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1. 发明授权

US5420126A 3,4-dihydro-2H-1,4-benzoxazine derivatives and pharmaceutical compositions containing the same 失效
标题翻译： 3,4-二氢-2H-1,4-苯并恶嗪衍生物和含有它们的药物组合物
公开(公告)号：US5420126A
公开(公告)日：1995-05-30
申请号：US982034
申请日：1992-11-24
申请人： Yuzo Matsumoto , Ryuji Tsuzuki , Akira Matsuhisa , Kazuhisa Takayama , Wataru Uchida , Masaharu Asano , Isao Yanagisawa , Toru Yoden
发明人： Yuzo Matsumoto , Ryuji Tsuzuki , Akira Matsuhisa , Kazuhisa Takayama , Wataru Uchida , Masaharu Asano , Isao Yanagisawa , Toru Yoden
IPC分类号： C07D265/36 , C07D413/04 , C07D413/06 , C07D273/01 , C07D413/02
CPC分类号： C07D413/04 , C07D265/36 , C07D413/06
摘要： Novel benzoxazine derivatives of the formula (I): ##STR1## are provided as well as their pharmaceutically acceptable salts and a method for their use as potassium channel activating agents 2-(3,4-Dihydro-2, 2-dimethyl-6-phenylsulfonyl-2H-1,4-benzoxazin-4-yl)pyridine N-oxide is illustrative of a benzoxazine derivative of formula (I). Also provided are intermediate compounds such as those of formula (II): ##STR2##
摘要翻译：提供了式（I）：新颖的（I）的苯并恶嗪衍生物：其中药学上可接受的盐及其作为钾通道活化剂的方法2-（3,4-二氢-2,2-二甲基 -6-苯基磺酰基-2H-1,4-苯并恶嗪-4-基）吡啶N-氧化物是式（I）的苯并恶嗪衍生物的说明。还提供了中间体化合物，例如式（II）的那些：（II）

2. 发明授权

US5817670A Naphthyridine derivatives and pharmaceutical compositions thereof 失效
标题翻译：萘啶衍生物及其药物组合物
公开(公告)号：US5817670A
公开(公告)日：1998-10-06
申请号：US776295
申请日：1997-01-30
申请人： Kazuhisa Takayama , Masahiro Iwata , Yoshinori Okamoto , Motonori Aoki , Akira Niwa , Yasuo Isomura
发明人： Kazuhisa Takayama , Masahiro Iwata , Yoshinori Okamoto , Motonori Aoki , Akira Niwa , Yasuo Isomura
IPC分类号： C07D471/04 , A61K31/435
CPC分类号： C07D471/04
摘要： 1,8-Naphthyridine derivatives represented by the following general formula (I), salts thereof, hydrates thereof and solvates thereof. ##STR1## They have an activity to inhibit type IV phosphodiesterase and are useful as agents for the prevention and treatment of respiratory diseases, inflammatory diseases accompanying organ transplantation, systemic or local arthropathy, proliferative diseases, micturition-related diseases and diseases in which tumor necrosis factor (TNF) and other cytokine (IL-1, IL-6 or the like) are concerned.
摘要翻译： PCT No.PCT / JP95 / 01700 Sec。 371日期1997年1月30日 102（e）日期1997年1月30日PCT 1995年8月28日PCT公布。公开号WO96 / 06843 日期：1993年3月7日，由以下通式（I）表示的8-萘啶衍生物，其盐，其水合物和溶剂化物。可用作预防和治疗呼吸系统疾病，伴随器官移植的炎性疾病，全身或局部关节病，增殖性疾病，排尿相关疾病和肿瘤坏死因子（TNF）等细胞因子（TNF-α） IL-1，IL-6等）。

3. 发明授权

US06571379B2 Semiconductor integrated circuit and semiconductor integrated circuit wiring layout method 失效
标题翻译：半导体集成电路和半导体集成电路布线方法
公开(公告)号：US06571379B2
公开(公告)日：2003-05-27
申请号：US09888992
申请日：2001-06-25
申请人： Kazuhisa Takayama
发明人： Kazuhisa Takayama
IPC分类号： G06F1750
CPC分类号： H01L23/528 , G06F17/5068 , H01L2924/0002 , H01L2924/00
摘要： A semiconductor integrated circuit includes a first wiring layer formed in a first direction, a second wiring layer formed in a second direction perpendicular to the first direction, and a third wiring layer formed in the second direction to sandwich the first wiring layer between the third wiring layer and the second wiring layer. The second and third wiring layers are shifted from each other by a predetermined distance in the first direction. An automatic layout method for a semiconductor integrated circuit, and a recording medium are also disclosed.
摘要翻译：半导体集成电路包括沿第一方向形成的第一布线层，沿与第一方向垂直的第二方向形成的第二布线层，以及沿第二方向形成的第三布线层，以将第一布线层夹在第三布线层和第二布线层。第二和第三布线层在第一方向上彼此偏移预定距离。还公开了半导体集成电路的自动布局方法和记录介质。

