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1. 发明授权

US5948637A Human and rat hypoxic stress proteins and DNAs encoding therefor 失效
标题翻译：人和大鼠缺氧胁迫蛋白及其编码的DNA
公开(公告)号：US5948637A
公开(公告)日：1999-09-07
申请号：US770301
申请日：1996-12-20
申请人： Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
发明人： Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
IPC分类号： A61K38/00 , C07K14/435 , C07K14/47 , C12N15/12 , C07K16/18 , C12N15/70
CPC分类号： C07K14/47 , C07K14/435 , A61K38/00
摘要： A polypeptide obtainable by inducement under hypoxic conditions having a sequence comprising: (a) the amino acid sequence of SEQ ID NO:1 or 3 or a fragment thereof; (b) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2 or 4 or a fragment thereof; or (c) an amino acid sequence resulting from deletion, addition, insertion or substitution of one or more amino acids in the amino acid sequence of SEQ ID NO:1 or 3; a polynucleotide encoding the above polypeptide or the fragment thereof useful for producing the above polypeptide by a biotechnological technique; and an antibody or fragment thereof specifically binding the above polypeptide.
摘要翻译：通过在缺氧条件下诱导获得的多肽，其具有包含以下序列的序列：（a）SEQ ID NO：1或3的氨基酸序列或其片段; （b）由SEQ ID NO：2或4的核苷酸序列或其片段编码的氨基酸序列; 或（c）由SEQ ID NO：1或3的氨基酸序列中的一个或多个氨基酸的缺失，添加，插入或取代产生的氨基酸序列; 编码上述多肽或其片段的多核苷酸可用于通过生物技术生产上述多肽; 以及特异性结合上述多肽的抗体或其片段。

2. 发明授权

US6034232A Stress proteins 失效
标题翻译：应激蛋白
公开(公告)号：US6034232A
公开(公告)日：2000-03-07
申请号：US175581
申请日：1998-10-20
申请人： Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
发明人： Jun Ikeda , Sumiko Kaneda , Hideki Yanagi , Masayasu Matsumoto , Takashi Yura
IPC分类号： A61K38/00 , C07K14/435 , C07K14/47 , C12N15/12 , C12N15/67 , C12N15/85
CPC分类号： C07K14/47 , C07K14/435 , A61K38/00
摘要： A polypeptide obtainable by inducement under hypoxic conditions having a sequence comprising:(a) the amino acid sequence of SEQ ID NO:1 or 3 or a fragment thereof; (b) an amino acid sequence encoded by the nucleotide sequence of SEQ ID NO: 2 or 4 or a fragment thereof; or (c) an amino acid sequence resulting from deletion, addition, insertion or substitution of one or more amino acids in the amino acid sequence of SEQ ID NO:1 or 3; a polynucleotide encoding the above polypeptide or the fragment thereof useful for producing the above polypeptide by a biotechnological technique; and an antibody or fragment thereof specifically binding the above polypeptide.
摘要翻译：通过在缺氧条件下诱导获得的多肽，其具有包含以下序列的序列：（a）SEQ ID NO：1或3的氨基酸序列或其片段; （b）由SEQ ID NO：2或4的核苷酸序列或其片段编码的氨基酸序列; 或（c）由SEQ ID NO：1或3的氨基酸序列中的一个或多个氨基酸的缺失，添加，插入或取代产生的氨基酸序列; 编码上述多肽或其片段的多核苷酸可用于通过生物技术生产上述多肽; 以及特异性结合上述多肽的抗体或其片段。

