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1. 发明授权

US08107158B2 Fluorescent imaging device and fluorescent image acquiring method 有权
标题翻译：荧光成像装置和荧光图像获取方法
公开(公告)号：US08107158B2
公开(公告)日：2012-01-31
申请号：US12853751
申请日：2010-08-10
申请人： Kenji Yamazaki , Nobuyuki Doguchi , Shunji Takei , Sakae Takehana
发明人： Kenji Yamazaki , Nobuyuki Doguchi , Shunji Takei , Sakae Takehana
IPC分类号： G02B26/00
CPC分类号： A61B5/0071 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0075 , A61B5/0084
摘要： A fluorescent imaging device includes an irradiation section that irradiates an object to be examined with excitation light and reference light, an image pickup section that picks up a fluorescence image based on the excitation light and a reflected light image based on the reference light, a comparison section that compares relative intensity between the fluorescent image generated from the fluorescence image and the reflected light image generated from the reflected light image, and a selection section that selectively outputs one of the reflected light image and the fluorescent image based on the comparison result.
摘要翻译：荧光成像装置包括：用激发光和参照光照射待检查对象的照射部，基于激发光拍摄荧光图像的摄像部和基于参照光的反射光图像;比较比较从荧光图像生成的荧光图像与从反射光图像生成的反射光图像之间的相对强度的比较部分，以及基于比较结果选择性地输出反射光图像和荧光图像之一的选择部分。

2. 发明授权

US07226412B2 Endoscope system using normal light and fluorescence 有权
标题翻译：内窥镜系统使用正常光和荧光
公开(公告)号：US07226412B2
公开(公告)日：2007-06-05
申请号：US10853846
申请日：2004-05-25
申请人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
发明人： Hitoshi Ueno , Takeshi Ozawa , Kazunari Nakamura , Isami Hirao , Hiroshi Ibe , Koichi Yoshimitsu , Yuichi Morizane , Mamoru Kaneko , Shunya Akimoto , Masaki Terakubo , Katsuichi Imaizumi , Nobuyuki Doguchi , Sakae Takehana , Kazuhiro Gono
IPC分类号： A61B1/05 , A61B1/06
CPC分类号： A61B1/00059 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084
摘要： An endoscope system in accordance with an embodiment of the present invention includes an endoscope with a monochrome image pickup device for capturing reflected light and fluorescence from the body cavity, an excitation light cut filter which is installed in front of the image pickup device for shielding excitation light, and an endoscope ID which includes information on the type of the endoscope. A light source unit includes a first switching filter that irradiates light including excitation light for a fluorescent image mode and a filter for generating continuous light for a normal-light image mode. The filters switch based between the fluorescent image mode and the normal-light image mode. A second switching filter with a limiting filter that limits certain wavelengths of excitation light of the first switching filter is provided. The limiting filters are switched according to the endoscope ID or observation state in the fluorescence mode. The excitation light cut filter shields excitation light generated by the first and second filters.
摘要翻译：根据本发明的实施例的内窥镜系统包括：内窥镜，具有用于从体腔捕获反射光和荧光的单色图像拾取装置，安装在用于屏蔽激励的图像拾取装置的前方的激发截止滤光器光和内窥镜ID，其包括关于内窥镜的类型的信息。光源单元包括照射包括用于荧光图像模式的激发光的光的第一切换滤光器和用于产生用于正常光图像模式的连续光的滤光器。滤光片基于荧光图像模式和普通光图像模式之间切换。提供了具有限制第一开关滤波器的某些波长的激发光的限制滤波器的第二开关滤波器。根据荧光模式中的内窥镜ID或观察状态来切换限制滤光片。激发光截止滤光器屏蔽由第一和第二滤光器产生的激发光。

