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1. 发明授权

US07473698B2 Secondary amino anilinic piperidines as MCH1 antagonists and uses thereof 失效
标题翻译：仲氨基苯胺哌啶类作为MCH1拮抗剂及其应用
公开(公告)号：US07473698B2
公开(公告)日：2009-01-06
申请号：US10518675
申请日：2003-07-03
申请人： Mohammad R. Marzabadi , Yu Jiang , Kai Lu , Chien-An Chen , John E. De Leon , John Wetzel
发明人： Mohammad R. Marzabadi , Yu Jiang , Kai Lu , Chien-An Chen , John E. De Leon , John Wetzel
IPC分类号： A61K31/4465
CPC分类号： C07D211/26 , C07D401/12
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compounds of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物与药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用有效治疗受试者抑郁症和/或焦虑的量的本发明化合物。本发明还提供了治疗患有尿失禁的受试者的方法。

2. 发明申请

US20080139555A1 Arylthiobenzylpiperidine Derivatives 审中-公开
标题翻译：芳硫基苄基哌啶衍生物
公开(公告)号：US20080139555A1
公开(公告)日：2008-06-12
申请号：US12028094
申请日：2008-02-08
申请人： Mohammad R. Marzabadi , Yu Jiang , Chien-An Chen , Kai Lu , Kim Andersen
发明人： Mohammad R. Marzabadi , Yu Jiang , Chien-An Chen , Kai Lu , Kim Andersen
IPC分类号： A61K31/4545 , A61K31/5377 , C07D413/14 , C07D401/14 , A61P25/24 , A61P25/00 , A61P3/04 , C07D403/14 , A61K31/496
CPC分类号： C07D401/04 , C07D211/26 , C07D211/62 , C07D401/12 , C07D401/14
摘要： This invention is directed to Arylthiobenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject a therapeutically effective amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的芳硫基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括向受试者施用治疗有效量的本发明化合物。

3. 发明申请

US20070282813A1 Searching with Consideration of User Convenience 审中-公开
标题翻译：考虑用户便利性的搜索
公开(公告)号：US20070282813A1
公开(公告)日：2007-12-06
申请号：US11694930
申请日：2007-03-30
申请人： Yu Cao , Feng Lu , Kai Lu , Woodrow Cannon
发明人： Yu Cao , Feng Lu , Kai Lu , Woodrow Cannon
IPC分类号： G06F17/30
CPC分类号： G06Q30/0273 , G06F16/951 , G06Q30/0275 , G06Q30/0277
摘要： A system that enables the search for providers of services or products, for a given user query that's in free text, and typically the services or products are focused on a particular area, such as an industry, a sector, etc. The system thus enables a searcher to submit queries that are substantially similar to those asked to an expert in the area, and get back results that are helpful in their decision making in obtaining services or products. Thus the searcher's experience is substantially similar to that of consulting a human expert. The system employs methods in matching and placing advertisements in relation to user queries and the concepts contained in these queries. Still further, it employs other various methods to enhance the searcher's effectiveness in their decision making. Finally, the system searches for queries that are composes of at least two languages. The system further comprises a method to (a) turn a large number of records, typically web pages crawled from the entire Web, into hundreds or even thousands of logical partitions, where each partition is associated with an identifier; and (b) take a user query that typically contains an identifier or several identifiers, and match records in those partitions with the identifier(s), or alternatively, take a user query, return multiple results, and then take the user's selection of identifier(s) and re-process the results so that only those associated with the selected identifier(s) are returned to the user.
摘要翻译：一种能够搜索服务或产品提供商的系统，针对给定的用户查询是免费文本，通常是服务或产品集中在一个特定的领域，如行业，部门等。因此，系统启用搜索者提交与该地区的专家所提出的查询大致相似的查询，并返回有助于他们在获取服务或产品方面的决策。因此，搜索者的经验与咨询人类专家的经验基本相似。该系统采用与用户查询和这些查询中包含的概念相匹配和放置广告的方法。此外，它采用其他各种方法来提高搜索者在决策中的有效性。最后，系统搜索至少包含两种语言的查询。该系统还包括以下方法：（a）将大量记录（通常是从整个Web爬行的网页）转换成数百或甚至数千个逻辑分区，其中每个分区与标识符相关联; （b）采取通常包含标识符或多个标识符的用户查询，并在具有标识符的那些分区中匹配记录，或者替代地，进行用户查询，返回多个结果，然后取得用户对标识符的选择并重新处理结果，使得只有与所选择的标识符相关联的那些被返回给用户。

