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1. 发明授权

US07226786B2 Envelope gene-deficient Paramyxovirus vector 有权
标题翻译：包膜基因缺陷型副粘病毒载体
公开(公告)号：US07226786B2
公开(公告)日：2007-06-05
申请号：US10316535
申请日：2002-12-10
申请人： Kaio Kitazato , Tsugumine Shu , Hidekazu Kuma , Yasuji Ueda , Makoto Asakawa , Mamoru Hasegawa , Akihiro Iida , Fumino Tokito , Takahiro Hirata , Tsuyoshi Tokusumi , Makoto Inoue , Yumiko Tokusumi
发明人： Kaio Kitazato , Tsugumine Shu , Hidekazu Kuma , Yasuji Ueda , Makoto Asakawa , Mamoru Hasegawa , Akihiro Iida , Fumino Tokito , Takahiro Hirata , Tsuyoshi Tokusumi , Makoto Inoue , Yumiko Tokusumi
IPC分类号： C12N15/00 , C12N15/86
CPC分类号： C12N15/86 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N2760/18823 , C12N2760/18843 , C12N2760/18845 , C12N2760/18861 , C12N2800/30 , C12N2810/6081
摘要： F gene-deficient virus virions are successfully recovered by using an F gene-deficient Sendai virus genomic cDNA. Further, F gene-deficient infectious viral particles are successfully constructed by using F-expressing cells as helper cells. Also, F gene and HN gene-deficient virus virions are successfully recovered by using a virus genomic cDNA deficient in both F gene and HN gene. Further, F gene and HN gene-deficient infectious viral particles are successfully produced by using F- and HN-expressing cells as helper cells. A virus deficient in F gene and HN gene and having F protein is constructed by using F-expressing cells as helper cells. In addition, M gene-deficient infectious virus particles were produced using helper cells expressing M protein. From cells infected with M gene-deficient viruses, release of virus-like particles was inhibited. Further, a VSV-G pseudo type virus is successfully constructed by using VSV-G-expressing cells. Techniques for constructing these deficient viruses contribute to the development of vectors of Paramyxoviridae usable in gene therapy.
摘要翻译：通过使用F基因缺陷的仙台病毒基因组cDNA成功地回收了F基因缺陷型病毒粒子。此外，通过使用F表达细胞作为辅助细胞，成功构建了F基因缺陷型感染性病毒颗粒。此外，通过使用F基因和HN基因缺陷的病毒基因组cDNA，成功地回收了F基因和HN基因缺陷型病毒粒子。此外，通过使用F-和HN表达细胞作为辅助细胞，F基因和HN基因缺陷型感染性病毒颗粒成功产生。通过使用F表达细胞作为辅助细胞构建F基因和HN基因并具有F蛋白的病毒。此外，使用表达M蛋白的辅助细胞产生M基因缺陷型感染性病毒颗粒。从感染M基因缺陷病毒的细胞中，病毒样颗粒的释放被抑制。此外，通过使用表达VSV-G的细胞成功地构建了VSV-G伪型病毒。用于构建这些缺陷病毒的技术有助于可用于基因治疗的副粘病毒科的载体的发育。

2. 发明申请

US20070009949A1 Paramyxovirus-derived RNP 审中-公开
标题翻译：副粘病毒衍生的RNP
公开(公告)号：US20070009949A1
公开(公告)日：2007-01-11
申请号：US11515341
申请日：2006-09-01
申请人： Kaio Kitazato , Tsugumine Shu , Hidekazu Kuma , Yasuji Ueda , Makoto Asakawa , Mamoru Hasegawa , Akihiro Iida , Takahiro Hirata , Makoto Inoue , Yumiko Tokusumi
发明人： Kaio Kitazato , Tsugumine Shu , Hidekazu Kuma , Yasuji Ueda , Makoto Asakawa , Mamoru Hasegawa , Akihiro Iida , Takahiro Hirata , Makoto Inoue , Yumiko Tokusumi
IPC分类号： C12Q1/68 , C12N7/00 , C12N5/00 , C12N7/01 , C12N5/02
CPC分类号： C07K14/005 , A61K48/00 , A61K2039/5254 , A61K2039/5256 , C12N7/00 , C12N15/86 , C12N2710/24143 , C12N2760/18811 , C12N2760/18822 , C12N2760/18823 , C12N2760/18843 , C12N2760/18845 , C12N2760/18861 , C12N2760/20222 , C12N2800/30 , C12N2810/6081
摘要： A functional RNP containing negative-strand single-stranded RNA derived from Sendai virus, which has been modified so as not to express at least one envelope protein, has been successfully prepared. An RNP comprising a foreign gene is prepared and inserted into a cell with the use of a cationic liposome, thereby successfully expressing the foreign gene.
摘要翻译：已经成功地制备了已经被修饰以便不表达至少一种包膜蛋白的来源于仙台病毒的负链单链RNA的功能性RNP。制备包含外来基因的RNP，并使用阳离子脂质体将其插入细胞中，从而成功地表达外源基因。

