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1. 发明申请

US20080261878A1 Method of inducing the formation of neurofibrillary tangles in transgenic animals 失效
标题翻译：诱导转基因动物神经原纤维缠结形成的方法
公开(公告)号：US20080261878A1
公开(公告)日：2008-10-23
申请号：US11976318
申请日：2007-10-23
申请人： Jurgen Gotz , Roger Nitsch , Feng Chen
发明人： Jurgen Gotz , Roger Nitsch , Feng Chen
IPC分类号： A61K38/00 , A61P25/00
CPC分类号： C07K14/4711 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C12N15/8509
摘要： The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative diseases associated with the formation of neurofibrillary tangles, in particular Alzheimer's disease. The present invention is based on the surprising-finding that injection of β-amyloid Aβ42 fibrils into brains of P301L mutant tau transgenic mice caused several-fold increases in the numbers and an accelerated production of neurofibrillary tangles in cell bodies predominantly within the amygdala. The induced neurofibrillary tangles occurred as early as 18 days after Aβ42 injections and displayed striking features of neurofibrillary tangles of several human neurodegenerative diseases, particularly Alzheimer's disease.
摘要翻译：本发明公开了一种可用于鉴定和测试调节剂的方法和体内测定系统，以及用于验证与形成神经原纤维缠结，特别是阿尔茨海默病有关的神经变性疾病的疗法。本发明基于令人惊奇的发现，即将β-淀粉样蛋白Aβ2-2原纤维注射到P301L突变体tau转基因小鼠的脑中导致数量增加数倍，并且加速了神经原纤维缠结的产生细胞体主要位于杏仁核内。诱导的神经原纤维缠结发生早于Abeta 42注射后18天，并显示几种人类神经变性疾病，特别是阿尔茨海默病的神经原纤维缠结的显着特征。

2. 发明申请

US20050015819A1 Method of inducing the formation of neurofibrillary tangles in transgenic animals 审中-公开
标题翻译：诱导转基因动物神经原纤维缠结形成的方法
公开(公告)号：US20050015819A1
公开(公告)日：2005-01-20
申请号：US10487546
申请日：2002-08-24
申请人： Jurgen Gotz , Roger Nitsch , Feng Chen
发明人： Jurgen Gotz , Roger Nitsch , Feng Chen
IPC分类号： A01K67/027 , C07K14/47 , C12N15/09 , C12N15/85 , C12N15/00
CPC分类号： C07K14/4711 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/105 , A01K2267/0312 , A01K2267/0318 , C12N15/8509
摘要： The present invention discloses a method and an in-vivo assay system useful for the identification and testing of modulating agents as well as for the validation of therapies of neurodegenerative diseases associated with the formation of neurofibrillary tangles, in particular Alzheimer's disease. The present invention is based on the surprising finding that injection of β-amyloid Aβ42 fibrils into brains of P301L mutant tau transgenic mice caused several-fold increases in the numbers and an accelerated production of neurofibrillary tangles in cell bodies predominantly within the amygdala. The induced neurofibrillary tangles occurred as early as 18 days after Aβ42 injections and displayed striking features of neurofibrillary tangles of several human neurodegenerative diseases, particularly Alzheimer's disease.
摘要翻译：本发明公开了一种可用于鉴定和测试调节剂的方法和体内测定系统，以及用于验证与形成神经原纤维缠结，特别是阿尔茨海默病有关的神经变性疾病的疗法。本发明基于惊人的发现，即将β-淀粉状蛋白Aβ42原纤维注射到P301L突变体tau转基因小鼠的脑中，导致数量增加了数倍，并且主要在杏仁核内的细胞体中加速了神经原纤维缠结的产生。诱导的神经原纤维缠结发生早于Abeta42注射后18天，并显示出几种人类神经变性疾病，特别是阿尔茨海默病的神经原纤维缠结的显着特征。

