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1. 发明授权

US06673779B2 Method of treating ciliary dyskinesia with dinucleoside polyphosphate compounds or UTP analogues 有权
标题翻译：用二核苷多磷酸盐化合物或UTP类似物治疗睫状肌运动障碍的方法
公开(公告)号：US06673779B2
公开(公告)日：2004-01-06
申请号：US10163804
申请日：2002-06-05
申请人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cara Geary , Eduardo R. Lazarowski
发明人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cara Geary , Eduardo R. Lazarowski
IPC分类号： A61K3170
CPC分类号： A61K31/7076 , A61K9/0048 , A61K31/70 , A61K31/7072 , C07H19/10 , C07H19/20 , C07H21/00
摘要： The present invention is directed to a method of stimulating ciliary beat frequency to promote mucociliary or cough clearance of retained mucus secretions from the lungs, sinuses, upper airways, ears, eyes, genito-urinary tract, spermatozoa, ovaries, fallopian tubes, neutrophils, and macrophages of a patient. The method comprises administering uridine triphosphates, adenosine triphosphates, cytidine triphosphates, or dinucleoside tetraphosphates and the derivatives thereof to an affected body of a patient, to treat dysfunction of the mucociliary clearance system as a result of impaired ciliary movement in the patient.
摘要翻译：本发明涉及一种刺激睫状脉搏频率以促进从肺，鼻窦，上呼吸道，耳朵，眼睛，生殖泌尿道，精子，卵巢，输卵管，嗜中性粒细胞，粘液分泌物中保留的粘液分泌物的粘液纤毛或咳嗽清除的方法，和巨噬细胞。该方法包括给患者的受影响的体内施用三磷酸尿苷，三磷酸腺苷，胞苷三磷酸或二核苷四磷酸及其衍生物，以治疗患者睫状肌移动受损的粘液纤毛清除系统的功能障碍。

2. 外观设计

USD960147S1 Kiosk display apparatus 有权
公开(公告)号：USD960147S1
公开(公告)日：2022-08-09
申请号：US29678146
申请日：2019-01-25
申请人： Michael K. James
设计人： Michael K. James

3. 外观设计

USD415118S Cable enclosure 失效
公开(公告)号：USD415118S
公开(公告)日：1999-10-12
申请号：US97348
申请日：1998-12-04
申请人： Andrew G. Stanush , Michael K. James
设计人： Andrew G. Stanush , Michael K. James

4. 发明授权

US5019583A N-phenyl-N-(4-piperidinyl)amides useful as analgesics 失效
标题翻译： N-苯基-N-（4-哌啶基）酰胺，可用作止痛剂
公开(公告)号：US5019583A
公开(公告)日：1991-05-28
申请号：US448497
申请日：1989-12-11
申请人： Paul L. Feldman , Michael K. James , Marcus F. Brackeen , Michael R. Johnson , Harry J. Leighton
发明人： Paul L. Feldman , Michael K. James , Marcus F. Brackeen , Michael R. Johnson , Harry J. Leighton
IPC分类号： A61K31/445 , A61K31/4465 , A61P25/04 , C07B57/00 , C07D211/58
CPC分类号： C07D211/58
摘要： N-Phenyl-N-(4-piperdinyl)amide derivatives are disclosed having the general formula (I): ##STR1## wherein X is a member selected from the group consisting of alkoxy-carbonyl-lower alkyl, lower alkyl-carbonyloxy-lower alkyl, alkenyloxy-carbonyl-lower alkyl, and (C.sub.1-2)alkoxy-(C.sub.1-2)-alkoxy-carbonyl-lower alkyl, and Ar, R, R.sup.1 and R.sup.2 are defined hereinafter, including isomeric forms thereof and acid addition salts thereof. The compounds exhibit analgesic activity having relatively short durations of analgesic action. The invention embraces the compounds (I), pharmaceutical compositions of (I) and methods of providing analgesia with (I). Also included are certain novel intermediates for making (I).

