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1. 发明授权

US09001321B2 Microscope and observation method 有权
标题翻译：显微镜和观察方法
公开(公告)号：US09001321B2
公开(公告)日：2015-04-07
申请号：US13578164
申请日：2011-02-08
申请人： Katsumasa Fujita , Shogo Kawano , Masahito Yamanaka , Satoshi Kawata
发明人： Katsumasa Fujita , Shogo Kawano , Masahito Yamanaka , Satoshi Kawata
IPC分类号： G01J3/44 , G02B21/00 , G01N21/65
CPC分类号： G02B21/002 , G01N2021/653 , G01N2021/655 , G02B2207/114
摘要： Provided is a microscope and an observation method which can improve spatial resolution. A microscope according to an aspect of the invention includes a laser light source (10), an objective lens (16) that focuses light from the laser light source on a sample, and a detector (22) that detects the laser light as signal light from a sample (17) when the sample (17) is irradiated with the laser light. The light is applied to the sample with an intensity changed to obtain a nonlinear region where intensities of the light and the signal light have a nonlinear relation due to occurrence of saturation or nonlinear increase of the signal light when the light has a maximum intensity, and the detector (22) detects the signal light according to the intensity of the laser light to perform observation based on a saturation component or a nonlinear increase component of the signal light.
摘要翻译：提供了可以提高空间分辨率的显微镜和观察方法。根据本发明的一个方面的显微镜包括激光源（10），将来自激光光源的光聚焦在样本上的物镜（16）以及检测器（22），其将激光检测为信号光来自样品（17）当样品（17）被激光照射时。将光以强度变化的方式施加到样品，以获得非线性区域，其中当光具有最大强度时，光和信号光的强度由于饱和度的发生或信号光的非线性增加而具有非线性关系，以及检测器（22）根据激光的强度检测信号光，以基于信号光的饱和分量或非线性增加分量进行观察。

2. 发明申请

US20120307238A1 MICROSCOPE AND OBSERVATION METHOD 有权
标题翻译：显微镜和观察方法
公开(公告)号：US20120307238A1
公开(公告)日：2012-12-06
申请号：US13578164
申请日：2011-02-08
申请人： Katsumasa Fujita , Shogo Kawano , Masahito Yamanaka , Satoshi Kawata
发明人： Katsumasa Fujita , Shogo Kawano , Masahito Yamanaka , Satoshi Kawata
IPC分类号： G02B21/14 , G01J3/44 , G01N21/59 , G01N21/17 , G01N21/47 , G01J3/50
CPC分类号： G02B21/002 , G01N2021/653 , G01N2021/655 , G02B2207/114
摘要： Provided is a microscope and an observation method which can improve spatial resolution. A microscope according to an aspect of the invention includes a laser light source (10), an objective lens (16) that focuses light from the laser light source on a sample, and a detector (22) that detects the laser light as signal light from a sample (17) when the sample (17) is irradiated with the laser light. The light is applied to the sample with an intensity changed to obtain a nonlinear region where intensities of the light and the signal light have a nonlinear relation due to occurrence of saturation or nonlinear increase of the signal light when the light has a maximum intensity, and the detector (22) detects the signal light according to the intensity of the laser light to perform observation based on a saturation component or a nonlinear increase component of the signal light.
摘要翻译：提供了可以提高空间分辨率的显微镜和观察方法。根据本发明的一个方面的显微镜包括激光源（10），将来自激光光源的光聚焦在样本上的物镜（16）以及检测器（22），其将激光检测为信号光来自样品（17）当样品（17）被激光照射时。将光以强度变化的方式施加到样品，以获得非线性区域，其中当光具有最大强度时，光和信号光的强度由于饱和度的发生或信号光的非线性增加而具有非线性关系，以及检测器（22）根据激光的强度检测信号光，以基于信号光的饱和分量或非线性增加分量进行观察。

