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1. 发明申请

US20070237947A1 Superhydrophobic fibers produced by electrospinning and chemical vapor deposition 失效
标题翻译：通过静电纺丝和化学气相沉积生产的超疏水纤维
公开(公告)号：US20070237947A1
公开(公告)日：2007-10-11
申请号：US11229062
申请日：2005-09-16
申请人： Karen Gleason , Gregory Rutledge , Malancha Gupta , Minglin Ma , Yu Mao
发明人： Karen Gleason , Gregory Rutledge , Malancha Gupta , Minglin Ma , Yu Mao
IPC分类号： C23C16/00 , B32B1/00 , B32B27/00
CPC分类号： B05D1/60 , B05D2256/00 , D06M10/08 , D06M14/32 , D06M15/277 , D06M2101/32 , Y10T428/249924 , Y10T428/265 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967 , Y10T428/31536 , Y10T428/3154 , Y10T428/31544 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： Disclosed is a versatile method to produce superhydrophobic surfaces by combining electrospinning and initiated chemical vapor deposition (iCVD). A wide variety of surfaces, including electrospun polyester fibers, may be coated by the inventive method. In one embodiment, poly(caprolactone) (PCL) was electrospun and then coated by iCVD with a thin layer of hydrophobic polymerized perfluoroalkyl ethyl methacrylate (PPFEMA). In certain embodiments said coated surfaces exhibit water contact angles of above 150 degrees, oleophobicities of at least Grade-8 and sliding angles of less than 12 degrees (for a water droplet of about 20 mg).
摘要翻译：公开了通过组合静电纺丝和起始化学气相沉积（iCVD）制备超疏水表面的通用方法。可以通过本发明的方法涂覆各种表面，包括电纺聚酯纤维。在一个实施方案中，将聚（己内酯）（PCL）静电纺丝，然后通过iCVD用疏水聚合的全氟烷基乙基甲基丙烯酸酯（PPFEMA）薄层涂覆。在某些实施方案中，所述涂覆表面表现出高于150度的水接触角，至少等级-8的疏油性和小于12度的滑动角（对于约20毫克的水滴）。

2. 发明授权

US07651760B2 Superhydrophobic fibers produced by electrospinning and chemical vapor deposition 失效
标题翻译：通过静电纺丝和化学气相沉积生产的超疏水纤维
公开(公告)号：US07651760B2
公开(公告)日：2010-01-26
申请号：US11229062
申请日：2005-09-16
申请人： Karen K. Gleason , Gregory C. Rutledge , Malancha Gupta , Minglin Ma , Yu Mao
发明人： Karen K. Gleason , Gregory C. Rutledge , Malancha Gupta , Minglin Ma , Yu Mao
IPC分类号： B32B27/12
CPC分类号： B05D1/60 , B05D2256/00 , D06M10/08 , D06M14/32 , D06M15/277 , D06M2101/32 , Y10T428/249924 , Y10T428/265 , Y10T428/2933 , Y10T428/2938 , Y10T428/2967 , Y10T428/31536 , Y10T428/3154 , Y10T428/31544 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： Disclosed is a versatile method to produce superhydrophobic surfaces by combining electrospinning and initiated chemical vapor deposition (iCVD). A wide variety of surfaces, including electrospun polyester fibers, may be coated by the inventive method. In one embodiment, poly(caprolactone) (PCL) was electrospun and then coated by iCVD with a thin layer of hydrophobic polymerized perfluoroalkyl ethyl methacrylate (PPFEMA). In certain embodiments said coated surfaces exhibit water contact angles of above 150 degrees, oleophobicities of at least Grade-8 and sliding angles of less than 12 degrees (for a water droplet of about 20 mg).
摘要翻译：公开了通过组合静电纺丝和起始化学气相沉积（iCVD）制备超疏水表面的通用方法。可以通过本发明的方法涂覆各种表面，包括电纺聚酯纤维。在一个实施方案中，将聚（己内酯）（PCL）静电纺丝，然后通过iCVD用疏水聚合的全氟烷基乙基甲基丙烯酸酯（PPFEMA）薄层涂覆。在某些实施方案中，所述涂覆表面表现出高于150度的水接触角，至少等级-8的疏油性和小于12度的滑动角（对于约20毫克的水滴）。