5. 外观设计

USD583795S1 Enclosure for housing communications equipment 有权
标题翻译：住房通讯设备外壳
公开(公告)号：USD583795S1
公开(公告)日：2008-12-30
申请号：US29264332
申请日：2006-08-08
申请人： John A. Keenum , Brad N. Grunwald , John J. Napiorski , Scott C. Burns , Liem H. Higa , Michael K. James
设计人： John A. Keenum , Brad N. Grunwald , John J. Napiorski , Scott C. Burns , Liem H. Higa , Michael K. James

6. 发明授权

US06795552B1 Enhanced services network interface device 失效
标题翻译：增强型服务网络接口设备
公开(公告)号：US06795552B1
公开(公告)日：2004-09-21
申请号：US09460790
申请日：1999-12-14
申请人： Andrew G. Stanush , Michael K. James
发明人： Andrew G. Stanush , Michael K. James
IPC分类号： H04M100
CPC分类号： H04Q1/028 , H04Q1/026 , H04Q1/03 , H04Q1/116 , H04Q1/144 , H04Q2201/10 , H04Q2201/12 , H04Q2201/16 , H04Q2201/802
摘要： A network interface device includes an enclosure that houses active electronics for accommodating twisted-pair telephone wires and coaxial cable. The housing has a base that connects to a building wall. A shield locates within the housing, the shield having a platform and a perimeter wall that extends around the platform. A printed circuit board mounts within the shield between the base and the platform. The shield is hinged to the base so that it may be readily removed with the printed circuit board if repair is needed. A subscriber bridge module mounts on the platform. The subscriber bridge module has subscriber line termination points on one side that electrically connect with the subscriber lines. The subscriber bridge module also has telephone jacks electrically connected between the subscriber termination points and the provider line. This provides a demarcation between the subscriber lines and the provider line. An inner cover encloses a provider line port, any voltage protecting devices mounted on the platform, and power terminals on the subscriber bridge module.
摘要翻译：网络接口设备包括容纳用于容纳双绞线电话线和同轴电缆的有源电子装置的外壳。外壳具有连接到建筑物墙壁的基座。护罩位于外壳内，护罩具有平台和围绕平台延伸的周边壁。印刷电路板安装在基座和平台之间的屏蔽层内。屏蔽件铰接到基座上，以便如果需要维修，可以很容易地与印刷电路板一起移除。用户桥模块安装在平台上。用户桥模块在一侧具有与用户线路电连接的用户线路终端点。用户桥模块还具有电连接在用户终端点和提供商线路之间的电话插孔。这提供了用户线路和提供商线路之间的划分。内盖包括提供商线路端口，安装在平台上的任何电压保护设备以及用户桥接模块上的电源端子。

7. 发明授权

US06420347B1 Method of treating ciliary dyskinesia with uridine triphosphates and related compounds 失效
标题翻译：用尿苷三磷酸和相关化合物治疗睫状肌运动障碍的方法
公开(公告)号：US06420347B1
公开(公告)日：2002-07-16
申请号：US09101840
申请日：1998-07-17
申请人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cary Geary , Edwardo R. Lazarowski
发明人： Karla M. Jacobus , Benjamin R. Yerxa , William Pendergast , Richard C. Boucher, Jr. , Janet L. Rideout , David J. Drutz , Michael K. James , Monroe Jackson Stutts , Cary Geary , Edwardo R. Lazarowski
IPC分类号： A61K3170
CPC分类号： A61K31/70
摘要： A method of stimulating ciliary beat frequency in a subject in need of such treatment is disclosed. The method comprises administering to the airways, ears, eyes, or genito-urinary tract of the subject a triphosphate nucleotide such as uridine 5′-triphosphate (UTP), an analog of UTP, or any other analog, in an amount effective to stimulate ciliary beat frequency. This method is useful for treating patients afflicted with ciliary dyskinesia, Kartagener's syndrome, or any other disease involving dysfunction of ciliary movement, such as male infertility caused by impairment of propulsion of the spermatozoa or immune deficiency caused by impairment of ciliary movement in neutrophils or macrophages. Pharmaceutical formulations and methods of making the same are also disclosed. Methods of administering the same would include any liquid suspension (including nasal spray or nasal or eye drops), oral, inhaled by nebulization, topical, injected, suppository, intra-operative by instillation or application, or ex vivo direct application to spermatozoa.
摘要翻译：公开了一种在需要这种治疗的受试者中刺激睫状肌搏动频率的方法。该方法包括向受试者的气道，耳朵，眼睛或生殖泌尿道施用有效刺激的量的三磷酸核苷酸，例如尿苷5'-三磷酸（UTP），UTP类似物或任何其它类似物睫毛拍频。该方法可用于治疗患有睫状肌运动障碍，Kartagener综合征或涉及睫状肌运动功能障碍的任何其他疾病，例如由嗜中性粒细胞或巨噬细胞的睫状肌运动损伤引起的精子推进或免疫缺陷引起的男性不育症。还公开了药物制剂及其制备方法。给药方法包括任何液体悬浮液（包括鼻喷雾或鼻腔或滴眼液），口服，通过雾化吸入，局部注射，注射，栓剂，通过滴注或施用手术，或离体直接施用于精子。

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