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1. 发明授权

US5279960A 25 KD coccidial antigen of eimeria tenella 失效
标题翻译：艾美球虫的25 KD球虫抗原
公开(公告)号：US5279960A
公开(公告)日：1994-01-18
申请号：US879137
申请日：1992-05-05
申请人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
发明人： David M. Anderson , Russell J. McCandliss , Susan L. Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012 , C07K15/04 , C12N15/30 , C12N15/67
CPC分类号： C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , C12N2830/002 , C12N2830/15 , Y10S530/822
摘要： A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
摘要翻译：克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

2. 发明授权

US5709862A Isolated protein from Eimeria useful as a cross species vaccine 失效
标题翻译：来自艾美球虫的分离的蛋白质可用作交叉疫苗
公开(公告)号：US5709862A
公开(公告)日：1998-01-20
申请号：US148279
申请日：1993-11-08
申请人： David M. Anderson , Russell J. McCandliss , Susan Lee Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
发明人： David M. Anderson , Russell J. McCandliss , Susan Lee Strausberg , Robert L. Strausberg , Michael D. Ruff , Harry D. Danforth , Patricia C. Augustine
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/002 , A61K39/012
CPC分类号： C07K14/455 , C12N15/70 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , C12N2830/002 , C12N2830/15 , Y10S530/822
摘要： A cloned gene or fragment thereof encodes antigenic proteins that bind with a monoclonal or polyvalent antibody that is directed against an antigenic protein of avian coccidia.
摘要翻译：克隆的基因或其片段编码与针对禽类球虫抗原蛋白的单克隆或多价抗体结合的抗原蛋白。

3. 发明授权

US5597571A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5597571A
公开(公告)日：1997-01-28
申请号：US484387
申请日：1995-06-07
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

4. 发明授权

US5482709A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
标题翻译：引起针对禽类球虫病抗体的艾美球虫抗原组合物
公开(公告)号：US5482709A
公开(公告)日：1996-01-09
申请号：US148432
申请日：1993-11-08
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

5. 发明授权

US5273901A Genetically engineered coccidiosis sporozoite 21.5 Kb antigen, ac-6b 失效
标题翻译：基因工程球孢子虫子孢子21.5 Kb抗原，ac-6b
公开(公告)号：US5273901A
公开(公告)日：1993-12-28
申请号：US581693
申请日：1990-09-12
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan L. Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/12 , C07K15/04
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.
摘要翻译：本发明涉及禽类球虫病的新型重组抗原蛋白及其含有抗原决定簇的片段，以及编码抗原肽的基因。本发明还涉及使用禽类球虫病的新型抗原蛋白质制备的疫苗以及针对禽类球虫免疫鸡的方法。

6. 发明授权

US5656485A Eimeria antigenic composition which elicits antibodies against avian coccidiosis 失效
公开(公告)号：US5656485A
公开(公告)日：1997-08-12
申请号：US691454
申请日：1996-08-02
申请人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
发明人： James W. Jacobson , Robert L. Strausberg , Susan D. Wilson , Sharon H. Pope , Susan Lee Strausberg , Michael D. Ruff , Patricia C. Augustine , Harry D. Danforth
IPC分类号： A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20 , C12N15/30 , C12N15/70 , C12N15/81 , C12N15/86 , C12N15/863 , A61K39/012
CPC分类号： C12N15/70 , C07K14/455 , C07K16/20 , C12N15/81 , C12N15/86 , A61K38/00 , A61K39/00 , C07K2319/00 , C07K2319/02 , C07K2319/40 , C07K2319/61 , C12N2795/10043 , Y10S530/822
摘要： This invention relates to novel recombinant antigenic proteins of avian coccidiosis, and fragments thereof containing antigenic determinants, and to the genes that encode the antigenic peptides. This invention also relates to vaccines made using the novel antigenic proteins of avian coccidiosis and to methods of immunizing chickens against avian coccidia.

