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1. 发明申请

US20120123155A1 BIOCATALYST FOR CATALYTIC HYDROAMINATION 审中-公开
标题翻译：生物催化剂用于催化水解
公开(公告)号：US20120123155A1
公开(公告)日：2012-05-17
申请号：US13387140
申请日：2010-07-27
申请人： Bernhard Hauer , Nina Schneider , Dejana Drew , Klaus Ditrich , Nick Turner , Bettina M. Nestl
发明人： Bernhard Hauer , Nina Schneider , Dejana Drew , Klaus Ditrich , Nick Turner , Bettina M. Nestl
IPC分类号： C07C229/36 , C12P13/22
CPC分类号： C12P13/001 , C07C211/27
摘要： The present invention relates to a method for the enzymatic hydroamination of C—C double bonds catalyzed by enzymes structurally and/or functionally related to phenylalanine ammonia lyase (PAL) isolated from microorganisms of Petroselinum crispum, Rhodoturula glutinis and/or functional active derivatives thereof.
摘要翻译：本发明涉及一种通过酶结构和/或功能性相关的苯丙氨酸氨裂解酶（PAL）分离的酶的催化C-C双键的方法，所述苯丙氨酸氨裂解酶（PAL）从石斛兰，红酵母和/或其功能活性衍生物的微生物分离。

2. 发明授权

US08012725B2 Method for the production of optically-active alcohols 有权
标题翻译：光学活性醇的制造方法
公开(公告)号：US08012725B2
公开(公告)日：2011-09-06
申请号：US11667721
申请日：2005-11-15
申请人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
发明人： Rainer Stürmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schröder
IPC分类号： C12P7/16 , C12P7/02 , C12P7/04 , C12Q1/26 , C12Q1/32 , C12N1/00 , C12N1/20 , C12N9/02 , C07H21/04
CPC分类号： C12P7/16 , Y02E50/10
摘要： The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
摘要翻译：本发明涉及制备S-丁-2-醇的酶法; 和用于进行所述方法的酶; 编码所述酶的核酸序列，含有所述核酸序列的表达盒，载体和重组宿主。

3. 发明申请

US20100291640A1 PROCESS FOR PREPARING URETHANE-CONTAINING (METH)ACRYLIC ESTERS 有权
标题翻译：制备含有（甲基）丙烯酸酯的方法
公开(公告)号：US20100291640A1
公开(公告)日：2010-11-18
申请号：US12776670
申请日：2010-05-10
申请人： Rainer Stuermer , Dejana Drew , Bernhard Hauer , Juergen Daeuwel , Uwe Meisenburg
发明人： Rainer Stuermer , Dejana Drew , Bernhard Hauer , Juergen Daeuwel , Uwe Meisenburg
IPC分类号： C12P13/00
CPC分类号： C12P13/02 , C12P7/62
摘要： A process for preparing urethane-containing (meth)acrylic esters (U) by reacting a urethane-containing alcohol (A) with a (meth)acrylic ester of a saturated alcohol (G) in the presence of at least one polymerization inhibitor (P) with an enzyme (E) as a catalyst in a reactor, wherein a) the saturated alcohol released and any entraining agent used form an azeotrope with the excess corresponding (meth)acrylic ester (G), the azeotrope is removed by distillation under reduced pressure and b) at least a substream from the bottom of the reactor is circulated via the top of the distillation column.
摘要翻译：在至少一种聚合抑制剂（P）的存在下，使含氨基甲酸酯的醇（A）与饱和醇（G）的（甲基）丙烯酸酯反应制备含氨基甲酸酯的（甲基）丙烯酸酯（U））与反应器中的催化剂（E）反应，其中a）所释放的饱和醇和任何使用的夹带剂与过量的相应的（甲基）丙烯酸酯（G）形成共沸物，通过在减压下蒸馏除去共沸物压力和b）来自反应器底部的至少一个子流经蒸馏塔的顶部循环。

4. 发明申请

US20080009046A1 Method for the Production of Optically-Active Alcohols 有权
标题翻译：光活性醇的制备方法
公开(公告)号：US20080009046A1
公开(公告)日：2008-01-10
申请号：US11667721
申请日：2005-11-15
申请人： Rainer Sturmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schroder
发明人： Rainer Sturmer , Bernhard Hauer , Dejana Drew , Michael Breuer , Hartwig Schroder
IPC分类号： C12P7/16
CPC分类号： C12P7/16 , Y02E50/10
摘要： The present invention relates to enzymic processes for preparing S-butan-2-ol; and to enzymes for carrying out said processes; to nucleic acid sequences coding for said enzymes, to expression cassettes, vectors and recombinant hosts containing said nucleic acid sequences.
摘要翻译：本发明涉及制备S-丁-2-醇的酶法; 和用于进行所述方法的酶; 编码所述酶的核酸序列，含有所述核酸序列的表达盒，载体和重组宿主。

5. 发明授权

US08399225B2 Process for preparing urethane-containing (meth)acrylic esters 有权
标题翻译：制备含氨基甲酸酯（甲基）丙烯酸酯的方法
公开(公告)号：US08399225B2
公开(公告)日：2013-03-19
申请号：US12776670
申请日：2010-05-10
申请人： Rainer Stürmer , Dejana Drew , Bernhard Hauer , Jürgen Däuwel , Uwe Meisenburg
发明人： Rainer Stürmer , Dejana Drew , Bernhard Hauer , Jürgen Däuwel , Uwe Meisenburg
IPC分类号： C12P7/60
CPC分类号： C12P13/02 , C12P7/62
摘要： The invention relates to a process for preparing urethane-containing acrylic- and (meth)acrylic esters by reacting a urethane-containing alcohol with a reactant acrylic- or (meth)acrylic ester of a saturated alcohol in the presence of at least one polymerization inhibitor and an enzyme as a catalyst within a reactor, wherein the saturated alcohol released in the process and optionally an entraining agent form an azeotrope with an excess of the reactant (meth)acrylic ester, such that the azeotrope is removed by distillation under reduced pressure and at least one substream from the bottom of the reactor is circulated through the top of the distillation column. Using this process, urethane-containing acrylic- and (meth)acrylic esters are prepared in high yields and high purities under mild conditions from economically obtainable reactants with no significant polymer formation.
摘要翻译：本发明涉及通过使含氨基甲酸酯的醇与饱和醇的反应性丙烯酸或（甲基）丙烯酸酯在至少一种聚合抑制剂的存在下反应来制备含氨基甲酸酯的丙烯酸和（甲基）丙烯酸酯的方法和作为反应器内的催化剂的酶，其中在该方法中释放的饱和醇和任选的夹带剂与过量的反应物（甲基）丙烯酸酯形成共沸物，使得通过减压蒸馏除去共沸物，来自反应器底部的至少一个子流通过蒸馏塔的顶部循环。使用该方法，在温和条件下从经济可获得的反应物中以高产率和高纯度制备含氨基甲酸酯的丙烯酸酯和（甲基）丙烯酸酯，没有显着的聚合物形成。

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