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1. 发明授权

US06986847B2 Method and apparatus for isolation and purification of biomolecules 失效
标题翻译：用于分离和纯化生物分子的方法和装置
公开(公告)号：US06986847B2
公开(公告)日：2006-01-17
申请号：US10436353
申请日：2003-05-12
申请人： Kamalesh K. Sirkar , Robert G. Luo , Yanke Xu , Xiao-Ping Dai
发明人： Kamalesh K. Sirkar , Robert G. Luo , Yanke Xu , Xiao-Ping Dai
IPC分类号： B01D61/18 , B01D15/08
CPC分类号： B01J20/28014 , B01D15/12 , B01D15/265 , B01D15/322 , B01D15/325 , B01D15/362 , B01D15/363 , B01D15/3804 , B01D61/00 , B01D63/021 , B01D69/00 , B01D69/125 , B01D2313/40 , C07K1/34
摘要： An apparatus and method for recovering bioproducts from a feed solution. In one embodiment, the apparatus includes a module housing, a membrane means disposed in the housing for filtering the bioproducts from the feed solution wherein a portion of the membrane means is coated with a polymeric coating, and an adsorbent bed disposed in the housing for retaining the bioproducts which permeate through the membrane, wherein the apparatus is adapted to allow fractionation and purification of the retained bioproducts from the bed by elution.
摘要翻译：一种用于从饲料溶液中回收生物产物的装置和方法。在一个实施例中，该装置包括模块壳体，设置在壳体中用于过滤来自进料溶液的生物产物的膜装置，其中膜装置的一部分涂覆有聚合物涂层，以及设置在壳体中用于保持渗透通过膜的生物产物，其中该装置适于通过洗脱来允许从床中分离和纯化保留的生物产物。

2. 发明授权

US6022477A Method and apparatus for isolation purification of biomolecules 失效
标题翻译：使用中空纤维膜组件进行生物分子纯化的色谱法
公开(公告)号：US6022477A
公开(公告)日：2000-02-08
申请号：US970986
申请日：1997-11-14
申请人： Robert G. Luo , Kamalesh K. Sirkar
发明人： Robert G. Luo , Kamalesh K. Sirkar
IPC分类号： B01D11/00 , B01D15/08 , B01D61/14 , C07K1/16 , C07K1/34 , C07K1/36
CPC分类号： B01D15/3804 , B01D63/02 , C07K1/22 , C07K1/34 , B01D2311/06 , B01D2311/26 , B01D2311/2626 , B01D2313/40
摘要： An apparatus and method for recovering bioproducts from a feed solution. In one embodiment, the apparatus includes a module housing, a membrane disposed in the housing for filtering the bioproducts from the feed solution, and an adsorbent bed disposed in the housing for retaining the bioproducts which permeate through the membrane, wherein the apparatus is adapted to allow fractionation and purification of the retained bioproducts from the bed by elution.
摘要翻译：一种用于从饲料溶液中回收生物产物的装置和方法。在一个实施方案中，所述装置包括模块壳体，设置在所述壳体中的用于过滤来自所述进料溶液的生物产物的膜和设置在所述壳体中的吸附床，用于保持渗透通过所述膜的生物产物，其中所述装置适于允许通过洗脱从床中分离和纯化保留的生物产物。

