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1. 发明授权

US06676960B2 Intraoral adhesive preparation 失效
标题翻译：口内胶粘剂制备
公开(公告)号：US06676960B2
公开(公告)日：2004-01-13
申请号：US09940946
申请日：2001-08-28
申请人： Junichi Saito , Kazuhisa Ninomiya , Masaaki Ito
发明人： Junichi Saito , Kazuhisa Ninomiya , Masaaki Ito
IPC分类号： A61F1302
CPC分类号： A61K9/006 , Y10T442/2525
摘要： An intraoral adhesive preparation is provided, which contains a support made of a nonwoven fabric mainly made of split type conjugated fibers, and an adhesive plaster layer containing a drug, which is formed on the support, wherein the split type conjugated fiber has an about triangular sectional shape after splitting, where the about triangle has the longest diameter (DL) of 5 &mgr;m-15 &mgr;m, and the longest line segment (DS) that vertically crosses the longest diameter of 2 &mgr;m-10 &mgr;m.
摘要翻译：提供了一种口腔内粘合剂制剂，其包含由主要由分裂型复合纤维制成的无纺布制成的支撑体和在支撑体上形成的含有药物的粘合膏药层，其中分裂型复合纤维具有约三角形分裂后的截面形状，其中近似三角形具有最大直径（DL）为5mum-15μm，以及垂直于最大直径为2mum-10mum的最长线段（DS）。

2. 发明申请

US20060286160A1 Nicotine transdermal delivery system 审中-公开
标题翻译：尼古丁透皮递送系统
公开(公告)号：US20060286160A1
公开(公告)日：2006-12-21
申请号：US11455740
申请日：2006-06-20
申请人： Shiro Satoda , Hidetoshi Kuroda , Junichi Saito , Kazuhisa Ninomiya
发明人： Shiro Satoda , Hidetoshi Kuroda , Junichi Saito , Kazuhisa Ninomiya
IPC分类号： A61K9/70
CPC分类号： A61K31/465 , A61K9/7061
摘要： The present invention provides a nicotine transdermal delivery system including an adhesive layer containing a free base nicotine and a liquid ingredient compatible with the adhesive, wherein the adhesive layer is crosslinked, and the liquid ingredient is contained in a proportion of 20-75 parts by weight, per 100 parts by weight of the adhesive layer as a whole. The nicotine transdermal delivery system has good adhesiveness and cohesion, and simultaneously achieves low irritation to the skin during peeling off and a fine feeling during adhesion.
摘要翻译：本发明提供了一种尼古丁透皮递送系统，其包括含有游离碱性尼古丁和与粘合剂相容的液体成分的粘合剂层，其中粘合剂层交联，并且液体成分的含量为20-75重量份，相对于粘合剂层整体100重量份。尼古丁透皮递送系统具有良好的粘附性和内聚力，同时在剥离期间对皮肤的刺激性低，并且粘合时的细微感觉。

3. 发明申请

US20070087043A1 Nicotine transdermal preparation and production method thereof 失效
标题翻译：尼古丁透皮制剂及其制备方法
公开(公告)号：US20070087043A1
公开(公告)日：2007-04-19
申请号：US11546302
申请日：2006-10-12
申请人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
发明人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
IPC分类号： A61K31/4439 , A61K9/70
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off. The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译：本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感，与剥离时的皮肤刺激性降低，粘合性优异。本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

4. 发明申请

US20070026055A1 Production method of nicotine transdermal preparation 审中-公开
标题翻译：尼古丁透皮制剂的制备方法
公开(公告)号：US20070026055A1
公开(公告)日：2007-02-01
申请号：US11495603
申请日：2006-07-31
申请人： Kazuhisa Ninomiya , Shiro Satoda , Junichi Saito , Hidetoshi Kuroda
发明人： Kazuhisa Ninomiya , Shiro Satoda , Junichi Saito , Hidetoshi Kuroda
IPC分类号： A61K9/70
CPC分类号： A61K9/7061 , A61F2013/0296 , A61K31/465
摘要： The present invention provides a production method of a nicotine transdermal preparation, which includes a step of forming, on a support, an adhesive layer containing an adhesive and a liquid ingredient compatible with the adhesive, and a step of impregnating the adhesive layer with nicotine by continuously applying nicotine to the adhesive layer. The production method of the present invention permits direct application of nicotine to the adhesive layer, which is not possible by conventional techniques, and the nicotine transdermal preparation provided by the method is associated with less physical skin irritation on peeling off and affords a good feeling during adhesion.
摘要翻译：本发明提供了一种尼古丁透皮制剂的制造方法，其包括在载体上形成含有粘合剂的粘合剂层和与粘合剂相容的液体成分的工序，以及通过使用尼古丁浸渍粘合剂层的工序将尼古丁连续地施加到粘合剂层。本发明的制造方法允许将尼古丁直接施用于粘合剂层，这通过常规技术是不可能的，并且通过该方法提供的尼古丁透皮制剂与剥离时较少的物理皮肤刺激相关联并且在剥离期间提供良好的感觉附着力。