3. 发明授权

US06635751B1 Isolated nucleic acids encoding activated and suppressive forms of ATF6 失效
标题翻译：分离的核酸编码ATF6的激活和抑制形式
公开(公告)号：US06635751B1
公开(公告)日：2003-10-21
申请号：US09831642
申请日：2001-08-13
申请人： Kyosuke Haze , Hiderou Yoshida , Kazutoshi Mori , Hideki Yanagi , Takashi Yura
发明人： Kyosuke Haze , Hiderou Yoshida , Kazutoshi Mori , Hideki Yanagi , Takashi Yura
IPC分类号： C12N1512
CPC分类号： C07K14/4702
摘要： A factor capable of efficiently regulating expression of an endoplasmic chaperone gene, a nucleic acid encoding it, a complementary strand nucleic acid thereof, a method for regulating expression of an endoplasmic reticulum chaperone gene, and a method for expressing a foreign gene is provided. The endoplasmic reticulum stress transcription factor is capable of regulating transcription-inducing activity, wherein the transcription-inducing activity is exhibited by an element having the nucleotide sequence shown in SEQ ID NO:1 or an element having a nucleotide sequence resulting from substitution of 1 to 3 bases with other bases in the nucleotide sequence as shown in SEQ ID NO:1. A method for controlling expression of an endoplasmic reticulum chaperone, comprising expressing the factor; a method for expressing a foreign protein, comprising positively regulating expression of an endoplasmic reticulum chaperone gene by the method for controlling expression; and a nucleic acid encoding activated form of ATF6, activated form of CREB-RP, suppressive form of ATF6, or suppressive form of CREB-RP, or the complementary strand thereto are also provided. It is expected to be applied to treatment or prophylaxis of cancers, arteriosclerosis, cystic fibrosis, ischemic diseases, wounds or ulcers.
摘要翻译：提供能够有效调节内质谱伴侣基因表达的因子，编码它的核酸，其互补链核酸，调节内质网伴侣蛋白基因表达的方法和表达外源基因的方法。内质网应激转录因子能够调节转录诱导活性，其中转录诱导活性由具有SEQ ID NO：1所示核苷酸序列的元件或具有1〜 3碱基与核苷酸序列中的其他碱基如SEQ ID NO：1所示。一种控制内质网伴侣蛋白表达的方法，包括表达因子; 用于表达外源蛋白质的方法，其包括通过控制表达的方法阳性调节内质网伴侣蛋白基因的表达; 并且还提供编码ATF6的活化形式，CREB-RP的活化形式，ATF6的抑制形式或CREB-RP的抑制形式或其互补链的核酸。预期可用于治疗或预防癌症，动脉硬化，囊性纤维化，缺血性疾病，伤口或溃疡。

4. 发明授权

US06197547B1 Trigger factor expression plasmids 失效
标题翻译：触发因子表达质粒
公开(公告)号：US06197547B1
公开(公告)日：2001-03-06
申请号：US09472971
申请日：1999-12-28
申请人： Kazuyo Sogo , Hideki Yanagi , Takashi Yura
发明人： Kazuyo Sogo , Hideki Yanagi , Takashi Yura
IPC分类号： C12N1563
CPC分类号： C12N15/70 , C07K14/47 , C07K14/78
摘要： An artificial operon comprising genes encoding each of a trigger factor, GroEL and GroES, an expression plasmid carrying the operon, an expression plasmid carrying a gene encoding the trigger factor, a cotransformant harboring an expression vector for a foreign protein and any one of the expression plasmids, and a method for producing a foreign protein comprising expressing a foreign protein by the use of the cotransformant, which are capable of expressing a foreign protein in a solubilized form and in a state of having a correct conformation.
摘要翻译：包含编码触发因子，GroEL和GroES各自的基因的人造操纵子，携带操纵子的表达质粒，携带编码引发因子的基因的表达质粒，携带外源蛋白质的表达载体的共转化体和表达质粒和生产外源蛋白的方法，其包括通过使用能够以增溶形式表达外源蛋白并且具有正确构象的状态的共转化体来表达外源蛋白。

