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1. 发明申请

US20070054851A1 Methods of and compositions for stimulation of glucose uptake into muscle cells and treatment of diseases 审中-公开
标题翻译：刺激葡萄糖摄入肌肉细胞和治疗疾病的方法和组合物
公开(公告)号：US20070054851A1
公开(公告)日：2007-03-08
申请号：US11442244
申请日：2006-05-30
申请人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis Williams
发明人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis Williams
IPC分类号： A61K38/18
CPC分类号： A61K38/1883 , A61K31/155 , A61K31/18 , A61K31/195 , A61K31/197 , A61K38/1808 , A61K38/26 , A61K38/28 , A61K45/06 , A61K47/60 , A61K2300/00
摘要： The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.
摘要翻译：本发明涉及ErbB配体（包括β细胞素）的治疗用途。治疗用途包括单独使用ErbB配体家族化合物或与其它药物联合用于降低血糖水平，治疗I型和II型糖尿病，肥胖症，肌肉消瘦疾病和心脏毒性的方法。

2. 发明申请

US20110319324A1 METHODS OF AND COMPOSITIONS FOR STIMULATION OF GLUCOSE UPTAKE INTO MUSCLE CELLS AND TREATMENT OF DISEASES 审中-公开
标题翻译：用于刺激葡萄糖摄入到肌肉细胞和治疗疾病的方法和组合物
公开(公告)号：US20110319324A1
公开(公告)日：2011-12-29
申请号：US12955779
申请日：2010-11-29
申请人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis T. Williams
发明人： Junyu Lin , Srinivas Kothakota , Ge Wu , Stephen Doberstein , Thomas Brennan , Lorianne Masuoka , Minmin Qin , Shannon Marshall , Yan Wang , Diane Hollenbaugh , Lewis T. Williams
IPC分类号： A61K38/18 , A61P3/10 , A61K38/28
CPC分类号： A61K38/28 , A61K31/155 , A61K38/1808 , A61K38/26 , A61K38/00
摘要： The present invention relates to therapeutic uses of ErbB ligands, including betacellulin. The therapeutic uses include methods of using ErbB ligand family compounds alone, or in conjunction with other agents, for reducing blood glucose levels, treating Type I and Type II diabetes, obesity, muscle wasting diseases, and cardiotoxicity.
摘要翻译：本发明涉及ErbB配体（包括β细胞素）的治疗用途。治疗用途包括单独使用ErbB配体家族化合物或与其它药物联合用于降低血糖水平，治疗I型和II型糖尿病，肥胖症，肌肉消瘦疾病和心脏毒性的方法。

3. 发明授权

US08766875B2 Lightweight stiffener with integrated RF cavity-backed radiator for flexible RF emitters 有权
标题翻译：轻便的加强筋，具有集成RF腔背散热器，适用于柔性射频发射器
公开(公告)号：US08766875B2
公开(公告)日：2014-07-01
申请号：US13476764
申请日：2012-05-21
申请人： Robert Brett Williams , Kyle W. Maxhimer , Larry L. Lai , Thomas Brennan , Clifton Quan , Fangchou Yang
发明人： Robert Brett Williams , Kyle W. Maxhimer , Larry L. Lai , Thomas Brennan , Clifton Quan , Fangchou Yang
IPC分类号： H01Q15/14 , H01Q1/28
CPC分类号： H01Q15/144 , H01Q1/28 , H01Q19/106 , H01Q21/0087 , H01Q21/061
摘要： An integrated stiffener and RF reflector (stiffener/reflector) (100) for a RF emitter which includes: a plurality of vertical ribs (102) constituting side walls of the stiffener/reflector; a plurality of horizontal ribs (104) formed in a width direction of the stiffener/reflector; a top cover (204) including metallization layer (308), the top cover being electrically coupled to a ground layer (312) of the RF emitter and configured in such a way to direct all of RF energy in an opposite direction to the top cover. Each of the vertical (102) and horizontal (104) ribs has a sandwich structure, which includes: a foam core layer (302) disposed on a layer of the RF emitter (314); a thin film layer (306) bonded to sides and top of the rib to form facesheets of the sandwich structure.
摘要翻译：用于RF发射器的集成加强件和RF反射器（加强件/反射器）（100），其包括：构成加强件/反射器的侧壁的多个垂直肋条（102）在加强件/反射器的宽度方向上形成的多个水平肋（104）包括金属化层（308）的顶盖（204），所述顶盖电耦合到所述RF发射器的接地层（312），并且被配置为以与顶盖相反的方向引导所有RF能量。垂直（102）和水平（104）肋中的每一个具有夹层结构，其包括：布置在RF发射器（314）的层上的泡沫芯层（302）; 粘合到所述肋的侧面和顶部的薄膜层（306），以形成所述夹层结构的面板。