4. 发明授权

US06947236B2 Magnetic signal recording method and magnetic recording-reproduction apparatus 有权
标题翻译：磁信号记录方法和磁记录再现装置
公开(公告)号：US06947236B2
公开(公告)日：2005-09-20
申请号：US09925907
申请日：2001-08-09
申请人： Masaki Hamamoto , Hiroyuki Katayama , Kunio Kojima , Junichi Sato , Kazuhisa Takayama , Kosuke Watanabe
发明人： Masaki Hamamoto , Hiroyuki Katayama , Kunio Kojima , Junichi Sato , Kazuhisa Takayama , Kosuke Watanabe
IPC分类号： G11B11/10 , G11B5/00 , G11B5/02 , G11B11/105
CPC分类号： G11B5/00 , G11B2005/0002 , G11B2005/0021
摘要： A magnetic signal recording method of the present invention superimposes a recording edge of a recordable region on a region where there is substantial equality between (a) a coercive force in a region on a magnetic recording medium in which the coercive force has been varied, and (b) magnetic field intensity, which is generated by a magnetic recording head. The magnetic field intensity has a magnetic field distribution whose lowering rate in an in-track position is maximum in the region. The magnetic recording head, whose recording magnetic field is distributed in a rectangular shape, is used in this way so as to form a magnetic bit having a rectangular shape that is suitable for reproduction performed by a common reproduction head having a rectangular reproduction region, thereby improving an S/N of a reproduction signal dramatically.
摘要翻译：本发明的磁信号记录方法将可记录区域的记录边缘叠加在（a）在矫顽力已经变化的磁记录介质上的区域中的矫顽力之间基本相等的区域，以及（b）由磁记录头产生的磁场强度。磁场强度具有磁场分布，其在轨道位置的下降率在该区域中是最大的。以这种方式使用其记录磁场分布为矩形形状的磁记录头，以便形成具有矩形形状的磁头，该矩形形状适于由具有矩形再现区域的共同再现头执行的再现，由此大大提高了再生信号的S / N。

5. 发明授权

US6136810A Pyrido[2,3-D]pyrimidine derivatives and pharmaceutical compositions thereof 失效
标题翻译：吡啶并[2,3-D]嘧啶衍生物及其药物组合物
公开(公告)号：US6136810A
公开(公告)日：2000-10-24
申请号：US66370
申请日：1998-04-30
申请人： Kazuhisa Takayama , Hiroyuki Hisamichi , Masahiro Iwata , Hideki Kubota , Motonori Aoki
发明人： Kazuhisa Takayama , Hiroyuki Hisamichi , Masahiro Iwata , Hideki Kubota , Motonori Aoki
IPC分类号： C07D471/04 , A61K31/505
CPC分类号： C07D471/04
摘要： This invention relates to compounds (I) or pharmaceutically acceptable salts thereof, having a function to inhibit type IV phosphodiesterase (PDE) ##STR1## [X: an oxygen atom or a sulfur atom, R.sup.1 : a lower alkyl group, a cycloalkyl-lower alkyl group or a cycloalkyl group,R.sup.2 : a hydrogen atom, a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxy-lower alkyl group, a mercapto-lower alkyl group, a lower alkoxy-lower alkyl group, a lower alkylthio-lower alkyl group, a lower alkanoyloxy-lower alkyl group, a lower alkanoylthio-lower alkyl group, a lower alkanoyl-lower alkyl group, a hydroxyimino-lower alkyl group, a lower alkoxyimino-lower alkyl group, a cycloalkyl group, an aryl group or a lower alkanoyl group,R.sup.3 : a hydrogen atom, a halogen atom or a lower alkyl group,R.sup.4 : a hydrogen atom or a lower alkyl group,R.sup.5 : a cycloalkyl group; a naphthyl group substituted; a five- or six-membered monocyclic hetero ring group having 1 to 4 hetero atoms selected from nitrogen atom, oxygen atom and sulfur atom; or a group represented by the formula ##STR2## amd F.sup.6 : a halogen atom, a lower alkyl group, a halogeno-lower alkyl group, a hydroxyl group, a lower alkoxy group, a cyano group or a nitro group].
摘要翻译： PCT No.PCT / JP96 / 03389。 371日期：1998年4月30日 102（e）1998年4月30日PCT PCT 1996年11月20日PCT公布。公开号WO97 / 19078 日期：1997年5月29日本发明涉及具有抑制IV型磷酸二酯酶（PDE）的功能的化合物（I）或其药学上可接受的盐[X：氧原子或硫原子，R 1：低级烷基，环烷基 - 低级烷基或环烷基，R2：氢原子，卤素原子，低级烷基，卤代低级烷基，羟基低级烷基，巯基低级烷基，低级烷氧基 - 低级烷基低级烷酰氧基 - 低级烷基，低级烷酰硫基 - 低级烷基，低级烷酰基 - 低级烷基，低级烷酰基 - 低级烷基，羟基亚氨基 - 低级烷基，低级烷氧基亚氨基 - 低级烷基，低级烷酰氧基 - 低级烷基环烷基，芳基或低级烷酰基，R3：氢原子，卤素原子或低级烷基，R4表示氢原子或低级烷基，R5表示环烷基。萘基取代; 具有1-4个选自氮原子，氧原子和硫原子的杂原子的五元或六元单环杂环基; 或由式amd F6表示的基团：卤素原子，低级烷基，卤代低级烷基，羟基，低级烷氧基，氰基或硝基]。

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