3. 发明授权

US08741650B2 Methods for producing minus-strand RNA viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken β-actin promoter 有权
标题翻译：使用包含巨细胞病毒增强子和鸡和肌动蛋白启动子的混合启动子产生负链RNA病毒载体的方法
公开(公告)号：US08741650B2
公开(公告)日：2014-06-03
申请号：US10586142
申请日：2005-01-20
申请人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
发明人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
IPC分类号： C12N15/86
CPC分类号： C12N15/86 , C12N2770/36143 , C12N2800/108 , C12N2800/30 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/90
摘要： The present invention provides methods for producing a minus-strand RNA viral vector, which comprise using a promoter comprising a cytomegalovirus enhancer and a chicken β-actin promoter, to induce the transcription of the genome RNA of a minus-strand RNA viral vector and the expression of minus-strand RNA viral proteins that form a ribonucleoprotein with the genome RNA. The methods of the present invention enable high efficiency production of highly safe minus-strand RNA viral vectors. The methods of the present invention are particularly useful for producing minus-strand RNA viral vectors that are deficient in envelope-constituting protein genes.
摘要翻译：本发明提供了用于产生负链RNA病毒载体的方法，其包括使用包含巨细胞病毒增强子和鸡和肌动蛋白启动子的启动子，以诱导负链RNA病毒载体的基因组RNA的转录，以及与基因组RNA形成核糖核蛋白的负链RNA病毒蛋白的表达。本发明的方法能高效生产高度安全的负链RNA病毒载体。本发明的方法特别可用于产生缺失包膜蛋白基因的负链RNA病毒载体。

4. 发明申请

US20070161110A1 Methods for producing minus-strand rna viral vectors using hybrid promoter comprising cytomegalovirus enhancer and chicken beta-actin promoter 有权
标题翻译：使用包含巨细胞病毒增强子和鸡β-肌动蛋白启动子的杂合启动子产生负链rna病毒载体的方法
公开(公告)号：US20070161110A1
公开(公告)日：2007-07-12
申请号：US10586142
申请日：2005-01-20
申请人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
发明人： Akihiro Iida , Hiroshi Ban , Makoto Inoue , Takahiro Hirata , Mamoru Hasegawa
IPC分类号： C12N15/86 , C07H21/04 , C12N7/00
CPC分类号： C12N15/86 , C12N2770/36143 , C12N2800/108 , C12N2800/30 , C12N2830/00 , C12N2830/15 , C12N2830/42 , C12N2830/90
摘要： The present invention provides methods for producing a minus-strand RNA viral vector, which comprise using a promoter comprising a cytomegalovirus enhancer and a chicken β-actin promoter, to induce the transcription of the genome RNA of a minus-strand RNA viral vector and the expression of minus-strand RNA viral proteins that form a ribonucleoprotein with the genome RNA. The methods of the present invention enable high efficiency production of highly safe minus-strand RNA viral vectors. The methods of the present invention are particularly useful for producing minus-strand RNA viral vectors that are deficient in envelope-constituting protein genes.
摘要翻译：本发明提供了产生负链RNA病毒载体的方法，其包括使用包含巨细胞病毒增强子和鸡β-肌动蛋白启动子的启动子来诱导负链RNA病毒载体的基因组RNA的转录，表达与基因组RNA形成核糖核蛋白的负链RNA病毒蛋白。本发明的方法能高效生产高度安全的负链RNA病毒载体。本发明的方法特别可用于产生缺失包膜蛋白基因的负链RNA病毒载体。

