发明涉及一种新型化合物，其组合物及其药物以及抑制细胞增殖，血小板聚集（各种因素诱导）并抑制肿瘤细胞恶性表型的方法，例如具有转移性的肿瘤细胞，以及调节细胞粘附分子表达和功能使用所述化合物，组合物或药物。 N，N，N-三甲基鞘氨醇具有优于细胞增殖抑制相对于相关化合物的抗转移活性。

2. 发明授权

US5248824A Method of preparing N,N,N-trimethylsphingosine 失效
标题翻译：制备N，N，N-三甲基鞘氨醇的方法
公开(公告)号：US5248824A
公开(公告)日：1993-09-28
申请号：US879332
申请日：1992-05-07
申请人： Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
发明人： Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
IPC分类号： C07C215/40
CPC分类号： C07C215/40
摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
摘要翻译：本发明涉及一种新型化合物，其组合物及其药物，以及抑制细胞增殖，血小板聚集（各种因素诱导），抑制肿瘤细胞恶性表型的方法，使用所述化合物，组合物或药物。 N，N，N-三甲基鞘氨醇对相关化合物显示出优异的细胞增殖抑制和抗转移活性。

3. 发明授权

US5137919A Effect of N,N,N,-trimethylsphingosine on protein kinase C activity melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation 失效
标题翻译： N，N，N， - 三甲基鞘氨醇对蛋白激酶C活性的影响;体外黑素瘤细胞生长; 体内转移潜能和人血小板聚集
公开(公告)号：US5137919A
公开(公告)日：1992-08-11
申请号：US636353
申请日：1990-12-31
申请人： Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
发明人： Yasuyuki Igarashi , Mahammad N. Ahmad , Hirofumi Okoshi , Sen-Itiroh Hakomori
IPC分类号： C07C215/40
CPC分类号： C07C215/40
摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors), and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
摘要翻译：本发明涉及一种新型化合物，其组合物及其药物，以及抑制细胞增殖，血小板聚集（各种因素诱导），抑制肿瘤细胞恶性表型的方法，使用所述化合物，组合物或药物。 N，N，N-三甲基鞘氨醇对相关化合物显示出优异的细胞增殖抑制和抗转移活性。

4. 发明授权

US5331014A Effect of N,N,N-trimethylsphingosine on protein kinase-C activity; melanoma cell growth in vitro; metastatic potential in vivo and human platelet aggregation 失效
标题翻译： N，N，N-三甲基鞘氨醇对蛋白激酶C活性的影响; 体外黑素瘤细胞生长; 体内转移潜能和人血小板聚集
公开(公告)号：US5331014A
公开(公告)日：1994-07-19
申请号：US81383
申请日：1993-06-30
申请人： Satoshi Kimura , Yasuyuki Igarashi , Sen-itiroh Hakomori , Mohammad N. Ahmad , Hirofumi Okoshi , Kazuko Handa
发明人： Satoshi Kimura , Yasuyuki Igarashi , Sen-itiroh Hakomori , Mohammad N. Ahmad , Hirofumi Okoshi , Kazuko Handa
IPC分类号： A61K31/13 , A61K31/133 , A61P7/02 , A61P29/00 , A61P35/00 , A61P37/00 , A61P43/00 , C07C215/40 , A61K31/14
CPC分类号： C07C215/40
摘要： The invention relates to a novel compound, compositions and medicaments thereof and a method of inhibiting cell proliferation, platelet aggregation (induced by various factors) and inhibiting malignant phenotypes of tumor cells such as those having a metastatic property, and modulating cell adhesion molecule expression and function using said compound, composition or medicament. N,N,N-trimethylsphingosine shows superior cell proliferation inhibitory and anti-metastatic activity over related compounds.
摘要翻译： PCT No.PCT / US91 / 09196 Sec。 371日期：1993年6月30日 102（e）日期1993年6月30日PCT 1991年12月23日PCT PCT。公开号WO92 / 12119 本发明涉及一种新型化合物，其组合物和药物，以及抑制细胞增殖，血小板聚集（各种因素诱导）和抑制肿瘤细胞恶性表型的方法，例如具有转移性的那些，并使用所述化合物，组合物或药物调节细胞粘附分子的表达和功能。 N，N，N-三甲基鞘氨醇对相关化合物显示出优异的细胞增殖抑制和抗转移活性。

