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1. 发明申请

US20060210985A1 Dna fragment amplification method, reaction apparatus for amplifying dna fragment and process for producing the same 审中-公开
标题翻译： Dna片段扩增法，扩增dna片段的反应装置及其制备方法
公开(公告)号：US20060210985A1
公开(公告)日：2006-09-21
申请号：US10548590
申请日：2004-03-17
申请人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
发明人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
IPC分类号： C12Q1/68 , C12P19/34
CPC分类号： G01N33/54366 , C12Q1/686 , C12Q2565/518 , C12Q2523/307
摘要： A reaction apparatus (10) includes a substrate (12) and a plurality of columnar members (14) formed on the substrate (12). Oligonucleotides for immobilization (16) having sequences complementary to sequences of both ends of a starting template DNA (18) is adhered on the surfaces of the substrate (12) and the columnar members (14). The starting template DNA (18) can be immobilized over the adjacent columnar members (14) by introducing the starting template DNA (18) under the elongated condition. PCR is conducted in such condition.
摘要翻译：反应装置（10）包括基板（12）和形成在基板（12）上的多个柱状部件（14）。具有与起始模板DNA（18）两端的序列互补的序列的固定化寡核苷酸（16）粘附在基材（12）和柱状构件（14）的表面上。通过在细长条件下引入起始模板DNA（18），起始模板DNA（18）可以固定在相邻的柱状构件（14）上。 PCR在这种条件下进行。

2. 发明申请

US20060172436A1 Diagnosis supporting system 审中-公开
标题翻译：诊断支持系统
公开(公告)号：US20060172436A1
公开(公告)日：2006-08-03
申请号：US10549116
申请日：2004-02-26
申请人： Wataru Hattori , Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
发明人： Wataru Hattori , Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Hiroko Someya
IPC分类号： G01N33/543 , G06F19/00
CPC分类号： G01N27/44717 , G16H10/60 , G16H15/00
摘要： A diagnosis supporting system (10) includes a diagnosis data obtaining unit (20) that obtains diagnosis data in which a movement parameter reflecting a movement speed of each component in separating a sample collected from a test subject into plural components with a chip (12) and a character of each component is in correspondence, a parameter storing unit (34) that stores the movement parameter of a characteristic component showing a state of suffering from a specific disease in correspondence with the disease, a relationship data storing unit (35) that stores relationship data showing a relationship between the character of the characteristic component and a possibility of suffering from a specific disease, a detecting unit (21) that detects the characteristic component from the diagnosis data based on the movement parameter of the characteristic component and the movement parameter of the diagnosis data by making reference to the parameter storing unit (34), and an inference processing unit (22) that infers the possibility that the test subject is suffering by making reference to the relationship data storing unit (35) based on the character of the detected characteristic component.
摘要翻译：诊断支持系统（10）包括诊断数据获取单元（20），该诊断数据获取单元（20）获取诊断数据，其中，用芯片（12）将反映从测试对象收集的样本的每个组件的移动速度反映成多个组件的移动参数，并且每个部件的字符相对应，存储与疾病相对应地显示出患有特定疾病的状态的特征部件的移动参数的参数存储部（34），关系数据存储部（35），其中，存储表示特征成分的特征与患有特定疾病的可能性之间的关系的关系数据，根据特征成分的移动参数和运动来检测来自诊断数据的特征成分的检测部（21）参考存储单元（34）的诊断数据的参数，以及inf （22），其基于检测到的特征成分的特性，通过参照所述关系数据存储部（35）推测出所述检测对象所遭受的可能性。

3. 发明申请

US20060102836A1 Liquid switch, and microchip and mass-analyzing system using the same 失效
标题翻译：液体开关，微芯片和质量分析系统使用相同
公开(公告)号：US20060102836A1
公开(公告)日：2006-05-18
申请号：US10537295
申请日：2003-12-02
申请人： Kazuhiro Iida , Masakazu Baba , Hisao Kawaura , Toru Sano , Noriyuki Iguchi , Hiroko Someya , Wataru Hattori , Minoru Asogawa
发明人： Kazuhiro Iida , Masakazu Baba , Hisao Kawaura , Toru Sano , Noriyuki Iguchi , Hiroko Someya , Wataru Hattori , Minoru Asogawa
IPC分类号： H01J49/00
CPC分类号： B01L3/502738 , B01L3/502746 , B01L2200/0621 , B01L2400/0688 , G01N30/20 , H01J49/04 , Y10T137/4891
摘要： A liquid sample (104) introduced in a main flow passage (101) is held in a dam portion (105), and a trigger liquid (106) is filled in a trigger flow passage (102). In this state, the trigger liquid (106) is further introduced at desired timing into the trigger flow passage (102) so that the front end portion of the level of the trigger liquid (106) is advanced and the front end portion is brought to be into contact with the dam portion (105). This causes the liquid sample (104) to move to the right (downstream side) in the figure, resulting in the liquid sample (104) flowing out to the downstream side of the main flow passage (101). This means that the trigger liquid (106) provides priming to realize a liquid switch.
摘要翻译：引入到主流路（101）中的液体样品（104）保持在坝部（105）中，并且将触发液体（106）填充在触发流路（102）中。在这种状态下，触发液体（106）在所需的时刻被进一步引入到触发流路（102）中，使得触发液体（106）的高度的前端部分前进，前端部分与坝部（105）接触。这使得液体样品（104）移动到图中的右侧（下游侧），导致液体样品（104）流出到主流动通道（101）的下游侧。这意味着触发液体（106）提供启动以实现液体开关。