3. 发明申请

US20070100207A1 ENDOSCOPE SYSTEM USING NORMAL LIGHT AND FLUORESCENCE 有权
标题翻译：使用正常光和荧光的内窥镜系统
公开(公告)号：US20070100207A1
公开(公告)日：2007-05-03
申请号：US11611929
申请日：2006-12-18
申请人： Hitoshi UENO , Takeshi OZAWA , Kazunari NAKAMURA , Isami HIRAO , Hiroshi IBE , Koichi YOSHIMITSU , Yuichi MORIZANE , Mamoru KANEKO , Shunya AKIMOTO , Masaki TERAKUBO , Katsuichi IMAIZUMI , Nobuyuki DOGUCHI , Sakae TAKEHANA , Kazuhiro GONO
发明人： Hitoshi UENO , Takeshi OZAWA , Kazunari NAKAMURA , Isami HIRAO , Hiroshi IBE , Koichi YOSHIMITSU , Yuichi MORIZANE , Mamoru KANEKO , Shunya AKIMOTO , Masaki TERAKUBO , Katsuichi IMAIZUMI , Nobuyuki DOGUCHI , Sakae TAKEHANA , Kazuhiro GONO
IPC分类号： A61B1/06 , A61B6/00
CPC分类号： A61B1/00059 , A61B1/00009 , A61B1/00186 , A61B1/043 , A61B1/045 , A61B1/0638 , A61B1/0646 , A61B1/0669 , A61B5/0071 , A61B5/0084
摘要： In the light source unit 3A, a switching filter section 14, which can switch the RGB filter for normal-light observation and a filter for fluorescent observation on the optical path, is installed in front of the lamp 12, where if the fluorescent image mode is selected, the excitation light in a part of the blue wavelength band is supplied to the electronic endoscope 2A, and the excitation light reflected by the subject side is shielded by the excitation light cut filter 27 in front of the CCD 28 so as to obtain the fluorescent image, and also the signal of the fluorescent image and the signals of the two reflected light images which are set in a predetermined wavelength band are passed through the image processing circuit 38, where a matrix circuit for appropriately allocating the color signals of the R, G and B channels is installed, and as a result, the images can be displayed on the monitor 5 in pseudo-colors in hues which allow easy identification of a normal tissue and a pathologically affected tissue.
摘要翻译：在光源单元3A中，在灯12的前方安装可以切换用于普通光观察的RGB滤光器的开关滤波器部分14和用于荧光观察的滤光器，其中如果荧光图像选择蓝色波长带的一部分中的激发光被供给到电子内窥镜2A，并且由CCD 28反射的激励光被CCD28前方的激发光截止滤光器27遮蔽，从而以获得荧光图像，并且将荧光图像的信号和设置在预定波长带中的两个反射光图像的信号通过图像处理电路38，其中用于适当地分配颜色信号的矩阵电路安装了R，G和B通道，结果，图像可以以色调的伪色显示在监视器5上，这允许容易地识别正常组织和路径受影响的组织。

4. 发明授权

US06790174B2 Fluorescent imaging device 失效
标题翻译：荧光成像装置
公开(公告)号：US06790174B2
公开(公告)日：2004-09-14
申请号：US10045979
申请日：2002-01-10
申请人： Mamoru Kaneko , Hitoshi Ueno , Sakae Takehana , Isami Hirao , Nobuyuki Doguchi , Takeshi Ozawa , Takefumi Uesugi , Katsuichi Imaizumi , Yasukazu Kogen , Makoto Tomioka , Tadashi Hirata , Masahiro Kawauchi
发明人： Mamoru Kaneko , Hitoshi Ueno , Sakae Takehana , Isami Hirao , Nobuyuki Doguchi , Takeshi Ozawa , Takefumi Uesugi , Katsuichi Imaizumi , Yasukazu Kogen , Makoto Tomioka , Tadashi Hirata , Masahiro Kawauchi
IPC分类号： A61B1045
CPC分类号： A61B1/045 , A61B1/00009 , A61B1/0005 , A61B1/00186 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B5/0071 , A61B5/0084 , H04N2005/2255
摘要： An imaging system for use with an endoscope, including a light source which emits white light and excitation light which will produce a fluorescence response by an object under inspection, an imaging camera including separate paths for processing images produced by white light and excitation light, a selection device that causes the imaging device to operate in a white light mode or an excitation light mode, and a protective device that prevents damage to high-sensitivity imaging components from exposure to excessive light input. Fluorescent image data are separated into at least red and green color bands which are separately processed to produced a video display in which normal tissue is displayed in predetermined specific color, and abnormal tissue in one or more distinctly different colors. In one embodiment, an image color interpretation guide is provided in the form of multiple color bars which are superimposed on a single video display device with the image display. of different kinds. In another embodiment, color control is provided by adjusting the amplification of the imaging components for each of the color bands while viewing tissue known to be normal using a recursive algorithm until the ratio of the maximum values of the color separation signals fall within a predetermined range. The high-sensitivity imaging components are protected by controlling impingement of light on the imagining components, selectively controlling emission of white and excitation light from the light source, and controlling the power source for the imaging components.
摘要翻译：一种与内窥镜一起使用的成像系统，包括发出白光的光源和由被检查物体产生荧光响应的激发光，包括用于处理由白光和激发光产生的图像的分离路径的成像摄像机，选择装置，其使得成像装置在白光模式或激发光模式下操作;以及保护装置，其防止对高灵敏度成像部件的损害暴露于过度的光输入。荧光图像数据被分成至少红色和绿色色带，其分开处理以产生其中以预定特定颜色显示正常组织的视频显示，以及以一种或多种明显不同的颜色显示异常组织。在一个实施例中，以多个彩条的形式提供图像颜色解释指南，所述多个彩条叠加在具有图像显示的单个视频显示装置上。不同种类。在另一个实施例中，通过调整每个色带的成像部件的放大率来提供颜色控制，同时使用递归算法观察已知为正常的组织，直到颜色分离信号的最大值的比率落在预定范围内。高灵敏度成像组件通过控制对想像组件的光的照射来保护，选择性地控制来自光源的白光和激发光的发射，以及控制成像组件的电源。