5. 发明授权

US07100595B2 Diamond blade 失效
标题翻译：钻石刀片
公开(公告)号：US07100595B2
公开(公告)日：2006-09-05
申请号：US10509196
申请日：2003-03-28
申请人： Akihiro Koike , Takahiro Hirata
发明人： Akihiro Koike , Takahiro Hirata
IPC分类号： B08D1/04 , B23F21/03
CPC分类号： B28D1/121 , B23D61/025 , B24D5/12
摘要： In relation to a blade cutting stone or concrete, a blade, preventing wearing of a core while preventing the core from wobbling, cuttable at a stable speed is provided. In a blade formed by providing slots on the outer peripheral edge of a circular core and fixing a superabrasive layer to a portion of the outer peripheral surface of the core located between the slots, the superabrasive layer consists of a first superabrasive layer having an extension formed by partially extending the superabrasive layer toward the inner periphery of the core and a second superabrasive layer. A reinforcing superabrasive layer extending from the outer periphery toward the inner periphery of the core is formed on the inner peripheral side of the second superabrasive layer while the reinforcing superabrasive layer is located closer to the outer periphery than a radial central portion of the core, and an outer peripheral end of the reinforcing superabrasive layer is located closer to the outer periphery than an inner peripheral end of the extension of the first superabrasive layer. The second superabrasive layer can also be provided with an extension having a relatively short radial length with respect to the extension of the first superabrasive layer.
摘要翻译：关于刀片切割石或混凝土，提供了防止芯体磨损的同时防止芯体摆动的刀片，其可以稳定的速度切割。在通过在圆形芯的外周边缘上提供槽并且将超磨料层固定到位于槽之间的芯的外周表面的一部分而形成的刀片中，超级磨料层由形成有延伸部的第一超磨料层通过将超研磨层部分地延伸到芯的内周边和第二超级磨料层。在第二超级磨料层的内周侧形成有从芯的外周向内周延伸的强化超研磨层，同时加强超硬磨料层位于比芯的径向中央部更靠近外周的位置，加强超硬磨料层的外周端位于比第一超级磨料层的延伸部的内周端更靠近外周的位置。第二超级磨料层还可以设置有相对于第一超级磨料层的延伸部具有相对短的径向长度的延伸部。

6. 发明申请

US20050287541A1 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US20050287541A1
公开(公告)日：2005-12-29
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M1/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 1 to 96 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of Seq. ID No. 97 to 200 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸序列Seq。 ID No.1至96或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交并选自104个多核苷酸由Seq的核苷酸序列组成。 ID号97至200或其部分连续序列或其互补链。

7. 发明授权

US07601532B2 Microarray for predicting the prognosis of neuroblastoma and method for predicting the prognosis of neuroblastoma 有权
标题翻译：用于预测神经母细胞瘤预后的微阵列和预测神经母细胞瘤预后的方法
公开(公告)号：US07601532B2
公开(公告)日：2009-10-13
申请号：US10947249
申请日：2004-09-23
申请人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
发明人： Akira Nakagawara , Miki Ohira , Shin Ishii , Takeshi Goto , Hiroyuki Kubo , Takahiro Hirata , Yasuko Yoshida , Saichi Yamada
IPC分类号： C12M3/00 , C12M1/34 , C07H21/02 , C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6886 , C12Q2600/118
摘要： A microarray for predicting the prognosis of neuroblastoma, wherein the microarray has 25 to 45 probes related to good prognosis, which are hybridized to a gene transcript whose expression is increased in a good prognosis patient with neuroblastoma and are selected from 96 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 1, 5, 6, 14. 16, 17, 19, 22-24, 28, 29, 31, 37, 39, 40, 43, 44, 47-52, 54, 57-60, 62, 64, 65, 67, 68, 72-75, 77, 78, 80-82, 84, 87, 89-91, 94, 100, 103, 112, 113, 118, 120, 129, 130, 132, 136, 138, 142, 144, 145, 148, 150-153, 155, 158-160, 163-165, 169-171, 173, 174, 177, 178, 180-182, 184, 186, 187, 189, 191, 192, 194, 195, 198-200 or their partial continuous sequences or their complementary strands, and 25 to 45 probes related to poor prognosis, which are hybridized to a gene transcript whose expression is increased in a poor prognosis patient with neuroblastoma and are selected from 104 polynucleotides consisting of the nucleotide sequences of SEQ. ID NOs. 2-4, 7-13, 15, 18, 20, 21, 25-27, 30, 32-36, 38, 41, 42, 45, 46, 53, 55, 56, 61, 63, 66, 69-71, 76, 79, 83, 85, 86, 88, 92, 93, 95-99, 101, 102, 104-111, 114-117, 119, 121-128, 131, 133-135, 137, 139-141, 143, 146, 147, 149, 154, 156, 157, 161, 162, 166-168, 172, 175, 176, 179, 183, 185, 188, 190, 193, 196, 197 or their partial continuous sequences or their complementary strands.
摘要翻译：一种用于预测神经母细胞瘤的预后的微阵列，其中所述微阵列具有与良好预后相关的25至45个探针，其与在具有神经母细胞瘤的良好预后患者中表达增加的基因转录物杂交，并且选自96个由核苷酸 SEQ。身份证号 1，5，6，14，16，17，19，22-24，28，29，31，37，39，40，43，44，47-52，54，57-60，62，64，65， 67，68，72-75，77，78，80-82，84，87，89-91，94，100，103，112，113，118，120，129，130，132，136，138， 144,145,148,150-153,155,158-160,163-165,169-171,173,174,177,178,180-182,184,186,187,189,191,192,194， 195，198-200或其部分连续序列或其互补链，以及与不良预后相关的25至45个探针，其与在具有神经母细胞瘤的不良预后患者中表达增加的基因转录物杂交，并且选自104个多核苷酸的SEQ ID NO：身份证号 2-4，7-13，15，18，20，21，25-27，30，32-36，38，41，42，45，46，53，55，56，61，63，66，69- 71,76,79,83,85,86,88,92,93,95-99,101,102,104-111,114-117,119,121-128,131,133-135,137,139- 141,143,146,147,149,154,156,157,161,162,166-168,172,175,176,179,183,185,188,190,193,196,197或其部分连续序列或其互补链。