5. 发明授权

US06387392B1 Intraoral adhesive preparation 失效
标题翻译：口内胶粘剂制备
公开(公告)号：US06387392B1
公开(公告)日：2002-05-14
申请号：US09935437
申请日：2001-08-23
申请人： Junichi Saito , Kazuhisa Ninomiya
发明人： Junichi Saito , Kazuhisa Ninomiya
IPC分类号： A61F1300
CPC分类号： A61K9/006 , Y10T442/2525
摘要： An intraoral adhesive preparation is provided, which has a support made of a cloth, and a pressure-sensitive adhesive layer containing a drug, which is formed on one surface of the support, wherein the dissolution of the drug into water from the surface of the support, which surface being free of a pressure-sensitive adhesive layer, after immersion in water at 32° C. for 20 minutes, is not more than 25 wt % of the total content of the drug.
摘要翻译：提供了一种口腔内粘合剂制剂，其具有由布制成的支撑体和在载体的一个表面上形成的含有药物的压敏粘合剂层，其中药物从水溶液在32℃水中浸渍20分钟后，表面不含压敏粘合剂层的载体不超过药物总含量的25重量％。

6. 发明授权

US08506991B2 Nicotine transdermal preparation and production method thereof 失效
标题翻译：尼古丁透皮制剂及其制备方法
公开(公告)号：US08506991B2
公开(公告)日：2013-08-13
申请号：US11546302
申请日：2006-10-12
申请人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
发明人： Shiro Satoda , Kazuhisa Ninomiya , Junichi Saito , Kensuke Matsuoka , Shunetsu Kikuchi
IPC分类号： A61L15/16 , A61K9/70 , A61K31/465 , A61K47/14
CPC分类号： A61K9/7061 , A61K31/465 , A61K47/14
摘要： The present invention provides a production method of a nicotine transdermal preparation, which is capable of producing a nicotine transdermal preparation conveniently and economically, while maintaining highly precise content uniformity, which is capable of producing a preparation simultaneously achieving fixedness and a soft feeling during adhesion, associated with reduced skin irritation upon peeling off and superior in adhesive property. The present invention provides a nicotine transdermal preparation superior in content uniformity, simultaneously achieving fixedness and a soft feeling during adhesion, and showing reduced skin irritation upon peeling off.The present invention provides a method of producing a preparation containing a support and an adhesive layer formed thereon, which adhesive layer containing nicotine and a liquid ingredient compatible with the adhesive, which method includes (1) providing the adhesive layer wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°, and (2) applying nicotine to the adhesive layer to allow absorption of nicotine into the adhesive layer, as well as a preparation containing a support and an adhesive layer formed thereon, which adhesive layer including nicotine and a liquid ingredient compatible with the adhesive, wherein a contact angle of nicotine with the adhesive layer before containing nicotine is 20-60°.
摘要翻译：本发明提供了一种尼古丁透皮制剂的制备方法，其能够方便且经济地制备尼古丁透皮制剂，同时保持高精度的含量均匀性，其能够同时制备粘合期间的固定性和柔软感，与剥离时的皮肤刺激性降低，粘合性优异。本发明提供了含量均匀性优异的尼古丁透皮制剂，同时达到粘合时的固定性和柔软感，并且在剥离时显示出减少的皮肤刺激性。本发明提供一种制备含有载体和粘合剂层的制剂的方法，该粘合剂层含有尼古丁和与粘合剂相容的液体成分的粘合剂层，该方法包括（1）提供粘合剂层，其中尼古丁的接触角含尼古丁之前的粘合剂层为20-60°，和（2）向粘合剂层施加尼古丁以允许将尼古丁吸收到粘合剂层中，以及含有形成在其上的载体和粘合剂层的制剂，该粘合剂包括尼古丁和与粘合剂相容的液体成分的层，其中尼古丁与包含尼古丁之前的粘合剂层的接触角为20-60°。

7. 发明申请

US20050271713A1 Topical anesthetic preparation for pretreatment for upper gastrointestinal endoscopy 审中-公开
标题翻译：用于上消化道内窥镜检查的局部麻醉剂预处理
公开(公告)号：US20050271713A1
公开(公告)日：2005-12-08
申请号：US11146335
申请日：2005-06-06
申请人： Junichi Saito , Kazuhisa Ninomiya
发明人： Junichi Saito , Kazuhisa Ninomiya
IPC分类号： A61K9/00 , A61K9/70 , A61K45/00 , A61K47/30 , A61P23/02 , A61F13/02 , A61L15/16
CPC分类号： A61K9/0053 , A61K9/006 , A61K9/7061
摘要： The topical anesthetic preparation of the present invention for a pretreatment for upper gastrointestinal endoscopy includes a long support having a stiffness of 40-150 mm, and a plaster layer containing at least a topical anesthetic and an adhesive polymer, which is formed on one surface or both surfaces of one end in the longitudinal direction of the support, and preferably, a gripper of a given structure. The topical anesthetic preparation shows a high drug utilization rate and preferably can easily identify use or non-use.
摘要翻译：用于上消化道内窥镜检查的预处理的本发明的局部麻醉剂制剂包括具有40-150mm的刚度的长支撑体和至少含有局部麻醉剂和粘合剂聚合物的膏药层，其形成在一个表面上或在支撑件的纵向方向上的一端的两个表面，并且优选地，具有给定结构的夹持器。局部麻醉剂制剂显示出高的药物利用率，优选可以容易地鉴定使用或不使用。