4. 发明申请

US20060212480A1 System and method for matter clusters in an IP management system 审中-公开
标题翻译：知识产权管理系统中物质集群的系统和方法
公开(公告)号：US20060212480A1
公开(公告)日：2006-09-21
申请号：US11085813
申请日：2005-03-21
申请人： Steven Lundberg , Janal Kalis , Shal Jain , Pradeep Sinha , Thomas Brennan
发明人： Steven Lundberg , Janal Kalis , Shal Jain , Pradeep Sinha , Thomas Brennan
IPC分类号： G06F17/00
CPC分类号： G06Q10/10
摘要： Method and apparatus are disclosed for managing intellectual property information including organizing intellectual property data in a data processing system according to file clusters. A method comprises organizing intellectual property data in an intellectual property data management system, wherein the management system tracks events and data related to a plurality of patent matters processed by one or more government agencies and owned by at least one patent owner. Representations of the patent matters are entered into a data structure in the data management system. A user of the data management system can selectively associate patent matters together into clusters wherein the clusters have names and wherein at least one of a plurality of clusters maintained in the system can be located and viewed. One of the matters associated with the cluster can be selected and the data of the matter viewed or processed by a user. Further, the clusters can be organized and categorized so that selected users can not view the clusters.
摘要翻译：公开了用于管理知识产权信息的方法和装置，包括根据文件簇在数据处理系统中组织知识产权数据。一种方法包括在知识产权数据管理系统中组织知识产权数据，其中管理系统跟踪由一个或多个政府机构处理并由至少一个专利所有者拥有的与多个专利事务有关的事件和数据。专利事务的陈述被输入数据管理系统的数据结构。数据管理系统的用户可以选择性地将专利事项关联到群集中，其中群集具有姓名，并且其中可以定位和查看系统中维护的多个群集中的至少一个。可以选择与集群相关的事项之一，以及用户查看或处理的事项的数据。此外，可以组织和分类集群，使得所选择的用户不能查看集群。

5. 发明申请

US20060206345A1 System and method for obtaining and disseminating secured on-line data 审中-公开
标题翻译：用于获取和传播安全在线数据的系统和方法
公开(公告)号：US20060206345A1
公开(公告)日：2006-09-14
申请号：US11062119
申请日：2005-02-18
申请人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
发明人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
IPC分类号： G06Q99/00
CPC分类号： G06Q10/00 , G06Q50/184
摘要： There is disclosed method and apparatus for downloading private intellectual property information from a first secured data source maintained by a government agency, wherein access to the private intellectual property information is secured with one or more security mechanisms, and storing at least some of the downloaded information into a first data management system accessible to a first group of users specified by a law firm. At least some of the downloaded information is copied into a second data management system accessible to a second group of users specified by a corporation represented by the law firm. An intellectual property management system is maintained and includes data associated with a plurality of intellectual property matters and data associated with a plurality of intellectual property events occurring relative to the matters, wherein the events originate from a government agency and further wherein the intellectual property matters indicated in the management system are managed at least in part by a legal representative. The private intellectual property information is downloaded from a first secured data source maintained by the government agency, wherein the information relates to intellectual property matters that the secured data source indicates are related at least in part with the legal representative, and access to the private intellectual property information is secured with one or more security mechanisms associated with the legal representative. The system further automatically compares at least some of the downloaded information with data maintained in the intellectual property management system to determine discrepancies between the intellectual property matters indicated in the management system as related to the legal representative and intellectual property matters indicated in the secured data source as associated with the legal representative.
摘要翻译：公开了一种从由政府机构维护的第一安全数据源下载私人知识产权信息的方法和装置，其中利用一个或多个安全机制保护对私有知识产权信息的访问，并且存储至少一些所下载的信息成为由律师事务所指定的第一组用户可访问的第一个数据管理系统。至少一些下载的信息被复制到由律师事务所代理的公司指定的第二组用户可访问的第二数据管理系统中。维护知识产权管理系统，并包括与多个知识产权相关的数据和与相关事宜相关的多个知识产权事件相关的数据，其中事件源于政府机构，其中知识产权事项表明在管理体系中至少部分由法定代表人管理。私人知识产权信息是从政府机构维护的第一个安全数据源中下载的，其中所述信息涉及安全数据源表明的知识产权问题至少部分与法定代表人相关，并且访问私人知识产权财产信息由与法定代表人相关联的一个或多个安全机制确保。该系统进一步自动将所下载的信息中的至少一些与维护在知识产权管理系统中的数据进行比较，以确定管理系统中指出的与法定代表人有关的知识产权事项与安全数据源中指出的知识产权事项之间的差异与法定代表人有关。

