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1. 发明授权

US4618607A 1,4-dihydropyridine-3,5-dicarboxylic acid ester derivatives and pharmaceutical compositions 失效
标题翻译： 1,4-二氢吡啶-3,5-二羧酸酯衍生物和药物组合物
公开(公告)号：US4618607A
公开(公告)日：1986-10-21
申请号：US448576
申请日：1982-12-10
申请人： Kazuhiko Araki , Hideki Ao , Jun Inui , Kenichi Aihara
发明人： Kazuhiko Araki , Hideki Ao , Jun Inui , Kenichi Aihara
IPC分类号： C07D211/90 , C07D213/89 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D407/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10 , A61K31/445 , A61K31/55 , C07D401/14
CPC分类号： C07D213/89 , C07D211/90 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/12 , C07D409/04 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/04 , C07D417/12 , C07D491/10
摘要： 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives of the general formula: ##STR1## or acid addition salts thereof, wherein W is --CH.dbd. or --N.dbd.; Y is --CH.dbd.CH--, --O--, --S--, --CH.dbd.N(O)p-- (p is zero or 1) or --N(R)-- (R is hydrogen or lower alkyl); X.sup.1, X.sup.2 and X.sup.3 are the same or different, and are each hydrogen, halogen, nitro, trifluoromethyl, cyano or lower alkylthio; Z is aryl or 5- or 6-membered aromatic heterocyclic ring (which may have a substituent or two or three substituents which may be the same or different, and the substituent may be halogen, lower alkyl, lower alkoxy, lower alkanoylamino, cyano, nitro, lower alkylthio, trifluoromethyl, sulfamoyl, di-lower alkylsulfamoyl, amino or di-lower alkylamino); ##STR2## is 5- to 7-membered heterocyclic ring which may have nitrogen atom, oxygen atom, sulfur atom or unsaturated bond on the ring, and may be substituted by lower alkyl, lower alkoxycarbonyl, lower alkanoylamino, ethylenedioxy or --(CH.sub.2).sub.m --OR.sup.4 (R.sup.4 is hydrogen, lower alkyl or lower alkanoyl and m is 0, 1 or 2); R.sup.1 and R.sup.2 are the same or different, and are each lower alkyl; R.sup.3 is lower alkyl, aralkyl, heteroaralkyl; and n is an integer 1 to 5. Such compounds are useful as antihypertensive agents and as therapeutic agents for cardiac and cerebral circulation disorders.
摘要翻译： 1,4-二氢吡啶-3,5-二羧酸酯衍生物或其酸加成盐，其中W是-CH =或-N =; Y是-CH = CH-，-O-，-S-，-CH = N（O）p - （p是0或1）或-N（R） - （R是氢或低级烷基） X1，X2和X3相同或不同，各自为氢，卤素，硝基，三氟甲基，氰基或低级烷硫基; Z是芳基或5-或6-元芳族杂环（其可以具有取代基或两个或三个可以相同或不同的取代基，并且取代基可以是卤素，低级烷基，低级烷氧基，低级烷酰基氨基，氰基，硝基，低级烷硫基，三氟甲基，氨磺酰基，二低级烷基氨磺酰基，氨基或二低级烷基氨基）。可以在环上具有氮原子，氧原子，硫原子或不饱和键的5-至7-元杂环，并且可被低级烷基，低级烷氧基羰基，低级烷酰基氨基，亚乙二氧基或 - （CH 2） m-OR4（R4是氢，低级烷基或低级烷酰基，m是0,1或2）。 R 1和R 2相同或不同，并且各自为低级烷基; R3是低级烷基，芳烷基，杂芳烷基; 并且n为1至5的整数。这些化合物可用作抗高血压剂和作为心脏和脑循环障碍的治疗剂。

