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1. 发明授权

US07906645B2 Heterocyclic compounds as ccr2b antagonists 失效
标题翻译：杂环化合物作为ccr2b拮抗剂
公开(公告)号：US07906645B2
公开(公告)日：2011-03-15
申请号：US11793606
申请日：2005-12-19
申请人： Justin Fairfield Bower , Jeffrey Philip Poyser , David Waterson
发明人： Justin Fairfield Bower , Jeffrey Philip Poyser , David Waterson
IPC分类号： C07D241/02 , A61K31/495
CPC分类号： C07D295/195 , C07D207/09 , C07D211/26 , C07D211/46 , C07D211/60 , C07D265/30 , C07D295/02 , C07D295/215 , C07D401/06 , C07D405/06 , C07D409/06 , C07D409/12 , C07D413/06 , C07D413/12 , C07D417/06
摘要： Compounds of formula (I) Q-L-W—C(═X)—Z—P wherein Q is an amine of the formula —N(R1)(R2); L is an alkyl or heterocyclyl-alkyl linker; W is a 6- or 7-membered aliphatic ring comprising ring atoms Y1 and Y2 which are linked to groups L and C(X) respectively and Y1 and Y2 are independently selected from N and C; X is O, N, N—CN or S; Z is NR3; P is an optionally substituted monocyclic or bicyclic aryl or heteroaryl group; and pharmaceutically acceptable salts or solvates thereof, are useful in the treatment of C-C chemokine mediated conditions.
摘要翻译：式（I）化合物Q-L-W-C（= X）-Z-P其中Q是式-N（R1）（R2）的胺; L是烷基或杂环基 - 烷基接头; W是分别连接到基团L和C（X）的环原子Y1和Y2的6或7元脂肪环，Y1和Y2独立地选自N和C; X是O，N，N-CN或S; Z为NR3; P是任选取代的单环或双环芳基或杂芳基; 和其药学上可接受的盐或溶剂化物，可用于治疗C-C趋化因子介导的病症。

2. 发明申请

US20070197542A1 N-{'4-substituted piperazine-1-sulfonylmethyl!alkyl}-n-hydroxyfomamide compounds as metalloproteinase inhibitors 失效
标题翻译： N - {'4-取代哌嗪-1-磺酰基甲基}烷基} -N-羟基甲酰胺化合物作为金属蛋白酶抑制剂
公开(公告)号：US20070197542A1
公开(公告)日：2007-08-23
申请号：US10561747
申请日：2004-06-23
申请人： Maurice Raymond Finlay , David Waterson
发明人： Maurice Raymond Finlay , David Waterson
IPC分类号： A61K31/506 , A61K31/496 , A61K31/495 , C07D403/04
CPC分类号： C07D239/47 , C07D295/26 , C07D309/04 , C07D401/12 , C07D405/12
摘要： The invention provides compounds of formula (I): or a pharmaceutically acceptable salt, prodrug or solvate thereof, wherein ring B represents a monocyclic aryl ring having six ring atoms or a monocyclic heteroaryl ring having up to six ring atoms and containing one or more ring heteroatoms wherein each said heteroatom is nitrogen; R2 represents a group selected from C1-6 alkyl or aryl, which said group is substituted by one or more fluorine groups; n is 1, 2 or 3; and R1 represents an optionally substituted group selected from C1-6 alkyl, C5-7 cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-6 alkyl-aryl, C1-6 alkyl-heteroaryl, C1-6 alkyl-cycloalkyl or C1-6 alkyl-heterocycloalkyl. Processes for their preparation; pharmaceutical compositions containing them; and their use in the treatment of a disease condition mediated by one or more metalloproteinase enzymes.
摘要翻译：本发明提供式（I）化合物或其药学上可接受的盐，前药或溶剂化物，其中环B表示具有六个环原子的单环芳基环或具有至多六个环原子并含有一个或多个环的单环杂芳基环其中每个所述杂原子是氮的杂原子; R2表示选自C1-6烷基或芳基的基团，所述基团被一个或多个氟基团取代; n为1,2或3; 并且R 1表示任选取代的基团，其选自C 1-6烷基，C 5-7环烷基，杂环烷基，芳基，杂芳基，C 1-6烷基 - 芳基，C 1-6烷基 - 杂芳基，C 1-6烷基 - 环烷基或C 1-6烷基 - 杂环烷基。其准备过程; 含有它们的药物组合物; 以及它们用于治疗由一种或多种金属蛋白酶介导的疾病状况的用途。

3. 发明授权

US07153857B2 Arylpiperazines and arylpiperidines and their use as metalloproteinase inhibiting agents 失效
公开(公告)号：US07153857B2
公开(公告)日：2006-12-26
申请号：US10485409
申请日：2002-08-08
申请人： Maurice Raymond Verschoyle Finlay , Howard Tucker , David Waterson
发明人： Maurice Raymond Verschoyle Finlay , Howard Tucker , David Waterson
IPC分类号： A61K31/496 , C07D241/04
CPC分类号： C07D295/26 , A61K31/496 , A61K31/506 , C07D401/12 , C07D401/14 , C07D409/14
摘要： Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.

