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1. 发明授权

US5851394A Module for blood purification, blood purification membrane and its production 失效
标题翻译：血液净化，血液净化膜及其生产模块
公开(公告)号：US5851394A
公开(公告)日：1998-12-22
申请号：US573785
申请日：1995-12-18
申请人： Kazuhisa Shibata , Motoki Kyo , Hidehiko Sakurai , Makoto Ohno
发明人： Kazuhisa Shibata , Motoki Kyo , Hidehiko Sakurai , Makoto Ohno
IPC分类号： B01D69/02 , B01D69/08 , B01D63/00 , B01D69/00
CPC分类号： B01D69/02 , B01D69/08
摘要： A blood purification membrane having a membrane thickness of 10 to 35 .mu.m, an inner diameter of 100 to 300 .mu.m, a porosity of 50 to 85%, a water permeability (ultrafiltration rate) at 37.degree. C. of not less than 20 ml/m.sup.2 .multidot.Hr.multidot.mmHg and a sieving coefficient of albumin of not more than 0.01, a substantially homogeneous interior structure, and a smooth surface structure. A process for producing the membrane and a module are also provided.
摘要翻译：将膜厚为10〜35μm，内径为100〜300μm，孔隙率为50〜85％，37℃下的透水性（超滤速度）为20以上的血液净化膜 ml / m2xHrxmmHg，白蛋白筛分系数不大于0.01，基本均匀的内部结构和光滑的表面结构。还提供了制造膜和模块的方法。

2. 发明授权

US06241886B1 Plasma separation filter 失效
标题翻译：等离子体分离过滤器
公开(公告)号：US06241886B1
公开(公告)日：2001-06-05
申请号：US08665025
申请日：1996-06-07
申请人： Tomohiro Kitagawa , Hidehiko Sakurai , Takafumi Hayashi , Makoto Ohno
发明人： Tomohiro Kitagawa , Hidehiko Sakurai , Takafumi Hayashi , Makoto Ohno
IPC分类号： B01D2901
CPC分类号： B01D39/083 , B01D2239/0421 , B01D2239/0478 , B01D2239/065 , B01D2239/1233 , B01D2239/1291 , G01N33/491
摘要： The present invention provides a plasma separation filter capable of easily, speedily and safely separating plasma from a small quantity of blood without damaging blood cell components in the blood. The plasma retains the same protein concentration as in the blood. The present invention also provides a method using such a filter and an apparatus comprising such a filter. The filter of the present invention comprises a micro fiber medium formed of micro fibers with an average hydraulic radius of 0.5 &mgr;m to 3.0 &mgr;m. Such a micro fiber medium is placed in a container having an inlet and an outlet so that a ratio (L/D) of a blood flow passage length (L) to a blood flow passage diameter (D) is 0.15 to 6. The present invention provides such a filter, a plasma separation method using the filter, and a plasma separation apparatus comprising the filter. The present invention can significantly contribute to promote the automation and enhance speediness and safety in clinical tests.
摘要翻译：本发明提供一种血浆分离过滤器，其能够容易地，快速且安全地将血浆从少量血液分离而不损害血液中的血细胞成分。血浆保持与血液中相同的蛋白质浓度。本发明还提供了一种使用这种过滤器的方法和包括这种过滤器的装置。本发明的过滤器包括由平均水力半径为0.5μm至3.0μm的微纤维形成的微纤维介质。这样的微纤维介质被放置在具有入口和出口的容器中，使得血流通道长度（L）与血流通道直径（D）的比（L / D）为0.15至6。本发明提供了这种过滤器，使用该过滤器的等离子体分离方法，以及包括该过滤器的等离子体分离装置。本发明可显着促进临床试验中的自动化，提高快速性和安全性。