2. 发明授权

US4423052A 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives 失效
标题翻译： 1,4-二氢吡啶-3,5-二羧酸酯衍生物
公开(公告)号：US4423052A
公开(公告)日：1983-12-27
申请号：US387856
申请日：1982-06-01
申请人： Kazuhiko Araki , Hideki Ao , Kenichi Aihara , Tomohiko Kimura
发明人： Kazuhiko Araki , Hideki Ao , Kenichi Aihara , Tomohiko Kimura
IPC分类号： A61K31/455 , A61P9/08 , A61P9/10 , A61P9/12 , C07D211/90 , C07D213/55 , A61K31/44
CPC分类号： C07D211/90
摘要： 1,4-Dihydropyridine-3,5-dicarboxylic acid ester derivatives represented by the formula ##STR1## (wherein Ar.sup.1 and Ar.sup.2 are each the same or different and represent an aryl group; R.sup.1 represents a lower alkyl group; R.sup.2 and R.sup.3 are each the same or different and represent a lower alkyl or aralkyl group; n is 1 or 2; and R.sup.4 represents a lower alkyl) or the acid addition salts thereof. These compounds are useful as antihypertensive agents and as agents for treating the disturbances of cardiac or cerebral circulation.
摘要翻译： PCT No.PCT / JP81 / 00262 Sec。 371日期1982年6月1日 102（e）日期1982年6月1日PCT提交1981年10月2日PCT公布。出版物WO82 / 01185 PCT 1982年4月15日，由式“IMAGE”表示的1,4-二氢吡啶-3,5-二羧酸酯衍生物（其中Ar1和Ar2各自相同或不同，表示芳基; R1表示低级烷基; R2和R3各自相同或不同，表示低级烷基或芳烷基; n为1或2; R4表示低级烷基）或其酸加成盐。这些化合物可用作抗高血压药物和用作治疗心脏或脑循环紊乱的药剂。

3. 发明授权

US4450165A Dihydropyridine compounds 失效
标题翻译：二氢吡啶化合物
公开(公告)号：US4450165A
公开(公告)日：1984-05-22
申请号：US385141
申请日：1982-06-04
申请人： Kazuhiko Araki , Hideki Ao , Tomohiko Kimura , Kenichi Aihara
发明人： Kazuhiko Araki , Hideki Ao , Tomohiko Kimura , Kenichi Aihara
IPC分类号： A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/455 , A61P9/00 , A61P9/08 , A61P9/12 , C07D307/52 , C07D333/20 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , A61K31/47 , C07D213/79 , C07D215/58
CPC分类号： C07D401/12 , C07D307/52 , C07D333/20 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： A dihydropyridine compound of the formula: ##STR1## or a pharmaceutically acceptable acid addition salt thereof, wherein Het is 5- or 6-membered aromatic heteroaryl, R.sup.1 and R.sup.2 are each lower alkyl, R.sup.3 is lower alkyl, R.sup.4 is hydrogen, lower alkyl or aralkyl, R.sup.5 is lower alkyl or aralkyl, and n is 1 or 2. Such compounds are useful as therapeutic agents for myocardial and cerebral ischemic syndroms and hypertension.
摘要翻译：下式的二氢吡啶化合物或其药学上可接受的酸加成盐，其中Het为5-或6-元芳族杂芳基，R 1和R 2各自为低级烷基，R 3为低级烷基，R 4为氢，低级烷基或芳烷基，R5是低级烷基或芳烷基，n是1或2.这些化合物可用作心肌和脑缺血综合征和高血压的治疗剂。

4. 发明授权

US4918074A Polyazaheterocycle compounds 失效
标题翻译：多氮杂环化合物
公开(公告)号：US4918074A
公开(公告)日：1990-04-17
申请号：US154398
申请日：1988-02-10
申请人： Yoshinao Tsuda , Tadashi Mishina , Minoru Obata , Kazuhiko Araki , Jun Inui , Tadao Nakamura
发明人： Yoshinao Tsuda , Tadashi Mishina , Minoru Obata , Kazuhiko Araki , Jun Inui , Tadao Nakamura
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： A polyazaheterocycle compound of the formula: ##STR1## or a pharmaceutically acceptable salt thereof, wherein each symbol is as defined in the specification.Said compounds exhibit calcium antagonistic and/or calcium agonistic activities.
摘要翻译：下式的多元杂环化合物：其中每个符号如说明书中所定义。所述化合物表现出钙拮抗和/或钙激动活性。

