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1. 发明授权

US06455684B1 Insitu assay of substance in biological sample using labeled probe 失效
标题翻译：使用标记探针对生物样品中的物质进行原位测定
公开(公告)号：US06455684B1
公开(公告)日：2002-09-24
申请号：US09967361
申请日：2001-09-28
申请人： Kazuhiro Matsui , Katsunori Ikeda , Shinichi Teshima , Yoshihisa Kawamura , Kazuko Matsumoto
发明人： Kazuhiro Matsui , Katsunori Ikeda , Shinichi Teshima , Yoshihisa Kawamura , Kazuko Matsumoto
IPC分类号： C07H2102
CPC分类号： G01N33/582 , G01N2458/40
摘要： A method for analyzing an objective substance, comprising reacting a labeled probe with an objective substance on a biological sample, said probe comprising a label substance of the formula (I): wherein A1 is an aromatic group, R1 is a hydrogen or —COCH2COCnF2n+1 and n is an integer of 1-6, which is bonded to a probe selected from the group consisting of nucleic acid, nucleic acid binding protein, low molecular ligand and receptor for ligand (except antibody) to give a fluorescent complex, reacting the complex with an objective substance on a biological sample and assaying fluorescence of the resultant fluorescent complex, a labeled nucleic acid probe and a labeled nucleotide. According to the method of the present invention, defects such as hindrance of fluorescence due to contaminant substance, low sensitivity and the like can be resolved, thereby enabling analysis on a tissue.
摘要翻译：一种用于分析目标物质的方法，包括使标记的探针与生物样品上的目标物质反应，所述探针包含式（I）的标记物质：其中A1为芳族基团，R1为氢或-COCH2COCnF2n + 1和n是1-6的整数，其与选自核酸，核酸结合蛋白，低分子配体和配体（抗体除外）的受体的探针结合，得到荧光复合物，使与生物样品上的目标物质复合，并测定所得荧光复合物，标记的核酸探针和标记的核苷酸的荧光。根据本发明的方法，可以解决诸如由于污染物质引起的荧光阻碍，低灵敏度等的缺陷，从而能够对组织进行分析。

2. 发明授权

US06339172B1 Assay of substance in biological sample using labeled probe 失效
标题翻译：使用标记探针对生物样品中的物质进行原位测定
公开(公告)号：US06339172B1
公开(公告)日：2002-01-15
申请号：US09301406
申请日：1999-04-28
申请人： Kazuhiro Matsui , Katsunori Ikeda , Shinichi Teshima , Yoshihisa Kawamura , Kazuko Matsumoto
发明人： Kazuhiro Matsui , Katsunori Ikeda , Shinichi Teshima , Yoshihisa Kawamura , Kazuko Matsumoto
IPC分类号： C07C30900
CPC分类号： G01N33/582 , G01N2458/40
摘要： A method for analyzing an objective substance, comprsing reacting a labeled probe with an objective substance on a biological sample, said probe comprsing a label substance of the formula (I): wherein A1 is an aromatic group, R1 is a hydrogen or —COCH2COCnF2n+1 and n is an integer of 1-6, which is bonded to a probe selected from the group consisting of nucleic acid, nudeic acid binding potein, low molecular ligand and receptor for ligand (except antibody) to give a fluorescent complex, reacting the complex with an objective substance on a biolgical sample and assaying fluorescence of the resultant fluorescent complex, a labeled nucleic acid probe and a labeled nucleotide. According to the method of the present invention, defects such as hindrance of fluorescence due to contaminant substance, low sensitivity and the like can be resolved, thereby enabling analysis on a tissue.
摘要翻译：一种用于分析目标物质的方法，包括使标记的探针与生物样品上的目标物质反应，所述探针包含式（I）的标记物质：其中A1是芳族基团，R1是氢或-COCH2COCnF2n + 1，n为1-6的整数，其与选自核酸，裸露酸结合蛋白，低分子配体和配体受体（抗体除外）的探针结合，得到荧光复合物，使与目标物质在生物样品上复合并测定所得荧光复合物的荧光，标记的核酸探针和标记的核苷酸。根据本发明的方法，可以解决诸如由于污染物质引起的荧光阻碍，低灵敏度等的缺陷，从而能够对组织进行分析。