4. 发明申请

US20060084649A9 Substituted alkyl amido piperidines 失效
标题翻译：取代的烷基酰氨基哌啶
公开(公告)号：US20060084649A9
公开(公告)日：2006-04-20
申请号：US10753057
申请日：2004-01-06
申请人： Mohammad Marzabadi , John Wetzel , Chien-An Chen , Yu Jiang , Kai Lu
发明人： Mohammad Marzabadi , John Wetzel , Chien-An Chen , Yu Jiang , Kai Lu
IPC分类号： A61K31/53 , A61K31/506 , A61K31/497 , C07D43/04
CPC分类号： C07D211/26 , C07D211/28 , C07D211/90 , C07D231/12 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D405/06 , C07D405/12 , C07D409/06 , C07D409/10 , C07D409/12 , C07D409/14 , C07D413/12 , C07D417/06 , C07D417/10 , C07D471/04 , C07D495/04
摘要： This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

5. 发明授权

US5955958A Holiday candy jar with light and sound effects 失效
标题翻译：假日糖果罐与光和声音效果
公开(公告)号：US5955958A
公开(公告)日：1999-09-21
申请号：US166717
申请日：1998-10-05
申请人： Kai Lu
发明人： Kai Lu
IPC分类号： A47G33/00 , G08B3/00
CPC分类号： A47G33/00
摘要： A holiday candy jar with light and sound effects having a signal sensor (10) which gets continuous signal from a signal source (12). When someone puts his/her hand into the jar trying to get a candy, the signal between the signal source and the signal sensor will be blocked. A control circuit board (20) is connected to the signal sensor (10) through wires (16). When signal is blocked, the control circuit board controls color lights (14) blinking and a speaker (20) producing a special sound for holidays.
摘要翻译：具有光和声音效果的假日糖果罐具有从信号源（12）获得连续信号的信号传感器（10）。当有人把手放进罐子试图取得糖果时，信号源和信号传感器之间的信号将被阻挡。控制电路板（20）通过导线（16）连接到信号传感器（10）。当信号被阻塞时，控制电路板控制彩色灯（14）闪烁，扬声器（20）产生特殊的声音用于假日。

6. 发明申请

US20120287087A1 TOUCH SCREEN CALIBRATION PARAMETER OBTAINING METHOD AND DEVICE 审中-公开
标题翻译：触摸屏校准参数获取方法和设备
公开(公告)号：US20120287087A1
公开(公告)日：2012-11-15
申请号：US13513554
申请日：2010-04-15
申请人： Kai Lu , Jun Xie
发明人： Kai Lu , Jun Xie
IPC分类号： G06F3/041
CPC分类号： G06F3/0418
摘要： The invention discloses a method for obtaining calibration parameters of a touch screen comprising displaying at least two preset calibration reference points on a LCD; obtaining physical coordinates of sampling points obtained by clicking on positions corresponding to the calibration reference points on the touch screen and displaying the sampling points according to the physical coordinates and the calibration parameters; and if it is determined that the displayed sampling points are not coincident with their corresponding calibration reference points, adjusting distances between the sampling points and their corresponding calibration reference points, determining a minimal deviation between the adjusted sampling points and their corresponding calibration reference points and applying the minimal deviation to update the calibration parameters. The invention also provides an apparatus for obtaining calibration parameters of a touch screen. The invention improves use experience of users when performing calibration and assists the users in obtaining more accurate calibration parameters.
摘要翻译：本发明公开了一种用于获得触摸屏的校准参数的方法，包括在LCD上显示至少两个预设校准参考点; 通过点击与触摸屏上的校准基准点相对应的位置获得的采样点的物理坐标，并根据物理坐标和校准参数显示采样点; 并且如果确定显示的采样点与其对应的校准参考点不一致，则调整采样点与其对应的校准参考点之间的距离，确定经调整的采样点与其对应的校准参考点之间的最小偏差并应用最小偏差更新校准参数。本发明还提供一种用于获得触摸屏的校准参数的装置。本发明在执行校准时改善了用户的使用体验，并且帮助用户获得更准确的校准参数。

7. 发明申请

US20060079522A1 Amino substituted aryloxybenzylpiperidine derivatives 审中-公开
标题翻译：氨基取代的芳氧基苄基哌啶衍生物
公开(公告)号：US20060079522A1
公开(公告)日：2006-04-13
申请号：US10962099
申请日：2004-10-08
申请人： Mohammad Marzabadi , Chien-An Chen , Yu Jiang , Kai Lu , Kim Andersen
发明人： Mohammad Marzabadi , Chien-An Chen , Yu Jiang , Kai Lu , Kim Andersen
IPC分类号： A61K31/5377 , A61K31/496 , A61K31/4545 , C07D403/14 , C07D413/14
CPC分类号： C07D211/26 , C07D401/12 , C07D403/12
摘要： This invention is directed to Amino substituted Aryloxybenzylpiperidine derivatives which are ligands at the MCH1 receptor. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a pharmaceutical composition made by admixing a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the subject invention. This invention also provides a method of treating a subject suffering from obesity which comprises administering to the subject an amount of a compound of the subject invention.
摘要翻译：本发明涉及作为MCH1受体的配体的氨基取代的芳氧基苄基哌啶衍生物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明还提供通过混合治疗有效量的本发明化合物和药学上可接受的载体制备的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的本发明化合物。本发明还提供了治疗患有肥胖症的受试者的方法，其包括给予受试者一定量的本发明化合物。