3. 发明申请

US20090272686A1 BLOOD PURIFIER 审中-公开
标题翻译：血液净化器
公开(公告)号：US20090272686A1
公开(公告)日：2009-11-05
申请号：US11910627
申请日：2006-04-03
申请人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
发明人： Kimihiro Mabuchi , Hideyuki Yokota , Katsuaki Kuze , Noriko Monden , Noriaki Kato , Makoto Ohno , Mitsuru Suzuki
IPC分类号： B01D69/08
CPC分类号： B01D69/02 , A61M1/16 , A61M2209/06 , B01D67/0011 , B01D67/009 , B01D69/08 , B01D71/44 , B01D71/68 , B01D2325/20 , B01D2325/28 , C02F1/44 , C02F2103/026
摘要： [Purpose] To provide a blood purifier which has high levels of blood compatibility, performance-retaining property when in contact with blood, and safety, and which shows an excellent water permeability-exhibiting rate after a priming treatment and has high reliability in long-term storage.[Solution] A blood purifier assembled using a polyvinyl pyrrolidone-containing polysulfone-based permselective hollow fiber membrane bundle, characterized in that the amount of polyvinyl pyrrolidone which elutes from the hollow fiber membrane bundle is 10 ppm or less, the amounts of hydrogen peroxide which elute from extracts from all the sites of the hollow fiber membrane bundle are 5 ppm or less, when the hollow fiber membrane bundle is divided into 10 portions in the lengthwise direction to test the sites of all the 10 portions according to the method regulated in the Approval Standard for Dialysis-Type Artificial Kidney Apparatus, and the water permeability of the blood purifier found at a point of time when 10 minutes has passed since the priming treatment of the blood purifier is 90% or more of the water permeability of the same found at a point of time when 24 hours has passed since the priming treatment thereof.
摘要翻译： [目的]提供一种具有高血液相容性，与血液接触时的性能保持性和安全性的血液净化器，并且在预处理后显示出优异的透水性，并且在长期使用中具有高可靠性，长期存储。 [解决方案]使用含聚乙烯吡咯烷酮的聚砜系渗透性中空纤维膜束组装的血液净化器，其特征在于，从中空纤维膜束洗出的聚乙烯吡咯烷酮的量为10ppm以下，过氧化氢的量从中空纤维膜束的所有位置的提取物中洗脱出的浓度为5ppm以下，将中空纤维膜束沿长度方向分割成10份，按照本发明的方法透析型人造肾器的认可标准和自血液净化器起动处理10分钟后发现的血液净化器的透水性为同一发现的透水性的90％以上在自启动处理24小时后的时间点。

4. 发明授权

US4507059A Variable delivery compressor 失效
标题翻译：可变输送压缩机
公开(公告)号：US4507059A
公开(公告)日：1985-03-26
申请号：US574681
申请日：1984-01-27
申请人： Hisao Kobayashi , Makoto Ohno , Shinichi Suzuki
发明人： Hisao Kobayashi , Makoto Ohno , Shinichi Suzuki
IPC分类号： F04B27/14 , F04B39/10 , F04B1/16 , F04B1/18
CPC分类号： F04B39/1073 , Y10T137/789 , Y10T137/7892
摘要： A variable delivery compressor having therein a plurality of compression chambers is adapted for compressing a refrigerant gas of a cooling circuit. The compressor has a first delivery chamber communicating with the compression chambers by way of a fixedly arranged valve and a second delivery chamber communicating with the compression chambers by way of a movably arranged delivery valve. This movable valve is formed to include a base portion, a plurality of reed portions formed to radially extend from the outer circumference of the base portion and arranged to face delivery ports, and at least one protrusion formed to radially extend from the outer circumference of the base portion for suppressing the warp of the base portion.
摘要翻译：其中具有多个压缩室的可变输送压缩机适于压缩冷却回路的制冷剂气体。压缩机具有通过固定布置的阀与压缩室连通的第一输送室和通过可移动布置的输送阀与压缩室连通的第二输送室。该可动阀形成为包括基部，多个簧片部，形成为从基部的外周径向延伸并且布置成面向输送口，并且至少一个突起形成为从外周延伸，基部，用于抑制基部的翘曲。