5. 发明申请

US20100138573A1 SYSTEM INCLUDING TRANSMITTER AND RECEIVER 审中-公开
标题翻译：包括发射机和接收机的系统
公开(公告)号：US20100138573A1
公开(公告)日：2010-06-03
申请号：US12623522
申请日：2009-11-23
申请人： Yoshihiko Sano , Kouji Sano , Kazuhiko Araki
发明人： Yoshihiko Sano , Kouji Sano , Kazuhiko Araki
IPC分类号： G06F13/42
CPC分类号： H04L1/0082 , H04L1/007 , H04L1/0072 , H04L1/08 , H04L25/14 , H04L2001/0096
摘要： A system includes a transmitter, a receiver and a plurality of paths connecting the transmitter and the receiver, the transmitter being configured to transmit a command and data to the receiver, the transmitter including a plurality of transmitting units that transmit the command and the data, a dividing unit that divides data into a plurality of segments, and that enables each of the transmitting units to transmit each of the segments of the data, and a duplicating unit that duplicates the command, and that enables each of the transmitting units to transmit each of the duplicated commands, the receiver including a plurality of receiving units that receive the command and the data, a merging unit that merges the segments of data back into a data, and a controller that receives the duplicated commands from the transmitting units via the paths.
摘要翻译：系统包括发射机，接收机和连接发射机和接收机的多个路径，发射机被配置为向接收机发送命令和数据，发射机包括发送命令和数据的多个发射单元，分割单元，其将数据分割成多个段，并且使每个发送单元能够发送数据的每个段;以及复制单元，其复制该命令，并且使每个发送单元能够发送每个的复制命令，接收机包括接收命令和数据的多个接收单元，将数据段合并回数据的合并单元以及经由路径从发送单元接收复制命令的控制器。

6. 发明授权

US06428454B1 Tool pot separation type chain 有权
标题翻译：工具罐分离式链条
公开(公告)号：US06428454B1
公开(公告)日：2002-08-06
申请号：US09632421
申请日：2000-08-04
申请人： Hiroshi Yokota , Kazuhiko Araki , Michio Oitaka
发明人： Hiroshi Yokota , Kazuhiko Araki , Michio Oitaka
IPC分类号： B23Q3157
CPC分类号： B23Q3/15526 , B65G17/323 , B65G2201/02 , Y10S483/902 , Y10T483/1809 , Y10T483/1864 , Y10T483/1891
摘要： A tool pot separation type chain for use in a tool magazine includes a plurality of tool pots, and a plurality of pairs of laterally spaced link plates each adjacent ones of which are connected to each other by a connection pin. Each of the pairs of link plates has a tool pot receiving section for removably receiving one of the tool pots therein. Each of the tool pots has a pair of bearings mounted thereon such that outer races of the bearings are movable in rolling contact on a guide rail or a tool pot jumping-out preventing rail provided in an opposing relationship with the guide rail in the tool magazine. With this construction, the tool pot separation type chain is able to minimizes the traveling resistance thereof during carrying of the tool pots to reduce the driving force, prevent abrasion of the tool pots and the rails and suppress generation of noise and also facilitates a carrying in or carrying out operation of each tool pot at a tool pot loading/unloading position.
摘要翻译：用于工具仓的工具罐分离型链包括多个工具罐，以及多对横向隔开的链板，每个连接板通过连接销彼此连接。每对连杆板具有用于可拆卸地容纳其中一个工具罐的工具箱容纳部分。每个工具罐具有安装在其上的一对轴承，使得轴承的外圈可滚动接触地在与工具箱中的导轨相对置的导轨或工具罐跳出防止导轨上移动。利用这种结构，工具罐分离式链条能够在运送工具罐期间使其行进阻力最小化，以减少驱动力，防止工具罐和导轨的磨损，并且抑制噪音的产生，并且还便于携带或在工具箱装载/卸载位置执行每个工具罐的操作。

