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1. 发明授权

US07585674B2 Host microorganisms 失效
标题翻译：宿主微生物
公开(公告)号：US07585674B2
公开(公告)日：2009-09-08
申请号：US10479214
申请日：2002-05-28
申请人： Kazuhisa Sawada , Keiji Endo , Tadahiro Ozawa , Masatoshi Tohata , Katsuya Ozaki
发明人： Kazuhisa Sawada , Keiji Endo , Tadahiro Ozawa , Masatoshi Tohata , Katsuya Ozaki
IPC分类号： C12N5/06 , G01N33/53
CPC分类号： C07K14/32 , C07K2319/00 , C12N1/20
摘要： A microorganism wherein one or more genes selected from the group of genes participating in sporulation in the middle to late stages of sporulation have been deleted or inactivated; and a process for producing a target product (a protein) by use the microorganism. No spore is formed when this microorganism is employed, thereby enabling production of a target product (a protein) while decreasing energy loss, production of a by-product and specific production speed to decrease unnecessary consumption of a medium. Moreover, the production period can be prolonged, whereby the target product (the protein) can be produced efficiently.
摘要翻译：一种微生物，其中一个或多个选自参与孢子形成中期至晚期孢子形成的基因的基因已被删除或失活; 以及通过使用微生物生产目标产物（蛋白质）的方法。当使用该微生物时不形成孢子，从而能够减少能量损失，副产物的产生和特定的生产速度，从而能够生产目标产物（蛋白质），从而减少不必要的培养基消耗。此外，可以延长生产周期，由此有效地生产目标产物（蛋白质）。

2. 发明申请

US20080081352A1 Recombinant Microorganism 失效
标题翻译：重组微生物
公开(公告)号：US20080081352A1
公开(公告)日：2008-04-03
申请号：US10578615
申请日：2004-11-05
申请人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Junichi Sekiguchi
发明人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Junichi Sekiguchi
IPC分类号： C12P21/04 , C12N1/20
CPC分类号： C12N9/2437 , C12N15/75 , C12P21/00 , C12Y302/01004
摘要： The present invention provides a recombinant microorganism obtained by transferring, into a host microorganism which is capable of producing protein or polypeptide with increased productivity and which was identified by the present inventors, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by use of the recombinant microorganism. The recombinant microorganism is prepared by transferring, to a mutant strain of microorganism from which any of at least one gene participating in membrane permeation of maltose has been deleted or knocked out, a gene encoding a heterologous protein or polypeptide.
摘要翻译：本发明提供了一种重组微生物，其通过将能够产生蛋白质或多肽的生物能力提高的宿主微生物转移到本发明人鉴定出的编码蛋白质或多肽的基因以及产生蛋白质的方法中或多肽。将重组微生物通过转移到至少一种参与麦芽糖的膜渗透的基因中的任何一种已被缺失或敲除的微生物的突变菌株，编码异源蛋白质或多肽的基因。

3. 发明授权

US07563611B2 Recombinant microorganism 失效
标题翻译：重组微生物
公开(公告)号：US07563611B2
公开(公告)日：2009-07-21
申请号：US10578615
申请日：2004-11-05
申请人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Junichi Sekiguchi
发明人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Junichi Sekiguchi
IPC分类号： C12N1/20
CPC分类号： C12N9/2437 , C12N15/75 , C12P21/00 , C12Y302/01004
摘要： The present invention provides a recombinant microorganism obtained by transferring, into a host microorganism which is capable of producing protein or polypeptide with increased productivity and which was identified by the present inventors, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by use of the recombinant microorganism.
摘要翻译：本发明提供了一种重组微生物，其通过将能够产生蛋白质或多肽的生物能力提高的宿主微生物转移到本发明人鉴定出的编码蛋白质或多肽的基因以及产生蛋白质的方法中或多肽。