5. 发明授权

US06673569B1 DsbA/DsbB/DsbC/DsbD expression plasmid 失效
标题翻译： DsbA / DsbB / DsbC / DsbD表达质粒
公开(公告)号：US06673569B1
公开(公告)日：2004-01-06
申请号：US09393171
申请日：1999-09-09
申请人： Yoichi Kurokawa , Hideki Yanagi , Takashi Yura
发明人： Yoichi Kurokawa , Hideki Yanagi , Takashi Yura
IPC分类号： C12P2106
CPC分类号： C12N9/0051 , C07K1/1133 , C07K14/245
摘要： An artificial operon comprising polynucleotides encoding each of DsbA, DsbB, DsbC and DsbD; an expression plasmid carrying the above artificial operon, usable for expression of DsbA, DsbB, DsbC and DsbD; a cotransformant harboring the above expression plasmid and an expression vector for a foreign protein; and a method for producing a foreign protein comprising culturing the cotransformant.
摘要翻译：包含编码DsbA，DsbB，DsbC和DsbD各自的多核苷酸的人造操纵子; 携带上述人造操纵子的表达质粒，可用于表达DsbA，DsbB，DsbC和DsbD; 含有上述表达质粒的共转化体和外来蛋白质的表达载体; 以及外源蛋白质的制造方法，其特征在于，含有培养共转化体。

6. 发明授权

US06485936B1 Heat shock transcription factor-binding protein 失效
标题翻译：热休克转录因子结合蛋白
公开(公告)号：US06485936B1
公开(公告)日：2002-11-26
申请号：US09582441
申请日：2000-08-14
申请人： Tadahiko Yoshima , Hideki Yanagi , Takashi Yura
发明人： Tadahiko Yoshima , Hideki Yanagi , Takashi Yura
IPC分类号： C12N1500
CPC分类号： C07K14/4705
摘要： To provide a heat shock transcription factor (HSF) 2 binding factor, which can be involved in the transcriptional regulation of HSP70.2 playing an essential role in spermatogenesis; a DNA encoding the binding factor; an expression vector carrying the DNA; a transformant harboring the expression vector; a process for preparing a recombinant protein comprising the step of culturing the transformant; an antibody or a fragment thereof capable of specifically binding to the binding factor; an antisense DNA or antisense RNA complementary to the DNA; and an oligonudeotide probe or primer capable of specifically hybridizing to the DNA.
摘要翻译：提供热休克转录因子（HSF）2结合因子，其可参与HSP70.2的转录调控，在精子发生中起重要作用; 编码结合因子的DNA; 携带DNA的表达载体; 携带表达载体的转化体; 一种制备重组蛋白质的方法，包括培养转化体的步骤; 能够特异性结合结合因子的抗体或其片段; 与DNA互补的反义DNA或反义RNA; 以及能够与DNA特异性杂交的寡核苷酸探针或引物。

7. 发明授权

US6159708A Chaperone expression plasmids 失效
标题翻译：伴侣表达质粒
公开(公告)号：US6159708A
公开(公告)日：2000-12-12
申请号：US100110
申请日：1998-06-19
申请人： Kazuyo Sogo , Hideki Yanagi , Takashi Yura
发明人： Kazuyo Sogo , Hideki Yanagi , Takashi Yura
IPC分类号： C12N15/09 , C07K14/005 , C07K14/245 , C07K14/415 , C07K14/47 , C07K14/48 , C07K14/49 , C07K14/50 , C07K14/51 , C07K14/52 , C07K14/61 , C07K14/62 , C07K14/65 , C07K14/705 , C07K14/745 , C07K14/765 , C07K14/81 , C07K16/18 , C12N1/21 , C12N9/12 , C12N9/64 , C12N15/70 , C12P21/02 , C12R1/19 , C12P21/06
CPC分类号： C12N15/70 , C07K14/245 , C07K14/415 , C07K14/47
摘要： An artificial operon comprising polynucleotides encoding each of chaperones DnaK, DnaJ and GrpE; an expression plasmid carrying the operon; a cotransformant prepared by introducing the expression plasmid into E. coli together with a foreign protein expression vector; and a method for producing a foreign protein comprising using the cotransformant.
摘要翻译：包含编码伴侣伴侣DnaK，DnaJ和GrpE各自的多核苷酸的人造操纵子; 携带操纵子的表达质粒; 通过将表达质粒与外来蛋白质表达载体一起导入大肠杆菌中制备的共转化体; 以及包含使用共转化体的外源蛋白质的制造方法。

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