3. 发明申请

US20060292369A1 Superhydrophobic fibers and methods of preparation and use thereof 失效
公开(公告)号：US20060292369A1
公开(公告)日：2006-12-28
申请号：US11371223
申请日：2006-03-09
申请人： Gregory Rutledge , Randal Hill , Joseph Lowery , Minglin Ma , Sergey Fridrikh
发明人： Gregory Rutledge , Randal Hill , Joseph Lowery , Minglin Ma , Sergey Fridrikh
IPC分类号： D02G3/00
CPC分类号： D01D5/0038 , D01F6/42 , D01F6/92 , D01F6/96 , Y10T428/249924 , Y10T428/25 , Y10T428/29 , Y10T428/2913 , Y10T428/2933 , Y10T428/2967 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： The present invention relates to fibers exhibiting a water contact angle of above 150° and water contact angle hysteresis of below 15°, methods of producing the same, and applications thereof. The present invention further relates to superhydrophobic fiber mats, methods of producing the same, and applications thereof.

4. 发明授权

US09193827B2 Poly(beta-amino alcohols), their preparation, and uses thereof 有权
标题翻译：聚（β-氨基醇），它们的制备及其用途
公开(公告)号：US09193827B2
公开(公告)日：2015-11-24
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , A61L31/10 , C09D5/16 , C08G59/22 , C08G59/30 , C08G59/50 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

5. 发明授权

US08939294B2 Block copolymer membranes and associated methods for making the same 有权
标题翻译：嵌段共聚物膜及其制备方法
公开(公告)号：US08939294B2
公开(公告)日：2015-01-27
申请号：US12751824
申请日：2010-03-31
申请人： David Roger Moore , Hongyi Zhou , Matthew Jeremiah Misner , Xiaohui Chen , Lifeng Zhang , Daniel Joseph Brunelle , Minglin Ma
发明人： David Roger Moore , Hongyi Zhou , Matthew Jeremiah Misner , Xiaohui Chen , Lifeng Zhang , Daniel Joseph Brunelle , Minglin Ma
IPC分类号： B01D71/68 , B01D71/80 , B01D67/00 , C08L81/06 , B01D69/10
CPC分类号： B01D71/80 , B01D67/0006 , B01D67/0011 , B01D69/10 , B01D71/68 , B01D2323/22 , B01D2325/28 , B01D2325/36 , C08L81/06
摘要： A separation matrix comprises a porous surface layer; and a bulk porous support, wherein both the porous surface layer and the bulk porous support comprising a block copolymer. The block copolymer comprises A-B or A-B-A repeating units, wherein A and B at each occurrence are two different blocks of oligomer, or polymer. A structural unit of block A is derived from one or more atom transfer radical polymerization (ATRP)-active monomer or oligomer and a structural unit of block B is derived from a thermoplastic ATRP-active macro initiator. A poly dispersity index of the block copolymer is at least about 2.
摘要翻译：分离基质包括多孔表面层; 和多孔支撑体，其中多孔表面层和本体多孔载体均包含嵌段共聚物。嵌段共聚物包含A-B或A-B-A重复单元，其中A和B每次出现时是两个不同的低聚物或聚合物嵌段。嵌段A的结构单元衍生自一种或多种原子转移自由基聚合（ATRP）活性单体或低聚物，并且嵌段B的结构单元衍生自热塑性ATRP活性的大分子引发剂。嵌段共聚物的聚分散指数为至少约2。