5. 发明授权

US5328796A Diazo type recording material utilizing microencapsulated diazo compound, a coupler and a hydroxyphenylsulfone derivative 失效
标题翻译：使用微囊化重氮化合物的重氮型记录材料，成色剂和羟苯基砜衍生物
公开(公告)号：US5328796A
公开(公告)日：1994-07-12
申请号：US53381
申请日：1993-04-28
申请人： Akihiro Shimomura , Taketatsu Sugiyama , Makoto Ohno , Toshiharu Tanaka
发明人： Akihiro Shimomura , Taketatsu Sugiyama , Makoto Ohno , Toshiharu Tanaka
IPC分类号： B41M5/323 , B41M5/28 , B41M5/30 , G03C1/00 , G03C1/52 , G03C1/58 , G03C1/91
CPC分类号： G03C1/52 , G03C1/002
摘要： A diazo type recording material, which has a substantially unstained background, a superior preservability, and is capable of producing images of high density, wherein the diazo recording material comprises a support having thereon a recording layer comprising a photosensitive diazo compound, a hydroxyphenylsulfone derivative and a coupling component which forms a color by reacting with the diazo compound, with the diazo compound being enclosed in microcapsules.
摘要翻译：一种重氮型记录材料，其具有基本上未染色的背景，优异的保存性，并且能够产生高密度的图像，其中重氮记录材料包括其上具有包含光敏重氮化合物，羟基苯基砜衍生物和通过与重氮化合物反应形成颜色的偶联组分，重氮化合物封闭在微胶囊中。

6. 发明授权

US5304452A Heat sensitive diazo type recording material utilizing microencapsulated diazo compound and a coupling component 失效
标题翻译：使用微囊化重氮化合物和偶联组分的热敏重氮型记录材料
公开(公告)号：US5304452A
公开(公告)日：1994-04-19
申请号：US958751
申请日：1992-10-09
申请人： Makoto Ohno , Akihiro Shimomura , Toshiharu Tanaka
发明人： Makoto Ohno , Akihiro Shimomura , Toshiharu Tanaka
IPC分类号： B41M5/323 , B41M5/28 , B41M5/30 , G03C1/00 , G03C1/52 , G03C5/18 , G03F7/021
CPC分类号： G03C1/52 , G03C1/002 , G03C5/18
摘要： A recording material comprising a support coated with a photosensitive layer comprising a photosensitive diazo compound enclosed in microcapsules and a coupling component. The microcapsules are produced by forming an organic solution containing the diazo compound and a wall monomer, and emulsifying the organic solution in an aqueous solution containing an anionic surface-active agent and polyvinylpyrrolidone to produce oil droplets containing the wall monomer. The wall monomer is polymerized to form a wall around the oil droplets. When heat is applied to the photosensitive layer under alkaline conditions, the coupling component reacts with the diazo compound to form a color.
摘要翻译：一种记录材料，包括涂覆有包含微胶囊中的光敏重氮化合物的光敏层的支持体和偶联组分。通过形成含有重氮化合物和壁单体的有机溶液，并将含有阴离子表面活性剂和聚乙烯吡咯烷酮的水溶液中的有机溶液乳化以制备含有壁单体的油滴来制备微胶囊。聚合壁单体以形成围绕油滴的壁。当在碱性条件下向感光层施加热量时，偶合组分与重氮化合物反应形成一种颜色。

7. 发明授权

US4587168A Hollow fiber membrane for dialysis 失效
标题翻译：中空纤维膜用于透析
公开(公告)号：US4587168A
公开(公告)日：1986-05-06
申请号：US596974
申请日：1984-04-05
申请人： Morio Miyagi , Makoto Ohno , Masaru Kanaizumi
发明人： Morio Miyagi , Makoto Ohno , Masaru Kanaizumi
IPC分类号： B01D69/02 , B01D69/08 , B01D39/00 , D02G3/00
CPC分类号： B01D69/02 , B01D69/08 , B01D69/084 , Y10T428/2922 , Y10T428/2975
摘要： A hollow fiber membrane of a cellulose ester for dialysis which has a membrane thickness of less than 20.mu., and a yield strength S.sub.b (g/filament) after heat-treatment at 80.degree. C. for 20 hours satisfying the following formula (I):0.90.ltoreq.S.sub.b /S.sub.a .ltoreq.1.10 (I)wherein S.sub.a represents the yield strength (g/filament) of the hollow fiber membrane which is measured before heat treatment, which is suitable for dialysis of body liquids, particularly for dialysis of blood, because it has excellent dialysis performance while keeping excellent storage stability and excellent UFR retention during storage and during the hemodialysis.
摘要翻译：用于透析的纤维素酯的中空纤维膜，其膜厚度小于20μm，在80℃下热处理20小时后的屈服强度Sb（g /长丝）满足下式（I）：0.90

8. 发明授权

US08920778B2 Targeting agent for tumor site 有权
公开(公告)号：US08920778B2
公开(公告)日：2014-12-30
申请号：US13520827
申请日：2011-01-07
申请人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
发明人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
IPC分类号： A61K51/08 , A61K49/00
摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X-Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X-Y sequences may be the same or different.