3. 发明授权

US5120946A Device for receiving datacards 失效
标题翻译：接收数据的设备
公开(公告)号：US5120946A
公开(公告)日：1992-06-09
申请号：US489453
申请日：1990-03-06
申请人： Klaus Hug , Otmar Modest , Jurgen Gotz
发明人： Klaus Hug , Otmar Modest , Jurgen Gotz
IPC分类号： G06K17/00 , G06K7/00 , G06K13/07
CPC分类号： G06K13/0875 , G06K13/085 , G06K7/0021
摘要： A device for receiving data cards, including an essentially square-shaped housing; a guide chute for the data cards, the housing having a loading/output slot which forms an access to the guide chute; arrangement for read-in and readout of data from the data cards; mechanism for locking and unlocking the data cards, including a movable stop provided so as to cooperate with an end side of a loaded data card pointing inwards into the device; a gear connection for connecting the at least one latch with the movable stop; and a safety catch engageable with the geared connection, the at least one latch being arranged so as to embrace an outwardly pointing end side of the data card when the data card is in an end position in the device, the geared connection including a slide having one end connected to the movable stop for the inwardly pointing end side of the datacard, and a second end provided with a set of teeth the latch having a toothed quadrant and being rotatable supported and meshing with the set of teeth of the slide by way of the toothed quadrant.
摘要翻译：一种用于接收数据卡的设备，包括基本上为方形的外壳; 用于数据卡的导槽，所述壳体具有形成对所述导槽的通路的装载/输出槽; 用于从数据卡读取和读出数据的布置; 用于锁定和解锁数据卡的机构，包括设置为与向内指向装置的加载数据卡的端侧配合的可移动止动件; 用于将所述至少一个闩锁与所述可移动止动件连接的齿轮连接件; 以及可与所述齿轮传动连接部配合的安全钩，所述至少一个闩锁布置成当所述数据卡处于所述装置的终端位置时包围所述数据卡的向外指向的端侧，所述齿轮连接包括具有一端连接到数据卡的向内指向端侧的可移动止动件，第二端设置有一组齿，该闩锁具有齿形象限，并且可转动地支撑并与滑块的一组齿啮合，通过齿形象限。

4. 发明申请

US20100114362A1 Horizontal Circuit Storage System 有权
标题翻译：水平电路存储系统
公开(公告)号：US20100114362A1
公开(公告)日：2010-05-06
申请号：US11992501
申请日：2006-06-22
申请人： Werner Zumbrunn , Stefan Kobler , Gregor Burkhard , Norbert Bouche , Jurgen Gotz , Rene Talon
发明人： Werner Zumbrunn , Stefan Kobler , Gregor Burkhard , Norbert Bouche , Jurgen Gotz , Rene Talon
IPC分类号： B65G1/133 , G06F7/00
CPC分类号： B65G1/133
摘要： The invention relates to a horizontal circuit storage system (1) for storing storage goods carried by load-carriers. The horizontal circuit storage system has a storage zone (2) with a plurality of stacked horizontal storage planes (5). A plurality of load-carriers (6) are arranged in a row in each of the storage planes. The storage zone (2) is located between two vertical conveyers (3, 4) which interconnect the storage planes vertically in each case. The load-carriers (6) can be moved horizontally in the storage planes (5) to the vertical conveyers (3, 4) by horizontal conveyers (8) which are associated each with a storage plane (5). According to the invention, a control unit is provided in order to permit faster access to individual load-carriers and, depending on a control signal from the control unit, the storage system can be brought into a condition in which a horizontal circuit is formed for the load-carriers (6). The invention also relates to a method for accessing a particular load-carrier (6) which receives a storage good in a horizontal circuit storage system (1) in which such a horizontal circuit (65) is formed.
摘要翻译：本发明涉及一种用于存储由负载载体承载的存储货物的水平电路存储系统（1）。水平电路存储系统具有具有多个堆叠的水平存储平面（5）的存储区（2）。多个负载载体（6）在每个存储平面中排列成一行。存储区域（2）位于在每种情况下垂直连接存储平面的两个垂直输送机（3,4）之间。负载载体（6）可以通过水平输送机（8）在储存平面（5）中水平移动到垂直输送机（3），每个输送机与存储平面（5）相关联。根据本发明，提供了一种控制单元，以便更快地访问各个负载载波，并且根据来自控制单元的控制信号，存储系统可以进入形成水平电路的状态，负载载体（6）。本发明还涉及用于访问在其中形成这样的水平电路（65）的水平电路存储系统（1）中接收存储产品的特定负载载体（6）的方法。