6. 发明申请

US20120308650A1 MODIFIED ALGINATES FOR CELL ENCAPSULATION AND CELL THERAPY 有权
标题翻译：用于细胞增殖和细胞治疗的修饰的ALGINATE
公开(公告)号：US20120308650A1
公开(公告)日：2012-12-06
申请号：US13487524
申请日：2012-06-04
申请人： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
发明人： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
IPC分类号： C08B37/04 , C40B30/10 , A61K9/50 , A61K9/48 , A61K35/39 , A61P3/10 , C40B30/06 , C40B50/00
CPC分类号： A61K9/5036 , A61K9/0024 , A61K9/5161 , A61K35/39 , A61K45/06 , C08B37/0084
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
摘要翻译：本文公开了具有增强的生物相容性和定制的理化性质的共价改性的藻酸盐聚合物，以及其制备和使用方法。共价修饰的藻酸盐可用作细胞的包封和移植的基质。还公开了用于表征改性藻酸盐聚合物的生物相容性和物理化学性质的高通量方法。

7. 发明授权

US09422373B2 Modified alginates for cell encapsulation and cell therapy 有权
标题翻译：用于细胞包封和细胞治疗的改性藻酸盐
公开(公告)号：US09422373B2
公开(公告)日：2016-08-23
申请号：US13487524
申请日：2012-06-04
申请人： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
发明人： Arturo J. Vegas , Minglin Ma , Kaitlin M. Bratlie , Daniel G. Anderson , Robert S. Langer
IPC分类号： C08B37/04 , C08B37/00 , A61K9/00 , A61K9/51
CPC分类号： A61K9/5036 , A61K9/0024 , A61K9/5161 , A61K35/39 , A61K45/06 , C08B37/0084
摘要： Covalently modified alginate polymers, possessing enhanced biocompatibility and tailored physiochemical properties, as well as methods of making and use thereof, are disclosed herein. The covalently modified alginates are useful as a matrix for the encapsulation and transplantation of cells. Also disclosed are high throughput methods for the characterizing the biocompatibility and physiochemical properties of modified alginate polymers.
摘要翻译：本文公开了具有增强的生物相容性和定制的理化性质的共价改性的藻酸盐聚合物，以及其制备和使用方法。共价修饰的藻酸盐可用作细胞的包封和移植的基质。还公开了用于表征改性藻酸盐聚合物的生物相容性和物理化学性质的高通量方法。

8. 发明授权

US08574713B2 Superhydrophobic fibers and methods of preparation and use thereof 失效
标题翻译：超疏水纤维及其制备方法及用途
公开(公告)号：US08574713B2
公开(公告)日：2013-11-05
申请号：US11371223
申请日：2006-03-09
申请人： Gregory C. Rutledge , Randal M. Hill , Joseph L Lowery , Minglin Ma , Sergey Fridrikh
发明人： Gregory C. Rutledge , Randal M. Hill , Joseph L Lowery , Minglin Ma , Sergey Fridrikh
IPC分类号： D02G3/00 , D04H1/00 , B32B19/00 , B32B5/02 , B32B27/04
CPC分类号： D01D5/0038 , D01F6/42 , D01F6/92 , D01F6/96 , Y10T428/249924 , Y10T428/25 , Y10T428/29 , Y10T428/2913 , Y10T428/2933 , Y10T428/2967 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： The present invention relates to fibers exhibiting a water contact angle of above 150° and water contact angle hysteresis of below 15°, methods of producing the same, and applications thereof. The present invention further relates to superhydrophobic fiber mats, methods of producing the same, and applications thereof.
摘要翻译：本发明涉及水接触角高于150°，水接触角滞后小于15°的纤维，其制备方法及其应用。本发明还涉及超疏水纤维垫，其制备方法及其应用。

