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1. 发明授权

US07258663B2 Endoscope system with irradiated light switching feature 有权
标题翻译：具有照射光切换功能的内窥镜系统
公开(公告)号：US07258663B2
公开(公告)日：2007-08-21
申请号：US10755559
申请日：2004-01-12
申请人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
发明人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
IPC分类号： A61B1/045 , A61B1/06
CPC分类号： H04N7/183 , A61B1/00059 , A61B1/043 , A61B1/045 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , G02B23/24 , G02B23/2469 , G02B23/2484 , G02B26/008 , H04N2005/2255
摘要： An endoscope 2 has a CCD 9 incorporated in the distal part of an insertion unit 6 thereof. The sensitivity of the CCD 9 can be varied by applying a plurality of pulsating driving signals so as to change an electron multiplication rate. The endoscope 2 is connected to a processor 3 so that it can be disconnected freely. Information representing a type of endoscope stored in advance in a ROM 48 is transmitted to a controller 21 incorporated in the processor 3. The control means 21 uses a CCD sensitivity control means 12 to control the sensitivity of the CCD 9 according to the type of connected endoscope 2. Consequently, a view image of proper brightness can be produced irrespective of the type of endoscope 2.
摘要翻译：内窥镜2具有并入其插入单元6的远端部的CCD 9。可以通过施加多个脉动驱动信号来改变CCD 9的灵敏度，以改变电子倍增率。内窥镜2与处理器3连接，能够自由断开。表示预先存储在ROM48中的内窥镜的信息的信息被发送到结合在处理器3中的控制器21。控制装置21使用CCD灵敏度控制装置12根据连接的内窥镜2的类型来控制CCD 9的灵敏度。因此，无论内窥镜2的种类如何，都可以产生适当亮度的视野图像。

2. 发明授权

US06902527B1 Endoscope system with charge multiplying imaging device and automatic gain control 有权
标题翻译：具有充电倍增成像装置和自动增益控制的内窥镜系统
公开(公告)号：US06902527B1
公开(公告)日：2005-06-07
申请号：US09743994
申请日：2000-05-16
申请人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
发明人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
IPC分类号： A61B1/04 , A61B1/045 , A61B1/05 , A61B5/00 , G02B7/00 , G02B23/24 , H04N3/15 , H04N5/225 , H04N7/18 , A61B1/06
CPC分类号： H04N7/183 , A61B1/00059 , A61B1/043 , A61B1/045 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , G02B23/24 , G02B23/2469 , G02B23/2484 , G02B26/008 , H04N2005/2255
摘要： An endoscope 2 has a CCD 9 incorporated in the distal part of an insertion unit 6 thereof. The sensitivity of the CCD 9 can be varied by applying a plurality of pulsating driving signals so as to change an electron multiplication rate. The endoscope 2 is connected to a processor 3 so that it can be disconnected freely. Information representing a type of endoscope stored in advance in a ROM 48 is transmitted to a controller 21 incorporated in the processor 3. The control means 21 uses a CCD sensitivity control means 12 to control the sensitivity of the CCD 9 according to the type of connected endoscope 2. In addition, an automatic gain control circuit supplementarily amplifies a signal output from the CCD 9 so that the level of the signal becomes a predetermined level. Consequently, a view image of proper brightness can be produced irrespective of the type of endoscope 2.
摘要翻译：内窥镜2具有并入其插入单元6的远端部的CCD 9。可以通过施加多个脉动驱动信号来改变CCD 9的灵敏度，以改变电子倍增率。内窥镜2与处理器3连接，能够自由断开。表示预先存储在ROM48中的内窥镜的信息的信息被发送到结合在处理器3中的控制器21。控制装置21使用CCD灵敏度控制装置12根据连接的内窥镜2的类型来控制CCD 9的灵敏度。此外，自动增益控制电路补充放大从CCD 9输出的信号，使信号的电平成为预定的电平。因此，无论内窥镜2的种类如何，都可以产生适当亮度的视野图像。