3. 发明授权

US5993515A Apparatus and process for selectively removing a component from a multicomponent aqueous solution by pervaporation 失效
标题翻译：通过渗透蒸发从多组分水溶液中选择性地除去组分的装置和方法
公开(公告)号：US5993515A
公开(公告)日：1999-11-30
申请号：US972437
申请日：1997-11-18
申请人： Kamalesh K. Sirkar
发明人： Kamalesh K. Sirkar
IPC分类号： B01D61/36 , B01D69/08 , B01D69/12 , C02F1/44 , B01D19/00 , B01D53/22
CPC分类号： B01D61/362 , B01D69/08 , B01D69/12 , B01D69/127 , C02F1/44 , C02F1/444 , C02F1/448
摘要： A pervaporation process for selectively removing a component from a multicomponent aqueous solution which is practiced with an assembly comprising a feed chamber for holding and introducting the multicomponent aqueous solution to be treated therein, the feed chamber having a pressure, an exit chamber having a pressure, and located adjacent to the feed chamber and downstream thereof; at least one membrane composite located between the feed chamber and the exit chamber and adapted for fluid registry therewith, the membrane composite comprised of a porous membrane having a first and second surface, and a nonporous membrane permanently disposed on the second surface of the porous membrane, and having a permeability selective to the component, the membrane composite aligned such that the nonporous membrane is connected to the feed chamber; and a vacuum pump connected to the exit chamber for evacuating the component from the chamber. The process comprises the steps of introducing the multicomponent aqueous solution into the feed chamber, evacuating the component from the exit chamber, so that the pressure in the exit chamber is less than the pressure in the feed chamber, contacting the multicomponent aqueous solution with the first surface of the porous membrane.
摘要翻译：一种用于选择性地从多组分水溶液中除去组分的渗透蒸发方法，该组合物包括用于保持和引入待处理的多组分水溶液的进料室，所述进料腔具有压力，具有压力的出口室，并且位于邻近进料室并在其下游; 至少一个膜复合材料位于进料室和出口室之间并且适于与其流体对准，所述膜复合物由具有第一和第二表面的多孔膜和永久地设置在多孔膜的第二表面上的无孔膜组成并且具有对组分选择性的渗透性，所述膜复合物对齐，使得所述无孔膜连接到所述进料室; 以及连接到出口室的真空泵，用于将部件从腔室排出。该方法包括以下步骤：将多组分水溶液引入进料室，将组分从出口室排出，使得出口室中的压力小于进料室中的压力，使多组分水溶液与第一多孔膜的表面。

4. 发明授权

US4789468A Immobilized-interface solute-transfer apparatus 失效
标题翻译：固定界面溶质转移装置
公开(公告)号：US4789468A
公开(公告)日：1988-12-06
申请号：US644895
申请日：1984-08-28
申请人： Kamalesh K. Sirkar
发明人： Kamalesh K. Sirkar
IPC分类号： B01D11/04 , B01D61/24 , B01D61/28 , B01D61/32 , B01D63/04 , B01D13/00
CPC分类号： B01D61/246 , B01D11/0415 , B01D61/28 , B01D61/32 , B01D63/043 , B01D2313/50
摘要： An immobilized-interface solute-transfer unit for transferring solute from a feed solution to an extractant liquid comprises a fluid-tight housing and a porous membrane which divides the housing into a feed solution chamber and an extractant chamber. The housing has feed solution inlet and outlet ports which communicate with the feed solution chamber, and extractant inlet an outlet ports which communicate with the extractant chamber. The solute-transfer unit also includes a presure difference controller for maintaining a difference between a liquid pressure of a feed solution in the feed solution chamber and a liquid presure of an extractant in the extractant chamber substantially within a predetermined pressure range so that an interface between the feed solution and the extractant is substantially immobilized at the membrane. The solute-transfer unit is particularly adapted for transferring a solute from a feed solution to an extractant, which feed solution and extractant are immiscible with one another when in direct contact.
摘要翻译：用于将溶质从进料溶液输送到萃取剂液体的固定界面溶质转移单元包括流体密封壳体和将壳体分成进料溶液室和萃取室的多孔膜。壳体具有与进料溶液室连通的进料溶液入口和出口，萃取剂入口与萃取室连通。溶质转移单元还包括压差差值控制器，用于保持进料溶液室中的进料溶液的液体压力与萃取剂室中的萃取剂的液体压力之间的差异，基本上在预定压力范围内，进料溶液和萃取剂基本上固定在膜上。溶质转移单元特别适于将溶质从进料溶液转移到萃取剂中，该进料溶液和萃取剂在直接接触时彼此不混溶。