4. 发明申请

US20080009039A1 Recombinant Microorganism 审中-公开
标题翻译：重组微生物
公开(公告)号：US20080009039A1
公开(公告)日：2008-01-10
申请号：US10578613
申请日：2004-11-05
申请人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Kazuo Kobayashi , Naotake Ogasawara
发明人： Masatoshi Tohata , Kazuhisa Sawada , Katsuya Ozaki , Kazuo Kobayashi , Naotake Ogasawara
IPC分类号： C12P21/04 , C12N1/21
CPC分类号： C12N15/75 , C12P21/00
摘要： A recombinant microorganism obtained by transferring, into a host microorganism capable of producing protein or polypeptide with increased productivity, a gene encoding a protein or polypeptide, and a method for producing a protein or polypeptide by use of the recombinant microorganism. The recombinant microorganism is prepared by transferring, to a mutant strain of microorganism from which any of Bacillus subtilis genes comA, yopO, treR, yvbA, cspB, yvaN, yttP, yurK, yozA, licR, sigL, mntR, glcT, yvdE, ykvE, sir, rocR, ccpA, yaaT, yyaA, yycH, yacP, hprK, rsiX, yhdK, and yibO, or one or more genes functionally equivalent to any of these genes have been deleted or knocked out, a gene encoding a heterologous protein or polypeptide.
摘要翻译：通过将能够产生生产能力的蛋白质或多肽的宿主微生物，编码蛋白质或多肽的基因，以及通过使用重组微生物产生蛋白质或多肽的方法而获得的重组微生物。通过转移到枯草芽孢杆菌基因comA，yopO，treR，yvbA，cspB，yvaN，yttP，yurK，yozA，licR，sigL，mntR，glcT，yvdE，ykvE中的任一种的微生物突变菌株来制备重组微生物，先生，rocR，ccpA，yaaT，yyaA，yycH，yacP，hprK，rsiX，yhdK和yibO，或者与这些基因中的任何一个功能等同的一个或多个基因已被缺失或敲除，编码异源蛋白的基因或多肽。

5. 发明授权

US07033981B2 Alkaline cellulase variants 有权
标题翻译：碱性纤维素酶变体
公开(公告)号：US07033981B2
公开(公告)日：2006-04-25
申请号：US10383630
申请日：2003-03-10
申请人： Yoshihiro Hakamada , Kazuhisa Sawada , Keiji Endo , Hiroshi Kodama , Yasunao Wada , Shitsu Shikata , Tohru Kobayashi
发明人： Yoshihiro Hakamada , Kazuhisa Sawada , Keiji Endo , Hiroshi Kodama , Yasunao Wada , Shitsu Shikata , Tohru Kobayashi
IPC分类号： C11D3/386 , C12N9/42 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/2437 , C11D3/38645 , C12Y302/01004
摘要： The present invention relates to alkaline cellulase variants having an amino acid sequence which exhibits at least 95% homology with the amino acid sequence of SEQ ID NO: 2, wherein said alkaline cellulase variant is mutated to include at least one substitution at (a) position 10, (b) position 16, (c) position 22, (d) position 33, (e) position 39, (f) position 76, (g) position 109, (h) position 242, (i) position 263, (j) position 308, (k) position 462, (l) position 466, (m) position 468, (n) position 552, (o) position 564, or (p) position 608 in SEQ ID NO: 2, or at a position corresponding thereto, wherein said alkaline cellulase variant has alkaline cellulase activity. The present invention also relates to a gene encoding the variant; a vector containing the gene; a transformant containing the vector; and a detergent composition containing the alkaline cellulase variant.
摘要翻译：本发明涉及具有与SEQ ID NO：2的氨基酸序列具有至少95％同源性的氨基酸序列的碱性纤维素酶变体，其中所述碱性纤维素酶变体突变以在（a）位置包括至少一个取代 10，（b）位置16，（c）位置22，（d）位置33，（e）位置39，（f）位置76，（g）位置109，（h）位置242，（i）位置263，（j）位置308，（k）SEQ ID NO：2中的位置462，（l）位置466，（m）位置468，（n）位置552，（o）位置564或（p）位置608，或在相应的位置，其中所述碱性纤维素酶变体具有碱性纤维素酶活性。本发明还涉及编码该变体的基因; 含有该基因的载体; 含有载体的转化体和含有碱性纤维素酶变体的洗涤剂组合物。

