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1. 发明授权

US07112641B2 Monomer, polymers, and ophthalmic lenses and contact lenses made by using the same 有权
标题翻译：单体，聚合物和眼科镜片及使用其制成的隐形眼镜
公开(公告)号：US07112641B2
公开(公告)日：2006-09-26
申请号：US10473488
申请日：2002-03-13
申请人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
发明人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
IPC分类号： C08F130/08
CPC分类号： C08F30/08 , C07F7/0838 , G02B1/043 , C08L43/04
摘要： A monomer as represented by general formula (a) or (a′) below, with which a polymer having high oxygen permeability and transparency and suited to an ophthalmic lens is obtained, is provided. Suitable monomers include: wherein A is a siloxanyl group; R1 is H or a methyl group; R2 is a substituted group that is selected from the group consisting of alkyl groups with 1 to 20 carbon atoms that may be substituted, aryl groups with 6 to 20 carbon atoms that may be substituted and formula (c) below.
摘要翻译：提供了由通式（a）或（a'）表示的单体，其具有高透氧性和透明度并且适合于眼用透镜的聚合物。合适的单体包括：其中A是硅氧烷基; R 1是H或甲基; R 2是选自可以被取代的具有1至20个碳原子的烷基，可以被取代的具有6至20个碳原子的芳基的取代基和式（c ）。

2. 发明授权

US07329694B2 Ocular lens 有权
标题翻译：眼镜片
公开(公告)号：US07329694B2
公开(公告)日：2008-02-12
申请号：US10488089
申请日：2001-08-28
申请人： Masataka Nakamura , Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
发明人： Masataka Nakamura , Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
IPC分类号： G02B1/04
CPC分类号： C08F20/58 , G02B1/043 , C08L33/26 , C08L33/24 , C08L43/04
摘要： This invention provides an ophthalmic lens of high tensile elongation (i.e., that does not break easily). It is an ophthalmic lens comprising, as a polymerization component, monomers represented by formula (a) below: wherein, in formula (a), R1 is H or a methyl group; R2 is a group that is selected from alkyl groups with 1 to 8 carbon atoms, aralkyl groups with 7 to 12 carbon atoms and aryl groups with 6 to 10 carbon atoms; L1 is a substituent that is selected from ethylene groups, 1,2-propylene groups, 1,3-propylene groups and 1,4-butylene groups; and L2 is a substituent that is selected from methylene groups, ethylene groups, 1,2-propylene groups, 1,3-propylene groups and 1,4-butylene groups.
摘要翻译：本发明提供了一种具有高拉伸伸长率（即不容易破裂）的眼科镜片。作为聚合成分的眼用透镜，含有由下式（a）表示的单体：式（a）中，R 1为H或甲基; R 2是选自具有1至8个碳原子的烷基，具有7至12个碳原子的芳烷基和具有6至10个碳原子的芳基的基团; L 1是选自亚乙基，1,2-亚丙基，1,3-亚丙基和1,4-亚丁基的取代基; L 2是选自亚甲基，亚乙基，1,2-亚丙基，1,3-亚丙基和1,4-亚丁基的取代基。

3. 发明授权

US06818719B2 Polymers and ophthalmic lenses in which they are used 有权
公开(公告)号：US06818719B2
公开(公告)日：2004-11-16
申请号：US10398919
申请日：2003-04-11
申请人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
发明人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
IPC分类号： C08F12010
CPC分类号： G02B1/043 , A61L27/16 , C08F230/08 , C08L43/04 , C08L33/26
摘要： Polymers of high oxygen permeability and a low modulus of elasticity and ophthalmic lenses and contact lenses using the same are provided. The polymers are characterized in that they are obtained by copolymerizing 5 to 90 parts by weight of a monomer (SiMAA) represented by the formula below, 5 to 90 parts by weight of 3-tris (trimethylsiloxy) silyl propyl methacrylate (TRIS), 5 to 70 parts by weight of N,N-dimethyl acrylamide (DMAA) and 0.1 to 3 parts by weight of monomer having two or more copolymerizable carbon-carbon unsaturated bonds in 1 molecule (provided that the total quantity of SiMAA, TRIS and DMAA is 100 parts by weight and that the total quantity of SiMAA and TRIS is 30 to 95 parts by weight), and which are used for ophthalmic lenses.