7. 发明授权

US5122471A Cloned genes coding for avian coccidiosis antigens which induce a cell-mediated immune response 失效
标题翻译：编码诱导细胞介导的免疫应答的禽类球虫抗原的克隆基因
公开(公告)号：US5122471A
公开(公告)日：1992-06-16
申请号：US308219
申请日：1989-02-09
申请人： Mark C. Jenkins , Hyun S. Lillehoj , John B. Dame , Harry D. Danforth , Michael D. Ruff
发明人： Mark C. Jenkins , Hyun S. Lillehoj , John B. Dame , Harry D. Danforth , Michael D. Ruff
IPC分类号： A61K39/00 , C07K14/455 , C07K16/20 , C12N1/21
CPC分类号： C07K14/455 , C07K16/20 , A61K39/00
摘要： Disclosed are DnA sequences which code for antigenic proteins, methods for identifying such DNA sequences, and antigens coded for by such DNA sequences.The first step of the method is to provide a multiplicity of DNA sequences. These sequences are then inserted into DNA expression vectors to form recombinant expression vectors. The expression vectors are inserted into suitable hosts to form transformants which express the DNA sequences. The transformants are then contacted with antibodies directed against Eimeria antigens to identify transformants containing DNA sequences which code for Eimeria antigens. These antigens are then produced from the DNA sequences identified as coding for the antigens. The antigens so produced are contacted with white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein, to thereby identify DNA sequences which code for antigens that induce a cell-mediated immune response to avian coccidiosis.The DNA sequences of the present invention comprise cloned genes or fragments thereof that code on expression for an antigenic protein that activates white blood cells which effect a cell-mediated immune response, which white blood cells are sensitized to an antigenic Eimeria protein.
摘要翻译：公开了编码抗原蛋白质的DnA序列，鉴定此类DNA序列的方法和由该DNA序列编码的抗原。该方法的第一步是提供多个DNA序列。然后将这些序列插入DNA表达载体中以形成重组表达载体。将表达载体插入合适的宿主中以形成表达DNA序列的转化体。然后将转化体与针对艾美球虫抗原的抗体接触，以鉴定含有编码艾美球虫抗原的DNA序列的转化体。然后从鉴定为编码抗原的DNA序列产生这些抗原。这样产生的抗原与影响细胞介导的免疫应答的白细胞接触，白血球对抗原性艾美球虫蛋白致敏，从而鉴定编码诱导细胞介导的免疫应答的抗原的DNA序列球虫病本发明的DNA序列包含编码激活影响细胞介导的免疫应答的白细胞的抗原性蛋白质的表达的克隆基因或其片段，所述白细胞对抗原性艾美球虫蛋白致敏。

8. 发明授权

US5763493A Stabilized pharmaceutical 失效
标题翻译：稳定药物
公开(公告)号：US5763493A
公开(公告)日：1998-06-09
申请号：US667239
申请日：1996-06-21
申请人： Michael D. Ruff , Sanvasi R. Kalidindi , Joel Elmore Sutton, Jr.
发明人： Michael D. Ruff , Sanvasi R. Kalidindi , Joel Elmore Sutton, Jr.
IPC分类号： A61K9/20 , A61K9/48 , A61K31/135 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/22 , A01N37/18 , A61K31/165
CPC分类号： A61K31/135 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/22 , A61K9/2013 , A61K9/4858
摘要： This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
摘要翻译：本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

9. 发明授权

US5541231A Stabilized Pharmaceutical 失效
标题翻译：稳定药物
公开(公告)号：US5541231A
公开(公告)日：1996-07-30
申请号：US296252
申请日：1994-08-25
申请人： Michael D. Ruff , Sanvasi R. Kalidindi , Joel E. Sutton, Jr.
发明人： Michael D. Ruff , Sanvasi R. Kalidindi , Joel E. Sutton, Jr.
IPC分类号： A61K9/20 , A61K9/48 , A61K31/135 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/22
CPC分类号： A61K31/135 , A61K31/137 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/22 , A61K9/2013 , A61K9/4858
摘要： This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
摘要翻译：本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

10. 发明授权

US5358970A Pharmaceutical composition containing bupropion hydrochloride and a stabilizer 失效
标题翻译：含有安非他酮盐酸盐和稳定剂的药物组合物
公开(公告)号：US5358970A
公开(公告)日：1994-10-25
申请号：US105437
申请日：1993-08-12
申请人： Michael D. Ruff , Sanyasi R. Kalidindi , Joel E. Sutton, Jr.
发明人： Michael D. Ruff , Sanyasi R. Kalidindi , Joel E. Sutton, Jr.
IPC分类号： A61K9/20 , A61K9/48 , A61K31/135 , A61K47/02 , A61K47/12 , A61K47/18 , A61K47/22
CPC分类号： A61K9/2013 , A61K31/135 , A61K47/02 , A61K47/12 , A61K47/183 , A61K47/22 , A61K9/4858
摘要： This application discloses a method of inhibiting degradation of the antidepressant bupropion hydrochloride in a solid pharmaceutical formulation, so that the pharmaceutical formulation will maintain at least 80% of its initial bupropion potency after one year.
摘要翻译：本申请公开了一种抑制固体药物制剂中抗抑郁药物安非他酮降解的方法，使药物制剂在一年后维持其初始安非他酮效力的至少80％。

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