6. 发明授权

US5266865A Structure of lead conductor for third electrode of three-electrode type electroluminescent lamp 失效
标题翻译：三电极型电致发光灯用第三电极引线导体结构
公开(公告)号：US5266865A
公开(公告)日：1993-11-30
申请号：US570533
申请日：1990-08-21
申请人： Masahiro Haizumi , Hisahumi Tanaka , Hiromu Yamada , Kazuhisa Sawada
发明人： Masahiro Haizumi , Hisahumi Tanaka , Hiromu Yamada , Kazuhisa Sawada
IPC分类号： H05B33/06 , H05B33/26 , H01J1/62
CPC分类号： H05B33/06 , H05B33/26
摘要： A three-electrode type electroluminescent lamp has a transparent electrode connected to a rear side lead conductor, and an electroluminescent body sandwiched between the transplant electrode and the backing electrode. A third plate-like electrode is laid over the backing electrode in an electrical insulation relation with the backing electrode, and a third lead conductor is formed of an integral extension of the third electrode. The integral extension of the third electrode extends outwardly from an edge of the third electrode near to the edge region of the transparent electrode connected to the base end portion of the first lead conductor, so as to avoid the edge region of the transparent electrode on which the base end portion of the first lead conductor is laid and also to extend along the first lead conductor excluding the base end portion. A printed-wiring board having a plurality of printed wirings is mounted on the electroluminescent lamp. The third lead conductor is electrically connected at its tip end to a corresponding one of the printed wirings by a mechanical solderless connection using a clamping member.
摘要翻译：三电极型电致发光灯具有连接到后侧引线导体的透明电极和夹在移植电极和背衬电极之间的电致发光体。第三板状电极与背衬电极以电绝缘关系布置在背衬电极上，并且第三引线导体由第三电极的整体延伸部形成。第三电极的整体延伸部从第三电极的边缘向外延伸到与第一引线导体的基端部连接的透明电极的边缘区域附近，以避免透明电极的边缘区域第一引线导体的基端部被铺设，并且也沿除了基端部分之外的第一引线导体延伸。具有多个印刷布线的印刷电路板安装在电致发光灯上。第三引线导体在其尖端处通过使用夹紧构件的机械无焊接电连接到相应的一个印刷布线。

7. 发明授权

US5080421A Apparatus for preventing discharge of fuel vapor 失效
标题翻译：用于防止燃料蒸汽排放的装置
公开(公告)号：US5080421A
公开(公告)日：1992-01-14
申请号：US496995
申请日：1990-03-21
申请人： Hidekazu Otowa , Kazuhiro Okada , Hidefumi Sonoda , Tadao Kaneko , Kazuhisa Sawada
发明人： Hidekazu Otowa , Kazuhiro Okada , Hidefumi Sonoda , Tadao Kaneko , Kazuhisa Sawada
IPC分类号： B60K15/035 , B60K15/05
CPC分类号： E05B83/34 , B60K15/03504 , B60K15/05 , B60K2015/0576
摘要： An apparatus for preventing discharge of fuel vapor to the atmosphere by allowing fuel vapor in a fuel tank to be adsorbed by an adsorbing device when a fuel lid is opened. A switch is turned on by the movement of a locking member for locking and unlocking the fuel lid so as to detect the opening of the fuel lid. The arrangement facilitates adjustment of the relative positions of the switch and the locking member. In addition, the switch is turned on when the fuel lid is opened by remote control, while the switch is turned off when the fuel lid is manually closed. The discharge of fuel vapor to the atmosphere during refueling and the influx of fuel vapor into the adsorbing device after the charging of fuel are prevented.
摘要翻译：一种用于通过当燃料盖打开时允许燃料箱中的燃料蒸汽被吸附装置吸附来防止燃料蒸气排放到大气中的装置。通过用于锁定和解锁燃料盖的锁定构件的移动来开启开关，以便检测燃料盖的打开。该装置有助于调节开关和锁定构件的相对位置。此外，当燃料盖通过遥控器打开时，开关打开，同时在手动关闭燃油盖时关闭开关。在加油期间将燃料蒸气排放到大气中，并且防止燃料蒸汽在燃料充入之后进入吸附装置。