6. 发明申请

US20060190495A1 System and method for purging messages in a legal information system 审中-公开
标题翻译：在法律信息系统中清除邮件的系统和方法
公开(公告)号：US20060190495A1
公开(公告)日：2006-08-24
申请号：US11061385
申请日：2005-02-18
申请人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
发明人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
IPC分类号： G06F17/30
CPC分类号： G06Q10/10
摘要： There is disclosed method and apparatus for storing and processing information in a data storage and processing system used by attorneys, and recording attorney-client communications and communications from a government agency respecting a legal matter. At least some of the attorney-client communications can be designated with a indication that allows them to be identified automatically. These communications can then be automatically identifying and purging at least some of the attorney-client communications upon a request by a user.
摘要翻译：公开了用于在律师使用的数据存储和处理系统中存储和处理信息的方法和装置，并且从法律事务的政府机构记录律师和客户的通信和通信。至少一些律师 - 客户端通信可以被指定为允许自动识别的指示。然后，根据用户的请求，这些通信可以自动识别和清除至少一些律师 - 客户端通信。

7. 发明授权

US08445445B2 Method of promoting hair growth using FGFR4 extracellular domains 有权
标题翻译：使用FGFR4细胞外结构域促进毛发生长的方法
公开(公告)号：US08445445B2
公开(公告)日：2013-05-21
申请号：US13496182
申请日：2010-09-15
申请人： Thomas Brennan , Robert Dean , W. Michael Kavanaugh , Janine Powers
发明人： Thomas Brennan , Robert Dean , W. Michael Kavanaugh , Janine Powers
IPC分类号： A61K38/00 , A61K38/18 , A61K38/16 , C07K14/475 , C07K14/50
CPC分类号： A61Q7/00 , A61K8/64 , A61K2800/86
摘要： The present invention relates to a method of promoting hair growth comprising administering a fibroblast growth factor receptor 4 (FGFR4) extracellular domain (ECD), including native FGFR4 ECDs, variants, fragments, and fusion molecules, to a subject in an amount sufficient to promote hair growth.
摘要翻译：促进毛发生长的方法本发明涉及一种促进毛发生长的方法，其包括以足以促进毛发生长的量给予受试者的成纤维细胞生长因子受体4（FGFR4）细胞外结构域（ECD），包括天然FGFR4 ECD，变体，片段和融合分子头发生长。

8. 发明申请

US20120003222A1 FZD8 EXTRACELLULAR DOMAINS AND FZD8 EXTRACELLULAR DOMAIN FUSION MOLECULES AND TREATMENTS USING SAME 有权
标题翻译： FZD8细胞域和FZD8细胞域融合分子和治疗方法
公开(公告)号：US20120003222A1
公开(公告)日：2012-01-05
申请号：US13169900
申请日：2011-06-27
申请人： Thomas Brennan , Ernestine Lee , Steven Smith
发明人： Thomas Brennan , Ernestine Lee , Steven Smith
IPC分类号： A61K39/395 , C07K14/47 , C07K19/00 , C12N15/62 , C12N15/12 , A61P9/12 , A61P3/10 , A61P3/06 , A61P9/00 , A61P19/08 , A61P11/00 , A61K38/17 , A61P3/04
CPC分类号： A61K38/17 , C07K14/71 , C07K2319/00 , C07K2319/02 , C07K2319/21 , C07K2319/30 , C07K2319/31 , C07K2319/42
摘要： Methods of treatment using Fzd8 extracellular domains (ECDs), Fzd8 ECD fusion molecules, and/or antibodies that bind Fzd8 are provided. Such methods include, but are not limited to, methods of treating obesity and obesity-related conditions. Fzd8 ECDs and Fzd8 ECD fusion molecules are also provided. Polypeptide and polynucleotide sequences, vectors, host cells, and compositions comprising or encoding such molecules are provided. Methods of making and using Fzd8 ECDs, Fzd8 ECD fusion molecules, and antibodies that bind Fzd8 are also provided.
摘要翻译：提供了使用Fzd8细胞外结构域（ECD），Fzd8 ECD融合分子和/或结合Fzd8的抗体的治疗方法。这些方法包括但不限于治疗肥胖症和肥胖相关病症的方法。还提供Fzd8 ECDs和Fzd8 ECD融合分子。提供了多肽和多核苷酸序列，载体，宿主细胞和包含或编码这些分子的组合物。还提供了制备和使用Fzd8 ECDs，Fzd8 ECD融合分子和结合Fzd8的抗体的方法。

