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1. 发明申请

US20050020658A1 Selective cyclooxygenase-2 inhibitor patch 审中-公开
标题翻译：选择性环加氧酶-2抑制剂贴片
公开(公告)号：US20050020658A1
公开(公告)日：2005-01-27
申请号：US10683623
申请日：2003-10-10
申请人： Katsuyuki Inoo , Ken-Ichi Hattori , Noriko Shimizu
发明人： Katsuyuki Inoo , Ken-Ichi Hattori , Noriko Shimizu
IPC分类号： A61K9/70 , A61K31/415 , A61K31/42 , A61K31/18
CPC分类号： A61K9/7053 , A61K9/7061 , A61K9/7076 , A61K31/415 , A61K31/42
摘要： A pharmaceutical composition for application to an area of skin of a subject for local and/or systemic treatment of a COX-2 mediated disorder comprises a backing sheet that is flexibly conformable to the area of skin, the backing sheet having opposing surfaces that are respectively distal and proximal to the skin when applied; and a coating on the proximal surface of the backing sheet that comprises (a) an adhesive, (b) an active agent comprising a selective COX-2 inhibitory sulfonamide drug of low water solubility, and (c) a solvent system for the active agent, wherein the active agent is in a therapeutically effective total amount and the solvent system is selected with regard to composition and amount thereof to be effective to maintain the active agent substantially completely in solubilized form. A method of local treatment of a site of pain and/or inflammation in a subject comprises applying the composition to a skin surface of the subject, preferably at a locus overlying or adjacent to the site of pain and/or inflammation, and leaving the composition in place for a time period effective to permit delivery of a locally therapeutic amount of the active agent. A method of systemic treatment of a subject having a COX-2 mediated disorder comprises applying the composition to a skin surface of the subject, and leaving the composition in place for a time period effective to permit transdermal delivery of a therapeutic amount of the active agent.
摘要翻译：用于局部和/或全身治疗COX-2介导的病症的受试者皮肤区域的药物组合物包括柔性地适应皮肤区域的背衬片，背衬片分别具有相对的表面应用时远端和皮肤近端; 和背衬片的近侧表面上的涂层，其包含（a）粘合剂，（b）包含低水溶性的选择性COX-2抑制性磺酰胺药物的活性剂，和（c）活性剂的溶剂体系其中活性剂处于治疗有效的总量，并且关于其组成和量的选择溶剂体系以有效地维持活性剂基本上完全为溶解形式。局部治疗受试者的疼痛和/或炎症部位的方法包括将组合物施用于受试者的皮肤表面，优选在位于疼痛和/或炎症部位的上方或邻近的部位，并使组合物在一段时间内有效地允许递送局部治疗量的活性剂。具有COX-2介导的病症的受试者的全身治疗的方法包括将组合物施用于受试者的皮肤表面，并将组合物置于适当的时间段，以有效地允许经皮递送治疗量的活性剂。

2. 发明申请

US20110002967A1 Methods of Transdermally Administering an Indole Serotonin Receptor Agonist and Transdermal Compositions for Use in the Same 失效
标题翻译：透皮给药吲哚类5-羟色胺受体激动剂和透皮组合物的方法
公开(公告)号：US20110002967A1
公开(公告)日：2011-01-06
申请号：US12877848
申请日：2010-09-08
申请人： Kunio Yoneto , Katsuyuki Inoo
发明人： Kunio Yoneto , Katsuyuki Inoo
IPC分类号： A61K31/422 , A61K9/00 , A61P29/00
CPC分类号： A61K31/405 , A61K9/7053 , A61K9/7061
摘要： Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin receptor agonist to an individual in need thereof, are provided. Also provided are transdermal formulations of indole serotonin receptor agonists that find use in practicing the subject methods.
摘要翻译：提供了将治疗量的吲哚5-羟色胺受体激动剂透皮递送给有需要的个体的方法，例如向有需要的个体提供治疗水平的吲哚5-羟色胺受体激动剂。还提供了可用于实践本发明方法的吲哚5-羟色胺受体激动剂的透皮制剂。