9. 发明申请

US20130302401A1 POLY(BETA-AMINO ALCOHOLS), THEIR PREPARATION, AND USES THEREOF 有权
标题翻译：聚（氨基 - 氨基醇），其制备及其用途
公开(公告)号：US20130302401A1
公开(公告)日：2013-11-14
申请号：US13819280
申请日：2011-08-26
申请人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
发明人： Minglin Ma , Wendy F. Liu , Robert S. Langer , Daniel Griffith Anderson
IPC分类号： C08G73/02 , C09D179/02
CPC分类号： C08G73/0206 , A61K9/1273 , A61K31/7088 , A61K47/34 , A61K47/59 , A61L31/10 , C08G59/22 , C08G59/306 , C08G59/50 , C08G73/02 , C09D5/1637 , C09D179/02 , Y10T428/31725
摘要： A new class of poly(beta-amino alcohols) (PBAAs) has been prepared using combinatorial polymerization. The inventive PBAAs may be used in biotechnology and biomedical applications as coatings (such as coatings of films or multilayer films for medical devices or implants), additives, materials, excipients, non-biofouling agents, micropatterning agents, and cellular encapsulation agents. When used as surface coatings, these PBAAs elicited different levels of inflammation, both in vitro and in vivo, depending on their chemical structures. The large chemical diversity of this class of materials allowed us to identify polymer coatings that inhibit macrophage activation in vitro. Furthermore, these coatings reduce the recruitment of inflammatory cells, and reduce fibrosis, following the subcutaneous implantation of carboxylated polystyrene microparticles. These polymers may be used to form polyelectrolyte complex capsules for cell encapsulation. The invention may also have many other biological applications such as antimicrobial coatings, DNA or siRNA delivery, and stem cell tissue engineering.
摘要翻译：使用组合聚合制备了一类新的聚（β-氨基醇）（PBAAs）。本发明的PBAAs可用于生物技术和生物医学应用中，作为涂层（例如用于医疗装置或植入物的膜或多层膜的涂层），添加剂，材料，赋形剂，非生物污垢剂，微图案化剂和细胞包封剂。当用作表面涂层时，这些PBAAs根据其化学结构在体外和体内引起不同程度的炎症。这类材料的大化学多样性使我们能够鉴定体外抑制巨噬细胞活化的聚合物涂层。此外，在皮下植入羧化聚苯乙烯微粒之后，这些涂层减少了炎性细胞的募集，并减少了纤维化。这些聚合物可用于形成用于细胞包封的聚电解质复合物胶囊。本发明还可以具有许多其他生物学应用，例如抗微生物涂层，DNA或siRNA递送以及干细胞组织工程。

10. 发明申请

US20110240550A1 BLOCK COPOLYMER MEMBRANES AND ASSOCIATED METHODS FOR MAKING THE SAME 有权
标题翻译：嵌段共聚物膜及其制备方法
公开(公告)号：US20110240550A1
公开(公告)日：2011-10-06
申请号：US12751824
申请日：2010-03-31
申请人： David Roger Moore , Hongyi Zhou , Matthew Jeremiah Misner , Xiaohui Chen , Lifeng Zhang , Daniel Joseph Brunelle , Minglin Ma
发明人： David Roger Moore , Hongyi Zhou , Matthew Jeremiah Misner , Xiaohui Chen , Lifeng Zhang , Daniel Joseph Brunelle , Minglin Ma
IPC分类号： B01D71/80 , C08L81/06 , B01D69/10
CPC分类号： B01D71/80 , B01D67/0006 , B01D67/0011 , B01D69/10 , B01D71/68 , B01D2323/22 , B01D2325/28 , B01D2325/36 , C08L81/06
摘要： A separation matrix comprises a porous surface layer; and a bulk porous support, wherein both the porous surface layer and the bulk porous support comprising a block copolymer. The block copolymer comprises A-B or A-B-A repeating units, wherein A and B at each occurrence are two different blocks of oligomer, or polymer. A structural unit of block A is derived from one or more atom transfer radical polymerization (ATRP)-active monomer or oligomer and a structural unit of block B is derived from a thermoplastic ATRP-active macro initiator. A poly dispersity index of the block copolymer is at least about 2.
摘要翻译：分离基质包括多孔表面层; 和多孔支撑体，其中多孔表面层和本体多孔载体均包含嵌段共聚物。嵌段共聚物包含A-B或A-B-A重复单元，其中A和B每次出现时是两个不同的低聚物或聚合物嵌段。嵌段A的结构单元衍生自一种或多种原子转移自由基聚合（ATRP）活性单体或低聚物，并且嵌段B的结构单元衍生自热塑性ATRP活性的大分子引发剂。嵌段共聚物的聚分散指数为至少约2。

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