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1. 发明授权

US06476253B1 Process for preparing monoacetylated hydroquinone compounds 失效
标题翻译：制备单乙酰氢醌化合物的方法
公开(公告)号：US06476253B1
公开(公告)日：2002-11-05
申请号：US09677860
申请日：2000-10-03
申请人： Karin Schein , Kai-Uwe Baldenius , Wolfgang Siegel , Rainer Stürmer , Detlef Ruff , Hagen Jaedicke
发明人： Karin Schein , Kai-Uwe Baldenius , Wolfgang Siegel , Rainer Stürmer , Detlef Ruff , Hagen Jaedicke
IPC分类号： C07C6700
CPC分类号： C07C69/017 , C07C45/46 , C07C67/42 , C07C49/825 , C07C69/16
摘要： The present invention relates to a process for preparing monoacetylated hydroquinone compounds of the formula I, to the novel final products of the process and to a process for preparing the precursors.
摘要翻译：本发明涉及一种制备式I的单乙酰氢醌化合物的方法，涉及本方法的新型最终产物和制备该前体的方法。

2. 发明授权

US06977270B2 Tocotrienolquinone cyclization product with an anti-hypercholesterol effect 有权
标题翻译：生育三烯酚环化产物具有抗高胆固醇的作用
公开(公告)号：US06977270B2
公开(公告)日：2005-12-20
申请号：US10332863
申请日：2001-07-13
申请人： Kai-Uwe Baldenius , Hartwig Schröder , Klaus Krämer , Karin Schein , Rainer Stürmer
发明人： Kai-Uwe Baldenius , Hartwig Schröder , Klaus Krämer , Karin Schein , Rainer Stürmer
IPC分类号： A23L33/105 , A61K31/343 , A61P3/00 , A61P3/06 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , C07C46/06 , C07C50/28 , C07D307/94 , C07D317/72 , H61K31/343
CPC分类号： C07D307/94 , A23L33/105
摘要： A description is given of the use of at least one compound of the formula I where R1, R2, R3 and R4 independently of one another are H or C1-C6-alkyl; and the use of a compound of the formula I for medical use.
摘要翻译：给出了使用至少一种式I的化合物的用途，其中R 1，R 2，R 3，R 3和R 2 > 4个彼此独立地是H或C 1 -C 6 - 烷基; 以及使用式I化合物用于医疗用途。

3. 发明授权

US08597915B2 Process for the reduction of cinnamaldehyde derivative employing enoate reductases 有权
标题翻译：用烯酸还原酶还原肉桂醛衍生物的方法
公开(公告)号：US08597915B2
公开(公告)日：2013-12-03
申请号：US13576280
申请日：2011-02-01
申请人： Bernhard Hauer , Rainer Stürmer , Clemens Stückler , Kurt Faber
发明人： Bernhard Hauer , Rainer Stürmer , Clemens Stückler , Kurt Faber
IPC分类号： C12P7/24 , C12P17/06
CPC分类号： C12P7/24 , C12P41/002
摘要： The present invention relates to a novel enzymatically catalyzed method for the production of asymmetric aromatic aldehydes in an aqueous reaction medium containing certain organic co-solvents.
摘要翻译：本发明涉及一种在含有某些有机助溶剂的含水反应介质中生产不对称芳族醛的新的酶促催化方法。

4. 发明授权

US08206957B2 Process for the enzymatic preparation of citronellal 有权
标题翻译：香茅醛酶的制备方法
公开(公告)号：US08206957B2
公开(公告)日：2012-06-26
申请号：US12159531
申请日：2006-12-19
申请人： Andreas Schädler , Thomas Friedrich , Rainer Stürmer , Sabine Rinck
发明人： Andreas Schädler , Thomas Friedrich , Rainer Stürmer , Sabine Rinck
IPC分类号： C12P7/24
CPC分类号： C12P7/24 , C12N9/001
摘要： A process for preparing optically active saturated aldehydes or alcohols of the formula (2) from α,β-unsaturated aldehydes of the formula (1) by reduction in the presence of an enoate reductase (i) having the polypeptide sequence SEQ ID No. 1 or 2, or (ii) having a polypeptide sequence which is at least 80% identical to the sequence of SEQ ID No. 1 or 2.
摘要翻译：通过在具有多肽序列SEQ ID No.的烯酸还原酶（i）的存在下还原从式（1）的α，β-不饱和醛制备式（2）的旋光性饱和醛或醇的方法。 1或2，或（ii）具有与SEQ ID No.1或2的序列至少80％相同的多肽序列。