3. 发明授权

US07226412B2 Endoscope system using normal light and fluorescence 有权
标题翻译：内窥镜系统使用正常光和荧光
公开(公告)号：US07226412B2
公开(公告)日：2007-06-05
申请号：US10853846
申请日：2004-05-25
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
IPC分类号： A61B1/05 , A61B1/06
CPC分类号： A61B1/00059 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084
摘要： An endoscope system in accordance with an embodiment of the present invention includes an endoscope with a monochrome image pickup device for capturing reflected light and fluorescence from the body cavity, an excitation light cut filter which is installed in front of the image pickup device for shielding excitation light, and an endoscope ID which includes information on the type of the endoscope. A light source unit includes a first switching filter that irradiates light including excitation light for a fluorescent image mode and a filter for generating continuous light for a normal-light image mode. The filters switch based between the fluorescent image mode and the normal-light image mode. A second switching filter with a limiting filter that limits certain wavelengths of excitation light of the first switching filter is provided. The limiting filters are switched according to the endoscope ID or observation state in the fluorescence mode. The excitation light cut filter shields excitation light generated by the first and second filters.
摘要翻译：根据本发明的实施例的内窥镜系统包括：内窥镜，具有用于从体腔捕获反射光和荧光的单色图像拾取装置，安装在用于屏蔽激励的图像拾取装置的前方的激发截止滤光器光和内窥镜ID，其包括关于内窥镜的类型的信息。光源单元包括照射包括用于荧光图像模式的激发光的光的第一切换滤光器和用于产生用于正常光图像模式的连续光的滤光器。滤光片基于荧光图像模式和普通光图像模式之间切换。提供了具有限制第一开关滤波器的某些波长的激发光的限制滤波器的第二开关滤波器。根据荧光模式中的内窥镜ID或观察状态来切换限制滤光片。激发光截止滤光器屏蔽由第一和第二滤光器产生的激发光。

4. 发明授权

US06692429B1 Fluorescent endoscope system enabling simultaneous achievement of normal light observation based on reflected light and fluorescence observation based on light with wavelengths in infrared spectrum 有权
标题翻译：荧光内窥镜系统能够基于反射光和基于具有红外光谱波长的光的荧光观察同时实现正常光观察
公开(公告)号：US06692429B1
公开(公告)日：2004-02-17
申请号：US09533366
申请日：2000-03-22
申请人： Katsuichi Imaizumi , Kazunari Nakamura
发明人： Katsuichi Imaizumi , Kazunari Nakamura
IPC分类号： A61B104
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/04 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071
摘要： Excitation light for normal light observation with wavelengths in the visible spectrum, which is output from a lamp, and excitation light with wavelengths in the infrared spectrum for exciting a fluorescent substance characteristic of being accumulated readily in a lesion are irradiated simultaneously to a living tissue, to which the fluorescent substance has been administered, through an endoscope. Fluorescence components are separated from light stemming from the living tissue by means of a separator such as a dichroic mirror, introduced to a first imaging device, and then imaged. Light components with wavelengths in the visible spectrum are introduced to a second imaging device and then imaged. Signals representing the images are subjected to signal processing, whereby a video signal is produced. For better diagnosis, two images are displayed while, for example, one of the images is superimposed on the other.
摘要翻译：对于从灯输出的可见光谱中的波长的正常光观察的激发光和在红外光谱中具有波长的激发光用于激发在损伤中容易积聚的特征的荧光物质的激发光同时照射到生物体组织，通过内窥镜给予荧光物质。通过引入第一成像装置的分色器（例如分色镜）将荧光成分与来自生物体组织的光分离，然后成像。将具有可见光谱波长的光分量引入第二成像装置，然后成像。对表示图像的信号进行信号处理，由此产生视频信号。为了更好的诊断，显示两个图像，例如，其中一个图像被叠加在另一个上。

5. 发明授权

US06293911B1 Fluorescent endoscope system enabling simultaneous normal light observation and fluorescence observation in infrared spectrum 失效
标题翻译：荧光内窥镜系统能够在红外光谱中同时进行正常的光线观察和荧光观察
公开(公告)号：US06293911B1
公开(公告)日：2001-09-25
申请号：US08974531
申请日：1997-11-19
申请人： Katsuichi Imaizumi , Kazunari Nakamura
发明人： Katsuichi Imaizumi , Kazunari Nakamura
IPC分类号： A61B104
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/043 , A61B1/0646 , A61B5/0071
摘要： Excitation light for normal light observation with wavelengths in the visible spectrum, which is output from a lamp, and excitation light with wavelengths in the infrared spectrum for exciting a fluorescent substance characteristic of being accumulated readily in a lesion are irradiated simultaneously to a living tissue, to which the fluorescent substance has been administered, through an endoscope. Fluorescence components are separated from light stemming from the living tissue by means of a separator such as a dichroic mirror, introduced to a first imaging device, and then imaged. Light components with wavelengths in the visible spectrum are introduced to a second imaging device and then imaged. Signals representing the images are subjected to signal processing, whereby a video signal is produced. For better diagnosis, two images are displayed while, for example, one of the images is superimposed on the other.
摘要翻译：对于从灯输出的可见光谱中的波长的正常光观察的激发光和在红外光谱中具有波长的激发光用于激发在损伤中容易积聚的特征的荧光物质的激发光同时照射到生物体组织，通过内窥镜给予荧光物质。通过引入第一成像装置的分色器（例如分色镜）将荧光成分与来自生物体组织的光分离，然后成像。将具有可见光谱波长的光分量引入第二成像装置，然后成像。对表示图像的信号进行信号处理，由此产生视频信号。为了更好的诊断，显示两个图像，例如，其中一个图像被叠加在另一个上。