3. 发明申请

US20100323293A1 Optical recording material, optical recording method, photosensitive material, photolithography method, photopolymerization initiator, and photosensitizer 有权
标题翻译：光记录材料，光记录方法，感光材料，光刻法，光聚合引发剂和光敏剂
公开(公告)号：US20100323293A1
公开(公告)日：2010-12-23
申请号：US12735579
申请日：2009-01-28
申请人： Katsumasa Fujita , Minoru Kobayashi , Kazuya Kikuchi , Shin Mizukami , Satoshi Kawata , Shogo Kawano
发明人： Katsumasa Fujita , Minoru Kobayashi , Kazuya Kikuchi , Shin Mizukami , Satoshi Kawata , Shogo Kawano
IPC分类号： G03F7/004 , G03F7/20
CPC分类号： G03F7/028 , G02F1/0063 , G02F1/3526 , G03F7/2053 , G11B7/245 , G11B7/2467 , G11B2007/24624
摘要： Provided is a nonlinear optical material, an optical recording material, an optical recording method, a photosensitive material, a photopolymerization initiator, and a photosensitizer. One exemplary aspect of the present invention is a photosensitive material used for photolithography for forming a pattern by irradiating a photoresist with excitation light which includes a donor molecule 11 that is excited by the excitation light, and an acceptor molecule 12 that is excited by energy transfer or charge transfer from the excited donor 11.
摘要翻译：提供了非线性光学材料，光学记录材料，光学记录方法，感光材料，光聚合引发剂和光敏剂。本发明的一个示例性方面是用于光刻的感光材料，用于通过用激发光照射光致抗蚀剂来形成图案，所述激发光包括由激发光激发的施主分子11和受能量转移而被激发的受主分子12 或从受激供体11的电荷转移。

4. 发明授权

US08518631B2 Optical recording material, optical recording method, photosensitive material and method 有权
标题翻译：光记录材料，光记录方法，感光材料及方法
公开(公告)号：US08518631B2
公开(公告)日：2013-08-27
申请号：US12735579
申请日：2009-01-28
申请人： Katsumasa Fujita , Minoru Kobayashi , Kazuya Kikuchi , Shin Mizukami , Satoshi Kawata , Shogo Kawano
发明人： Katsumasa Fujita , Minoru Kobayashi , Kazuya Kikuchi , Shin Mizukami , Satoshi Kawata , Shogo Kawano
IPC分类号： G03F7/004 , G11B7/24 , G03C1/73
CPC分类号： G03F7/028 , G02F1/0063 , G02F1/3526 , G03F7/2053 , G11B7/245 , G11B7/2467 , G11B2007/24624
摘要： Provided is a nonlinear optical material, an optical recording material, an optical recording method, a photosensitive material, a photopolymerization initiator, and a photosensitizer. One exemplary aspect of the present invention is a photosensitive material used for photolithography for forming a pattern by irradiating a photoresist with excitation light which includes a donor molecule 11 that is excited by the excitation light, and an acceptor molecule 12 that is excited by energy transfer or charge transfer from the excited donor 11.
摘要翻译：提供了非线性光学材料，光学记录材料，光学记录方法，感光材料，光聚合引发剂和光敏剂。本发明的一个示例性方面是用于光刻的感光材料，用于通过用激发光照射光致抗蚀剂来形成图案，所述激发光包括由激发光激发的施主分子11和受能量转移而被激发的受主分子12 或从受激供体11的电荷转移。

5. 发明授权

US08940906B2 Nonlinear luminescent molecule, fluorescent stain, and observation method 有权
标题翻译：非线性发光分子，荧光染料和观察方法
公开(公告)号：US08940906B2
公开(公告)日：2015-01-27
申请号：US13380749
申请日：2010-06-21
申请人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
发明人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
IPC分类号： C07F5/02 , G01N21/64 , C09B23/04 , C09B57/10
CPC分类号： C07F5/022 , C09B23/04 , C09B57/10 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to a nonlinear fluorescent molecule that generates a nonlinear fluorescence reaction by incidence of excitation light. This nonlinear fluorescence molecule includes donors and, and an acceptor that is coupled to the donors and. As the donor is excited by the incidence of the excitation light, electric charge moves from the donor to the acceptor. Then, the donor and the acceptor form a charge separated state. In a state in which the charge separated state is maintained, the donor fluoresces when transiting from an excited state to a ground state.
摘要翻译：本发明涉及通过激发光的入射产生非线性荧光反应的非线性荧光分子。这种非线性荧光分子包括供体和与供体偶联的受体。当供体被激发光的发生激发时，电荷从供体移动到受体。然后，供体和受体形成电荷分离状态。在保持电荷分离状态的状态下，当从激发态转变为基态时，供体发荧光。

