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1. 发明申请

US20090215726A1 Phosphono-Pent-2-en-1-yl Nucleosides and Analogs 有权
标题翻译：膦酰基 - 戊-2-烯-1-基核苷和类似物
公开(公告)号：US20090215726A1
公开(公告)日：2009-08-27
申请号：US11887502
申请日：2006-03-30
申请人： Karl Y. Hosterler , James R. Beadle , Hyunah Choo
发明人： Karl Y. Hosterler , James R. Beadle , Hyunah Choo
IPC分类号： A61K31/675 , C07F9/6512 , A61P31/12 , A61P35/00
CPC分类号： C07F9/65616 , C07F9/6512 , C07H19/10 , C07H19/20
摘要： Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.
摘要翻译：提供化合物和组合物用于治疗，预防或改善与病毒感染和/或细胞增殖相关的多种医学病症。本文提供的化合物是5-膦酰基 - 戊-2-烯-1-基核苷及其酯。

2. 发明授权

US08222257B2 Phosphono-pent-2-en-1-yl nucleosides and analogs 有权
标题翻译：膦酰 - 戊-2-烯-1-基核苷和类似物
公开(公告)号：US08222257B2
公开(公告)日：2012-07-17
申请号：US11887502
申请日：2006-03-30
申请人： Karl Y. Hostetler , James R. Beadle , Hyunah Choo
发明人： Karl Y. Hostetler , James R. Beadle , Hyunah Choo
IPC分类号： A01N43/54 , A01N43/90 , A61K31/522 , A61K31/52 , A61K31/505 , C07D245/00 , C07D225/02 , C07D487/00 , C07D239/02 , C07D475/00 , C07D473/00 , C07F9/02
CPC分类号： C07F9/65616 , C07F9/6512 , C07H19/10 , C07H19/20
摘要： Compounds and compositions are provided for treatment, prevention, or amelioration of a variety of medical disorders associated with viral infections and/or cell proliferation. The compounds provided herein are 5-phosphono-pent-2-en-1-yl nucleosides and esters thereof.
摘要翻译：提供化合物和组合物用于治疗，预防或改善与病毒感染和/或细胞增殖相关的多种医学病症。本文提供的化合物是5-膦酰基 - 戊-2-烯-1-基核苷及其酯。

3. 发明授权

US07790703B2 Phosphonate compounds 有权
公开(公告)号：US07790703B2
公开(公告)日：2010-09-07
申请号：US11715604
申请日：2007-03-07
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/52 , A61K31/505 , A61K31/665 , C07D239/22 , C07D473/00
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.

4. 发明授权

US07687480B2 Phosphonate compounds 有权
标题翻译：膦酸酯化合物
公开(公告)号：US07687480B2
公开(公告)日：2010-03-30
申请号：US11925309
申请日：2007-10-26
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/675 , C07D239/70
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
摘要翻译：本发明涉及膦酸酯化合物，含有它们的组合物，获得它们的方法及其用于治疗多种医学病症，例如骨质疏松症和其他骨代谢疾病，癌症，病毒感染等的用途。

5. 发明授权

US06686462B2 Antiviral compounds and methods of administration 失效
标题翻译：抗病毒化合物和给药方法
公开(公告)号：US06686462B2
公开(公告)日：2004-02-03
申请号：US08808847
申请日：1997-02-28
申请人： Andre Rosowsky , Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini , Douglas D. Richman
发明人： Andre Rosowsky , Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini , Douglas D. Richman
IPC分类号： A61K3170
CPC分类号： C07H19/10 , C07H19/20
摘要： The invention provides lipophilic phosphonoacid/nucleoside conjugates that exhibit exceptional antiviral activity, including activity against drug-resistant HIV strains. Compounds of the invention include phosphonoacid/nucleoside conjugates where the carboxyl group and phosphonyl groups of the phosphonacid are esterified whereby the compound contains at least one lipophilic group and at least one nucleoside group.
摘要翻译：本发明提供亲油性膦酰基/核苷缀合物，其表现出非凡的抗病毒活性，包括抗药物抗性HIV株的活性。本发明的化合物包括膦酰基/核苷缀合物，其中膦酰基的羧基和膦酰基被酯化，由此化合物含有至少一个亲油基团和至少一个核苷基团。

6. 发明授权

US5215591A Crystalline form of D-gulose 失效
标题翻译： D-酮糖的结晶形式
公开(公告)号：US5215591A
公开(公告)日：1993-06-01
申请号：US856638
申请日：1992-03-24
申请人： James R. Beadle , Gilbert V. Levin , Lee R. Zehner
发明人： James R. Beadle , Gilbert V. Levin , Lee R. Zehner
IPC分类号： C07H3/02 , C13K13/00
CPC分类号： C07H3/02 , C13K13/00
摘要： Free flowing, substantially pure, non-hygroscopic, crystalline .beta.-D-gulopyranose is disclosed. This crystalline form of D-gulose is characterized by a sharp melting point of 130.degree.-132.degree. C., a specific optical rotation of -40.degree. and characteristic mutarotation. A method for preparation of crystalline .beta.-D-gulopyranose from D-gulose syrup is also disclosed. This method involves dilution of the D-gulose syrup, followed by initiation of crystallization, and isolation of .beta.-D-gulopyranose crystals. Crystalline .beta.-D-gulopyranose may be used as an excipient, a chelating agent, a pharmaceutical intermediate, a cleaning agent for glass and metals, a food additive, and as an additive for detergents.
摘要翻译：公开了自由流动的，基本上纯的，非吸湿性的结晶β-D-吡喃葡萄糖。该D-形木糖的结晶形式的特征在于尖锐的熔点为130℃-132℃，比旋光度为-40度，具有特殊的旋转作用。还公开了从D-木糖糖浆制备结晶β-D-吡喃葡萄糖的方法。该方法包括稀释D-木糖糖浆，随后开始结晶，并分离β-D-吡喃葡萄糖晶体。结晶β-D-吡喃葡萄糖可用作赋形剂，螯合剂，药物中间体，玻璃和金属用清洁剂，食品添加剂和用作洗涤剂的添加剂。

