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    • 5. 发明授权
    • Method of treating dry eye disease with purinergic receptor agonists
    • 用嘌呤能受体激动剂治疗干眼病的方法
    • US07759322B2
    • 2010-07-20
    • US11821091
    • 2007-06-20
    • Benjamin R. YerxaKarla M. JacobusWilliam PendergastJanet L. Rideout
    • Benjamin R. YerxaKarla M. JacobusWilliam PendergastJanet L. Rideout
    • A01N43/04A61K31/70
    • C07H19/10A61K9/0048A61K31/7084A61K45/06C07H19/20C07H21/00Y10S514/912Y10S514/915
    • A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucleotides, cytidine 5′-triphosphate (CTP), adenosine 5′-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
    • 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸(UTP),二核苷酸,胞苷5'-三磷酸(CTP),腺苷5'-三磷酸(ATP)或其治疗上有用的 类似物和衍生物,其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括:通过液体,凝胶,霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药,通过喷雾器或其它装置吸入,口服形式(液体或丸剂),可注射的,术中滴注或栓剂形式。
    • 6. 发明授权
    • Method of treating dry eye disease with purinergic receptor agonists
    • 用嘌呤能受体激动剂治疗干眼病的方法
    • US06921755B2
    • 2005-07-26
    • US10010055
    • 2001-11-09
    • Benjamin R. YerxaKarla M. JacobusWilliam PendergastJanet L. Rideout
    • Benjamin R. YerxaKarla M. JacobusWilliam PendergastJanet L. Rideout
    • A61K45/06A61K31/70
    • A61K45/06Y10S514/912
    • A method and preparation for the stimulation of tear secretion in a subject in need of such treatment is disclosed. The method comprises administering to the ocular surfaces of the subject a purinergic receptor agonist such as uridine 5′-triphosphate (UTP), dinucleotides, cytidine 5′-triphosphate (CTP), adenosine 5′-triphosphate (ATP), or their therapeutically useful analogs and derivatives, in an amount effective to stimulate tear fluid secretion and enhance drainage of the lacrimal system. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include: topical administration via a liquid, gel, cream, or as part of a contact lens or selective release membrane; or systemic administration via nasal drops or spray, inhalation by nebulizer or other device, oral form (liquid or pill), injectable, intra-operative instillation or suppository form.
    • 公开了用于刺激需要这种治疗的受试者的泪液分泌的方法和制剂。 该方法包括向受试者的眼表面施用嘌呤能受体激动剂如尿苷5'-三磷酸(UTP),二核苷酸,胞苷5'-三磷酸(CTP),腺苷5'-三磷酸(ATP)或其治疗上有用的 类似物和衍生物,其量有效地刺激泪液分泌并增强泪液系统的引流。 还公开了药物制剂及其制备方法。 施用该方法的方法将包括:通过液体,凝胶,霜剂或作为隐形眼镜或选择性释放膜的一部分局部给药; 或通过鼻滴或喷雾进行全身给药,通过喷雾器或其它装置吸入,口服形式(液体或丸剂),可注射的,术中滴注或栓剂形式。