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    • 6. 发明授权
    • Stent
    • 支架
    • US08523938B2
    • 2013-09-03
    • US13044663
    • 2011-03-10
    • Ryohei TakeuchiKazuhiro MaruyamaNoboru Saito
    • Ryohei TakeuchiKazuhiro MaruyamaNoboru Saito
    • A61F2/06B05D5/00
    • A61L31/16A61F2/91A61F2/915A61F2002/91575A61F2230/0054A61F2250/0067A61F2310/00389A61L31/10A61L31/14A61L2300/606
    • A stent includes a stent body in which struts are joined mutually while intersecting and which is formed tubularly as a whole, and a drug coat layer on the outer surface of the struts. The strut has a bend which is deformed as the stent body expands/contracts in the radial direction, and the drug coat layer with which the bend is coated is formed in such a manner that the drug coat layer is mountain-shaped in a cross-section perpendicular to the axis of the strut and the ridgeline of the mountain shape extends in a wavy shape along the longitudinal direction of the strut. The drug coat layer deforms relatively easily without using plasticizer as the stent deforms and is not so susceptible to causing problems such as peeling, destruction, damage or falling off of the drug coat later.
    • 支架包括支架,其中支柱相互交叉地相互连接并且整体上形成为管状,支架外表面上的药物涂层。 支架具有随着支架主体沿径向方向扩张/收缩而变形的弯曲部,并且以这样的方式形成涂覆有弯曲部的药物涂层,使得药物涂层在横截面中呈山形, 垂直于支柱的轴线的截面和山形的脊线沿着支柱的纵向方向呈波浪形状延伸。 当涂层变形时,药物涂层相对容易变形而不使用增塑剂,并且不太容易引起诸如以后的药物外皮的剥离,破坏,损坏或脱落等问题。
    • 8. 发明授权
    • Method for producing copper phthalocyanine using thiols
    • 使用硫醇生产铜酞菁的方法
    • US5496939A
    • 1996-03-05
    • US400863
    • 1995-03-08
    • Kazuhiro Maruyama
    • Kazuhiro Maruyama
    • C09B47/06C09B47/04
    • C09B47/06
    • A method for producing copper phthalocyanine, which comprises heating and reacting phthalic acid or a phthalic acid derivative, urea or a urea derivative, and a copper compound, using molybdenum or a molybdenum compound as a catalyst, in the presence or absence of an inert organic solvent, wherein at least one compound selected from the group consisting of an aromatic dithiol compound of the following formula (I), a saturated aliphatic dithiol compound of the following formula (II), and their precursors, or at least one compound selected from the group consisting of a ruthenium compound and an osmium compound, is added to the reaction system: ##STR1##C.sub.m H.sub.2m-x R.sub.x (SH).sub.2 (II)wherein ring A in the formula (I) is a 6-membered single carbon ring or polycyclic condensed carbon ring aromatic compound, R for R.sub.n in the formula (I) or for R.sub.x in the formula (II) is a mercapto group (--SH), a substituted mercapto group (--SR' wherein R' is a substituent inert in the reaction system), or a substituent substantially inert in the reaction system, m is an integer of from 2 to 4, and n and x are optional integers of from 0 to the maximum number of substitutable positions of the respective compounds other than the positions for the mercapto groups.
    • 一种生产铜酞菁的方法,其包括在存在或不存在惰性有机物的情况下,使用钼或钼化合物作为催化剂加热和反应邻苯二甲酸或邻苯二甲酸衍生物,脲或脲衍生物和铜化合物 溶剂,其中至少一种选自下式(I)的芳族二硫醇化合物,下式(II)的饱和脂族二硫醇化合物及其前体)或至少一种选自 式(I)中的A为6元单碳环或多环稠环碳芳香族化合物,式(I)中的R 1为R, 或式(II)中的R x为巯基(-SH),取代的巯基(-SR',其中R'为反应体系中惰性的取代基)或在反应体系中基本上为惰性的取代基 m为2〜4的整数,n和x为0〜可选择的除巯基以外的各化合物的可取代位置数的整数。