8. 发明申请

US20050237629A1 Projection lens and display device 有权
标题翻译：投影镜头和显示装置
公开(公告)号：US20050237629A1
公开(公告)日：2005-10-27
申请号：US11090370
申请日：2005-03-25
申请人： Kai Lu , Ernesto Rodriguez
发明人： Kai Lu , Ernesto Rodriguez
IPC分类号： G02B9/00 , G02B9/12 , G02B13/06 , G02B15/177 , G02B27/14
CPC分类号： G02B13/06 , G02B13/22 , G02B15/177 , G03B21/10
摘要： A wide angle projection lens include a first lens group of negative refractive power that has at least one aspheric surface. The wide angle projection lens can output an image at a half field angle of at least 45°, where the image has substantially no distortion and requires little or no keystone correction. The wide angle projection lens can be part of an optical engine that can be implemented in rear projection or front projection display devices.
摘要翻译：广角投影透镜包括具有至少一个非球面的负屈光力的第一透镜组。广角投影透镜可以以至少45°的半视角输出图像，其中图像基本上没有失真，并且几乎不需要梯形失真校正。广角投影透镜可以是可以在后投影或前投影显示装置中实现的光学引擎的一部分。

9. 发明申请

US20050154020A1 4-Aryl piperidines 审中-公开
标题翻译： 4-芳基哌啶
公开(公告)号：US20050154020A1
公开(公告)日：2005-07-14
申请号：US10757962
申请日：2004-01-14
申请人： Mohammad Marzabadi , John Wetzel , Chien-An Chen , John Deleon , Yu Jiang , Kai Lu
发明人： Mohammad Marzabadi , John Wetzel , Chien-An Chen , John Deleon , Yu Jiang , Kai Lu
IPC分类号： C07D211/26 , A61K31/4545 , C07D41/14
CPC分类号： C07D211/26
摘要： This invention is directed to 4-aryl piperidines and related heterocyclic compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject's depression and/or anxiety.
摘要翻译：本发明涉及作为黑色素浓缩激素-1（MCH1）受体的选择性拮抗剂的4-芳基哌啶和相关的杂环化合物。本发明提供了包含治疗有效量的本发明化合物和药学上可接受的载体的药物组合物。本发明提供通过将治疗有效量的本发明化合物与药学上可接受的载体组合而成的药物组合物。本发明还提供了制备药物组合物的方法，其包括将治疗有效量的本发明化合物和药学上可接受的载体组合。本发明还提供减少受试者体重的方法，其包括向受试者施用一定量的有效减少受试者体重的本发明化合物。本发明进一步提供了治疗患有抑郁症和/或焦虑症的受试者的方法，其包括给予受试者一定量的有效治疗受试者的抑郁症和/或焦虑症的本发明化合物。

10. 发明申请

US20120242553A1 ELLIPTICALLY OR CIRCULARLY POLARIZED DIELECTRIC BLOCK ANTENNA 有权
标题翻译：非线性或圆形极化电介质天线
公开(公告)号：US20120242553A1
公开(公告)日：2012-09-27
申请号：US13071714
申请日：2011-03-25
申请人： Kwok Wa Leung , Yong Mei Pan , Kai Lu
发明人： Kwok Wa Leung , Yong Mei Pan , Kai Lu
IPC分类号： H01Q19/09 , H01P11/00
CPC分类号： H01Q9/0492 , Y10T29/49016
摘要： An elliptically polarized (EP) dielectric block antenna comprises a linearly polarized (LP) dielectric block antenna and a wave polarizer integrated with the LP dielectric block antenna. The wave polarizer converts the LP wave of the LP dielectric block antenna into an EP wave or a circularly polarized (CP) wave. The wave polarizer is directly integrated with the LP dielectric block antenna by fabricating inclined slots on faces of the dielectric block at an oblique angle to the LP wave direction of polarization. This provides a very compact EP or CP antenna with a broadside or omnidirectional radiation pattern. The EP or CP antenna is excited by an inner conductor of a SubMiniature version A (SMA) connector that can be directly connected to a coaxial line thereby providing a simple feed network for the antenna.
摘要翻译：椭圆极化（EP）介质块天线包括线性极化（LP）介质块天线和与LP介质块天线集成的波偏振器。波偏振器将LP介质块天线的LP波变换为EP波或圆偏振（CP）波。通过在介电块的表面上以与倾斜的LP波方向倾斜的角度制造倾斜槽，将波偏振器直接与LP介质块天线集成。这提供了具有宽边或全向辐射图案的非常紧凑的EP或CP天线。 EP或CP天线由SubMiniature A型（SMA）连接器的内导体激励，该导体可以直接连接到同轴线，从而为天线提供简单的馈电网络。

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