3. 发明授权

US06638725B2 Method for assaying receptor binding property and reagent for the assay 失效
标题翻译：用于测定受体结合性质的方法和用于测定的试剂
公开(公告)号：US06638725B2
公开(公告)日：2003-10-28
申请号：US09490053
申请日：2000-01-24
申请人： Yoshihiro Soya , Shigeaki Nishii , Kazuhiro Matsui , Takuya Ishibashi , Yoshihisa Kawamura
发明人： Yoshihiro Soya , Shigeaki Nishii , Kazuhiro Matsui , Takuya Ishibashi , Yoshihisa Kawamura
IPC分类号： G01N3353
CPC分类号： G01N33/743 , G01N33/53 , G01N33/54306 , G01N2333/723 , Y10S530/812 , Y10S530/816 , Y10S530/827
摘要： The present invention provides a method capable of simultaneous processing of plural test samples for the receptor binding property of a chemical substance, which does not require immobilization of the receptor or a special device, and a reagent to be used for this method. That is a method for assaying the receptor binding property of an assay target substance is provided, the method comprising the steps of (a) competitively reacting a known concentration of a ligand and the assay target substance with a known concentration of the receptor in a solution, (b) measuring, without physically removing the ligand bound with the receptor prior to the assay, the amount of a free ligand in the solution using one or more antibodies against the ligand, and (c) determining the receptor binding property of the assay target substance using the amount of the free ligand as an index.
摘要翻译：本发明提供一种能够同时处理多个测试样品用于不需要固定受体或特殊装置的化学物质的受体结合特性的试剂和用于该方法的试剂。这是一种用于测定测定目标物质的受体结合性质的方法，该方法包括以下步骤：（a）将已知浓度的配体和测定目标物质与已知浓度的受体在溶液中竞争性地反应，（b）在测定前物理除去与受体结合的配体，测量溶液中使用一种或多种针对配体的抗体的游离配体的量，以及（c）测定该测定的受体结合性质使用游离配体的量作为指标的目标物质。

4. 发明授权

US6144277A Electric noise absorber 失效
标题翻译：电噪声吸收器
公开(公告)号：US6144277A
公开(公告)日：2000-11-07
申请号：US87849
申请日：1993-07-02
申请人： Kazuhiro Matsui , Hiroji Kitagawa
发明人： Kazuhiro Matsui , Hiroji Kitagawa
IPC分类号： H01F17/06 , H01F27/02 , H04B15/02 , H01F27/26
CPC分类号： H04B15/02 , H01F17/06 , H01F27/027 , H01F2017/065
摘要： An electric noise absorber comprising at least two ferrite pieces having abutting planes, at least two case members containing the ferrite pieces respectively and being closed by means of engagement members, and a spring member provided in at least one of the case members for pressing the ferrite pieces against each other when the case members are closed. Since the case members for keeping the ferrite pieces in appropriate positions and the spring member for pushing up the ferrite pieces for close contact are separately molded, the case members are bestowed with strength and the spring member with elasticity, both suitable for their own purposes. The case members requires no apertures for biasing members and therefore outside magnetic substance is prevented from contacting with the ferrite pieces contained in the case members.
摘要翻译：一种电噪声抑制器，包括至少两个具有邻接平面的铁氧体片，至少两个壳体部件，分别包含铁氧体片，并且通过接合部件封闭;以及弹簧部件，设置在至少一个壳体部件中，用于将铁氧体当壳体构件关闭时，它们彼此相对。由于用于将铁氧体保持在适当位置的壳体构件和用于将铁氧体块推压紧密接触的弹簧构件被分开模制，所以壳体构件被赋予强度，并且弹性构件具有弹性，两者都适合于它们自己的目的。壳体部件不需要用于偏置部件的孔，因此防止外部磁性物质与包含在壳体部件中的铁氧体片接触。

5. 外观设计

USD326646S Electric noise absorber 失效
公开(公告)号：USD326646S
公开(公告)日：1992-06-02
申请号：US388370
申请日：1989-08-02
申请人： Kazuhiro Matsui
设计人： Kazuhiro Matsui