9. 发明申请

US20060248607A1 CCR6 chemokine receptor disruptions, compositions and methods relating thereto 审中-公开
标题翻译： CCR6趋化因子受体中断，组合物和方法
公开(公告)号：US20060248607A1
公开(公告)日：2006-11-02
申请号：US11392789
申请日：2006-03-28
申请人： Thomas Brennan , Christopher Kirk , Qin Zhang
发明人： Thomas Brennan , Christopher Kirk , Qin Zhang
IPC分类号： A01K67/027 , C12N5/06
CPC分类号： C07K14/7158 , A01K67/0276 , A01K2217/075 , A01K2227/105 , A01K2267/03 , C12N15/8509
摘要： The present disclosure relates to compositions and methods relating to the characterization and function of CCR6. Specifically, the present disclosure provides transgenic animals comprising disruptions in a CCR6 gene and methods of treating diseases conditions, such as pain, inflammatory bowel disease, rheumatoid arthritis and contact dermatitis. The present disclosure further relates to agents that modulate CCR6 and methods of screening for agents that modulate CCR6 for the treatment of diseases and conditions such as pain, inflammatory bowel disease, rheumatoid arthritis and contact dermatitis.
摘要翻译：本公开涉及与CCR6的表征和功能相关的组合物和方法。具体地，本公开提供了包含CCR6基因中断的转基因动物以及治疗诸如疼痛，炎性肠病，类风湿性关节炎和接触性皮炎等疾病疾病的方法。本公开还涉及调节CCR6的药剂和筛选调节CCR6以治疗疾病和病症例如疼痛，炎性肠病，类风湿性关节炎和接触性皮炎的药剂的方法。

10. 发明申请

US20060190541A1 System and method for public and private messages in an information management system 审中-公开
标题翻译：信息管理系统中公共和私人消息的系统和方法
公开(公告)号：US20060190541A1
公开(公告)日：2006-08-24
申请号：US11061312
申请日：2005-02-18
申请人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
发明人： Steven Lundberg , Thomas Brennan , Janal Kalis , Shal Jain , Pradeep Sinha
IPC分类号： G06F15/16
CPC分类号： G06Q10/10 , G06Q10/107 , H04L51/34
摘要： There is disclosed method and apparatus for storing and processing information in a data storage and processing system used by attorneys, wherein there is sent an electronic message from the processing system to one or more e-mail recipients. An electronic message is received in the processing system from an e-mail sender, with the electronic messages specifying one or more individuals or groups of individuals to receive the electronic message. Individuals specified to receive a message are allowed to view the message, and the message is in association with respective legal matters tracked by the system. Individuals not specified to receive a message are allowed to view a message if the message is designated available to be viewed by those other than the recipients. Further, a user not specified to receive a message viewing the message in connection with viewing data being tracked for a particular legal matter.
摘要翻译：公开了一种在由律师使用的数据存储和处理系统中存储和处理信息的方法和装置，其中从处理系统向一个或多个电子邮件接收者发送电子消息。在处理系统中从电子邮件发送者接收电子消息，其中电子消息指定一个或多个个人或个人组以接收电子消息。允许接收消息的个人查看消息，该消息与系统跟踪的各个法律事项相关联。未指定接收邮件的个人如果该邮件被指定为可被除了收件人之外的其他人查看，则允许查看邮件。此外，没有指定接收与查看数据有关的消息的消息的用户被特定法律事项跟踪。

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