5. 发明授权

US5877167A Method for inhibition of cell motility by sphingosine-1-phosphate and its derivatives 失效
标题翻译：抑制鞘氨醇-1-磷酸及其衍生物的细胞运动性的方法
公开(公告)号：US5877167A
公开(公告)日：1999-03-02
申请号：US797926
申请日：1997-02-12
申请人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fugiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic motility and/or chemoinvasion, a method of inhibiting phagokinetic activity of tumor cells and neutrophils, a method of inhibiting tumor cell metastasis and a method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising contacting the cells or administering to a host in need of treatment an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives is also described.
摘要翻译：一种抑制肿瘤细胞趋化运动和/或化学侵蚀的方法，抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法，抑制肿瘤细胞转移的方法以及抑制由于运动和侵入嗜中性粒细胞血管壁引起的炎症的方法，包括使细胞接触或向需要治疗的宿主施用抑制量的选自鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1-磷酸的模拟物的药剂，或衍生物和药学上可接受的盐。还描述了制备鞘氨醇-1-磷酸酯及其衍生物的方法。

6. 发明授权

US5663404A Sphingosine-1-phosphate essentially free of L-threo isomer 失效
标题翻译：基本上不含L-苏式异构体的鞘氨醇-1-磷酸
公开(公告)号：US5663404A
公开(公告)日：1997-09-02
申请号：US371866
申请日：1995-01-12
申请人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
发明人： Yasuyuki Igarashi , Fuqiang Ruan , Yoshito Sadahira , Shigeyuki Kawa , Sen-itiroh Hakomori
IPC分类号： A61K31/66 , A61P35/00 , C07F9/10 , C07F9/113 , C07F9/173 , C07F9/09
CPC分类号： A61K31/6615 , A61K31/66 , A61K31/661 , C07F9/113 , C07F9/173
摘要： A method of inhibiting tumor cell chemotactic and/or chemoinvasion motility comprising contacting the tumor cell with an inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting phagokinetic activity of tumor cells and neutrophils comprising contacting the cells with a phagokinetic inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives. A method of inhibiting tumor cell metastasis comprising administering to a host in need of treatment a metastasis inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of inhibiting inflammation due to motility and invasion into blood vessel walls of neutrophils comprising administering to a host in need of treatment an inflammation inhibitory amount of an agent selected from the group consisting of sphingosine-1-phosphate, derivatives of sphingosine-1-phosphate, and mimetics of the sphingosine-1-phosphate or of the derivatives, and pharmaceutically acceptable salts of the agent. A method of preparing sphingosine-1-phosphate and its derivatives.
摘要翻译：一种抑制肿瘤细胞趋化性和/或化学侵袭运动性的方法，包括使肿瘤细胞与抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞和嗜中性粒细胞的吞噬作用的方法包括使细胞与吞噬动力学抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或衍生物。一种抑制肿瘤细胞转移的方法，包括向需要治疗的宿主施用转移抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物和鞘氨醇-1的模拟物磷酸盐或其衍生物，以及药学上可接受的盐。抑制由于运动性而侵入嗜中性粒细胞的血管壁的炎症的方法，包括对需要治疗的宿主施用炎症抑制量的选自鞘氨醇-1-磷酸的鞘氨醇-1-磷酸，鞘氨醇-1-磷酸的衍生物，磷酸盐，以及鞘氨醇-1-磷酸酯或衍生物的模拟物，以及药物的药学上可接受的盐。鞘氨醇-1-磷酸及其衍生物的制备方法。