3. 发明授权

US08609134B2 Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same 失效
标题翻译：透皮给药吲哚类5-羟色胺受体激动剂的方法和用于其中的透皮组合物
公开(公告)号：US08609134B2
公开(公告)日：2013-12-17
申请号：US12877848
申请日：2010-09-08
申请人： Kunio Yoneto , Katsuyuki Inoo
发明人： Kunio Yoneto , Katsuyuki Inoo
IPC分类号： A61K9/70 , A61F13/00
CPC分类号： A61K31/405 , A61K9/7053 , A61K9/7061
摘要： Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin receptor agonist to an individual in need thereof, are provided. Also provided are transdermal formulations of indole serotonin receptor agonists that find use in practicing the subject methods.
摘要翻译：提供了将治疗量的吲哚5-羟色胺受体激动剂透皮递送给有需要的个体的方法，例如向有需要的个体提供治疗水平的吲哚5-羟色胺受体激动剂。还提供了可用于实践本发明方法的吲哚5-羟色胺受体激动剂的透皮制剂。

4. 发明申请

US20110160194A1 Anti-Inflammatory Analgesic External Preparation 审中-公开
标题翻译：抗炎镇痛外用药
公开(公告)号：US20110160194A1
公开(公告)日：2011-06-30
申请号：US12999164
申请日：2009-06-12
申请人： Katsuyuki Inoo , Mitsuhiro Kawada
发明人： Katsuyuki Inoo , Mitsuhiro Kawada
IPC分类号： A61K31/5415 , A61K31/405 , A61K31/192 , A61K31/196 , A61K31/24 , A61K31/381 , A61P25/00
CPC分类号： A61K9/7038 , A61K9/7023 , A61K31/165 , A61K31/192 , A61K31/245 , A61K31/381 , A61K31/405 , A61K31/5415 , A61K45/06 , A61K2300/00
摘要： An external preparation that effectively produces the anti-inflammatory analgesic effect of a non-steroidal anti-inflammatory analgesic agent, and reduces skin irritation on the application site of the preparation and has an excellent effect on pain associated with inflammation such as chronic rheumatoid arthritis, osteoarthritis, and also lumbago is provided. The external preparation includes a non-steroidal anti-inflammatory analgesic agent and oxybuprocaine or a pharmaceutically acceptable salt thereof. The external preparation includes the non-steroidal anti-inflammatory analgesic agent at a content of 0.1 to 10 wt % based on the total weight of the formulation and oxybuprocaine or a pharmaceutically acceptable salt thereof at a content of 0.01 to 60 wt % based on the total weight of the formulation. The external preparation has a dosage form as an external preparation wherein the dosage form is an ointment, a solution, a suspension, an emulsion, a lotion, a cataplasm, a tape, an aerosol, or a powder for external use.
摘要翻译：一种外用制剂，其有效地产生非甾体抗炎止痛剂的消炎镇痛作用，并减少制剂施用部位的皮肤刺激，并且对与炎症有关的疼痛具有优异的作用，例如慢性类风湿性关节炎，骨关节炎，还有腰痛。外用制剂包括非类固醇消炎止痛剂和羟普鲁卡因或其药学上可接受的盐。外用制剂包括非甾体抗炎止痛剂，其含量为0.1至10重量％，基于制剂的总重量和基于以下物质的0.01-60重量％的奥布对卡因或其药学上可接受的盐制剂的总重量。外用制剂具有作为外用制剂的剂型，其中剂型为软膏剂，溶液剂，悬浮液剂，乳剂剂，洗剂剂，粘膜剂，胶带剂，气雾剂或外用粉剂。