5. 发明授权

US5065741A Extracoporeal ultrasonic lithotripter with a variable focus 失效
标题翻译：具有可变焦点的超声波碎石机
公开(公告)号：US5065741A
公开(公告)日：1991-11-19
申请号：US639922
申请日：1991-01-09
申请人： Naoki Uchiyama , Takashi Tsukaya , Kouichiro Ishihara , Sakae Takehana , Tetsumaru Kubota , Syuichi Takayama , Akira Taniguchi , Nobuhiko Watanabe , Naomi Sekino , Hiroki Hibino , Masaaki Hayashi
发明人： Naoki Uchiyama , Takashi Tsukaya , Kouichiro Ishihara , Sakae Takehana , Tetsumaru Kubota , Syuichi Takayama , Akira Taniguchi , Nobuhiko Watanabe , Naomi Sekino , Hiroki Hibino , Masaaki Hayashi
IPC分类号： A61B17/00 , A61B17/22
CPC分类号： A61B17/2255 , A61B17/2256 , A61B2017/00699
摘要： A therapeutical apparatus includes a measuring apparatus including a probe which generates an X-ray or ultrasonic wave in order to detect the location of a target to be treated such as calculi situated within the kidney, liver, biliary ducts. A therapeutical energy generator generates a shock wave of sufficient energy for purposes of therapy externally of the physical body and focuses it upon the target. Structure is provided for causing a displacement of the generator and the measuring apparatus around the surface of a patient. Structure is provided to activate the generator.
摘要翻译：治疗装置包括测量装置，其包括产生X射线或超声波的探针，以便检测待处理的靶的位置，例如位于肾，肝，胆管内的结石。治疗能量发生器产生足够能量的冲击波，用于在身体外部治疗的目的，并将其聚焦在目标上。提供了用于使发生器和测量装置围绕患者表面的位移的结构。提供结构来激活发电机。

6. 发明授权

US4982725A Endoscope apparatus 失效
标题翻译：内窥镜装置
公开(公告)号：US4982725A
公开(公告)日：1991-01-08
申请号：US535216
申请日：1990-06-08
申请人： Hiroki Hibino , Yoshikatsu Nagayama , Mutsumi Yoshikawa , Toshiyuki Takara , Masahito Goto , Akira Suzuki , Sakae Takehana , Yoshinao Oaki , Koichi Yoshimitsu , Yoshisada Aoki
发明人： Hiroki Hibino , Yoshikatsu Nagayama , Mutsumi Yoshikawa , Toshiyuki Takara , Masahito Goto , Akira Suzuki , Sakae Takehana , Yoshinao Oaki , Koichi Yoshimitsu , Yoshisada Aoki
IPC分类号： A61B1/005 , A61B1/12
CPC分类号： A61B1/12 , A61B1/00039 , A61B1/00055 , A61B1/0016 , A61B1/0052 , A61B5/6885
摘要： The endoscope apparatus comprises an endoscope having an elongate insertable part having a bendable part and a driving apparatus for bending and driving the bendable part, a first bending controlling apparatus for controlling the driving apparatus and a second bending controlling apparatus for controlling the driving apparatus independently of the first bending controlling apparatus when the first bending controlling apparatus is controllable.
摘要翻译：所述内窥镜装置具有内窥镜，具有具有弯曲部的细长可插入部和用于弯曲和驱动所述弯曲部的驱动装置，用于控制所述驱动装置的第一弯曲控制装置和用于独立于所述驱动装置的所述驱动装置的控制的第二弯曲控制装置当第一弯曲控制装置是可控的时，第一弯曲控制装置。