7. 发明授权

US5583160A Methylsphingosine used to treat apoptosis 失效
标题翻译：用于治疗凋亡的甲基鞘氨醇
公开(公告)号：US5583160A
公开(公告)日：1996-12-10
申请号：US357306
申请日：1994-12-14
申请人： Yasuyuki Igarashi , Sen-Itiroh Hakomori
发明人： Yasuyuki Igarashi , Sen-Itiroh Hakomori
IPC分类号： A61K9/127 , A61K31/13 , A61K31/131 , A61K31/133 , A61P35/00 , A61P43/00 , A61K31/07 , A61K31/20
CPC分类号： A61K31/13 , A61K31/131
摘要： N-methylated sphingosine used to induce apoptosis.
摘要翻译： N-甲基化鞘氨醇用于诱导凋亡。

8. 发明授权

US5827830A Plasmalopsychosines and plasmalocerebrosides 失效
标题翻译：血浆丝氨酸和血浆脑苷脂
公开(公告)号：US5827830A
公开(公告)日：1998-10-27
申请号：US711100
申请日：1996-09-09
申请人： Edward Nudelman , Sen-Itiroh Hakomori , Steven B. Levery , Yasuyuki Igarashi , Khalid Sadozai
发明人： Edward Nudelman , Sen-Itiroh Hakomori , Steven B. Levery , Yasuyuki Igarashi , Khalid Sadozai
IPC分类号： C07H15/10 , A61K31/70 , C07H15/00
CPC分类号： A61K31/7048 , C07H15/10
摘要： An isolated plasmalopsychosine selected from the group consisting of compound A and compound B: ##STR1## wherein n1 is 0-50 or an isolated synthetic plasmalocerebroside selected from the group consisting of compound C and compound D: ##STR2## wherein n2 and n3 each is 0-50.
摘要翻译：（A）CH（CH 2）12 CH 3（B）CH（CH 2）12 CH 3，其中n1为0-50的分离的等离子体血红蛋白或选自化合物A和化合物B的分离的等离子体血红蛋白（C）＆lt; IMAGE＆gt;（D）＆lt; IMAGE＆gt;其中n2和n3分别为0-50。

9. 发明授权

US5693620A Plasmalopsychosines and plasmalocerebrosides 失效
标题翻译：血浆丝氨酸和血浆脑苷脂
公开(公告)号：US5693620A
公开(公告)日：1997-12-02
申请号：US355276
申请日：1994-12-12
申请人： Edward Nudelman , Sen-Itiroh Hakomori , Steven B. Levery , Yasuyuki Igarashi , Khalid Sadozai
发明人： Edward Nudelman , Sen-Itiroh Hakomori , Steven B. Levery , Yasuyuki Igarashi , Khalid Sadozai
IPC分类号： C07H15/10 , A61K31/70
CPC分类号： A61K31/7048 , C07H15/10
摘要： An isolated plasmalopsychosine selected from the group consisting of compound A and compound B: ##STR1## wherein n1 is 0-50 or an isolated synthetic plasmalocerebroside selected from the group consisting of compound C and compound D: ##STR2## wherein n2 and n3 each is 0-50.
摘要翻译：选自化合物A和化合物B的分离的等离子体血红蛋白：其中n1为0-50或选自化合物C和化合物D的分离的合成的血浆脱甲酰罗肽：（C）（D）其中n2和n3各自为0-50。

10. 发明授权

US6031135A Trimethylsphingosine derivatives 失效
标题翻译：三甲基鞘氨醇衍生物
公开(公告)号：US6031135A
公开(公告)日：2000-02-29
申请号：US645191
申请日：1996-05-13
申请人： Fuqiang Ruan , Yasuyuki Igarashi , Sen-Itiroh Hakomori
发明人： Fuqiang Ruan , Yasuyuki Igarashi , Sen-Itiroh Hakomori
IPC分类号： A61K31/13 , A61K31/133 , A61K31/135 , A61K31/14 , A61P7/02 , A61P29/00 , A61P35/00 , C07C215/40 , C07C229/30 , A61K31/23 , A61K31/20
CPC分类号： C07C215/40
摘要： The invention relates to trimethylsphingosine derivatives which have some or all of the activities of the parent compound.
摘要翻译：本发明涉及具有母体化合物的一些或全部活性的三甲基鞘氨醇衍生物。

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