5. 发明授权

US07816394B2 Methods of transdermally administering an indole serotonin receptor agonist and transdermal compositions for use in the same 失效
标题翻译：透皮给药吲哚类5-羟色胺受体激动剂的方法和用于其中的透皮组合物
公开(公告)号：US07816394B2
公开(公告)日：2010-10-19
申请号：US11561235
申请日：2006-11-17
申请人： Kunio Yoneto , Katsuyuki Inoo
发明人： Kunio Yoneto , Katsuyuki Inoo
IPC分类号： A61K31/40 , A61K31/42 , A01N57/00 , A01N43/52 , C07D211/26 , A01N43/76 , A61F13/02 , A61L15/16
CPC分类号： A61K31/405 , A61K9/7053 , A61K9/7061
摘要： Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin receptor agonist to an individual in need thereof, are provided. Also provided are transdermal formulations of indole serotonin receptor agonists that find use in practicing the subject methods.
摘要翻译：提供了将治疗量的吲哚5-羟色胺受体激动剂透皮递送给有需要的个体的方法，例如向有需要的个体提供治疗水平的吲哚5-羟色胺受体激动剂。还提供了可用于实践本发明方法的吲哚5-羟色胺受体激动剂的透皮制剂。

6. 发明申请

US20070140977A1 METHODS OF TRANSDERMALLY ADMINISTERING AN INDOLE SEROTONIN RECEPTOR AGONIST AND TRANSDERMAL COMPOSITIONS FOR USE IN THE SAME 失效
标题翻译：一种用于使用内含子糖蛋白受体激动剂和变态组合物进行转导的方法
公开(公告)号：US20070140977A1
公开(公告)日：2007-06-21
申请号：US11561235
申请日：2006-11-17
申请人： Kunio Yoneto , Katsuyuki Inoo
发明人： Kunio Yoneto , Katsuyuki Inoo
IPC分类号： A61K31/405 , A61K9/12
CPC分类号： A61K31/405 , A61K9/7053 , A61K9/7061
摘要： Methods of transdermally delivering a therapeutic amount of an indole serotonin receptor agonist to an individual in need thereof, e.g., to provide a therapeutic level of an indole serotonin receptor agonist to an individual in need thereof, are provided. Also provided are transdermal formulations of indole serotonin receptor agonists that find use in practicing the subject methods.
摘要翻译：提供了将治疗量的吲哚5-羟色胺受体激动剂透皮递送给有需要的个体的方法，例如向有需要的个体提供治疗水平的吲哚5-羟色胺受体激动剂。还提供了可用于实践本发明方法的吲哚5-羟色胺受体激动剂的透皮制剂。

7. 发明授权

US09833417B2 Felbinac-containing external patch 有权
公开(公告)号：US09833417B2
公开(公告)日：2017-12-05
申请号：US13882747
申请日：2011-11-01
申请人： Katsuyuki Inoo
发明人： Katsuyuki Inoo
IPC分类号： A61K9/70 , A61K31/192
CPC分类号： A61K9/7007 , A61K9/7053 , A61K31/192
摘要： Provided is a felbinac-containing external patch which can exhibit high drug release properties, low skin irritation, and high drug stability, wherein felbinac having an average particle diameter of 5 μm or more and less than 100 μm is dispersed and mixed in an adhesive base including a styrene-isoprene-styrene block copolymer, an alicyclic saturated hydrocarbon resin, a softener, and diethyl sebacate, and does not contain L-menthol. Specifically, in the felbinac-containing external patch, 0.1 to 10% by weight of felbinac having an average particle diameter of 5 μm or more and less than 100 μm is dispersed and mixed in an adhesive base including 10 to 30% by weight of a styrene-isoprene-styrene block copolymer, 10 to 50% by weight of an alicyclic saturated hydrocarbon resin, 10 to 75% by weight of a softener, and 0.1 to 10% by weight of diethyl sebacate.