6. 发明申请

US20120107960A1 NONLINEAR LUMINESCENT MOLECULE, FLUORESCENT STAIN, AND OBSERVATION METHOD(AS AMENDED) 有权
标题翻译：非线性荧光分子，荧光染料和观察方法（如修改）
公开(公告)号：US20120107960A1
公开(公告)日：2012-05-03
申请号：US13380749
申请日：2010-06-21
申请人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
发明人： Katsumasa Fujita , Shin Mizukami , Kazuya Kikuchi , Satoshi Kawata , Shogo Kawano
IPC分类号： G01N21/64 , C09K11/06 , C09B51/00
CPC分类号： C07F5/022 , C09B23/04 , C09B57/10 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , G01N2021/6441
摘要： The present invention relates to a nonlinear fluorescent molecule that generates a nonlinear fluorescence reaction by incidence of excitation light. This nonlinear fluorescence molecule includes donors and, and an acceptor that is coupled to the donors and. As the donor is excited by the incidence of the excitation light, electric charge moves from the donor to the acceptor. Then, the donor and the acceptor form a charge separated state. In a state in which the charge separated state is maintained, the donor fluoresces when transiting from an excited state to a ground state.
摘要翻译：本发明涉及通过激发光的入射产生非线性荧光反应的非线性荧光分子。这种非线性荧光分子包括供体和与供体偶联的受体。当供体被激发光的发生激发时，电荷从供体移动到受体。然后，供体和受体形成电荷分离状态。在保持电荷分离状态的状态下，当从激发态转变为基态时，供体发荧光。

7. 发明申请

US20100232459A1 Pulse Laser Light Timing Adjusting Device, Adjusting Method, and Optical Microscope 审中-公开
标题翻译：脉冲激光定时调节装置，调节方法和光学显微镜
公开(公告)号：US20100232459A1
公开(公告)日：2010-09-16
申请号：US12227412
申请日：2006-11-20
申请人： Mamoru Hashimoto , Takeo Minamikawa , Naoki Tanimoto , Minoru Kobayashi , Katsumasa Fujita , Satoshi Kawata , Tsutomu Araki
发明人： Mamoru Hashimoto , Takeo Minamikawa , Naoki Tanimoto , Minoru Kobayashi , Katsumasa Fujita , Satoshi Kawata , Tsutomu Araki
IPC分类号： G02F1/35
CPC分类号： G01J3/44 , G01J3/10 , G01J11/00 , G01N2021/653 , H01S3/139 , H01S3/2383
摘要： To provide a pulse laser light timing adjusting device capable of easily adjusting pulse laser light timing, a timing adjusting method, and an optical microscope. An optical microscope in accordance with the present invention includes mirror pairs 21 and 31 to generates the first timing adjusting optical beam in which the first pulse laser light ω1 is delayed from the second pulse laser light ω2 and the second timing adjusting optical beam in which the second pulse laser light ω2 is delayed from the first pulse laser light having a first wavelength from the optical beam extracted at the beam samplers 15 and 16, a first detector 23 and a second detector 33 to output a first detection signal and a second detection signal based on a nonlinear optical effect, and timing adjusting means 42 to adjust the timing based on the first detection signal and the second detection signal.
摘要翻译：提供能够容易地调整脉冲激光定时的脉冲激光定时调整装置，定时调整方法和光学显微镜。根据本发明的光学显微镜包括镜对21和31，用于产生第一定时调整光束，其中第一脉冲激光光源ω1从第二脉冲激光光源ω2延迟，第二定时调整光束第二脉冲激光器ω2从具有第一波长的第一脉冲激光从在光束采样器15和16处提取的光束被延迟，第一检测器23和第二检测器33输出第一检测信号和第二检测信号以及基于第一检测信号和第二检测信号来调整定时的定时调整装置42。

8. 发明申请

US20080215272A1 Fluorescence Microscope and Fluorescence Microscope Method 有权
标题翻译：荧光显微镜和荧光显微镜法
公开(公告)号：US20080215272A1
公开(公告)日：2008-09-04
申请号：US11792304
申请日：2005-10-14
申请人： Katsumasa Fujita , Satoshi Kawata , Naoko Nakamura , Osamu Nakamura , Minoru Kobayashi
发明人： Katsumasa Fujita , Satoshi Kawata , Naoko Nakamura , Osamu Nakamura , Minoru Kobayashi
IPC分类号： G06F15/00
CPC分类号： G01N21/6458 , G01N21/6408 , G01N21/6428 , G01N2201/0697 , G02B21/16
摘要： To increase spatial resolution by observing a sample based on saturated fluorescence components. A fluorescence microscope according to the present invention includes: a laser light source 10 emitting laser light as excitation light; an objective lens 13 focusing the laser light and applying the focused laser light to a sample 14; a detector 22 detecting fluorescence generated in the sample 14 with the laser light; and a stage 15 scanning the sample 14 while moving the sample 14 relative to the laser light, wherein the laser light is applied to the sample with varying intensities such that saturation of fluorescence occurs at the maximum intensity of the laser light, and fluorescence is detected with the detector in accordance with intensity of the laser light, and the sample is observed based on the saturation components of fluorescence.
摘要翻译：通过观察基于饱和荧光成分的样品来增加空间分辨率。根据本发明的荧光显微镜包括：发射激光作为激发光的激光光源10; 聚焦激光并将聚焦的激光施加到样品14的物镜13; 用激光检测样品14中产生的荧光的检测器22; 以及在样品14相对于激光移动的同时扫描样品14的阶段15，其中激光以不同的强度施加到样品，使得在激光的最大强度下发生荧光饱和，并且检测到荧光与检测器根据激光的强度，并且基于荧光的饱和分量观察样品。