4. 发明授权

US07071274B2 Monomer, polymer, and ocular lens and contact lens each obtained therefrom 有权
标题翻译：单体，聚合物，眼透镜和隐形眼镜各自由其获得
公开(公告)号：US07071274B2
公开(公告)日：2006-07-04
申请号：US10473487
申请日：2002-03-11
申请人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
发明人： Kazuhiko Fujisawa , Naoki Shimoyama , Mitsuru Yokota
IPC分类号： C08F130/08
CPC分类号： C08F283/12 , C07F7/0838 , C08F30/08 , C08F290/06 , C08F290/061 , C08F290/068 , G02B1/043 , C08L43/04 , C08L51/085
摘要： A monomer as represented by general formula (a) or (a′) below, with which a polymer having high oxygen permeability and transparency and suited to an ophthalmic lens is obtained, is provided. Suitable monomers have the formula: wherein A is a siloxanyl group; R1 and R2 are H or methyl groups; R3 is a substituted group that is selected from the group consisting of alkyl groups with 1 to 20 carbon atoms that may be substituted and aryl groups with 6 to 20 carbon atoms that may be substituted; m indicates an integer of 0 to 200.
摘要翻译：提供了由通式（a）或（a'）表示的单体，其具有高透氧性和透明度并且适合于眼用透镜的聚合物。合适的单体具有下式：其中A是硅氧烷基; R 1和R 2均为H或甲基; R 3是选自可以被取代的具有1〜20个碳原子的烷基和可以被取代的具有6〜20个碳原子的芳基的取代基; m表示0〜200的整数。

5. 发明授权

US07435452B2 Surface-treated plastic article and method of surface treatment 有权
标题翻译：表面处理塑料制品和表面处理方法
公开(公告)号：US07435452B2
公开(公告)日：2008-10-14
申请号：US10729748
申请日：2003-12-05
申请人： Naoki Shimoyama , Mitsuru Yokota , Tadahiro Uemura
发明人： Naoki Shimoyama , Mitsuru Yokota , Tadahiro Uemura
IPC分类号： B05D1/18
CPC分类号： C08J7/04 , A61M1/16 , C08J2300/14 , G02B1/043 , Y10T428/31667 , Y10T428/31928 , Y10T428/31935
摘要： The present invention relates to a surface-treated plastic article including a thin layer composed of a polymer complex on the surface. The surface-treated plastic article can be produced by a treatment with at least one kind of aqueous solutions of polymers having a weight average molecular weight of 200 or more. According to the present invention, the plastic articles, such as contact lenses, having superior transparency, wettability, oxygen permeability, and mechanical properties can be provided.
摘要翻译：本发明涉及一种表面处理的塑料制品，其包括由表面上的聚合物复合物构成的薄层。表面处理的塑料制品可以通过用至少一种重均分子量为200以上的聚合物的水溶液的处理来制造。根据本发明，可以提供具有优异透明性，润湿性，透氧性和机械性能的塑料制品，例如隐形眼镜。

6. 发明申请

US20080199524A1 Eyedrops containing particulate agar 审中-公开
标题翻译：含有颗粒状琼脂的滴眼液
公开(公告)号：US20080199524A1
公开(公告)日：2008-08-21
申请号：US11810524
申请日：2007-06-06
申请人： Masahiro Inohara , Masahito Yoshikawa , Takashi Taniguchi , Mitsuru Yokota , Naoki Shimoyama , Masaki Ue , Miho Araki , Yukiko Sugihara , Yoshihide Horibe , Mitsuaki Kuwano
发明人： Masahiro Inohara , Masahito Yoshikawa , Takashi Taniguchi , Mitsuru Yokota , Naoki Shimoyama , Masaki Ue , Miho Araki , Yukiko Sugihara , Yoshihide Horibe , Mitsuaki Kuwano
IPC分类号： A61K9/14
CPC分类号： A61K9/0048 , A61K9/08
摘要： It is intended to prepare a composition which contains polysaccharide at a high concentration and yet remains in the state of a liquid having low viscosity to thereby provide drugs, eyedrops, foods, cosmetics, toiletry products having a novel texture or function. The composition in the state of a liquid having low viscosity is obtained by heating polysaccharide at a high concentration in a water-containing liquid and then cooling under applying a shear force, which enables the provision of the above-described drugs. The composition is usable as an aqueous drug vehicle which is free from gelling due to temperature changes during storage and easily applied without pouring and/or streaming down. Eyedrops containing agar have an effect of enhancing ocular drug penetration. Eyedrops containing particulate agar maintain a low viscosity and, achieve easy instillation and impart a favorable feel in instillation.
摘要翻译：本发明的目的在于制备含有高浓度多糖但仍具有低粘度的液体状态的组合物，从而提供具有新颖的质地或功能的药物，滴眼剂，食品，化妆品，化妆品等。通过在含水液体中以高浓度加热多糖，然后在施加剪切力的条件下冷却，得到具有低粘度的液体状态的组合物，从而能够提供上述药物。该组合物可用作水性药物载体，其由于储存期间的温度变化而没有胶凝，并且容易施用而没有倾倒和/或流下。含有琼脂的滴眼液具有增强眼药物渗透的作用。含有颗粒状琼脂的喷雾剂保持低粘度，并且实现容易滴注并赋予滴注有利的感觉。

7. 发明授权

US06689480B2 Surface-treated plastic article and method of surface treatment 有权
公开(公告)号：US06689480B2
公开(公告)日：2004-02-10
申请号：US09842402
申请日：2001-04-26
申请人： Naoki Shimoyama , Mitsuru Yokota , Tadahiro Uemura
发明人： Naoki Shimoyama , Mitsuru Yokota , Tadahiro Uemura
IPC分类号： B32B2730
CPC分类号： C08J7/04 , A61M1/16 , C08J2300/14 , G02B1/043 , Y10T428/31667 , Y10T428/31928 , Y10T428/31935
摘要： The present invention relates to a surface-treated plastic article including a thin layer composed of a polymer complex on the surface. The surface-treated plastic article can be produced by a treatment with at least one kind of aqueous solutions of polymers having a weight average molecular weight of 200 or more. According to the present invention, the plastic articles, such as contact lenses, having superior transparency, wettability, oxygen permeability, and mechanical properties can be provided.