5. 发明申请

US20140260685A1 TORQUE SENSOR ARRANGEMENT AND SHAFT COMPRISING A TORQUE SENSOR ARRANGEMENT 有权
标题翻译：扭矩传感器布置和包含扭矩传感器布置的轴
公开(公告)号：US20140260685A1
公开(公告)日：2014-09-18
申请号：US14115203
申请日：2012-04-10
申请人： Hans-Gerd Brummel , Jurgen Gotz , Uwe Linnert , Carl Udo Maier , Jochen Ostermaier
发明人： Hans-Gerd Brummel , Jurgen Gotz , Uwe Linnert , Carl Udo Maier , Jochen Ostermaier
IPC分类号： G01L3/10 , F16C3/02
CPC分类号： G01L3/101 , F16C3/02 , G01L3/102
摘要： A torque sensor arrangement including a contactless torque sensor, in which the torque sensor is arranged on an electrically operating linear carriage is provided. A distance sensor is also arranged on the linear carriage such that it allows the distance to the object of which the torque is to be determined to be measured.
摘要翻译：提供了一种包括非接触转矩传感器的扭矩传感器装置，其中扭矩传感器布置在电操作的直线滑架上。距离传感器也布置在直线滑架上，使得其允许到要测量转矩的物体的距离。

6. 发明授权

US08818550B2 Horizontal circuit storage system 有权
标题翻译：水平电路存储系统
公开(公告)号：US08818550B2
公开(公告)日：2014-08-26
申请号：US11992501
申请日：2006-06-22
申请人： Werner Zumbrunn , Stefan Kobler , Gregor Burkhard , Norbert Bouche , Jurgen Gotz , Rene Talon
发明人： Werner Zumbrunn , Stefan Kobler , Gregor Burkhard , Norbert Bouche , Jurgen Gotz , Rene Talon
IPC分类号： G06F7/00 , B65G1/133
CPC分类号： B65G1/133
摘要： The invention relates to a horizontal circuit storage system (1) for storing storage goods carried by load-carriers. The horizontal circuit storage system has a storage zone (2) with a plurality of stacked horizontal storage planes (5). A plurality of load-carriers (6) are arranged in a row in each of the storage planes. The storage zone (2) is located between two vertical conveyers (3, 4) which interconnect the storage planes vertically in each case. The load-carriers (6) can be moved horizontally in the storage planes (5) to the vertical conveyers (3, 4) by horizontal conveyers (8) which are associated each with a storage plane (5). According to the invention, a control unit is provided in order to permit faster access to individual load-carriers and, depending on a control signal from the control unit, the storage system can be brought into a condition in which a horizontal circuit is formed for the load-carriers (6). The invention also relates to a method for accessing a particular load-carrier (6) which receives a storage good in a horizontal circuit storage system (1) in which such a horizontal circuit (65) is formed.
摘要翻译：本发明涉及一种用于存储由负载载体承载的存储货物的水平电路存储系统（1）。水平电路存储系统具有具有多个堆叠的水平存储平面（5）的存储区（2）。多个负载载体（6）在每个存储平面中排列成一行。存储区域（2）位于在每种情况下垂直连接存储平面的两个垂直输送机（3,4）之间。负载载体（6）可以通过水平输送机（8）在储存平面（5）中水平移动到垂直输送机（3），每个输送机与存储平面（5）相关联。根据本发明，提供了一种控制单元，以便更快地访问各个负载载波，并且根据来自控制单元的控制信号，存储系统可以进入形成水平电路的状态，负载载体（6）。本发明还涉及用于访问在其中形成这样的水平电路（65）的水平电路存储系统（1）中接收存储产品的特定负载载体（6）的方法。

7. 发明授权

US5072803A Method of setting an assisting force in power-assisted steering 失效
标题翻译：在功率辅助转向中设置辅助力的方法
公开(公告)号：US5072803A
公开(公告)日：1991-12-17
申请号：US550090
申请日：1990-07-09
申请人： Ulrich Kilian , Jurgen Gotz , Claus-Michael Hainbuch , Berthold Edenhofer
发明人： Ulrich Kilian , Jurgen Gotz , Claus-Michael Hainbuch , Berthold Edenhofer
IPC分类号： B62D6/00
CPC分类号： B62D6/00
摘要： A power-assisted steering method establishes or sets an auxiliary force by taking into account a plurality of variables such as transverse acceleration and vehicle speed characterizing the instantaneous driving conditions. The driving feel with regard to the state of the road surface and the instantaneous driving situation for the vehicle driver are thereby ensured.
摘要翻译：动力辅助转向方法通过考虑诸如横向加速度和表征瞬时驾驶条件的车辆速度的多个变量来建立或设定辅助力。由此，能够确保相对于路面状态的驾驶感觉和车辆驾驶员的瞬时驾驶状况。

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