8. 外观设计

USD692151S1 Adhesive skin patch 有权
公开(公告)号：USD692151S1
公开(公告)日：2013-10-22
申请号：US29431134
申请日：2012-09-04
申请人： Katsuyuki Inoo
设计人： Katsuyuki Inoo

9. 发明申请

US20110124727A1 Oxybuprocaine-Containing Analgesic/Antipruritic External Preparation 审中-公开
标题翻译：含有奥泊普卡因的镇痛/止痒剂外用制剂
公开(公告)号：US20110124727A1
公开(公告)日：2011-05-26
申请号：US12999195
申请日：2009-06-12
申请人： Katsuyuki Inoo , Mitsuhiro Kawada , Kenjiro Mori
发明人： Katsuyuki Inoo , Mitsuhiro Kawada , Kenjiro Mori
IPC分类号： A61K31/245 , C07C229/64 , A61P29/00 , A61P17/00 , A61P17/04
CPC分类号： A61K9/7053 , A61K9/7076 , A61K31/13 , A61K31/245
摘要： An analgesic/antipruritic external preparation that includes a local anesthetic, has fewer side effects, and has an excellent therapeutic effect on pain and itching of the skin is provided. The analgesic/antipruritic external preparation includes oxybuprocaine or a pharmaceutically acceptable salt thereof as an active ingredient, and the oxybuprocaine or a pharmaceutically acceptable salt thereof is contained in an amount of 0.1 to 60 wt %, more preferably 1 to 40 wt %, and most preferably 5 to 30 wt %. The analgesic/antipruritic external preparation has a dosage form as an external preparation wherein the dosage form is an ointment, a solution, a suspension, an emulsion, a lotion, a cataplasm, a tape, an aerosol, or a powder for external use.
摘要翻译：提供了包含局部麻醉剂的镇痛/止痒剂外用剂，副作用较少，对疼痛和皮肤瘙痒具有优异的治疗作用。止痛/止痒剂外用制剂包括活性成分的布比卡因或其药学上可接受的盐，并且含有布比卡因或其药学上可接受的盐的含量为0.1〜60重量％，更优选为1〜40重量％优选为5〜30重量％。止痛/止痒外用制剂具有作为外用制剂的剂型，其中剂型为软膏剂，溶液剂，悬浮液剂，乳剂剂，洗剂剂，粘膜剂，胶带剂，气雾剂或外用粉剂。

10. 发明授权

US09119861B2 Piroxicam-containing transdermally absorbable preparation 有权
标题翻译：含吡罗昔康的经皮吸收制剂
公开(公告)号：US09119861B2
公开(公告)日：2015-09-01
申请号：US13516014
申请日：2010-12-14
申请人： Akiko Katayama , Katsuyuki Inoo
发明人： Akiko Katayama , Katsuyuki Inoo
IPC分类号： A61K31/5415 , A61P29/00 , A61K31/245 , A61K9/70
CPC分类号： A61K31/5415 , A61K9/7053 , A61K31/245 , A61K2300/00
摘要： An adhesive patch is provided in which piroxicam is formulated as a non-steroidal anti-inflammatory analgesic. In particular, provided is a piroxicam-containing transdermally absorbable adhesive patch in which an absorption promoter to piroxicam is formulated to achieve high anti-inflammatory and analgesic effects without inhibiting releasing of these drugs. The piroxicam-containing transdermally absorbable adhesive patch contains piroxicam as a medicinal component and oxybuprocaine or a pharmaceutically acceptable salt thereof as an absorption promoter. In the piroxicam-containing transdermally absorbable adhesive patch, the content of piroxicam is from 0.1% to 5% by weight to the total weight of a drug-containing plaster and the content of oxybuprocaine or the pharmaceutically acceptable salt thereof is from 1% to 30% by weight to the total weight of the drug-containing plaster.
摘要翻译：提供了一种胶粘贴剂，其中吡罗昔康被配制成非甾体抗炎止痛剂。特别地，提供了含有喜树毒素的透皮吸收性粘合贴剂，其中将吡罗昔康的吸收促进剂配制成达到高抗炎和止痛作用而不抑制这些药物的释放。含有喜树碱的透皮吸收性粘合剂贴剂含有作为药物成分的吡罗昔康和作为吸收促进剂的氧麻黄碱或其药学上可接受的盐。在含有喜树毒素的透皮吸收性贴剂中，炎痛喜树碱的含量相对于含药膏体的总重量为0.1〜5重量％，并且奥布卡因或其药学上可接受的盐的含量为1〜30 相对于含药膏药的总重量的重量百分比。

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