5. 发明授权

US4750918A Selective-permeation gas-separation process and apparatus 失效
标题翻译：选择性渗透气体分离方法及装置
公开(公告)号：US4750918A
公开(公告)日：1988-06-14
申请号：US738793
申请日：1985-05-28
申请人： Kamalesh K. Sirkar
发明人： Kamalesh K. Sirkar
IPC分类号： B01D53/22 , B01D61/38
CPC分类号： B01D61/38 , B01D53/22 , B01D53/229 , B01D2251/304 , B01D2251/306 , B01D2251/606 , B01D2252/10 , B01D2252/20484 , B01D2252/20489 , B01D2256/245 , B01D2257/304 , B01D2257/502 , B01D2257/504 , B01D2258/05 , B01D2317/08 , B01D2319/06 , B01D53/1493 , Y02C10/10
摘要： A permeant gas is selectively transferred from a feed-gas mixture which comprises the permeant gas and at least one other component to an output fluid by the process of the invention. The process involves introducing a selective-permeation liquid into a permeation-transfer chamber. A gas-depletion channel and a gas-enrichment channel pass through the permeation chamber and are separated from the chamber respectively by porous walls. The selective-permeation liquid contacts the porous walls but does not flow into the gas-depletion or gas-enrichment channels. The feed-gas mixture is introduced into the gas-depletion channel so that permeant gas in the mixture can pass through the pores of the walls of the channel into the selective-permeation liquid and from the selective-permeation liquid through the pores of the walls of the gas-enrichment channel into the gas-enrichment channel. Permeant gas is withdrawn from the gas-enrichment channel and a stream of gas depleted in the permeant gas is withdrawn from the gas-depletion channel. A gas-transfer unit permits the process of the invention to be carried out effectively.
摘要翻译：通过本发明的方法，将渗透气体从包含透过气体和至少一种其它组分的进料 - 气体混合物中选择性转移到输出流体。该方法包括将选择性渗透液体引入渗透转移室。气体耗尽通道和气体富集通道穿过渗透室并分别通过多孔壁与腔室分离。选择性渗透液体接触多孔壁，但不流入气体消耗或气体浓缩通道。将进料 - 气体混合物引入气体消耗通道中，使得混合物中的渗透气体可以通过通道壁的孔进入选择性渗透液体，并从选择性渗透液体通过壁的孔的气体富集通道进入气体浓缩通道。从气体富集通道排出渗透气体，并且从气体消耗通道中排出贫化的渗透气体中的气体流。气体传递单元允许有效地执行本发明的方法。

6. 发明授权

US09988956B2 System and method for continuous removal of water from oil via membrane separation 有权
公开(公告)号：US09988956B2
公开(公告)日：2018-06-05
申请号：US13978333
申请日：2012-01-13
申请人： Kamalesh K. Sirkar , Li Yang
发明人： Kamalesh K. Sirkar , Li Yang
IPC分类号： F01M11/03 , F01M1/10 , F16N39/06 , F01M13/04
CPC分类号： F01M11/03 , F01M1/10 , F01M2013/0477 , F16N39/06
摘要： An oil circulation system and method for continuously purifying engine oil including an engine operably connected to an oil reservoir, wherein at least one stream of oil is conveyed from the oil reservoir to the engine via a conduit, and circulated through the engine and conduit via engine operating pressure and/or one or more pumps, and at least one membrane unit positioned in a path of the oil stream such that oil containing dissolved/emulsified droplets of water is fed continuously through the membrane unit. A cross flow hollow fiber module adapted to be positioned in a system for continuously purifying engine oil, the hollow fiber module having a central feed distributor tube, hollow fiber membranes positioned around the central feed distributor tube, end caps with ports for receiving and emitting a flow of sweep air, and optionally a shell casing, wherein the central feed distributor tube includes openings sized and positioned to allow oil to flowing into the feed distributor tube to flow out radially.

