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1. 发明申请

US20120264762A1 Heterocyclic Compounds as CCR2 Antagonists 审中-公开
标题翻译：杂环化合物作为CCR2拮抗剂
公开(公告)号：US20120264762A1
公开(公告)日：2012-10-18
申请号：US13490765
申请日：2012-06-07
申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
发明人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
IPC分类号： A61K31/496 , A61P1/00 , A61P11/00 , A61P9/10 , A61K31/506 , A61P29/00
CPC分类号： C07D295/195 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/60 , C07D265/30 , C07D295/02 , C07D295/215 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.
摘要翻译：式（I）化合物Q-L-W-C（= X）-Z-P其中Q是式-N（R1）（R2）的胺; L是烷基或杂环基 - 烷基接头; W是分别连接到基团L和C（X）的环原子Y1和Y2的6或7元脂肪环，Y1和Y2独立地选自N和C; X是O，N，N-CN或S; Z为NR3; P是任选取代的单环或双环芳基或杂芳基; 和其药学上可接受的盐或溶剂化物，可用于治疗C-C趋化因子介导的病症。

2. 发明申请

US20110136820A1 Heterocyclic Compounds as CCR2 Antagonists 审中-公开
标题翻译：杂环化合物作为CCR2拮抗剂
公开(公告)号：US20110136820A1
公开(公告)日：2011-06-09
申请号：US13018783
申请日：2011-02-01
申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
发明人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
IPC分类号： A61K31/496 , A61K31/506 , A61P11/00 , A61P11/06 , A61P29/00 , A61P19/10 , A61P19/02
CPC分类号： C07D295/195 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/60 , C07D265/30 , C07D295/02 , C07D295/215 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C—C chemokine mediated conditions.
摘要翻译：式（I）化合物Q-L-W-C（= X）-Z-P其中Q是式-N（R1）（R2）的胺; L是烷基或杂环基 - 烷基接头; W是分别连接到基团L和C（X）的环原子Y1和Y2的6或7元脂肪环，Y1和Y2独立地选自N和C; X是O，N，N-CN或S; Z为NR3; P是任选取代的单环或双环芳基或杂芳基; 和其药学上可接受的盐或溶剂化物，可用于治疗C-C趋化因子介导的病症。

3. 发明申请

US20090099156A1 Heterocyclic Compounds as Ccr2b antagonists 失效
标题翻译：杂环化合物作为Ccr2b拮抗剂
公开(公告)号：US20090099156A1
公开(公告)日：2009-04-16
申请号：US11793606
申请日：2005-12-19
申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
发明人： Justin Fairfield Bower , Jeffrey Philip Poyser , Paul Turner , David Waterson , Jon Winter
IPC分类号： A61K31/551 , C07D401/06 , A61K31/5377 , A61P1/00 , A61P35/00 , A61P19/02 , C07D413/06 , A61K31/496
CPC分类号： C07D295/195 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/60 , C07D265/30 , C07D295/02 , C07D295/215 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I) Q-L-W—C(═X)-Z-P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
摘要翻译：式（I）化合物Q-L-W-C（-X）-Z-P其中Q是式-N（R1）（R2）的胺; L是烷基或杂环基 - 烷基接头; W是分别连接到基团L和C（X）的环原子Y1和Y2的6或7元脂肪环，Y1和Y2独立地选自N和C; X是O，N，N-CN或S; Z为NR3; P是任选取代的单环或双环芳基或杂芳基; 和其药学上可接受的盐或溶剂化物，可用于治疗C-C趋化因子介导的病症。

4. 外观设计

USD684483S1 Container 有权
公开(公告)号：USD684483S1
公开(公告)日：2013-06-18
申请号：US29381382
申请日：2010-12-17
申请人： Adrian Jahina , Jon Winter
设计人： Adrian Jahina , Jon Winter

5. 发明申请

US20070244133A1 Thienopyrimidines and Thiazolopyrimidines for Use in Medicine 审中-公开
标题翻译：噻吩并嘧啶和噻唑并嘧啶用于医学
公开(公告)号：US20070244133A1
公开(公告)日：2007-10-18
申请号：US11628449
申请日：2005-05-31
申请人： Justin Bower , Alan Faull , Jon Winter
发明人： Justin Bower , Alan Faull , Jon Winter
IPC分类号： A61K31/519 , A61P1/00 , A61P11/00 , A61P17/06 , A61P35/00 , C07D239/70 , C07D495/04 , C07D513/04
CPC分类号： C07D495/04 , A61K31/519 , C07D513/04
摘要： The use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein X1, X2, X3, X4, Ra, p, R1, Z, Y, R2, R3 and R4 are as defined in the specification, in the preparation of a medicament for the treatment of C—C chemokine mediated conditions, such as inflammatory disease. Certain compounds of formula (I) are novel and these, together with their preparation are also described and claimed.
摘要翻译：使用式（I）化合物或其药学上可接受的盐或溶剂合物，其中X 1，X 2，X 3， R 4，R 9，R 11，R 12，R 12， 3和R 4如本说明书中所定义，用于制备用于治疗CC趋化因子介导的病症例如炎性疾病的药物。某些式（I）化合物是新颖的，并且这些化合物及其制备方法也被描述和要求保护。