6. 发明授权

US5104794A Quantitative determination of bilirubin and a reagent therefor 失效
标题翻译：胆红素及其试剂的定量测定
公开(公告)号：US5104794A
公开(公告)日：1992-04-14
申请号：US492572
申请日：1990-03-13
申请人： Hitoshi Kondo , Kazuhiro Matsui , Hiroshi Suzuki
发明人： Hitoshi Kondo , Kazuhiro Matsui , Hiroshi Suzuki
IPC分类号： C12Q1/26 , C12Q1/44 , G01N33/72
CPC分类号： G01N33/728 , C12Q1/26 , C12Q1/44 , Y10S436/903 , Y10T436/146666
摘要： Disclosed is a process for measuring an amount of all bilirubins in a specimen, comprising deconjugating conjugated bilirubins with a reagent comprising an enzyme capable of deconjugation to form the unconjugated bilirubin, and determining an amount of the unconjugated bilirubin in the specimen, and a reagent therefor. The present invention also provides a process for measuring an amount of the unconjugated bilirubin in a specimen, comprising oxidizing and eliminating conjugated bilirubins in the specimen with an oxidizing agent capable of oxidizing bilirubins, in the presence of a metal ion forming a complex with the bilirubins and a surfactant at pH 6.5 or less, and determining an amount of the unconjugated bilirubin in the specimen, and a reagent therefor.

7. 发明授权

US4873505A Electric noise absorber 失效
标题翻译：电噪声吸收器
公开(公告)号：US4873505A
公开(公告)日：1989-10-10
申请号：US180462
申请日：1988-04-11
申请人： Kazuhiro Matsui
发明人： Kazuhiro Matsui
IPC分类号： H05K9/00 , H01F17/06 , H01F27/06 , H01F27/33 , H01F27/02 , H01F27/26
CPC分类号： H01F27/33
摘要： An electric noise absorber for holding a conduit of an electronic device comprises a retaining case composed of two box-shaped cases and auxiliary cases. A sponge-like member is fitted into the auxiliary case to prevent longitudinal movement of the cord or cable. A box-shaped case contains a magnet having a recess for receiving the cord or cable. It is possible to easily and securely attach and detach the electric noise absorber to the cord or cable by simply opening and closing the cases.
摘要翻译：用于保持电子设备的导管的电噪声吸收器包括由两个箱形壳体和辅助壳体组成的保持壳体。海绵状构件装配到辅助壳体中以防止绳索或电缆的纵向移动。箱形壳体包含具有用于接收绳索或电缆的凹部的磁体。通过简单地打开和关闭壳体，可以方便，牢固地将电噪声吸收器附接到电缆或电缆上。

8. 发明授权

US4649788A String retaining mechanism for guitars and the like stringed instruments 失效
标题翻译：吉他弦乐器的琴弦保持机构
公开(公告)号：US4649788A
公开(公告)日：1987-03-17
申请号：US738055
申请日：1985-05-24
申请人： Kazuhiro Matsui
发明人： Kazuhiro Matsui
IPC分类号： G10D3/12 , G10D3/14 , G10D3/04
CPC分类号： G10D3/12
摘要： A bridge and means for mounting the rear end of each of a plurality of strings on said bridge, the bridge including a plurality of saddles to which strings are individually attached wherein each saddle is adjustable longitudinally of the string in order to vary the effective length of the string for harmonious tuning and the saddle is adjustable without varying the effective length of the string in order to provide a fine tuning variation in tension for pitch. The invention relates to the specific means of mounting the end of the string on its individual saddle of the bridge wherein a substantially tubular member is provided with a groove extending downwardly, substantially normal to the body of the instrument to which the bridge is secured. The string passes through said groove and a bead on the end of the string initially anchors the string with respect to the groove. The string is anchored with respect to the saddle by a clamping jaw bearing against the string and a bearing surface in the saddle moved into tight engagement by a screw. The string and its bearing surface extends on one side of the screw which effects the clamping operation and the adjustments for tension and effective length extend on the opposite side of the screw.
摘要翻译：一种桥和用于将多个弦中的每一个的后端安装在所述桥上的装置，所述桥包括多个鞍座，所述鞍座分别连接到所述鞍座上，其中每个鞍座可以在弦的纵向调节，以便改变弦的有效长度用于和谐调谐的琴弦和鞍座是可调节的，而不改变弦的有效长度，以便提供用于间距的张力的微调变化。本发明涉及将弦的端部安装在其桥的单个鞍座上的具体装置，其中基本上管状的构件设置有向下延伸的凹槽，该凹槽基本上垂直于仪器的主体而固定在桥上。弦线穿过所述凹槽，并且弦的端部上的珠子最初相对于凹槽固定弦。绳子相对于鞍座通过夹紧爪轴承抵靠绳子而锚固，并且鞍座中的支承表面通过螺钉进入紧密接合。绳和其支承表面在螺钉的一侧上延伸，其实现夹紧操作，并且用于张力和有效长度的调节在螺钉的相对侧上延伸。