4. 发明申请

US20060101128A1 System for preventing keystroke logging software from accessing or identifying keystrokes 有权
标题翻译：用于防止击键记录软件访问或识别击键的系统
公开(公告)号：US20060101128A1
公开(公告)日：2006-05-11
申请号：US11311133
申请日：2005-12-20
申请人： David Waterson
发明人： David Waterson
IPC分类号： G06F15/167
CPC分类号： H04L63/0428 , G06F21/52 , G06F21/554 , G06F21/83 , H04L63/1441
摘要： A computer program is adapted for securing user entry data against keyboard login attempts. The program masks user input data, either insulating the data from vulnerable parts of the operating system or application, or contaminating user data that is supplied to those vulnerable parts of the operating system or application. The program securely stores data, either intercepted prior to reaching the vulnerable parts of the operating system or extracted from the contaminated data, and securely provides the data directly to a verified application.
摘要翻译：计算机程序适于保护用户输入数据免受键盘登录尝试。该程序掩盖用户输入数据，将数据与操作系统或应用程序的弱点部分隔离，或者污染提供给操作系统或应用程序的这些易受攻击部分的用户数据。该程序安全地存储数据，在到达操作系统的易受攻击的部分之前被拦截或从受污染的数据中提取，并将数据直接提供给已验证的应用程序。

5. 发明授权

US06313127B1 Heterocyclic compounds useful as pharmaceutical agents 失效
标题翻译：用作药剂的杂环化合物
公开(公告)号：US06313127B1
公开(公告)日：2001-11-06
申请号：US09117523
申请日：1998-07-31
申请人： David Waterson , Elaine Sophie Elizabeth Stokes , George Robert Brown , John Graham Cumming , Nicholas John Newcombe , Robin Wood , William John Watkins
发明人： David Waterson , Elaine Sophie Elizabeth Stokes , George Robert Brown , John Graham Cumming , Nicholas John Newcombe , Robin Wood , William John Watkins
IPC分类号： A61K31496
CPC分类号： C07D239/42 , C07D213/74 , C07D401/04 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D513/04
摘要： Compounds of formula (I) in which all variables are defined in the description and their salts inhibit the enzyme oxido squalene cyclase and are useful in treating hypercholesterolemia and also as anti-fungal agents. Processes for their preparation are also described together with their use in medicine.
摘要翻译：其中所有变量在说明书中定义的式（I）化合物及其盐抑制酶氧化角鲨烯环化酶，并且可用于治疗高胆固醇血症，也可用作抗真菌剂。还描述了其制备方法及其在药物中的用途。

6. 发明授权

US08129412B2 Hydantoin derivatives useful as metalloproteinase inhibitors 失效
标题翻译：海因衍生物可用作金属蛋白酶抑制剂
公开(公告)号：US08129412B2
公开(公告)日：2012-03-06
申请号：US11793358
申请日：2005-12-14
申请人： David Waterson , David Jonas Persson
发明人： David Waterson , David Jonas Persson
IPC分类号： A61K31/445 , C07D401/12
CPC分类号： C07D401/12
摘要： Formula (I) wherein R1 is a (2-4C)alkyl and is substituted by two or more fluorine groups and R2 is methyl or ethyl, or a pharmaceutically acceptable salt thereof; processes for their preparation, pharmaceutical compositions containing them and their use in the treatment of diseases or medical conditions mediated by metalloproteinase enzymes.
摘要翻译：式（I）其中R1是（2-4C）烷基并被两个或更多个氟基取代，R2是甲基或乙基，或其药学上可接受的盐; 其制备方法，含有它们的药物组合物及其在治疗由金属蛋白酶介导的疾病或医学病症中的用途。