7. 发明授权

US5510257A Hollow fiber immobilization with chopped microporous hollow fibers 失效
标题翻译：中空纤维用切碎的微孔中空纤维固定
公开(公告)号：US5510257A
公开(公告)日：1996-04-23
申请号：US417981
申请日：1989-10-04
申请人： Kamalesh K. Sirkar , Rajesh K. Shukla
发明人： Kamalesh K. Sirkar , Rajesh K. Shukla
IPC分类号： C12M3/06 , C12N5/00 , C12N11/02 , C12N11/04 , C12M1/04 , C12M3/00 , C12M3/04 , C12N1/00 , C12N1/14 , C12N1/16 , C12N1/20
CPC分类号： C12N11/02 , C12M25/10 , C12N5/0068 , C12N2533/30
摘要： Most of the problems of prior art techniques for growing cells in hollow fiber devices can be avoided by growing the cells in short lengths (e.g., two inches (5.0 cm.) or less) of microporous hollow fibers. The fibers are prepared by chopping commercial lengths of hollow fibers into small pieces, preferably two inches (5 cm.) or smaller. Such chopped hollow fibers or bundles of hollow fibers are then added to a suitable medium for growth of cells and the medium is incubated. Very high cell densities have been observed in the chopped fibers.
摘要翻译：现有技术中用于在中空纤维器件中培养细胞的大多数问题可以通过生长细孔（例如，两英寸（5.0cm。）或更小））的微孔中空纤维来避免。通过将商业长度的中空纤维切割成小块，优选两英寸（5cm）或更小）来制备纤维。然后将这种切碎的中空纤维或中空纤维束加入合适的细胞培养基中，并培养培养基。在短切纤维中观察到非常高的细胞密度。

8. 发明授权

US08167143B2 Desalination devices and systems using porous hydrophobic hollow fibers and hydrophobic porous coatings 有权
标题翻译：使用多孔疏水中空纤维和疏水多孔涂层的海水淡化装置和系统
公开(公告)号：US08167143B2
公开(公告)日：2012-05-01
申请号：US11189213
申请日：2005-07-26
申请人： Kamalesh K. Sirkar , Baoan Li
发明人： Kamalesh K. Sirkar , Baoan Li
IPC分类号： B01D63/02 , B01D61/36 , B01D61/00
CPC分类号： B01D61/364 , B01D63/02 , B01D63/026 , B01D67/0088 , B01D69/02 , B01D69/08 , Y02A20/131
摘要： DCMD and VMD systems and methods for use in desalination applications are provided. The DCMD and VMD systems employ coated porous hydrophobic hollow fiber membranes. The coatings advantageously function to essentially eliminate pore wetting of the membrane, while permitting substantially unimpeded water vapor permeance through the fiber walls. The DCMD and VMD membranes are characterized by larger fiber bore diameters and wall thicknesses. The membranes substantially reduce the loss of brine sensible heat, e.g., heat loss via conductive heat flux through the membrane wall and the vapor space and, in exemplary embodiments, the brine-side heat transfer coefficient is dramatically enhanced by horizontal/vertical cross flow of brine over the outside surface of the coated fibers. Superior water vapor fluxes are achieved with the systems and methods.
摘要翻译：提供了用于脱盐应用的DCMD和VMD系统和方法。 DCMD和VMD系统采用涂覆的多孔疏水性中空纤维膜。涂层有利地基本上消除了膜的毛孔润湿，同时允许通过纤维壁的基本上无阻碍的水蒸气渗透。 DCMD和VMD膜的特征在于较大的纤维孔直径和壁厚。膜基本上减少了盐水显热的损失，例如通过膜壁和蒸汽空间的导热热通量的热损失，并且在示例性实施例中，盐水侧传热系数通过水平/垂直横流盐水在涂覆纤维的外表面上。通过系统和方法实现了卓越的水汽通量。