5. 发明授权

US07816107B2 Method for producing an optically active 2-methyl-alkane-1-ol from the corresponding 2-methylalk-2-en-1-al, comprising carbonyl-selective reduction, enantioselective hydration and lipase-catalyzed, stereoselective acylation in order to enrich the desired 有权
标题翻译：从相应的2-甲基-2-烯-1-烯制备光学活性2-甲基 - 烷-1-醇的方法，包括羰基选择性还原，对映选择性水合和脂肪酶催化的立体选择性酰化，以富集想要的
公开(公告)号：US07816107B2
公开(公告)日：2010-10-19
申请号：US11576317
申请日：2005-09-22
申请人： Christoph Jäkel , Gunnar Heydrich , Rainer Stürmer , Rocco Paciello
发明人： Christoph Jäkel , Gunnar Heydrich , Rainer Stürmer , Rocco Paciello
IPC分类号： C12P7/04
CPC分类号： C12P7/04 , C07B2200/07 , C07C29/14 , C07C29/141 , C07C29/172 , C12C11/02 , C07C33/025 , C07C31/125
摘要： A process for preparing optically active 2-methylalkan-1-ol of the general formula (III) comprising the following steps: (i) carbonyl-selective reduction of 2-methylalk-2-en-1-al of the general formula (I) to 2-methylalk-2-en-1-ol of the general formula (II), (ii) enantioselective hydrogenation of 2-methylalk-2-en-1-ol to the general formula (iii), (iii) increasing the optical yield of the optically active 2-methylalkan-1-ol (III) obtained in step (ii) by a lipase-catalyzed acylation reaction, where the radical R means C1-C10-alkyl.
摘要翻译：一种制备通式（III）的光学活性2-甲基烷-1-醇的方法，包括以下步骤：（i）通式（I）的2-甲基-α-烯-1-醇的羰基选择性还原）到通式（II）的2-甲基-2-烯-1-醇，（ii）2-甲基烯-2-烯-1-醇与通式（iii）的对映选择性氢化，（iii）增加通过脂肪酶催化的酰化反应在步骤（ii）中获得的光学活性2-甲基
链烷-1-醇（III）的光学收率，其中基团R是指C 1 -C 10 - 烷基。

6. 发明申请

US20100035315A1 PROCESS FOR ENZYMATIC REDUCTION OF ALKENE DERIVATIVES 失效
标题翻译：碱性衍生物的酶促还原过程
公开(公告)号：US20100035315A1
公开(公告)日：2010-02-11
申请号：US12514215
申请日：2007-11-13
申请人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
发明人： Rainer Stürmer , Bernhard Hauer , Thomas Friedrich , Kurt Faber , Melanie Hall
IPC分类号： C12P7/26
CPC分类号： C12P7/24 , C12P7/26 , C12P7/40 , C12P7/46 , C12P7/62 , C12P13/008 , C12P17/10 , C12P41/002
摘要： A method for enzymatic preparation of compounds of the general formula (2) from unsaturated alkene derivatives of the general formula (1) by reducing a compound of the formula (1) in the presence of a reductase, comprising at least one of the polypeptide sequences SEQ ID NO: 1, 2 or 3 or having a functionally equivalent polypeptide sequence which is at least 80% identical to SEQ ID NO: 1, 2 or 3.
摘要翻译：一种通过在还原酶的存在下还原式（1）的化合物，从通式（1）的不饱和烯烃衍生物中酶制备通式（2）的化合物的方法，所述方法包括至少一种多肽序列具有与SEQ ID NO：1,2或3至少80％相同的功能等同多肽序列的SEQ ID NO：1,2或3。

7. 发明授权

US07314739B2 Lipase variants 失效
标题翻译：脂肪酶变体
公开(公告)号：US07314739B2
公开(公告)日：2008-01-01
申请号：US10493210
申请日：2002-10-17
申请人： Markus Matuschek , Rainer Stürmer , Bernhard Hauer , Gerhard Klebe , Marco Bocola
发明人： Markus Matuschek , Rainer Stürmer , Bernhard Hauer , Gerhard Klebe , Marco Bocola
IPC分类号： C12P7/62 , C12P7/40 , C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/20
摘要： The invention relates to a lipase variant which can be prepared by carrying out, on the amino acid sequence of a starting lipase selected from the lipase homologous family I.1 or I.2, at least one amino acid substitution in those positions which correspond to the positions 17, 29, 30, 52, 86, 117, 122, 160, 163, 167, 265, 266, 286, 289 in the prototype lipase sequence SEQ ID NO: 1.
摘要翻译：本发明涉及脂酶变体，其可通过在选自脂肪酶同源家族I.1或I.2的起始脂肪酶的氨基酸序列上进行至少一个氨基酸取代而制备，原型脂肪酶序列SEQ ID NO：1中的位置17,29,30,25,66,117,122,160,163,167,265,266,286,289。