7. 发明授权

US07122551B2 Metalloproteinase inhibitor compounds 失效
标题翻译：金属蛋白酶抑制剂化合物
公开(公告)号：US07122551B2
公开(公告)日：2006-10-17
申请号：US10787813
申请日：2004-02-26
申请人： Bernard Christophe Barlaam , Robert Ian Dowell , Maurice Raymond Verschoyle Finlay , Nicholas John Newcombe , Howard Tucker , David Waterson
发明人： Bernard Christophe Barlaam , Robert Ian Dowell , Maurice Raymond Verschoyle Finlay , Nicholas John Newcombe , Howard Tucker , David Waterson
IPC分类号： C07D403/12 , C07D403/14 , A61K31/4545 , A61P9/10
CPC分类号： C07D213/64 , C07D213/61 , C07D213/74 , C07D239/26 , C07D239/30 , C07D241/12 , C07D241/16 , C07D401/12
摘要： Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
摘要翻译：用作金属蛋白酶抑制剂的式I化合物，特别是作为MMP 13的抑制剂。

8. 发明申请

US20050120230A1 System for preventing a computer virus accessing email addresses 审中-公开
标题翻译：防止计算机病毒访问电子邮件地址的系统
公开(公告)号：US20050120230A1
公开(公告)日：2005-06-02
申请号：US10920268
申请日：2004-08-18
申请人： David Waterson
发明人： David Waterson
IPC分类号： G06F21/00 , H04L29/06 , H04L9/32 , G06F11/30 , G06F12/14 , G06F15/167
CPC分类号： H04L63/0428 , G06F21/83 , H04L63/145
摘要： A system for preventing a computer virus from accessing message addresses is described. The system comprises an interception component or client plug-in that communicates with a messaging client and a messaging server. The interception component alters messages from the server and destined for the client. The interception component replaces message addresses in incoming messages with a unique identifier. The interception component also alters messages from the client destined for the server. The interception component replaces a unique identifier with a message addresses. A system for preventing keyboard sniffer programs from intercepting input, a system for preventing a computer virus from activating a send confirmation of a messaging client and a method for altering displayed objects to show encrypted data in decrypted form are also described and claimed.
摘要翻译：描述了用于防止计算机病毒访问消息地址的系统。该系统包括与消息传递客户端和消息传递服务器通信的拦截组件或客户端插件。拦截组件更改来自服务器并发往客户端的消息。拦截组件使用唯一标识符替换传入消息中的消息地址。拦截组件还会更改来自发往服务器的客户端的消息。拦截组件用消息地址替换唯一标识符。还描述和要求保护用于防止键盘嗅探程序拦截输入的系统，用于防止计算机病毒激活消息接发客户端的发送确认的系统和用于改变显示对象以显示加密数据的解密形式的方法。

9. 发明授权

US06734184B1 Arylpiperazines and their use as metalloproteinase inhibiting agents (MMP) 失效
标题翻译：芳基哌嗪及其作为金属蛋白酶抑制剂（MMP）
公开(公告)号：US06734184B1
公开(公告)日：2004-05-11
申请号：US09763709
申请日：2001-02-26
申请人： Bernard C Barlaam , Nicholas J Newcombe , Howard Tucker , David Waterson
发明人： Bernard C Barlaam , Nicholas J Newcombe , Howard Tucker , David Waterson
IPC分类号： A61K3144
CPC分类号： C07D213/42 , C07D213/74 , C07D215/12 , C07D239/42 , C07D241/12 , C07D295/26 , C07D333/20 , C07D401/12 , C07D417/12
摘要： Arylpiperazines of formula (I) useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
摘要翻译：用作金属蛋白酶抑制剂的式（I）的芳基哌嗪，特别是作为MMP 13的抑制剂。

10. 发明授权

US06734183B2 Compounds 失效
标题翻译：化合物
公开(公告)号：US06734183B2
公开(公告)日：2004-05-11
申请号：US09788687
申请日：2001-02-21
申请人： Christophe B Barlaam , Robert I Dowell , Maurice R V Finlay , Nicholas J Newcombe , Howard Tucker , David Waterson
发明人： Christophe B Barlaam , Robert I Dowell , Maurice R V Finlay , Nicholas J Newcombe , Howard Tucker , David Waterson
IPC分类号： A61K31496
CPC分类号： C07D213/64 , C07D213/61 , C07D213/74 , C07D239/26 , C07D239/30 , C07D241/12 , C07D241/16 , C07D401/12
摘要： Compounds of the formula I useful as metalloproteinase inhibitors, especially as inhibitors of MMP 13.
摘要翻译：作为金属蛋白酶抑制剂的化学式，特别是作为MMP 13的抑制剂。

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