7. 发明授权

US07258663B2 Endoscope system with irradiated light switching feature 有权
标题翻译：具有照射光切换功能的内窥镜系统
公开(公告)号：US07258663B2
公开(公告)日：2007-08-21
申请号：US10755559
申请日：2004-01-12
申请人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
发明人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
IPC分类号： A61B1/045 , A61B1/06
CPC分类号： H04N7/183 , A61B1/00059 , A61B1/043 , A61B1/045 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , G02B23/24 , G02B23/2469 , G02B23/2484 , G02B26/008 , H04N2005/2255
摘要： An endoscope 2 has a CCD 9 incorporated in the distal part of an insertion unit 6 thereof. The sensitivity of the CCD 9 can be varied by applying a plurality of pulsating driving signals so as to change an electron multiplication rate. The endoscope 2 is connected to a processor 3 so that it can be disconnected freely. Information representing a type of endoscope stored in advance in a ROM 48 is transmitted to a controller 21 incorporated in the processor 3. The control means 21 uses a CCD sensitivity control means 12 to control the sensitivity of the CCD 9 according to the type of connected endoscope 2. Consequently, a view image of proper brightness can be produced irrespective of the type of endoscope 2.
摘要翻译：内窥镜2具有并入其插入单元6的远端部的CCD 9。可以通过施加多个脉动驱动信号来改变CCD 9的灵敏度，以改变电子倍增率。内窥镜2与处理器3连接，能够自由断开。表示预先存储在ROM48中的内窥镜的信息的信息被发送到结合在处理器3中的控制器21。控制装置21使用CCD灵敏度控制装置12根据连接的内窥镜2的类型来控制CCD 9的灵敏度。因此，无论内窥镜2的种类如何，都可以产生适当亮度的视野图像。

8. 发明申请

US20060155166A1 Endoscope device 审中-公开
标题翻译：内窥镜装置
公开(公告)号：US20060155166A1
公开(公告)日：2006-07-13
申请号：US11305643
申请日：2005-12-16
申请人： Yoshinori Takahashi , Isami Hirao , Katsuichi Imaizumi , Takeshi Ozawa , Sakae Takehana , Nobuyuki Doguchi
发明人： Yoshinori Takahashi , Isami Hirao , Katsuichi Imaizumi , Takeshi Ozawa , Sakae Takehana , Nobuyuki Doguchi
IPC分类号： A61B1/00 , A61B1/04
CPC分类号： A61B1/045 , A61B1/00059 , A61B1/043 , A61B1/0638 , A61B1/0646 , A61B1/0669 , H04N2005/2255
摘要： An endoscope device according to the present invention includes an endoscope having an image pickup device for capturing an image of a subject, which can observe the subject in at least one observing mode, and a signal processing device, which has the function to receive a signal from the image pickup device and execute signal processing corresponding to a plurality of observing mode, comprising an identifying unit that identifies the observing mode of a connected endoscope based on information from the connected endoscope, wherein the signal processing device executes only signal processing corresponding to the observing mode identified by the identifying unit when the endoscope is connected to the signal processing device.
摘要翻译：根据本发明的内窥镜装置包括内窥镜，其具有用于拍摄能够以至少一种观察模式观察被检体的被检体的图像的图像拾取装置，以及具有接收信号的功能的信号处理装置从所述图像拾取装置执行与多个观察模式相对应的信号处理，所述信号处理装置包括识别单元，所述识别单元基于来自所连接的内窥镜的信息来识别所连接的内窥镜的观察模式，其中，所述信号处理装置仅执行对应于当内窥镜连接到信号处理装置时由识别单元识别的观察模式。