9. 发明申请

US20130017147A1 TARGETING AGENT FOR TUMOR SITE 有权
标题翻译： TUMOR SITE的目标代理
公开(公告)号：US20130017147A1
公开(公告)日：2013-01-17
申请号：US13520827
申请日：2011-01-07
申请人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
发明人： Kazutaka Ogiwara , Makoto Ohno , Masayoshi Kojima , Masayuki Kawakami , Chihaya Kakinuma , Tasuku Sasaki , Kiyohito Takada
IPC分类号： A61K49/00 , A61P35/00 , A61K51/12 , A61K49/18 , A61K9/00 , A61K9/127
CPC分类号： A61K49/0034 , A61K49/0063 , A61K49/0084
摘要： It is an object of the present invention to provide a targeting agent, which enables the delivery of a drug to tumor sites or the imaging of tumor sites by utilizing its effect of accumulating to such tumor sites. The present invention provides a targeting agent for tumor site, which comprises a hydrophilic polymer-modified carrier coated with a gelatin-like protein that has repeats of a sequence represented by Gly-X—Y characteristic to collagen and has two or more sequences of cell adhesion signals in a single molecule wherein X and Y each independently represent an amino acid and a plurality of Gly-X—Y sequences may be the same or different.
摘要翻译：本发明的目的是提供一种靶向剂，其能够通过利用其累积到这种肿瘤部位的作用，将药物递送到肿瘤部位或肿瘤部位成像。本发明提供了一种用于肿瘤部位的靶向剂，其包含涂覆有明胶样蛋白质的亲水性聚合物改性载体，其具有由胶原特征的Gly-X-Y表示的序列的重复并具有两个或更多个细胞序列单分子中的粘合信号，其中X和Y各自独立地表示氨基酸，并且多个Gly-X-Y序列可以相同或不同。

10. 发明申请

US20070008653A1 Magnetic disk drive with load/unload mechanism 失效
标题翻译：带负载/卸载机构的磁盘驱动器
公开(公告)号：US20070008653A1
公开(公告)日：2007-01-11
申请号：US11479321
申请日：2006-06-30
申请人： Makoto Ohno , Shin Nagahiro , Atsushi Katsuta , Gentarou Nakamura
发明人： Makoto Ohno , Shin Nagahiro , Atsushi Katsuta , Gentarou Nakamura
IPC分类号： G11B5/54
CPC分类号： G11B5/54
摘要： The conventional ramp mechanism constituting a load/unload mechanism for a magnetic disk is disadvantageous for increasing a storage capacity since an outer peripheral edge of the disk is not used as a data area. In one embodiment of the invention, a disk drive has a solenoid and spring for turning a ramp mechanism about a rotating shaft. When the drive operates, since the ramp mechanism moves out from the magnetic disk by the tensile force of the solenoid, the outer peripheral edge of a magnetic head that has formerly been unusable can be used as a data read/write region, without the magnetic head interfering with the fins of the ramp mechanism. During a non-operating state of the drive and in case of a power interruption, the tensile force of the spring returns the ramp mechanism to a position at which the magnetic head can be unloaded. This construction allows the storage capacity of the drive to be easily increased without sacrificing the shock resistance of the ramp mechanism.
摘要翻译：构成用于磁盘的加载/卸载机构的常规斜坡机构不利于增加存储容量，因为盘的外围边缘不用作数据区域。在本发明的一个实施例中，盘驱动器具有螺线管和弹簧，用于围绕旋转轴转动斜坡机构。当驱动器操作时，由于斜坡机构由螺线管的拉力从磁盘移出，所以先前不可用的磁头的外周边缘可以用作数据读/写区域，而不用磁头部干涉斜坡机构的翅片。在驱动器的非操作状态下，并且在断电的情况下，弹簧的张力将斜坡机构返回到可以卸载磁头的位置。这种结构允许容易地增加驱动器的存储容量，而不牺牲斜坡机构的抗冲击性。

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