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1. 发明授权

US5049504A Bioadhesive coding sequences 失效
标题翻译：生物粘附编码序列
公开(公告)号：US5049504A
公开(公告)日：1991-09-17
申请号：US530449
申请日：1990-05-30
申请人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
发明人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
IPC分类号： C07K14/435 , C09J189/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/12 , C12N15/71 , C12N15/81
CPC分类号： C12N9/6481 , C07K14/435 , C09J189/00 , C12N15/71 , C12N15/81 , C12N9/16 , C07K2319/00 , C07K2319/02
摘要： Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. The bioadhesive precursor protein can be expressed in transformants, recovered and converted to a bioadhesive protein by hydroxylation.
摘要翻译：提供能够在微生物转化体中表达具有选自贻贝，藤壶和牡蛎的海洋动物的生物粘附前体蛋白的天然氨基酸序列的蛋白质的载体。生物粘附前体蛋白可以在转化体中表达，回收并通过羟基化转化成生物粘附蛋白。

2. 发明授权

US5202256A Bioadhesive precursor protein expression vectors 失效
标题翻译：生物粘附前体蛋白表达载体
公开(公告)号：US5202256A
公开(公告)日：1993-04-13
申请号：US745695
申请日：1991-08-16
申请人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
发明人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg , Russ McCandliss , Tena Wei , David Filpula
IPC分类号： C07K14/435 , C09J189/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/12 , C12N15/71 , C12N15/81
CPC分类号： C12N9/6481 , C07K14/435 , C09J189/00 , C12N15/71 , C12N15/81 , C12N9/16
摘要： Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. The bioadhesive precursor protein can be expressed in transformants, recovered and converted to a bioadhesive protein by hydroxylation.
摘要翻译：提供能够在微生物转化体中表达具有选自贻贝，藤壶和牡蛎的海洋动物的生物粘附前体蛋白的天然氨基酸序列的蛋白质的载体。生物粘附前体蛋白可以在转化体中表达，回收并通过羟基化转化成生物粘附蛋白。

3. 发明授权

US5242808A Production of bioadhesive precursor protein analogs by genetically engineered organisms 失效
标题翻译：通过遗传工程生物生产生物粘附前体蛋白类似物
公开(公告)号：US5242808A
公开(公告)日：1993-09-07
申请号：US644745
申请日：1991-01-23
申请人： Kathy J. Maugh , David M. Anderson , Susan L. Strausberg , Robert Strausberg , Tena Wei
发明人： Kathy J. Maugh , David M. Anderson , Susan L. Strausberg , Robert Strausberg , Tena Wei
IPC分类号： C07K14/435 , C09J189/00 , C12N1/21 , C12N9/16 , C12N9/64 , C12N15/71 , C12N15/81
CPC分类号： C12N9/6481 , C07K14/435 , C09J189/00 , C12N15/71 , C12N15/81 , C12N15/815 , C12N9/16 , C07K2319/02
摘要： Recombinant production of bioadhesive precursor protein analogs is disclosed. The bioadhesive precursor protein analogs can be hydroxylated and used as an adhesive in wet environments.
摘要翻译：公开了生物粘附前体蛋白类似物的重组生产。生物粘附前体蛋白类似物可以被羟基化并用作湿环境中的粘合剂。

4. 发明授权

US5202236A Method of producing bioadhesive protein 失效
标题翻译：生物粘附蛋白的生产方法
公开(公告)号：US5202236A
公开(公告)日：1993-04-13
申请号：US528762
申请日：1990-05-25
申请人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg
发明人： Kathy J. Maugh , David M. Anderson , Robert Strausberg , Susan L. Strausberg
IPC分类号： C07K14/435 , C09J189/00 , C12N9/16 , C12N9/64 , C12N15/12 , C12N15/71 , C12N15/81
CPC分类号： C12N9/6481 , C07K14/435 , C09J189/00 , C12N15/71 , C12N15/81 , C12N9/16
摘要： Vectors are provided that are capable of expressing, in microbial transformants, a protein having the native amino acid sequence of a bioadhesive precursor protein of a marine animal selected from the group consisting of mussels, barnacles, and oysters. The bioadhesive precursor protein can be expressed in transformants, recovered and converted to a bioadhesive protein by hydroxylation.
摘要翻译：提供能够在微生物转化体中表达具有选自贻贝，藤壶和牡蛎的海洋动物的生物粘附前体蛋白的天然氨基酸序列的蛋白质的载体。生物粘附前体蛋白可以在转化体中表达，回收并通过羟基化转化成生物粘附蛋白。

5. 发明授权

US5279960A 25 KD coccidial antigen of eimeria tenella 失效
标题翻译：艾美球虫的25 KD球虫抗原
公开(公告)号：US5279960A
公开(公告)日：1994-01-18
申请号：US879137
申请日：1992-05-05
申请人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
发明人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012 , C07K15/04 , C12N15/30 , C12N15/67
CPC分类号： C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , C12N2830/002 , C12N2830/15 , Y10S530/822
摘要： A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
摘要翻译：克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

6. 发明授权

US5597571A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5597571A
公开(公告)日：1997-01-28
申请号：US484387
申请日：1995-06-07
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