9. 发明授权

US06902527B1 Endoscope system with charge multiplying imaging device and automatic gain control 有权
标题翻译：具有充电倍增成像装置和自动增益控制的内窥镜系统
公开(公告)号：US06902527B1
公开(公告)日：2005-06-07
申请号：US09743994
申请日：2000-05-16
申请人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
发明人： Nobuyuki Doguchi , Yasuo Komatsu , Kazunari Nakamura , Sakae Takehana , Katsuichi Imaizumi , Takayuki Hanawa
IPC分类号： A61B1/04 , A61B1/045 , A61B1/05 , A61B5/00 , G02B7/00 , G02B23/24 , H04N3/15 , H04N5/225 , H04N7/18 , A61B1/06
CPC分类号： H04N7/183 , A61B1/00059 , A61B1/043 , A61B1/045 , A61B1/05 , A61B1/0638 , A61B1/0646 , A61B1/0684 , A61B5/0071 , A61B5/0084 , G02B23/24 , G02B23/2469 , G02B23/2484 , G02B26/008 , H04N2005/2255
摘要： An endoscope 2 has a CCD 9 incorporated in the distal part of an insertion unit 6 thereof. The sensitivity of the CCD 9 can be varied by applying a plurality of pulsating driving signals so as to change an electron multiplication rate. The endoscope 2 is connected to a processor 3 so that it can be disconnected freely. Information representing a type of endoscope stored in advance in a ROM 48 is transmitted to a controller 21 incorporated in the processor 3. The control means 21 uses a CCD sensitivity control means 12 to control the sensitivity of the CCD 9 according to the type of connected endoscope 2. In addition, an automatic gain control circuit supplementarily amplifies a signal output from the CCD 9 so that the level of the signal becomes a predetermined level. Consequently, a view image of proper brightness can be produced irrespective of the type of endoscope 2.
摘要翻译：内窥镜2具有并入其插入单元6的远端部的CCD 9。可以通过施加多个脉动驱动信号来改变CCD 9的灵敏度，以改变电子倍增率。内窥镜2与处理器3连接，能够自由断开。表示预先存储在ROM48中的内窥镜的信息的信息被发送到结合在处理器3中的控制器21。控制装置21使用CCD灵敏度控制装置12根据连接的内窥镜2的类型来控制CCD 9的灵敏度。此外，自动增益控制电路补充放大从CCD 9输出的信号，使信号的电平成为预定的电平。因此，无论内窥镜2的种类如何，都可以产生适当亮度的视野图像。

10. 发明授权

US6069698A Optical imaging apparatus which radiates a low coherence light beam onto a test object, receives optical information from light scattered by the object, and constructs therefrom a cross-sectional image of the object 有权
标题翻译：将低相干光束照射到测试对象上的光学成像设备从由物体散射的光接收光学信息，并由其构造物体的横截面图像
公开(公告)号：US6069698A
公开(公告)日：2000-05-30
申请号：US141430
申请日：1998-08-27
申请人： Takeshi Ozawa , Mamoru Kaneko , Akihiro Horii , Hitoshi Ueno , Sakae Takehana , Hiroyuki Sangu , Isami Hirao , Hitoshi Mizuno , Toshimasa Kawai , Hiroki Hibino , Hideyuki Adachi , Hironobu Takizawa , Takefumi Uesugi , Masahiro Ohno , Hidemichi Aoki , Jun Hiroya , Katsuichi Imaizumi , Eiji Yasuda , Yoshinao Oaki , Kenji Yoshino
发明人： Takeshi Ozawa , Mamoru Kaneko , Akihiro Horii , Hitoshi Ueno , Sakae Takehana , Hiroyuki Sangu , Isami Hirao , Hitoshi Mizuno , Toshimasa Kawai , Hiroki Hibino , Hideyuki Adachi , Hironobu Takizawa , Takefumi Uesugi , Masahiro Ohno , Hidemichi Aoki , Jun Hiroya , Katsuichi Imaizumi , Eiji Yasuda , Yoshinao Oaki , Kenji Yoshino
IPC分类号： A61B5/00 , G01B9/02
CPC分类号： G01B9/02069 , A61B5/0062 , A61B5/0066 , A61B5/0084 , G01B9/0205 , G01B9/02064 , G01B9/02091 , A61B5/0086 , G01B2290/35 , G01B2290/65
摘要： A low coherence beam emitted by a low coherence light source is split into two portions. One portion is transmitted from the outward end of a first single mode fiber via a detachable connector to a beam scanning probe, and then to a biological tissue; and the other is transmitted from an optical coupler placed midway along the light path via a second single mode fiber to a light path modifier. The light path modifier includes a galvanometer mirror to modify the light path length in accordance with a scan range, and a uniaxial stage to adjust the light path length to absorb the variation in lengths of different beam scanning probes. The light path is adjusted by the uniaxial stage such that the beam interference is detected for the scan range, to ensure stable acquisition of tomographic images.
摘要翻译：由低相干光源发射的低相干光束被分成两部分。一部分从第一单模光纤的外端通过可拆卸连接器传输到光束扫描探针，然后传输到生物组织; 另一个从位于光路的中途的光耦合器经由第二单模光纤传输到光路修正器。光路修正器包括根据扫描范围修改光路长度的电流计镜，以及调整光路长度以吸收不同束扫描探针的长度变化的单轴阶段。通过单轴阶段调整光路，使得在扫描范围内检测光束干涉，以确保断层图像的稳定采集。

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