6. 发明申请

US20060167048A1 N-4-piperidinyl compounds as ccr5 modulators 审中-公开
标题翻译： N-4-哌啶基化合物作为ccr5调节剂
公开(公告)号：US20060167048A1
公开(公告)日：2006-07-27
申请号：US10525121
申请日：2003-08-19
申请人： John Cumming , Jon Winter
发明人： John Cumming , Jon Winter
IPC分类号： C07D401/02 , A61K31/4545
CPC分类号： C07D211/62 , C07D211/58
摘要： The invention provides a compound of formula (I): [Chemical formula should be inserted here. Please see paper copy.] wherein R1, R2, R3, R3a, R4, R4a, R5, and R6 are as defined; or a pharmaceutically acceptable salt thereof or a solvate thereof; compositions containing these compounds, processes for preparing them and their use as modulators of chemokine activity (especially CCR5 activity).
摘要翻译：本发明提供了式（I）化合物：[化学式应该插在这里。请参阅纸本。]其中R 1，R 2，R 3，R 3a，R SUB， > 4，R 4a，R 5和R 6定义如上; 或其药学上可接受的盐或其溶剂合物; 含有这些化合物的组合物，其制备方法及其作为趋化因子活性调节剂（特别是CCR5活性）的用途。

7. 发明授权

US06789975B1 Pen 有权
标题翻译：钢笔
公开(公告)号：US06789975B1
公开(公告)日：2004-09-14
申请号：US09979321
申请日：2002-05-08
申请人： Roy Nicoll , James R. Ambler , Jon Winter
发明人： Roy Nicoll , James R. Ambler , Jon Winter
IPC分类号： B43K518
CPC分类号： B43K5/1845
摘要： A reservoir pen includes a nib, a feed bar defining an ink channel and having an ink port, and a valve for controlling flow of ink from the ink port to an underside of the nib. The valve includes a seat, a valve member, and a resilient element engaging the valve member to bias the valve member away from the ink port toward an open position. The valve member is further positioned to engage the nib to urge the valve member against the resilient element and into sealing contact with the seat. The resilient member is disposed outside of the ink channel in at least the open position.
摘要翻译：贮存器笔包括笔尖，限定墨水通道并具有墨水口的进给杆，以及用于控制墨水从墨水口流到笔尖下侧的阀。阀包括座椅，阀构件和接合阀构件的弹性元件，以将阀构件偏离墨口朝向打开位置。阀构件进一步定位成接合笔尖以将阀构件推靠在弹性元件上并与阀座密封接触。弹性构件至少在打开位置设置在墨水通道的外部。

8. 外观设计

USD675527S1 Container with closure 有权
公开(公告)号：USD675527S1
公开(公告)日：2013-02-05
申请号：US29381380
申请日：2010-12-17
申请人： Chris Rogers , Adrian Jahina , Jon Winter
设计人： Chris Rogers , Adrian Jahina , Jon Winter

9. 外观设计

USD670167S1 Container with cap 有权
标题翻译：集装箱盖
公开(公告)号：USD670167S1
公开(公告)日：2012-11-06
申请号：US29381381
申请日：2010-12-17
申请人： Jon Winter , Chris Rogers , Adrian Jahina
设计人： Jon Winter , Chris Rogers , Adrian Jahina

10. 发明申请

US20080039499A1 Chemical Compounds 审中-公开
标题翻译：化学化合物
公开(公告)号：US20080039499A1
公开(公告)日：2008-02-14
申请号：US11628318
申请日：2005-05-31
申请人： Justin Bower , Gordon Hamlin , Jon Winter
发明人： Justin Bower , Gordon Hamlin , Jon Winter
IPC分类号： C07D417/12 , A61K31/426 , A61K31/445 , A61K31/4535 , C07D417/14 , A61K31/454 , A61P29/00 , C07D277/38
CPC分类号： C07D417/14 , C07D417/12
摘要： The use of a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1, Ra, R8, R2, R3 and R4 are as defined in the specification, in the preparation of a medicament for the treatment of C—C chemokine mediated conditions. Novel compounds of formula (I) and pharmaceutical compositions containing them are also described and claimed.
摘要翻译：使用式（I）化合物或其药学上可接受的盐或溶剂合物，其中R 1，R 2，R 8， R 2，R 3和R 4如本说明书中所定义，用于制备用于治疗CC趋化因子介导的病症的药物。还描述和要求保护新的式（I）化合物和含有它们的药物组合物。

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