8. 发明授权

US08153408B2 Biocatalytic racemisation of alpha-hydroxyketones 有权
标题翻译： α-羟基酮的生物催化外消旋化
公开(公告)号：US08153408B2
公开(公告)日：2012-04-10
申请号：US12278464
申请日：2007-01-31
申请人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
发明人： Bernhard Hauer , Rainer Stürmer , Bettina M. Nestl , Wolfgang Kroutil , Kurt Faber
IPC分类号： C12P7/26
CPC分类号： C12P41/004 , C12P7/36
摘要： A process for the racemization of an optically active alpha-hydroxyketone by incubating said alpha-hydroxyketone in the presence of an acetoin racemase of Lactobacillus.
摘要翻译：通过在乳杆菌的乙偶姻消旋酶存在下温育所述α-羟基酮来使光学活性α-羟基酮外消旋化的方法。

9. 发明授权

US08012725B2 Method for the production of optically-active alcohols 有权
标题翻译：光学活性醇的制造方法
公开(公告)号：US08012725B2
公开(公告)日：2011-09-06
申请号：US11667721
申请日：2005-11-15
申请人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/16 , C12P7/02 , C12P7/04 , C12Q1/26 , C12Q1/32 , C12N1/00 , C12N1/20 , C12N9/02 , C07H21/04
CPC分类号： C12P7/16 , Y02E50/10
摘要： The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
摘要翻译：本发明涉及制备S-丁-2-醇的酶法; 和用于进行所述方法的酶; 编码所述酶的核酸序列，含有所述核酸序列的表达盒，载体和重组宿主。

10. 发明授权

US07785847B2 Method for producing optically active alcohols from alkanones using a dehydrogenase of azoarcus 有权
标题翻译：使用azoarcus脱氢酶从链烷醇生产光学活性醇的方法
公开(公告)号：US07785847B2
公开(公告)日：2010-08-31
申请号：US11579292
申请日：2005-05-04
申请人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Maria Keβeler , Bernhard Haur , Thomas Friedrich , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/22 , C12P7/04 , C12P17/00 , C12N9/04 , C12N9/14 , C12N1/20 , C07H21/04
CPC分类号： C07D333/22 , C07D333/16 , C12P17/00
摘要： The invention relates to a method for producing the optically active alkanols of formula (I), wherein n is an integer of from 0 to 5; Cyc represents an optionally substituted, mononuclear or polynuclear, saturated or unsaturated, carbocylic or heterocyclic ring, and R1 represents halogen, SH, OH, NO2, NR2R3 or NR2R3R4+X−, wherein R2, R3 and R4 independently represent H or a lower alkyl or lower alkoxy group and X− represents a counterion. According to the invention, an enzyme (E) selected from the groups of dehydrogenases, aldehyde reductases and carbonyl reductases is incubated in a medium containing the alkanone of formula (II), wherein n, Cyc and R1 are defined as above, in the presence of reduction equivalents. The compound of formula (II) is enzymatically reduced to the compound of formula (I) and the reduction equivalents consumed during reaction are regenerated by reacting a sacrificial alcohol to the corresponding sacrificial ketone using enzyme (E) and at least partially removing the sacrificial ketone from the reaction medium, and then isolating the product (I) so produced.
摘要翻译：本发明涉及一种制备式（I）的光学活性链烷醇的方法，其中n为0-5的整数; Cyc表示任选取代的单核或多核，饱和或不饱和的碳环或杂环，并且R 1表示卤素，SH，OH，NO 2，NR 2 R 3或NR 2 R 3 R 4 + X - ，其中R 2，R 3和R 4独立地表示H或低级烷基或低级烷氧基，X-表示抗衡离子。根据本发明，在含有式（II）的烷酮的培养基中温育选自脱氢酶，醛还原酶和羰基还原酶的酶的酶（E），其中n，R 1和R 1如上定义，在存在下的还原当量。将式（II）化合物酶还原成式（I）化合物，并且通过使用酶（E）使牺牲醇与相应的牺牲酮反应，并且至少部分除去牺牲酮来再生反应期间消耗的还原当量从反应介质中分离出如此制备的产物（I）。

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