9. 发明授权

US07781711B2 Fluorescence microscope for which a sample is observed based on the saturation components of fluorescence and fluorescence microscopy method 有权
标题翻译：基于荧光和荧光显微镜法的饱和组分观察样品的荧光显微镜
公开(公告)号：US07781711B2
公开(公告)日：2010-08-24
申请号：US11792304
申请日：2005-10-14
申请人： Katsumasa Fujita , Satoshi Kawata , Osamu Nakamura , Naoko Nakamura, legal representative , Minoru Kobayashi
发明人： Katsumasa Fujita , Satoshi Kawata , Osamu Nakamura , Minoru Kobayashi
IPC分类号： G02B7/04
CPC分类号： G01N21/6458 , G01N21/6408 , G01N21/6428 , G01N2201/0697 , G02B21/16
摘要： To increase spatial resolution by observing a sample based on saturated fluorescence components. A fluorescence microscope according to the present invention includes: a laser light source 10 emitting laser light as excitation light; an objective lens 13 focusing the laser light and applying the focused laser light to a sample 14; a detector 22 detecting fluorescence generated in the sample 14 with the laser light; and a stage 15 scanning the sample 14 while moving the sample 14 relative to the laser light, wherein the laser light is applied to the sample with varying intensities such that saturation of fluorescence occurs at the maximum intensity of the laser light, and fluorescence is detected with the detector in accordance with intensity of the laser light, and the sample is observed based on the saturation components of fluorescence.
摘要翻译：通过观察基于饱和荧光成分的样品来增加空间分辨率。根据本发明的荧光显微镜包括：发射激光作为激发光的激光光源10; 聚焦激光并将聚焦的激光施加到样品14的物镜13; 用激光检测样品14中产生的荧光的检测器22; 以及在样品14相对于激光移动的同时扫描样品14的阶段15，其中激光以不同的强度施加到样品，使得在激光的最大强度下发生荧光饱和，并且检测到荧光与检测器根据激光的强度，并且基于荧光的饱和分量观察样品。

10. 发明授权

US09582088B2 Microscope 有权
标题翻译：显微镜
公开(公告)号：US09582088B2
公开(公告)日：2017-02-28
申请号：US14006500
申请日：2012-03-22
申请人： Satoshi Kawata , Minoru Kobayashi , Taisuke Ota , Tomoya Uchiyama , Naoyoshi Kubota , Shogo Kawano
发明人： Satoshi Kawata , Minoru Kobayashi , Taisuke Ota , Tomoya Uchiyama , Naoyoshi Kubota , Shogo Kawano
IPC分类号： H04N7/18 , H04N9/47 , G06F3/041 , G02B21/36
CPC分类号： G06F3/041 , G02B21/36 , H04N7/18
摘要： A touch screen (60) disposed on a display surface of a display means (58) is used as an inputting means so that a variety of actions of a microscope can be controlled with sufficient ease and precision.A variety of actions are controlled based on an operator's various finger gestures used on the touch screen disposed on the display surface of the display means, for example, making contact by a finger (tap), making two consecutive contacts by a finger (double-tap), making contact by a finger, and moving the finger without releasing it (drag), making contact by a finger and maintaining the contact for a predetermined time or longer (touch-and-hold), making simultaneous contact by two fingers, and increasing spacing between the fingers (pinch-out) or decreasing the spacing (pinch-in), and making simultaneous contact by two fingers, and moving the fingers in parallel (double-drag).
摘要翻译：基于操作者在显示装置的显示表面上设置的触摸屏上使用的各种手指手势来控制各种动作，例如通过手指（抽头）进行接触，通过手指（双重）进行两次连续的接触，点击），通过手指进行接触，并且移动手指而不释放（拖动），通过手指进行接触并将触点保持预定时间或更长时间（触摸并保持），同时通过两个手指接触，并增加手指之间的间距（挤出）或减小间距（夹紧），并通过两个手指进行同时接触，并平行移动手指（双重拖动）。

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