7. 发明授权

US4889857A Quinolonecarboxylic acid compounds and pharmaceutical use thereof 失效
标题翻译：喹诺酮羧酸化合物及其药物用途
公开(公告)号：US4889857A
公开(公告)日：1989-12-26
申请号：US250634
申请日：1988-09-29
申请人： Kazuhiko Araki , Tsuyoshi Kuroda , Satoru Uemori , Akihiko Moriguchi , Yoshifumi Ikeda
发明人： Kazuhiko Araki , Tsuyoshi Kuroda , Satoru Uemori , Akihiko Moriguchi , Yoshifumi Ikeda
IPC分类号： C07D413/04
CPC分类号： C07D413/04
摘要： A quinolonecarboxylic acid compound of the formula: ##STR1## wherein R.sup.1 is an alkyl group, a cycloalkyl group, a haloalkyl group, an alkenyl group, mono- or di-alkylamino groups, a phenyl group or a phenyl group substituted by one to three substituents selected from the group consisting of a halogen atom, an alkyl group, an alkoxy group, a hydroxy group, a nitro group or an amino group, R.sup.2 is a hydrogen atom, an alkyl group, a cycloalkyl group, an acyl group or an alkoxycarbonyl group, R.sup.3 is a hydrogen atom, an alkyl group or an aralkyl group, or R.sup.2 and R.sup.3 together with the adjacent nitrogen atom form a heterocyclic ring, R.sup.4 is a hydrogen atom or an alkyl group, R.sup.5 is a hydrogen atom, an alkyl group, an aralkyl group or an ester residue which is readily hydrolyzable in vivo, X is a hydrogen atom, a halogen atom or an alkyl group, n is interger of 1 to 3, and a salt thereof, and pharmaceutical use thereof.The compounds exhibit antibacterial activites and are useful for the treatment of various infectious diseases.

8. 发明申请

US20120064228A1 FORMING METHOD OF LIGHT EXTRACTING STRUCTURE, LIGHT-EMITTING SUBSTRATE HAVING LIGHT EXTRACTING STRUCTURE, AND MANUFACTURING METHOD OF IMAGE DISPLAY APPARATUS 审中-公开
标题翻译：光提取结构的形成方法，具有光提取结构的发光基板和图像显示装置的制造方法
公开(公告)号：US20120064228A1
公开(公告)日：2012-03-15
申请号：US13216764
申请日：2011-08-24
申请人： Shin Kitamura , Kazuhiko Araki , Shuji Yamada , Osamu Takamatsu
发明人： Shin Kitamura , Kazuhiko Araki , Shuji Yamada , Osamu Takamatsu
IPC分类号： B05D5/06
CPC分类号： H01J9/20
摘要： A light extracting structure which can efficiently extract light emitted from a light-emitting layer. A capture layer is formed onto a first translucent material film formed on a substrate. A dispersion liquid obtained by dispersing particles into a dispersion medium is coated onto the capture layer. The dispersion medium is volatilized. A particle sediment layer is formed onto the capture layer. The particles in the lowest layer of the sediment layer are captured into the capture layer at a filling rate of 93% or more for the 2-dimensional closest packing. The non-captured particles are removed. An etching is performed by using the captured particles as a mask. Concave portions are formed in the first translucent material film. The particles remaining after the etching and the capture layer are removed. Thereafter, the concave portions are embedded with a second translucent material having a different refractive index.
摘要翻译：能够有效地提取从发光层发出的光的光提取结构。捕获层形成在形成在基板上的第一半透明材料膜上。将分散在分散介质中的分散液涂布在捕获层上。分散介质挥发。在捕获层上形成颗粒沉积层。沉积层最低层中的颗粒以二维最接近填料的填充率为93％以上被捕获到捕获层中。去除未捕获的颗粒。通过使用捕获的粒子作为掩模来进行蚀刻。在第一半透明材料膜中形成凹部。去除蚀刻后残留的颗粒和捕获层。此后，凹部嵌入具有不同折射率的第二半透明材料。