7. 发明授权

US08309565B2 Phosphonate compounds 有权
标题翻译：膦酸酯化合物
公开(公告)号：US08309565B2
公开(公告)日：2012-11-13
申请号：US13220548
申请日：2011-08-29
申请人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
发明人： Karl Y. Hostetler , James R. Beadle , Ganesh D. Kini
IPC分类号： A61K31/506 , C07D239/22
CPC分类号： A61K31/675 , A61K9/0053 , A61K9/20 , A61K9/48 , C07F9/3873 , C07F9/404 , C07F9/405 , C07F9/48 , C07F9/5728 , C07F9/6512 , C07F9/65583 , C07F9/65616 , C07H19/04 , C07H19/10
摘要： The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
摘要翻译：本发明涉及膦酸酯化合物，含有它们的组合物，获得它们的方法及其用于治疗多种医学病症，例如骨质疏松症和其他骨代谢疾病，癌症，病毒感染等的用途。

8. 发明授权

US07994143B2 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权
标题翻译：抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐
公开(公告)号：US07994143B2
公开(公告)日：2011-08-09
申请号：US12797327
申请日：2010-06-09
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
IPC分类号： A01N43/04 , A61K31/70
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译：本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。

9. 发明授权

US07749983B2 Metabolically stable alkoxyalkyl esters of antiviral or antiproliferative phosphonates, nucleoside phosphonates and nucleoside phosphates 有权
标题翻译：抗病毒或抗增殖磷酸盐的代谢稳定的烷氧基烷基酯，核苷膦酸盐和核苷磷酸盐
公开(公告)号：US07749983B2
公开(公告)日：2010-07-06
申请号：US11736614
申请日：2007-04-18
申请人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
发明人： Karl Y. Hostetler , James R. Beadle , Jacqueline Ruiz , Merrick R. Almond , George R. Painter , Timothy A. Riley , Paula Francom
IPC分类号： A01N57/00 , A61K31/675
CPC分类号： C07F9/657172 , C07F9/6512 , C07F9/6552 , C07F9/65616
摘要： The present invention relates to phosphonate, nucleoside phosphonate or nucleoside phosphate compounds, compositions containing them, processes for obtaining them, and their use in treating a variety of medical disorders, in particular viral infections, cancers and the like.
摘要翻译：本发明涉及膦酸盐，核苷膦酸盐或核苷磷酸盐化合物，含有它们的组合物，获得它们的方法及其在治疗各种医学病症，特别是病毒感染，癌症等中的用途。

10. 发明授权

US5356879A D-tagatose as anti-hyperglycemic agent 失效
标题翻译： D-塔格糖作为抗高血糖药
公开(公告)号：US5356879A
公开(公告)日：1994-10-18
申请号：US835496
申请日：1992-02-14
申请人： Lee R. Zehner , Gilbert V. Levin , James P. Saunders , James R. Beadle
发明人： Lee R. Zehner , Gilbert V. Levin , James P. Saunders , James R. Beadle
IPC分类号： A61K31/70
CPC分类号： A61K31/7004 , Y10S514/866 , Y10S514/884
摘要： This invention discloses the usefulness of D-tagatose as a treatment for hyperglycemia, diabetes mellitus, and the inhibition of formation of advanced glycosylation end-products associated with the aging process.This invention discloses edible formulations and pharmaceutical compositions containing D-tagatose and the effect of consumption of such formulations on blood level of glucose. D-Tagatose was found to be an anti-hyperglycemic agent. In addition, consumption of D-tagatose in sweetened formulations to inhibit formation of advanced glycosylation end-products in mammals is disclosed. The combination of the anti-hyperglycemic effect and the inhibition of formation of glycosylated proteins and nucleic acids make D-tagatose an ideal agent for alleviating the complications resulting from hyperglycemia, including acceleration of the aging process.
摘要翻译：本发明公开了D-塔格糖作为治疗高血糖症，糖尿病以及与衰老过程相关的晚期糖基化终产物形成的抑制作用。本发明公开了含有D-塔格糖的食用制剂和药物组合物以及这种制剂的消耗对血糖水平的影响。 D塔达糖被发现是一种抗高血糖剂。此外，公开了在甜味制剂中消耗D-塔格糖以抑制哺乳动物中晚期糖基化终产物的形成。抗高血糖作用和抑制糖基化蛋白质和核酸形成的组合使D-塔格糖成为缓解由高血糖引起的并发症的理想药剂，包括加速老化过程。

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