9. 发明授权

US4611868A Lead wire holder 失效
标题翻译：导线架
公开(公告)号：US4611868A
公开(公告)日：1986-09-16
申请号：US681127
申请日：1984-12-13
申请人： Kazuhiro Matsui , Hideo Wada , Yoshihito Nakano , Toshihiro Hayashi
发明人： Kazuhiro Matsui , Hideo Wada , Yoshihito Nakano , Toshihiro Hayashi
IPC分类号： H05K7/00 , H01B17/58 , H01R11/00 , H01R12/55 , H02G3/32 , H05K3/30 , H05K3/34 , H05K7/02
CPC分类号： H01B17/58 , H01R12/515 , H01R12/58 , H05K3/301 , H01R12/7029 , H05K2201/10287 , H05K2201/10568 , H05K2201/10606 , H05K2203/167 , H05K3/3447
摘要： A lead wire holder including a first holding member and a second holding member. The first and second holding members are interconnected so that both can be folded and put together through a connecting portion. The holding members are provided on the inside thereof with opposed lead wire insertion recesses mounting legs for mounting the holder to a printed circuit board project downwardly from the lower end surface of either or both of the holding members. Elastic tongue portions for elastically holding lead wire are formed from a part of the wall portions of the lead wire insertion recesses. Narrow recesses are disposed on the lower end surface and extend from the insertion recesses, so that the insertion end of each lead wire is restricted when its coated end abuts against with the narrow portions. It is thereby possible to let downwardly projecting cores of the lead wires have a uniform projecting length.
摘要翻译：一种引线保持器，包括第一保持构件和第二保持构件。第一和第二保持构件互连，使得两者可以通过连接部分折叠并放置在一起。保持构件在其内侧设置有相对的引线插入凹槽安装腿，用于将保持器安装到印刷电路板上，从一个或两个保持构件的下端面向下突出。用于弹性保持引线的弹性舌部由导线插入凹槽的一部分壁部形成。窄的凹槽设置在下端表面上并且从插入凹槽延伸，使得每个引线的插入端在其涂覆端部与窄部分抵接时受到限制。因此，可以使引线的向下突出的芯具有均匀的突出长度。

10. 发明授权

US4513172A Clamp fixing device 失效
标题翻译：夹具固定装置
公开(公告)号：US4513172A
公开(公告)日：1985-04-23
申请号：US385396
申请日：1982-05-20
申请人： Kazuhiro Matsui
发明人： Kazuhiro Matsui
IPC分类号： H02G3/06 , H02G15/04 , H02G15/007
CPC分类号： H02G3/065 , H02G15/04
摘要： A cable fixing device which is constructed by superposing between an outer housing (1) and an inner housing (7) both of which can be fitted with each other by screwing, a hanging bell-shaped packing (14) having an inner hole, a guiding ring (19) having a guiding hole, and a tightening ring (20) having a plurality of flexible fins (21) reclining in the inward direction, and which is adapted for clamping an inserted cable with the flexible fins (21) of the tightening ring (20) by resiliently contacting the hanging bell-shaped packing (14) with the outer periphery of said cable and screwing the inner housing (7) into the outer housing (1). By the water protecting effect of the hanging bell-shaped packing (14) and the fixing effect of the tightening ring, it can prevent the penetration of water from the outside and simultaneously can securely fix cables of various diameters without changing the parts.
摘要翻译： PCT No.PCT / JP81 / 00228 Sec。 371日期1982年5月20日 102（e）日期1982年5月20日PCT提交1981年9月9日PCT公布。出版物WO82 / 01296 日期：1982年4月15日。一种电缆固定装置，其通过在外壳（1）和内壳体（7）之间叠加而构成，两者都可以通过旋拧相配合，一个悬挂的钟形填料），具有引导孔的引导环（19）和具有沿向内方向倾斜的多个柔性翅片（21）的紧固环（20），并且适于将插入的电缆夹紧通过将悬挂钟形填料（14）与所述电缆的外周弹性接触并将内壳体（7）拧入外壳体（1）中，使紧固环（20）的柔性翼片（21）。通过悬挂钟形填料（14）的防水效果和紧固环的固定效果，可以防止水从外部穿透，同时可以牢固固定各种直径的电缆，而不会改变零件。

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