9. 发明授权

US4010184A Thienodiazepines 失效
标题翻译：噻吩二氮
公开(公告)号：US4010184A
公开(公告)日：1977-03-01
申请号：US453117
申请日：1974-03-20
申请人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
发明人： Michio Nakanishi , Kazuhiko Araki , Tetsuya Tahara , Masami Shiroki
IPC分类号： C07D495/04 , C07D333/24
CPC分类号： C07D495/04
摘要： Thienodiazepines of the formula: ##STR1## wherein Ar is mono- or di-substituted phenyl [the substituents(s) being H, halogen, C.sub.1.sub.-4 alkyl or C.sub.1.sub.-4 alkoxy] or pyridyl; R.sup.1 is H or C.sub.1.sub.-4 alkyl; R.sup.2 is H, halogen or C.sub.1.sub.-4 alkyl; or R.sup.1 and R.sup.2 combinedly form -(CH.sub.2).sub.4 -; each of R.sup.3 and R.sup.4 is C.sub.1.sub.-4 alkyl, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form a heterocyclic group; A is C.sub.2.sub.-4 alkylene; and n is an integer of zero and 1; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as analgesics.
摘要翻译：其中Ar是单取代或二取代的苯基[取代基是H，卤素，C 1-4烷基或C 1-4烷氧基]或吡啶基; R1是H或C1-4烷基; R2是H，卤素或C1-4烷基; 或R 1和R 2结合形成 - （CH 2）4 - ; R 3和R 4各自为C 1-4烷基，或者R 3和R 4与相邻的氮原子一起形成杂环基; A是C 2-4亚烷基; 并且n是0和1的整数; 及其药学上可接受的酸加成盐。它们作为止痛剂是有用的。

10. 发明授权

US3952006A Thiophene derivatives 失效
标题翻译：噻吩衍生物
公开(公告)号：US3952006A
公开(公告)日：1976-04-20
申请号：US386819
申请日：1973-08-08
申请人： Tetsuya Tahara , Hideo Matsuki , Kazuhiko Araki , Masami Shiroki
发明人： Tetsuya Tahara , Hideo Matsuki , Kazuhiko Araki , Masami Shiroki
IPC分类号： C07D495/04 , C07D495/14 , C07D417/04
CPC分类号： C07D495/04 , C07D495/14
摘要： Thiophene derivatives of the formula: ##SPC1##Wherein R.sup.1 is H or CH.sub.3 ; R.sup.2 is CH.sub.3 or C.sub.2 H.sub.5, or R.sup.1 and R.sup.2 combinedly represent --(CH.sub.2).sub.4 --; each of R.sup.3 and R.sup.4 is H, alkyl of from 1 to 4 carbon atoms or cyclohexyl, or R.sup.3 and R.sup.4 together with the adjacent nitrogen atom form 1-pyrrolidinyl, piperidino, 4-methyl-1-piperazinyl or morpholino; X is H, halogen or OCH.sub.3 ; A is -CH= or --C(CH.sub.3)=, and B is =N-- or =CH--; or A is --C(CH.sub.2 OH)= or --N=, and B is =N--, and pharmaceutically acceptable acid addition salts thereof possess excellent pharmacological properties such as sedative, anxiolytic and anticonvulsant effects and protective effects against hypoxia or anoxia.
摘要翻译：下式的噻吩衍生物：

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