8. 外观设计

USD483631S1 Rotary cutting diamond grinder 失效
标题翻译：旋切切割金刚石磨床
公开(公告)号：USD483631S1
公开(公告)日：2003-12-16
申请号：US29165606
申请日：2002-08-13
申请人： Akihiro Koike , Takahiro Hirata
设计人： Akihiro Koike , Takahiro Hirata

9. 发明申请

US20050121017A1 Diamond blade 失效
标题翻译：钻石刀片
公开(公告)号：US20050121017A1
公开(公告)日：2005-06-09
申请号：US10509196
申请日：2003-03-28
申请人： Akihiro Koike , Takahiro Hirata
发明人： Akihiro Koike , Takahiro Hirata
IPC分类号： B23D61/02 , B24D5/12 , B28D1/12 , B28D1/04
CPC分类号： B28D1/121 , B23D61/025 , B24D5/12
摘要： In relation to a blade cutting stone or concrete, a blade, preventing wearing of a core while preventing the core from wobbling, cuttable at a stable speed is provided. In a blade formed by providing slots on the outer peripheral edge of a circular core and fixing a superabrasive layer to a portion of the outer peripheral surface of the core located between the slots, the superabrasive layer consists of a first superabrasive layer having an extension formed by partially extending the superabrasive layer toward the inner periphery of the core and a second superabrasive layer. A reinforcing superabrasive layer extending from the outer periphery toward the inner periphery of the core is formed on the inner peripheral side of the second superabrasive layer while the reinforcing superabrasive layer is located closer to the outer periphery than a radial central portion of the core, and an outer peripheral end of the reinforcing superabrasive layer is located closer to the outer periphery than an inner peripheral end of the extension of the first superabrasive layer. The second superabrasive layer can also be provided with an extension having a relatively short radial length with respect to the extension of the first superabrasive layer.
摘要翻译：关于刀片切割石或混凝土，提供了防止芯体磨损的同时防止芯体摆动的刀片，其可以稳定的速度切割。在通过在圆形芯的外周缘上设置槽并将超研磨层固定在位于槽之间的芯的外周表面的一部分而形成的刀片中，超磨料层由形成有延伸部的第一超磨料层通过将超研磨层部分地延伸到芯的内周边和第二超级磨料层。在第二超级磨料层的内周侧形成有从芯的外周向内周延伸的强化超研磨层，同时加强超硬磨料层位于比芯的径向中央部更靠近外周的位置，加强超硬磨料层的外周端位于比第一超级磨料层的延伸部的内周端更靠近外周的位置。第二超级磨料层还可以设置有相对于第一超级磨料层的延伸部具有相对短的径向长度的延伸部。

10. 发明授权

US4434319A POF Cable having outer pipe with curved offset sections to accommodate expansion of the core 失效
标题翻译： POF电缆具有外管，弯曲偏移部分以适应芯的膨胀
公开(公告)号：US4434319A
公开(公告)日：1984-02-28
申请号：US298160
申请日：1981-08-31
申请人： Yoshiaki Gomi , Takahiro Hirata , Michio Takaoka , Tsuneaki Mohtai , Kazuya Akashi
发明人： Yoshiaki Gomi , Takahiro Hirata , Michio Takaoka , Tsuneaki Mohtai , Kazuya Akashi
IPC分类号： H02G9/02 , H01B9/06
CPC分类号： H01B9/0611
摘要： A POF cable line which comprises a steel pipe and three cable cores drawn in the steel pipe. At least one curved offset section is arranged on the steel pipe at a part spaced from a cable joint at a predetermined distance, with a straight portion of the steel pipe interposed therebetween. The curved offset section prevents the cable cores in the part of the steel pipe from snaking hard and consequently prevents the insulation paper in the part from making soft spots or creases. The snaking occurs easily in the offset section when the cable core thermally expands.
摘要翻译： POF电缆线，其包括钢管和在钢管中拉出的三根电缆芯。在钢管上设置至少一个弯曲偏移部分，其间隔预定距离与电缆接头间隔开，钢管的直线部分插入其间。弯曲偏移部分防止钢管部分的电缆芯线变硬，从而防止部件中的绝缘纸发生软斑或折痕。当电缆芯热膨胀时，在偏移部分中容易发生蛇形。

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