6. 发明授权

US07172553B2 Endoscope system using normal light and fluorescence 有权
标题翻译：内窥镜系统使用正常光和荧光
公开(公告)号：US07172553B2
公开(公告)日：2007-02-06
申请号：US10146389
申请日：2002-05-14
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B1/00059 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084
摘要： In the light source unit 3A, a switching filter section 14, which can switch the RGB filter for normal-light observation and a filter for fluorescent observation on the optical path, is installed in front of the lamp 12, where if the fluorescent image mode is selected, the excitation light in a part of the blue wavelength band is supplied to the electronic endoscope 2A, and the excitation light reflected by the subject side is shielded by the excitation light cut filter 27 in front of the CCD 28 so as to obtain the fluorescent image, and also the signal of the fluorescent image and the signals of the two reflected light images which are set in a predetermined wavelength band are passed through the image processing circuit 38, where a matrix circuit for appropriately allocating the color signals of the R, G and B channels is installed, and as a result, the images can be displayed on the monitor 5 in pseudo-colors in hues which allow easy identification of a normal tissue and a pathologically affected tissue.
摘要翻译：在光源单元3A中，在灯12的前方安装可以切换用于普通光观察的RGB滤光器的开关滤波器部分14和用于荧光观察的滤光器，其中如果荧光图像选择蓝色波长带的一部分中的激发光被供给到电子内窥镜2A，并且由CCD 28反射的激励光被CCD28前方的激发光截止滤光器27遮蔽，从而以获得荧光图像，并且将荧光图像的信号和设置在预定波长带中的两个反射光图像的信号通过图像处理电路38，其中用于适当地分配颜色信号的矩阵电路安装了R，G和B通道，结果，图像可以以色调的伪色显示在监视器5上，这允许容易地识别正常组织和病态在逻辑上影响组织。

7. 发明授权

US07658710B2 Endoscope system using normal light and fluorescence 有权
标题翻译：内窥镜系统使用正常光和荧光
公开(公告)号：US07658710B2
公开(公告)日：2010-02-09
申请号：US11611929
申请日：2006-12-18
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
IPC分类号： A61B1/045
CPC分类号： A61B1/00059 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084
摘要： An endoscope system includes a light source for supplying three narrow wavelength bands including one wavelength band for exciting fluorescence, an excitation light cut filter for transmitting light having a wavelength greater than either 470 nm or 490 nm, and an image capturing unit for capturing the light transmitted by the excitation light cut filter and outputting three wavelength band signals corresponding to the three narrow wavelength bands of the light source. Also included are first, second and third frame memories for inputting and storing the three wavelength band signals, respectively, and first, second and third output ends for outputting first, second and third color signals, respectively, to a monitor for displaying an image. An image processor receives signals from the first, second and third frame memories respectively and selects among the first output end, the second output end and third output end for outputting the received signals to the monitor.
摘要翻译：一种内窥镜系统，包括用于提供包括用于激发荧光的一个波长带的三个窄波长带的光源，用于透射波长大于470nm或490nm的光的激发截止滤光器和用于捕获光的图像捕获单元由激发光截止滤波器传输并输出对应于光源的三个窄波长带的三个波长带信号。还包括用于分别输入和存储三个波长带信号的第一，第二和第三帧存储器，以及分别将第一，第二和第三颜色信号输出到用于显示图像的监视器的第一，第二和第三输出端。图像处理器分别从第一，第二和第三帧存储器接收信号，并在第一输出端，第二输出端和第三输出端之间进行选择，以将接收的信号输出到监视器。

