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1. 发明授权

US07674882B2 Silk biomaterials and methods of use thereof 有权
标题翻译：丝素生物材料及其使用方法
公开(公告)号：US07674882B2
公开(公告)日：2010-03-09
申请号：US11020650
申请日：2004-12-23
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K38/17 , A61L15/00
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

2. 发明申请

US20060292369A1 Superhydrophobic fibers and methods of preparation and use thereof 失效
公开(公告)号：US20060292369A1
公开(公告)日：2006-12-28
申请号：US11371223
申请日：2006-03-09
申请人： Gregory Rutledge , Randal Hill , Joseph Lowery , Minglin Ma , Sergey Fridrikh
发明人： Gregory Rutledge , Randal Hill , Joseph Lowery , Minglin Ma , Sergey Fridrikh
IPC分类号： D02G3/00
CPC分类号： D01D5/0038 , D01F6/42 , D01F6/92 , D01F6/96 , Y10T428/249924 , Y10T428/25 , Y10T428/29 , Y10T428/2913 , Y10T428/2933 , Y10T428/2967 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： The present invention relates to fibers exhibiting a water contact angle of above 150° and water contact angle hysteresis of below 15°, methods of producing the same, and applications thereof. The present invention further relates to superhydrophobic fiber mats, methods of producing the same, and applications thereof.

3. 发明授权

US08574713B2 Superhydrophobic fibers and methods of preparation and use thereof 失效
标题翻译：超疏水纤维及其制备方法及用途
公开(公告)号：US08574713B2
公开(公告)日：2013-11-05
申请号：US11371223
申请日：2006-03-09
申请人： Gregory C. Rutledge , Randal M. Hill , Joseph L Lowery , Minglin Ma , Sergey Fridrikh
发明人： Gregory C. Rutledge , Randal M. Hill , Joseph L Lowery , Minglin Ma , Sergey Fridrikh
IPC分类号： D02G3/00 , D04H1/00 , B32B19/00 , B32B5/02 , B32B27/04
CPC分类号： D01D5/0038 , D01F6/42 , D01F6/92 , D01F6/96 , Y10T428/249924 , Y10T428/25 , Y10T428/29 , Y10T428/2913 , Y10T428/2933 , Y10T428/2967 , Y10T442/2164 , Y10T442/2172 , Y10T442/2221 , Y10T442/2238
摘要： The present invention relates to fibers exhibiting a water contact angle of above 150° and water contact angle hysteresis of below 15°, methods of producing the same, and applications thereof. The present invention further relates to superhydrophobic fiber mats, methods of producing the same, and applications thereof.
摘要翻译：本发明涉及水接触角高于150°，水接触角滞后小于15°的纤维，其制备方法及其应用。本发明还涉及超疏水纤维垫，其制备方法及其应用。

4. 发明授权

US08071722B2 Silk biomaterials and methods of use thereof 有权
标题翻译：丝素生物材料及其使用方法
公开(公告)号：US08071722B2
公开(公告)日：2011-12-06
申请号：US12688014
申请日：2010-01-15
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K38/00 , C07K14/00
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

5. 发明申请

US20100196447A1 SILK BIOMATERIALS AND METHODS OF USE THEREOF 有权
标题翻译：丝状生物材料及其使用方法
公开(公告)号：US20100196447A1
公开(公告)日：2010-08-05
申请号：US12688014
申请日：2010-01-15
申请人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David L. Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61K9/70 , A61K31/56 , A61K38/30 , A61K38/16 , A61K31/715 , A61K47/42 , A61P17/02
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

6. 发明申请

US20060213829A1 Production of submicron diameter fibers by two-fluid electrospinning process 审中-公开
标题翻译：通过双液静电纺丝工艺生产亚微米直径的纤维
公开(公告)号：US20060213829A1
公开(公告)日：2006-09-28
申请号：US11089931
申请日：2005-03-25
申请人： Gregory Rutledge , Jian Yu , Sergey Fridrikh
发明人： Gregory Rutledge , Jian Yu , Sergey Fridrikh
IPC分类号： B01D24/00 , B01D39/00
CPC分类号： D01F8/02 , D01D5/0007 , D01F8/08 , D01F8/10 , D01F8/16
摘要： Electrospinning of materials that are difficult or impossible to process into nanofibers by conventional fiber-forming techniques or by electrospinning are prepared by an electrospinning procedure which uses an electrospinnable outer “shell” fluid around an inner “core” fluid, which may or may not be electrospinnable, to form nanofibers of the inner core fluid having a core/shell morphology. The resulting shell around the nanofiber can remain in place or be removed during post-processing with the core of the fiber remaining intact. The dual-fluid electrospinning process can produce core fibers having diameters less than 100 nm, insulated nanowires, as well as tough, bio-compatible silk fibers. Alternatively, the core can be removed leaving a hollow fiber of the shell fluid.
摘要翻译：通过常规纤维形成技术或静电纺丝将难以或不可能加工成纳米纤维的材料的静电纺丝通过静电纺丝方法制备，所述静电纺丝方法使用围绕内部“芯”流体的可电纺的外部“壳”流体，其可以是或可以不是电纺丝，形成具有核/壳形态的内芯流体的纳米纤维。纳米纤维周围的所得壳可以保留在适当位置，或者在后处理期间被除去，纤维的芯保持完整。双流体静电纺丝工艺可以生产直径小于100nm的芯纤维，绝缘纳米线以及坚韧的生物相容的丝纤维。或者，可以去除芯体，留下壳体流体的中空纤维。

7. 发明申请

US20050260706A1 Silk biomaterials and methods of use thereof 有权
标题翻译：丝素生物材料及其使用方法
公开(公告)号：US20050260706A1
公开(公告)日：2005-11-24
申请号：US11020650
申请日：2004-12-23
申请人： David Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
发明人： David Kaplan , Hyoung-Joon Jin , Gregory Rutledge , Sergey Fridrikh
IPC分类号： A61L27/22 , A61L27/36 , A61L27/44 , A61L27/48 , B32B27/06 , C07K14/435 , C08H1/00 , C08J20060101 , C08L89/00 , D01D5/00 , D01F4/02 , D01F6/88 , D02G3/04 , D06M13/17 , D06M15/00 , D06M15/03 , D06M15/11
CPC分类号： D01D5/0038 , A61L27/227 , A61L27/3604 , D01F1/02 , D01F4/02 , D01F6/94 , D06M13/17 , D06M15/03 , D06M15/11 , A61L27/48 , C08L71/02 , A61L27/44
摘要： The present invention provides an all-aqueous process and composition for production of silk biomaterials, e.g., fibers, films, foams and mats. In the process, at least one biocompatible polymer, such as poly(ethylene oxide) (PEO) (a well-documented biocompatible material), was blended with the silk protein prior to processing e.g., electrospinning. We discovered that this step avoids problems associated with conformational transitions of fibroin during solubilization and reprocessing from aqueous solution which lead to embrittled materials. Moreover, the process avoids the use of organic solvents that can pose problems when the processed biomaterials are exposed to cells in vitro or in vivo.
摘要翻译：本发明提供了用于生产丝状生物材料例如纤维，薄膜，泡沫和垫的全水性方法和组合物。在该方法中，在加工例如静电纺丝之前，将至少一种生物相容性聚合物，例如聚（环氧乙烷）（PEO）（良好记载的生物相容性材料）与丝蛋白混合。我们发现，这一步骤避免了在溶解和再水处理过程中与丝氨蛋白的构象转换有关的问题，这些问题导致了脆化的材料。此外，该方法避免使用当处理的生物材料在体外或体内暴露于细胞时可能引起问题的有机溶剂。

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