4. 发明申请

US20060214101A1 Mass spectrometric system and mass spectrometry 失效
标题翻译：质谱系统和质谱
公开(公告)号：US20060214101A1
公开(公告)日：2006-09-28
申请号：US10549587
申请日：2004-03-15
申请人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
发明人： Katsutoshi Takahashi , Kazuhiro Iida , Masakazu Baba , Noriyuki Iguchi , Toru Sano , Hisao Kawaura , Toshitsugu Sakamoto , Wataru Hattori , Hiroko Someya
IPC分类号： H01J49/00 , B01D59/44
CPC分类号： H01J49/0418 , B01L3/502746 , B01L3/502753 , B01L2200/0663 , B01L2200/10 , B01L2300/0681 , B01L2300/0816 , B01L2300/16 , B01L2400/086 , G01N1/22 , G01N30/84 , G01N2030/8452
摘要： After a sample is previously separated into plural components in a channel formed in a microchip (353), the channel is irradiated along a separation direction with a laser beam from a laser oscillator (361) to sequentially ionize each fraction separated in the channel. The ionized fraction is detected by a mass spectrometry unit (363) and analyzed by an analytical result analyzing unit (371). The analytical result is stored in a memory (369) while associated with position information in a driver control unit (367) and information on laser beam irradiation condition in a laser control unit (373), and the analytical result is imaged by an imaging unit (375). The imaged analytical result is displayed on a display (377).
摘要翻译：在将样品预先分离成在微芯片（353）中形成的通道中的多个部件之后，通过激光振荡器（361）的激光束沿着分离方向照射通道，以顺序地电离通道中分离的每个部分。通过质谱分析单元（363）检测离子化部分，并通过分析结果分析单元（371）进行分析。分析结果与激光控制单元（373）中的驱动器控制单元（367）中的位置信息和激光束照射条件的信息相关联地存储在存储器（369）中，并且分析结果由成像单元（375）。成像分析结果显示在显示器上（377）。

5. 发明申请

US20060035386A1 Fine particle handling unit, chip and sensor mounted with same, and methods for separating, capturing and sensing protein 有权
标题翻译：精细粒子处理单元，安装有芯片和传感器的传感器，以及分离，捕获和感测蛋白质的方法
公开(公告)号：US20060035386A1
公开(公告)日：2006-02-16
申请号：US10537292
申请日：2003-11-25
申请人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Hiroko Someya
发明人： Wataru Hattori , Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Hiroko Someya
IPC分类号： G01N33/558
CPC分类号： B01D61/18 , B01D29/00 , B01D67/0062 , B01D69/00 , B01D71/02 , B01D71/027 , B01L3/502746 , B01L3/502753 , B01L3/502761 , B01L2200/0647 , B01L2200/0652 , B01L2300/0816 , B01L2400/086 , G01N33/5302
摘要： A channel (1) formed in a substrate (41) branches into channels (2, 3) at a branch point (43). On this branch point, obstacles (8) having a columnar structure are aligned at certain intervals.
摘要翻译：形成在基板（41）中的通道（1）在分支点（43）处分支成通道（2,3）。在该分支点上，具有柱状结构的障碍物（8）以一定间隔对准。