9. 发明申请

US20080197070A1 Composite Membranes and Membrane Systems and Methods For Production and Utilization Thereof 审中-公开
标题翻译：复合膜和膜系统及其生产和利用方法
公开(公告)号：US20080197070A1
公开(公告)日：2008-08-21
申请号：US11929155
申请日：2007-10-30
申请人： Kamalesh K. Sirkar , Alexander P. Korikov , Praveen B. Kosaraju
发明人： Kamalesh K. Sirkar , Alexander P. Korikov , Praveen B. Kosaraju
IPC分类号： B01D39/16 , B05D3/10
CPC分类号： B01D71/26 , B01D67/009 , B01D67/0093 , B01D69/125 , B01D2323/02 , B01D2323/38
摘要： Thin film composite membranes on polyolefin structures may be prepared by interfacial polymerization on a polyolefin support. Polyolefin structures may have hollow and/or solid portions. The polyolefin structure may be hydrophilized prior to interfacial polymerization. The hydrophilized structure may also be treated with an aqueous monomer containing solution first, followed by the organic monomer containing solution. Alternatively, an organic monomer solution may be introduced first, followed by the aqueous monomer containing solution when treating a hydrophilized structure. The formed membrane may possess advantageous characteristics, including stability, hydrophilicity, predetermined pore sizes and/or solvent resistance.
摘要翻译：聚烯烃结构上的薄膜复合膜可以通过在聚烯烃载体上的界面聚合来制备。聚烯烃结构可以具有中空和/或固体部分。聚烯烃结构可以在界面聚合之前亲水化。亲水化的结构也可以首先用含水单体的溶液处理，然后是含有机单体的溶液。或者，首先可以引入有机单体溶液，然后在处理亲水化结构时接着含有含水单体的溶液。形成的膜可以具有包括稳定性，亲水性，预定孔径和/或耐溶剂性的有利特征。

10. 发明授权

US5928409A Method and apparatus for gas removal by cyclic flow swing membrane permeation 失效
标题翻译：通过循环流动挥发膜渗透气体去除的方法和装置
公开(公告)号：US5928409A
公开(公告)日：1999-07-27
申请号：US968705
申请日：1997-11-12
申请人： Kamalesh K. Sirkar
发明人： Kamalesh K. Sirkar
IPC分类号： B01D53/22 , B01D53/26
CPC分类号： B01D53/268 , B01D53/22 , B01D63/02 , B01D2313/18 , Y02C10/10 , Y02C20/20 , Y10S977/888
摘要： In one aspect, a method for selectively removing at least one target component from a multicomponent feed fluid using a removal system, the system including a feed chamber having an inlet and an outlet, a permeate chamber, and a membrane for separating the feed and permeate chambers. The membrane is selective for the at least one target component. The method includes: in a first period, introducing the feed fluid into the feed chamber through the inlet, thereby exposing the feed fluid to the membrane, while allowing flow out of the outlet, wherein at least a portion of the at least one target component in the feed chamber is removed, either by absorption or adsorption, by the membrane; in a second period, simultaneously halting flow through the inlet and the outlet of the feed chamber, thereby trapping the feed fluid within the feed chamber; and providing a component-gradient across the membrane in both the first and second periods, thereby continually removing the at least one target component and regenerating the membrane.
摘要翻译：一方面，一种使用去除系统从多组分进料流体中选择性地除去至少一种目标组分的方法，所述系统包括具有入口和出口的进料室，渗透室和用于分离进料和渗透物的膜房间。该膜对于至少一种靶组分是选择性的。该方法包括：在第一时段中，通过入口将进料流体引入进料室，从而将进料流体暴露于膜，同时允许流出出口，其中至少一部分目标组分在进料室中，通过吸收或吸附除去膜; 在第二时期，同时停止通过进料室的入口和出口的流动，从而将进料流体捕获在进料室内; 以及在所述第一和第二周期内在所述膜上提供组分梯度，从而连续地除去所述至少一种靶组分并再生所述膜。

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