8. 发明申请

US20060165764A1 Tape preparation 审中-公开
标题翻译：磁带准备
公开(公告)号：US20060165764A1
公开(公告)日：2006-07-27
申请号：US11334386
申请日：2006-01-19
申请人： Akinori Hanatani , Masaaki Ito , Junichi Saito
发明人： Akinori Hanatani , Masaaki Ito , Junichi Saito
IPC分类号： A61L15/16
CPC分类号： A61K9/7007 , A61K9/7053 , A61K9/7061 , A61K31/00 , C08K5/101 , C09J7/383 , C09J2205/102
摘要： The present invention provides a tape preparation including a support and an adhesive layer directly or indirectly formed on at least one surface of the support, wherein the adhesive layer contains a rubber adhesive containing at least one kind of rubber polymer and capsaicin as an active ingredient. Since the adhesive layer shows extremely fine adhesive property and superior capsaicin releaseability, a rapid pharmacological effect can be afforded with a small capsaicin content.
摘要翻译：本发明提供了一种胶带制剂，其包括直接或间接形成在载体的至少一个表面上的载体和粘合剂层，其中粘合剂层含有含有至少一种橡胶聚合物和辣椒素作为活性成分的橡胶粘合剂。由于粘合剂层显示出非常好的粘附性和优异的辣椒素释放性，所以可以获得较小的辣椒素含量的快速药理作用。

9. 发明授权

US09062844B2 Vehicular lamp 有权
标题翻译：车灯
公开(公告)号：US09062844B2
公开(公告)日：2015-06-23
申请号：US13794373
申请日：2013-03-11
申请人： Junichi Saito
发明人： Junichi Saito
IPC分类号： F21S8/10
CPC分类号： F21S48/1241 , F21S41/141 , F21S41/147 , F21S41/24 , F21S43/14 , F21S43/237 , F21S43/245 , F21S43/247 , F21S43/40
摘要： A clearance lamp (20) including a light source (21) and a light guide (23) that allows light from the light source (21) to enter from an end face of the light guide (23) and emits the light forward from an emitting surface (23b) while guiding the light in the interior of the light guide (23). The emitting surface (23b) extends along a direction in which the light guide (23) extends. The light guide (23) includes steps (23c) that reflect the light traveling through the light guide toward the emitting surface (23b), and it further includes a light-emitting surface (23d) that is formed at a position different from a position of the light-emitting surface (23b) and emits the light traveling through the light guide to the outside of the light guide.
摘要翻译：一种包括光源（21）和光导（23）的间隙灯（20），其允许来自光源（21）的光从光导（23）的端面入射并从光源（23b），同时引导光线（23）的内部的光。发射表面（23b）沿着光导（23）延伸的方向延伸。导光体（23）包括使穿过导光体的光朝向发光面（23b）反射的台阶（23c），还包括形成在与位置不同的位置的发光面（23d）（23b），并将通过导光体的光发射到光导的外部。

10. 发明申请

US20130188379A1 Vehicular Illumination Lamp 有权
标题翻译：车灯照明灯
公开(公告)号：US20130188379A1
公开(公告)日：2013-07-25
申请号：US13742622
申请日：2013-01-16
申请人： Junichi Saito , Hiroyuki Makino
发明人： Junichi Saito , Hiroyuki Makino
IPC分类号： F21S8/10
CPC分类号： F21S41/32 , F21S41/162 , F21S41/336 , F21S41/337 , F21S41/435
摘要： A parabola type vehicular illumination lamp that forms a low-beam distribution pattern with a horizontal cut-off line at its upper end, including a reflector (34) formed in its lower reflection area (34a1) with a light non-incident area (34aL1) on which light from a light source bulb (32) is not incident since the light is blocked by a shade (36) provided in front of the light source bulb (32). The light non-incident area (34aL1) of the reflector (34) has an additional reflection portion (34aL1A) for reflecting light, which is from the light source bulb (32) and reflected by the upper reflection area (34au) of the reflector (34) and then reflected by the upper area (14u) of a translucent cover (14), in a direction below the horizontal cut-off line of the low-beam distribution pattern.
摘要翻译：一种抛物线型车辆照明灯，其在其上端形成具有水平切断线的近光分布图案，包括形成在其下反射区域（34a1）中的反射器（34），具有光非入射区域（34aL1 ），由于光被设置在光源灯泡（32）前面的阴罩（36）遮挡，来自光源灯泡（32）的光不会入射。反射器（34）的光非入射区域（34aL1）具有用于反射来自光源灯泡（32）并由反射器的上反射区域（34au）反射的光的附加反射部分（34aL1A）（34），然后由半透明盖（14）的上部区域（14u）沿着远光分布图案的水平截止线的方向反射。

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