8. 发明申请

US20120108506A1 Agent For Suppressing Postprandial Elevation Of Blood Insulin Concentration 有权
标题翻译：抑制血胰岛素浓度餐后升高的药剂
公开(公告)号：US20120108506A1
公开(公告)日：2012-05-03
申请号：US13383665
申请日：2010-07-16
申请人： Kotomi Ishimaru , Kazuhisa Sawada , Akira Shimatoyodome
发明人： Kotomi Ishimaru , Kazuhisa Sawada , Akira Shimatoyodome
IPC分类号： A61K38/16 , A61P3/08
CPC分类号： A61K31/785 , C08G69/10
摘要： An agent for suppressing postprandial elevation of blood insulin concentration, comprising a polyglutamic acid as an active ingredient.
摘要翻译：一种用于抑制血胰岛素浓度的餐后升高的药剂，其包含聚谷氨酸作为活性成分。

9. 发明授权

US4759212A Abnormality determination device for a vehicle speed sensor 失效
标题翻译：车速传感器异常判定装置
公开(公告)号：US4759212A
公开(公告)日：1988-07-26
申请号：US936313
申请日：1986-12-01
申请人： Kazuhisa Sawada , Tatsuo Teratani
发明人： Kazuhisa Sawada , Tatsuo Teratani
IPC分类号： B60W10/04 , B60W10/00 , B60W10/10 , F16H59/10 , F16H59/44 , F16H61/12 , G01M15/04 , G01P21/02 , G01M13/02
CPC分类号： G01M15/046 , G01P21/02 , F02D2200/1015
摘要： Provided is an abnormality determination device for a vehicle speed sensor which can prevent a memory unit from storing the erroneous result of abnormality determination of a vehicle speed sensor due to the engine racing when the vehicle is stationary. The device of the invention includes a revolution speed sensor for detecting a revolution speed of an output shaft of an automatic transmission and generating a speed signal, abnormality determination elements for inputting the speed signal of the revolution speed sensor and for determining if the revolution speed sensor is abnormal and for generating an abnormality signal in response to the determined result, a memory for storing the abnormality signal, and halt elements for preventing the memory from storing the abnormality signal when the automatic transmission is set at a neutral position or at a parking position.
摘要翻译：本发明提供一种用于车辆速度传感器的异常判定装置，其能够防止存储单元在车辆静止时存储由于发动机赛车引起的车速传感器的异常判定的错误结果。本发明的装置包括用于检测自动变速器的输出轴的转速并产生速度信号的转速传感器，用于输入转速传感器的速度信号的异常确定元件，以及用于确定转速传感器异常并且响应于确定的结果产生异常信号，用于存储异常信号的存储器，以及当自动变速器被设置在中立位置或停车位置时停止用于防止存储器存储异常信号的元件。

10. 发明授权

US09056066B2 Agent for suppressing elevation of blood GIP level, agent for suppressing elevation of blood insulin level, agent for lowering blood triglyceride level after meal ingestion, and agent for suppressing elevation of blood glucose level 有权
标题翻译：用于抑制血液GIP水平升高的药剂，用于抑制血胰岛素水平升高的药剂，膳食摄入后降低血液甘油三酯水平的药剂和抑制血糖水平升高的药剂
公开(公告)号：US09056066B2
公开(公告)日：2015-06-16
申请号：US13996261
申请日：2011-12-20
申请人： Kotomi Ishimaru , Kazuhisa Sawada , Noriko Osaki
发明人： Kotomi Ishimaru , Kazuhisa Sawada , Noriko Osaki
IPC分类号： A61K31/785 , A61K38/00 , A23L1/305 , C08G69/10
CPC分类号： A61K38/00 , A23L33/17 , A23V2002/00 , A61K31/785 , A61P1/14 , A61P3/04 , A61P3/06 , A61P3/10 , C08G69/10 , A23V2200/328
摘要： An agent for suppressing elevation of blood GIP level, an agent for suppressing elevation of blood insulin level, an agent for lowering blood triglyceride level after meal ingestion and an agent for suppressing elevation of blood glucose level, these agents containing potassium polyglutamates as active ingredients.
摘要翻译：用于抑制血液GIP水平升高的药剂，用于抑制血浆胰岛素水平升高的药剂，降低膳食摄入后的血液甘油三酯水平降低剂和抑制血糖水平升高的药剂，含有聚谷氨酸钾作为活性成分的药剂。

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