7. 发明授权

US5567601A Subtilisin mutants lacking a primary calcium binding site 失效
标题翻译：缺乏初级钙结合位点的枯草杆菌蛋白酶突变体
公开(公告)号：US5567601A
公开(公告)日：1996-10-22
申请号：US309069
申请日：1994-09-20
申请人： Philip N. Bryan , Patrick A. Alexander , Susan L. Strausberg
发明人： Philip N. Bryan , Patrick A. Alexander , Susan L. Strausberg
IPC分类号： C12N15/09 , C12N9/54 , C12N15/57 , C12P21/02 , C12N9/56 , C12N15/11 , C12N15/75
CPC分类号： C12N9/54
摘要： Novel calcium free subtilisin mutants are taught, in particular subtilisins which have been mutated to eliminate amino acids 75-83 and which retain enzymatic activity and stability. Recombinant methods for producing same and recombinant DNA encoding for such subtilisin mutants are also provided.
摘要翻译：教导了新的无钙枯草杆菌蛋白酶突变体，特别是已被突变以消除氨基酸75-83并且保留酶活性和稳定性的枯草杆菌蛋白酶。还提供了用于生产相同的重组方法和编码这种枯草杆菌蛋白酶突变体的重组DNA。

8. 发明授权

US5013652A Composite yeast vectors 失效
标题翻译：复合酵母载体
公开(公告)号：US5013652A
公开(公告)日：1991-05-07
申请号：US918147
申请日：1986-10-14
申请人： Robert L. Strausberg , Susan L. Strausberg
发明人： Robert L. Strausberg , Susan L. Strausberg
IPC分类号： C07K14/39 , C07K14/81 , C12N15/62 , C12N15/81
CPC分类号： C07K14/8128 , C07K14/39 , C12N15/625 , C12N15/81 , C07K2319/036 , C07K2319/81
摘要： A DNA sequence comprising:(a) a hybrid first yeast promoter comprising the functional segment of the DNA sequence encoding the upstream activation site of a gene selected from the group consisting of GAL1, GAL7 and GAL10, operably linked to the functional segment of the transcription initiation site of MF-.alpha.-1;(b) the functional segment of a signal sequence substantially comprising preferred yeast codons;(c) the functional segment of the DNA sequence comprising a Saccharomyces GAPDH transcription terminator;(d) the functional segment of the Saccharomyces 2.mu. circle replication origin; and(e) the functional segment of the yeast LEU2-d selectable marker. The DNA sequence may further comprise, inserted in phase between the signal sequence and transcription terminator, the functional segment of a DNA sequence encoding a heterologous target peptide. DNA expression vectors comprising these sequences, DNA expression systems comprising these vectors and further comprising a source of the peptide encoded by the DNA sequence of the GAL4 structural gene, yeast hosts transformed with said expression vectors or expression systems, methods of producing heterologous target peptides in yeast hosts employing the sequences, vectors and systems of the invention, and heterologous target peptides produced according to these methods are disclosed. By means of the present invention, ultrahigh (greater than 1 gram/liter, or at least 10% of total yeast cell protein) expression of heterologous peptides may be effected.
摘要翻译：一种DNA序列，其包含：（a）混合的第一酵母启动子，其包含编码选自GAL1，GAL7和GAL10的基因的上游激活位点的DNA序列的功能区段，其可操作地连接到转录的功能区段 MF-α-1的起始位点; （b）基本上包含优选的酵母密码子的信号序列的功能片段; （c）包含酵母GAPDH转录终止子的DNA序列的功能区段; （d）酵母菌2亩复制起源的功能区段; 和（e）酵母LEU2-d选择标记的功能区段。 DNA序列可以进一步包含在信号序列和转录终止子之间的相位插入编码异源靶肽的DNA序列的功能区段。包含这些序列的DNA表达载体，包含这些载体的DNA表达系统，并且还包含由所述GAL4结构基因的DNA序列编码的肽的来源，用所述表达载体或表达系统转化的酵母宿主，在所述DNA表达系统中产生异源靶肽的方法公开了使用本发明的序列，载体和系统的酵母宿主，以及根据这些方法生产的异源靶肽。通过本发明，可以实现异源肽的超高（大于1克/升，或总酵母细胞蛋白的至少10％）的表达。

9. 发明授权

US5482709A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5482709A
公开(公告)日：1996-01-09
申请号：US148432
申请日：1993-11-08
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

10. 发明授权

US5470733A Calcium free subtilisin mutants 失效
标题翻译：无钙枯草杆菌蛋白酶突变体
公开(公告)号：US5470733A
公开(公告)日：1995-11-28
申请号：US69863
申请日：1993-06-01
申请人： Philip N. Bryan , Patrick A. Alexander , Susan L. Strausberg
发明人： Philip N. Bryan , Patrick A. Alexander , Susan L. Strausberg
IPC分类号： C12N9/54 , C12N15/57 , C12N9/56 , C12N15/00 , C12N15/63
CPC分类号： C12N9/54
摘要： Novel calcium free subtilisin mutants are taught, in particular a subtilisin which has been mutated to eliminate amino acids 75-83.
摘要翻译：教导了新的无钙枯草杆菌蛋白酶突变体，特别是已被突变以消除氨基酸75-83的枯草杆菌蛋白酶。

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