8. 发明申请

US20100317615A1 Method of enhancing ocular penetration of a drug in an eyedrop 审中-公开
标题翻译：增加眼药水眼药水渗透性的方法
公开(公告)号：US20100317615A1
公开(公告)日：2010-12-16
申请号：US12806550
申请日：2010-08-16
申请人： Masahiro Inohara , Masahito Yoshikawa , Takashi Taniguchi , Mitsuru Yokota , Naoki Shimoyama , Masaki Ue , Miho Araki
发明人： Masahiro Inohara , Masahito Yoshikawa , Takashi Taniguchi , Mitsuru Yokota , Naoki Shimoyama , Masaki Ue , Miho Araki
IPC分类号： A61K31/729 , A61P27/02
CPC分类号： A61K9/0048 , A61K9/08
摘要： A method of enhancing ocular penetration of a drug in an eyedrop by administering to an eye, an eyedrop containing, particulate agar having a weight-average molecular weight of from 5,000 to 1,200,000, the particulate agar being obtained by dissolving agar into an aqueous solution by heating and then cooling the resultant mixture to avoid gelling, while applying a stress by vibration, shearing, stirring, compression or pulverizing, wherein the particulate agar is in an amount of 0.1 to 10 wt %.
摘要翻译：通过向眼睛施用含有重均分子量为5,000至1,200,000的含有滴眼剂的颗粒状琼脂的眼睛，通过将琼脂溶解在水溶液中而获得的颗粒状琼脂通过加热，然后冷却所得混合物以避免胶凝，同时通过振动，剪切，搅拌，压缩或粉碎施加应力，其中颗粒状琼脂的量为0.1至10重量％。

9. 发明授权

US06885966B1 Device for providing a signal in response to a change of the ambient pressure 失效
标题翻译：用于响应于环境压力变化而提供信号的装置
公开(公告)号：US06885966B1
公开(公告)日：2005-04-26
申请号：US10363163
申请日：2000-09-06
申请人： Tobias Tyroller , Masataka Nakamura , Naoki Shimoyama , Mitsuru Yokota
发明人： Tobias Tyroller , Masataka Nakamura , Naoki Shimoyama , Mitsuru Yokota
IPC分类号： G01L23/00 , B60R21/00 , B60R21/01 , B60R21/16 , G01L19/12 , G01L23/08 , G06F15/00 , B60Q1/00
CPC分类号： B60R21/0136 , B60R2021/0006 , G01L19/12 , G01L23/08
摘要： The invention relates to a device for providing a signal in response to a change of the ambient pressure, comprising a pressure sensor (S) for providing a pressure signal (DS) depending on an ambient pressure (p), and a signal processing unit (SVE) mounted downstream of the pressure sensor (S) and comprising at least one analog logarithmic system and at least one high-pass filter system.
摘要翻译：本发明涉及一种用于响应于环境压力变化而提供信号的装置，包括用于根据环境压力（p）提供压力信号（DS）的压力传感器（S）和信号处理单元（ SVE），其安装在所述压力传感器（S）的下游，并且包括至少一个模拟对数系统和至少一个高通滤波器系统。

10. 发明授权

US08637589B2 Silicone prepolymer solutions 有权
标题翻译：硅氧烷预聚物溶液
公开(公告)号：US08637589B2
公开(公告)日：2014-01-28
申请号：US12962575
申请日：2010-12-07
申请人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
发明人： Kazuhiko Fujisawa , Mitsuru Yokota , Masataka Nakamura
IPC分类号： G02B1/04
CPC分类号： C08F230/08 , C08K5/06 , C08L39/06 , G02B1/043 , C08L43/04
摘要： In one aspect, the invention relates to silicone prepolymer compositions comprising a silicone prepolymer and a solvent. A soluble silicone prepolymer can be provided having increased average silicon content, thereby attaining a desired oxygen permeability. A solvent can be provided with a desired balance between hydrophilicity and hydrophobicity by selection and modification of the solvent molecular structure, resulting in molded polymer films and articles that exhibit minimal or nonexistent eye irritation and exhibit highly transparent products. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
摘要翻译：一方面，本发明涉及包含硅氧烷预聚物和溶剂的硅氧烷预聚物组合物。可以提供具有增加的平均硅含量的可溶性硅氧烷预聚物，从而获得所需的氧渗透性。通过选择和改变溶剂分子结构，可以提供亲水性和疏水性之间的所需平衡的溶剂，导致模制的聚合物膜和表现出极少的或不存在的眼睛刺激并且表现出高度透明的产品的制品。该摘要旨在作为用于在特定技术中进行搜索的扫描工具，而不意在限制本发明。

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