8. 发明授权

US07204803B2 Endoscope device, endoscope and image processing device for endoscope 有权
标题翻译：内窥镜装置，内窥镜及内窥镜用图像处理装置
公开(公告)号：US07204803B2
公开(公告)日：2007-04-17
申请号：US10647405
申请日：2003-08-25
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana
IPC分类号： A61B1/04
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/00059 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , H04N2005/2255 , Y10S600/921
摘要： An image processing device for an endoscope, wherein a wavelength band filter for shielding at least a part of the blue wavelength band is disposed in front of an image pickup element built into the endoscope, for image processing the signal output by said image pickup element includes means for generating color image signals whilst switching between a normal-light image mode using white light and a fluorescence image mode including fluorescence information and adjusting means for adjusting the gain of a prescribed color signal of said color image signals.
摘要翻译：一种用于内窥镜的图像处理装置，其中用于屏蔽蓝色波长带的至少一部分的波长带滤波器被布置在内置于内窥镜中的图像拾取元件的前面，用于对由所述图像拾取元件输出的信号进行图像处理包括用于在使用白光的正常光图像模式和包括荧光信息的荧光图像模式之间切换时产生彩色图像信号的装置和用于调节所述彩色图像信号的规定颜色信号的增益的调整装置。

9. 发明授权

US07179222B2 Fluorescent endoscope system enabling simultaneous achievement of normal light observation based on reflected light and fluorescence observation based on light with wavelengths in infrared spectrum 有权
标题翻译：荧光内窥镜系统能够基于反射光和基于具有红外光谱波长的光的荧光观察同时实现正常光观察
公开(公告)号：US07179222B2
公开(公告)日：2007-02-20
申请号：US10767755
申请日：2004-01-28
申请人： Katsuichi Imaizumi , Kazunari Nakamura
发明人： Katsuichi Imaizumi , Kazunari Nakamura
IPC分类号： A61B1/045 , A61B1/05
CPC分类号： A61B5/0084 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/04 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071
摘要： A visible light spectrum and a fluorescent light spectrum are received by a variable gain solid state imaging device provided to an endoscope. The variable gain solid state imaging device can be said to lower amplification levels for easily observed visible light spectrum, and higher amplification levels for low intensity fluorescent light spectrum observation. By varying the gain of the imaging device with the different spectrums, an object observed with the endoscope is displayed with approximately similar brightness in each white spectrum. A controller coupled to endoscope system switches different light spectrum to irradiate the observed object, while controlling amplification of the image device. The endoscope provides enhanced image detail to improve diagnosis and treatment of observed abnormal objects.
摘要翻译：通过设置在内窥镜上的可变增益固态成像装置接收可见光谱和荧光光谱。可变增益固态成像装置可以说是降低放大水平，便于观察到的可见光谱，而低强度荧光光谱观察的放大水平更高。通过用不同的光谱改变成像装置的增益，在每个白色光谱中以大致相似的亮度显示用内窥镜观察到的物体。耦合到内窥镜系统的控制器切换不同的光谱以照射被观察物体，同时控制图像装置的放大。内窥镜提供增强的图像细节，以改善观察到的异常物体的诊断和治疗。

10. 发明授权

US06960165B2 Endoscope with a single image pick-up element for fluorescent and normal-light images 有权
标题翻译：具有用于荧光和正常光图像的单个图像拾取元件的内窥镜
公开(公告)号：US06960165B2
公开(公告)日：2005-11-01
申请号：US10145966
申请日：2002-05-14
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana
IPC分类号： A61B1/04 , A61B1/045 , A61B5/00 , A61B1/06 , A61B6/00
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/00059 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084 , H04N2005/2255 , Y10S600/921
摘要： In a light source unit, a switchable filter section in which an RGB filter and a fluorescence observation filter can be shifted into the light path is disposed in front of a lamp. When fluorescence image mode is selected, excitation light in a part of the wavelength band of the blue wavelength band is supplied to an electronic endoscope, and the excitation light which is reflected by the subject is shielded by an excitation light shielding filter situated in front of a CCD, whereby a fluorescence image can be obtained. On the other hand, if normal-light image mode is selected, then R, G, B light is supplied sequentially, and even under illumination of B light, the color component image in the wavelength bands which are not shielded by the excitation light shielding filter are captured, thereby yielding a normal-light image also, and hence making it possible to capture both a fluorescence image and a normal-light image by means of a single image pickup element.
摘要翻译：在光源单元中，在灯的前面设置有可以将RGB滤光器和荧光观察滤光器移入光路的可切换滤光器部。当选择荧光图像模式时，蓝色波长带的波长带的一部分中的激发光被提供给电子内窥镜，被被摄体反射的激发光被位于前方的激发光屏蔽滤光器屏蔽 CCD，由此可以获得荧光图像。另一方面，如果选择了常规光图像模式，则顺序地提供R，G，B光，并且即使在B光照明下，也不会被激发光屏蔽屏蔽的波长带中的分色图像过滤器被捕获，从而也产生正常光图像，因此可以通过单个图像拾取元件捕获荧光图像和正常光图像。

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