6. 发明申请

US20060177350A1 Microchip, sampling method, sample separating method, sample analyzing method, and sample recovering method 审中-公开
标题翻译： Microchip，采样方法，样品分离方法，样品分析方法和样品回收方法
公开(公告)号：US20060177350A1
公开(公告)日：2006-08-10
申请号：US10549284
申请日：2004-03-19
申请人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
发明人： Toru Sano , Masakazu Baba , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya
IPC分类号： G01N1/10
CPC分类号： B01D57/02 , B01L3/502707 , B01L3/502746 , B01L3/502753 , B01L3/502784 , B01L2200/0668 , B01L2300/0681 , B01L2300/0816 , B01L2400/0415 , B01L2400/0454 , G01N1/40 , G01N27/44743 , G01N35/08
摘要： A sample-carrier complex (119) is introduced into a sample introducing portion (107), and the sample-carrier complex (119) is moved and deposited on a damming portion (111). The damming portion (111) is heated at a stage in which the predetermined amount of sample-carrier complex (119) is deposited on the damming portion (111). A temperature is increased to a predetermined temperature to break down the sample-carrier complex (119) into a sample (121) and a carrier (123). A voltage is applied between the sample introducing portion (107) and a sample recovery portion (109) to cause the sample (121) to pass through a gap between columnar bodies (115) and move into a second channel (106) to perform predetermined separation and analysis or recovery operation.
摘要翻译：将样本 - 载体复合体（119）引入到样本引入部分（107）中，并且样本 - 载体复合体（119）移动并沉积在阻挡部分（111）上。阻挡部分（111）在预定量的样品载体复合物（119）沉积在阻挡部分（111）上的阶段被加热。将温度升高到预定温度以将样品 - 载体复合物（119）分解成样品（121）和载体（123）。在样品导入部（107）和样品回收部（109）之间施加电压使样品（121）通过柱状体（115）之间的间隙并移动到第二通道（106）中，以进行预定的分离和分析或恢复操作。

7. 发明授权

US06881315B2 Fractionating apparatus having colonies of pillars arranged in migration passage at interval and process for fabricating pillars 失效
标题翻译：具有排列在移动通道中的柱的集落的分段装置，并且用于制造支柱的过程
公开(公告)号：US06881315B2
公开(公告)日：2005-04-19
申请号：US10207852
申请日：2002-07-31
申请人： Kazuhiro Iida , Hisao Kawaura , Masakazu Baba , Toshitsugu Sakamoto , Toru Sano , Noriyuki Iguchi
发明人： Kazuhiro Iida , Hisao Kawaura , Masakazu Baba , Toshitsugu Sakamoto , Toru Sano , Noriyuki Iguchi
IPC分类号： B01L99/00 , B01L3/00 , G01N15/10 , G01N15/14 , G01N27/447 , G01N30/02 , G01N30/28 , G01N30/60 , C07K1/26
CPC分类号： B01L3/502761 , B01L3/502753 , B01L2200/0647 , B01L2200/0652 , B01L2400/086 , G01N27/44704 , G01N27/44773 , G01N30/02 , G01N30/6052 , G01N2030/285 , B01D15/34
摘要： A fractionating apparatus is used for fractionating sample into micro-structures different in size, and includes a fractionating unit formed with a fractionating passage; the fractionating passage is defined in a groove formed in a substrate of the fractionating unit, and pillar patches are formed in the groove at intervals wider than the gap among the pillar patches; while the sample is migrated through the fractionating passage, small-sized DNA molecules are trapped in the pillar patches, and large-sized DNA molecules are smoothly migrated through the wide intervals; this results in that the large-sized DNA molecules reaches the end of the fractionating passage faster than the small-sized DNA molecules without clogging.
摘要翻译：分馏装置用于将样品分级成尺寸不同的微结构，并且包括由分馏通道形成的分馏单元; 分馏通道限定在形成在分馏单元的基板中的槽中，并且在凹槽中以比柱状体之间的间隙宽的间隔形成柱贴片; 当样品通过分馏通道迁移时，小尺寸的DNA分子被捕获在柱状贴片中，大尺寸的DNA分子通过宽间隔平滑地迁移; 这导致大尺寸DNA分子比小尺寸DNA分子更快地到达分级通道的末端而没有堵塞。

8. 发明授权

US07785533B2 Chip, device using the chip, and method of using the same 失效
标题翻译：使用芯片的芯片，器件及其使用方法
公开(公告)号：US07785533B2
公开(公告)日：2010-08-31
申请号：US10571585
申请日：2004-09-13
申请人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
发明人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
IPC分类号： G01N21/01
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/0689 , B01L2200/141 , B01L2300/041 , B01L2300/0816 , B82Y30/00 , B82Y35/00 , G01N27/44791
摘要： A channel formed on a chip is opened without contaminating contents of the channel. Channels (107a) and (107b) provided on a substrate (103) are covered by pressing a lid (113) composed of a resin layer (102) and a plate-like lid (101) to a surface of the substrate (103). A fixing device has a retainer plate (104), which retains the plate-like lid (101) of a chip (112), a board (108) on which the substrate (103) is placed, and a screw (106). When covering the channels (107a) and (107b), the screw (106) is fastened and the lid (113) is pressed to the substrate (103) to be fixed. And, when opening an upper portion of the channels (107a) and (107b), the screw (106) is turned upward and a pressure is released, and the lid (113) is removed from the upper potion of the substrate (103).
摘要翻译：形成在芯片上的通道打开而不污染通道的内容物。设置在基板（103）上的通道（107a）和（107b）通过将由树脂层（102）和板状盖（101）构成的盖（113）压在基板（103）的表面上而被覆盖，。定影装置具有保持片（112）的板状盖（101），放置有基板（103）的基板（108）和螺钉（106））的保持板（104）。当覆盖通道（107a）和（107b）时，螺钉（106）被紧固并且盖（113）被压到基板（103）上以被固定。并且，当打开通道（107a）和（107b）的上部时，螺杆（106）向上转动并释放压力，并且从基板（103）的上部移除盖（113）。

9. 发明申请

US20070048179A1 Chip, device using the chip, and method of using the same 失效
标题翻译：使用芯片的芯片，器件及其使用方法
公开(公告)号：US20070048179A1
公开(公告)日：2007-03-01
申请号：US10571585
申请日：2004-09-13
申请人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
发明人： Machiko Fujita , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Wataru Hattori , Masakazu Baba , Noriyuki Iguchi
IPC分类号： G01N31/22
CPC分类号： B01L3/502707 , B01L3/502715 , B01L3/502746 , B01L2200/0689 , B01L2200/141 , B01L2300/041 , B01L2300/0816 , B82Y30/00 , B82Y35/00 , G01N27/44791
摘要： A channel formed on a chip is opened without contaminating contents of the channel. Channels (107a) and (107b) provided on a substrate (103) are covered by pressing a lid (113) composed of a resin layer (102) and a plate-like lid (101) to a surface of the substrate (103). A fixing device has a retainer plate (104), which retains the plate-like lid (101) of a chip (112), a board (108) on which the substrate (103) is placed, and a screw (106). When covering the channels (107a) and (107b), the screw (106) is fastened and the lid (113) is pressed to the substrate (103) to be fixed. And, when opening an upper portion of the channels (107a) and (107b), the screw (106) is turned upward and a pressure is released, and the lid (113) is removed from the upper potion of the substrate (103).
摘要翻译：形成在芯片上的通道打开而不污染通道的内容物。设置在基板（103）上的通道（107a）和（107b）通过将由树脂层（102）和板状盖（101）构成的盖（113）压到基板的表面 103）。定影装置具有保持片（112）的板状盖（101），放置有基板（103）的基板（108）和螺钉（106））的保持板（104）。当覆盖通道（107a）和（107b）时，螺钉（106）被紧固并且盖（113）被压到基板（103）上以被固定。并且，当打开通道（107a）和（107b）的上部时，螺杆（106）向上转动并释放压力，并且将盖（113）从基板的上部移除（ 103）。

10. 发明申请

US20060070951A1 Microchip, solvent displacement method using the microchip, concentrating method, and mass spectrometry system 审中-公开
标题翻译： Microchip，使用微芯片的溶剂置换法，浓缩法和质谱系统
公开(公告)号：US20060070951A1
公开(公告)日：2006-04-06
申请号：US10536597
申请日：2003-11-28
申请人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
发明人： Masakazu Baba , Toru Sano , Kazuhiro Iida , Hisao Kawaura , Noriyuki Iguchi , Wataru Hattori , Hiroko Someya , Minoru Asogawa
IPC分类号： C02F1/44 , B01D15/08
CPC分类号： B01D67/0062 , B03C5/00 , G01N1/40
摘要： A particular component in a sample is recovered in a high concentration and solvent-replaced. A separator 100 is placed on a microchip and includes a channel 112 for flowing the particular component. The channel 112 includes a sample feeding channel 300 as well as a filtrate discharge channel 302 and a sample recovering part 308 which are branched from the sample feeding channel 300. There is formed a filter 304 for preventing passage of the particular component, at the inlet of the filtrate discharge channel 302 from the sample feeding channel 300. Furthermore, there is formed a damming area (hydrophobic area) 306 for preventing entering of a liquid sample while allowing for passage of the liquid sample by applying an external force equal to or larger than a given level, at the inlet of the sample recovering part 308 from the sample feeding channel 300.
摘要翻译：样品中的特定组分以高浓度回收并进行溶剂置换。分离器100放置在微芯片上，并且包括用于流动特定部件的通道112。通道112包括样品供给通道300以及从样品供给通道300分支的滤液排出通道302和样品回收部分308。在滤液排出通道302的入口处，从样品供给通道300形成防止特定成分通过的过滤器304。此外，在样品回收部的入口处形成防止液体样品进入的阻止区域（疏水区域）306，同时允许通过施加等于或大于给定水平的外力使液体样品通过 308。

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